Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A451EJ92_LEIDO

TriTrypDb:

LdBPK_010370.1 , LdCL_010008700 , LDHU3_01.0400

Length:

747

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A451EJ92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJ92

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	388	390	PF00675	0.439
CLV_NRD_NRD_1	395	397	PF00675	0.585
CLV_NRD_NRD_1	406	408	PF00675	0.492
CLV_NRD_NRD_1	45	47	PF00675	0.455
CLV_NRD_NRD_1	582	584	PF00675	0.494
CLV_NRD_NRD_1	742	744	PF00675	0.717
CLV_NRD_NRD_1	97	99	PF00675	0.516
CLV_PCSK_KEX2_1	390	392	PF00082	0.499
CLV_PCSK_KEX2_1	395	397	PF00082	0.605
CLV_PCSK_KEX2_1	406	408	PF00082	0.492
CLV_PCSK_KEX2_1	45	47	PF00082	0.445
CLV_PCSK_KEX2_1	582	584	PF00082	0.494
CLV_PCSK_KEX2_1	742	744	PF00082	0.717
CLV_PCSK_KEX2_1	97	99	PF00082	0.505
CLV_PCSK_PC1ET2_1	390	392	PF00082	0.499
CLV_PCSK_PC7_1	391	397	PF00082	0.657
CLV_PCSK_SKI1_1	330	334	PF00082	0.426
CLV_PCSK_SKI1_1	395	399	PF00082	0.650
CLV_PCSK_SKI1_1	442	446	PF00082	0.745
CLV_PCSK_SKI1_1	623	627	PF00082	0.563
DEG_APCC_DBOX_1	519	527	PF00400	0.623
DEG_SPOP_SBC_1	218	222	PF00917	0.598
DEG_SPOP_SBC_1	308	312	PF00917	0.439
DEG_SPOP_SBC_1	419	423	PF00917	0.834
DEG_SPOP_SBC_1	427	431	PF00917	0.777
DEG_SPOP_SBC_1	663	667	PF00917	0.508
DOC_CYCLIN_RxL_1	436	448	PF00134	0.583
DOC_CYCLIN_yClb5_NLxxxL_5	28	37	PF00134	0.518
DOC_CYCLIN_yCln2_LP_2	322	328	PF00134	0.495
DOC_CYCLIN_yCln2_LP_2	48	54	PF00134	0.364
DOC_MAPK_DCC_7	45	54	PF00069	0.484
DOC_MAPK_gen_1	333	342	PF00069	0.392
DOC_MAPK_gen_1	565	574	PF00069	0.531
DOC_MAPK_gen_1	97	104	PF00069	0.495
DOC_MAPK_HePTP_8	94	106	PF00069	0.483
DOC_MAPK_MEF2A_6	131	139	PF00069	0.420
DOC_MAPK_MEF2A_6	336	344	PF00069	0.386
DOC_MAPK_MEF2A_6	97	106	PF00069	0.519
DOC_MAPK_NFAT4_5	339	347	PF00069	0.370
DOC_PP1_RVXF_1	101	107	PF00149	0.496
DOC_PP1_RVXF_1	272	279	PF00149	0.377
DOC_PP2B_LxvP_1	322	325	PF13499	0.493
DOC_USP7_MATH_1	218	222	PF00917	0.609
DOC_USP7_MATH_1	250	254	PF00917	0.460
DOC_USP7_MATH_1	308	312	PF00917	0.530
DOC_USP7_MATH_1	418	422	PF00917	0.752
DOC_USP7_MATH_1	428	432	PF00917	0.789
DOC_USP7_MATH_1	548	552	PF00917	0.569
DOC_USP7_MATH_1	663	667	PF00917	0.650
DOC_USP7_MATH_1	688	692	PF00917	0.617
DOC_USP7_MATH_1	701	705	PF00917	0.622
DOC_USP7_UBL2_3	626	630	PF12436	0.566
DOC_WW_Pin1_4	296	301	PF00397	0.393
DOC_WW_Pin1_4	421	426	PF00397	0.772
DOC_WW_Pin1_4	7	12	PF00397	0.493
LIG_14-3-3_CanoR_1	154	164	PF00244	0.306
LIG_14-3-3_CanoR_1	208	212	PF00244	0.405
LIG_14-3-3_CanoR_1	292	297	PF00244	0.492
LIG_14-3-3_CanoR_1	371	375	PF00244	0.543
LIG_14-3-3_CanoR_1	378	386	PF00244	0.528
LIG_14-3-3_CanoR_1	389	394	PF00244	0.420
LIG_14-3-3_CanoR_1	395	400	PF00244	0.609
LIG_14-3-3_CanoR_1	436	445	PF00244	0.741
LIG_14-3-3_CanoR_1	45	49	PF00244	0.395
LIG_14-3-3_CanoR_1	452	460	PF00244	0.811
LIG_14-3-3_CanoR_1	528	533	PF00244	0.572
LIG_14-3-3_CanoR_1	582	588	PF00244	0.493
LIG_14-3-3_CanoR_1	597	606	PF00244	0.469
LIG_14-3-3_CanoR_1	623	629	PF00244	0.543
LIG_14-3-3_CanoR_1	641	647	PF00244	0.354
LIG_Actin_WH2_2	125	143	PF00022	0.524
LIG_Actin_WH2_2	229	246	PF00022	0.473
LIG_Actin_WH2_2	362	380	PF00022	0.585
LIG_Actin_WH2_2	574	591	PF00022	0.567
LIG_APCC_ABBA_1	143	148	PF00400	0.468
LIG_BIR_II_1	1	5	PF00653	0.413
LIG_BRCT_BRCA1_1	187	191	PF00533	0.470
LIG_eIF4E_1	297	303	PF01652	0.457
LIG_FHA_1	10	16	PF00498	0.360
LIG_FHA_1	231	237	PF00498	0.678
LIG_FHA_1	252	258	PF00498	0.451
LIG_FHA_1	377	383	PF00498	0.507
LIG_FHA_1	591	597	PF00498	0.604
LIG_FHA_2	371	377	PF00498	0.540
LIG_FHA_2	446	452	PF00498	0.760
LIG_FHA_2	599	605	PF00498	0.430
LIG_FHA_2	80	86	PF00498	0.475
LIG_GBD_Chelix_1	29	37	PF00786	0.391
LIG_IBAR_NPY_1	239	241	PF08397	0.410
LIG_LIR_Apic_2	294	300	PF02991	0.355
LIG_LIR_Gen_1	277	285	PF02991	0.450
LIG_LIR_Gen_1	323	334	PF02991	0.384
LIG_LIR_Gen_1	85	95	PF02991	0.456
LIG_LIR_LC3C_4	691	696	PF02991	0.479
LIG_LIR_Nem_3	109	114	PF02991	0.332
LIG_LIR_Nem_3	199	205	PF02991	0.334
LIG_LIR_Nem_3	277	281	PF02991	0.465
LIG_LIR_Nem_3	295	301	PF02991	0.399
LIG_LIR_Nem_3	323	329	PF02991	0.385
LIG_LIR_Nem_3	85	90	PF02991	0.453
LIG_MLH1_MIPbox_1	188	192	PF16413	0.443
LIG_MYND_1	734	738	PF01753	0.567
LIG_NRBOX	159	165	PF00104	0.457
LIG_NRBOX	3	9	PF00104	0.509
LIG_NRBOX	608	614	PF00104	0.427
LIG_REV1ctd_RIR_1	109	117	PF16727	0.389
LIG_RPA_C_Fungi	93	105	PF08784	0.483
LIG_SH2_GRB2like	500	503	PF00017	0.596
LIG_SH2_NCK_1	507	511	PF00017	0.707
LIG_SH2_PTP2	345	348	PF00017	0.508
LIG_SH2_SRC	326	329	PF00017	0.348
LIG_SH2_SRC	345	348	PF00017	0.513
LIG_SH2_SRC	500	503	PF00017	0.564
LIG_SH2_STAP1	570	574	PF00017	0.568
LIG_SH2_STAT3	681	684	PF00017	0.584
LIG_SH2_STAT5	241	244	PF00017	0.498
LIG_SH2_STAT5	297	300	PF00017	0.337
LIG_SH2_STAT5	321	324	PF00017	0.479
LIG_SH2_STAT5	345	348	PF00017	0.509
LIG_SH2_STAT5	42	45	PF00017	0.468
LIG_SH2_STAT5	500	503	PF00017	0.564
LIG_SH2_STAT5	681	684	PF00017	0.494
LIG_SH3_3	17	23	PF00018	0.526
LIG_SH3_3	302	308	PF00018	0.477
LIG_SH3_3	394	400	PF00018	0.734
LIG_SH3_3	422	428	PF00018	0.751
LIG_SUMO_SIM_anti_2	299	305	PF11976	0.382
LIG_SUMO_SIM_par_1	279	284	PF11976	0.410
LIG_SUMO_SIM_par_1	303	314	PF11976	0.498
LIG_SUMO_SIM_par_1	656	662	PF11976	0.678
LIG_TRAF2_1	491	494	PF00917	0.763
LIG_TRAF2_1	552	555	PF00917	0.575
LIG_TRAF2_1	77	80	PF00917	0.425
LIG_TYR_ITIM	324	329	PF00017	0.342
LIG_UBA3_1	638	643	PF00899	0.576
LIG_WRC_WIRS_1	275	280	PF05994	0.476
MOD_CK1_1	223	229	PF00069	0.660
MOD_CK1_1	279	285	PF00069	0.299
MOD_CK1_1	311	317	PF00069	0.690
MOD_CK1_1	421	427	PF00069	0.746
MOD_CK1_1	431	437	PF00069	0.686
MOD_CK1_1	659	665	PF00069	0.686
MOD_CK1_1	676	682	PF00069	0.484
MOD_CK1_1	9	15	PF00069	0.479
MOD_CK2_1	370	376	PF00069	0.612
MOD_CK2_1	445	451	PF00069	0.812
MOD_CK2_1	548	554	PF00069	0.615
MOD_CK2_1	560	566	PF00069	0.417
MOD_CK2_1	598	604	PF00069	0.555
MOD_GlcNHglycan	157	160	PF01048	0.426
MOD_GlcNHglycan	227	230	PF01048	0.633
MOD_GlcNHglycan	379	382	PF01048	0.411
MOD_GlcNHglycan	503	506	PF01048	0.685
MOD_GlcNHglycan	550	553	PF01048	0.582
MOD_GlcNHglycan	562	565	PF01048	0.589
MOD_GlcNHglycan	590	593	PF01048	0.563
MOD_GlcNHglycan	661	664	PF01048	0.649
MOD_GlcNHglycan	690	693	PF01048	0.579
MOD_GlcNHglycan	712	715	PF01048	0.746
MOD_GlcNHglycan	717	720	PF01048	0.770
MOD_GlcNHglycan	723	726	PF01048	0.613
MOD_GSK3_1	155	162	PF00069	0.307
MOD_GSK3_1	218	225	PF00069	0.581
MOD_GSK3_1	292	299	PF00069	0.454
MOD_GSK3_1	307	314	PF00069	0.637
MOD_GSK3_1	328	335	PF00069	0.395
MOD_GSK3_1	349	356	PF00069	0.419
MOD_GSK3_1	427	434	PF00069	0.674
MOD_GSK3_1	443	450	PF00069	0.787
MOD_GSK3_1	624	631	PF00069	0.515
MOD_GSK3_1	649	656	PF00069	0.506
MOD_GSK3_1	659	666	PF00069	0.526
MOD_GSK3_1	710	717	PF00069	0.690
MOD_N-GLC_1	250	255	PF02516	0.478
MOD_N-GLC_1	501	506	PF02516	0.666
MOD_N-GLC_2	155	157	PF02516	0.436
MOD_N-GLC_2	38	40	PF02516	0.460
MOD_NEK2_1	112	117	PF00069	0.329
MOD_NEK2_1	224	229	PF00069	0.615
MOD_NEK2_1	262	267	PF00069	0.372
MOD_NEK2_1	365	370	PF00069	0.395
MOD_NEK2_1	377	382	PF00069	0.423
MOD_NEK2_1	444	449	PF00069	0.746
MOD_NEK2_1	588	593	PF00069	0.550
MOD_NEK2_1	624	629	PF00069	0.527
MOD_PIKK_1	112	118	PF00454	0.334
MOD_PIKK_1	164	170	PF00454	0.480
MOD_PIKK_1	461	467	PF00454	0.668
MOD_PKA_1	389	395	PF00069	0.606
MOD_PKA_2	164	170	PF00069	0.371
MOD_PKA_2	207	213	PF00069	0.475
MOD_PKA_2	291	297	PF00069	0.489
MOD_PKA_2	370	376	PF00069	0.452
MOD_PKA_2	377	383	PF00069	0.389
MOD_PKA_2	395	401	PF00069	0.607
MOD_PKA_2	405	411	PF00069	0.679
MOD_PKA_2	44	50	PF00069	0.388
MOD_PKA_2	560	566	PF00069	0.515
MOD_PKA_2	581	587	PF00069	0.491
MOD_PKA_2	701	707	PF00069	0.706
MOD_PKA_2	719	725	PF00069	0.766
MOD_Plk_1	250	256	PF00069	0.519
MOD_Plk_1	286	292	PF00069	0.335
MOD_Plk_1	653	659	PF00069	0.579
MOD_Plk_4	207	213	PF00069	0.488
MOD_Plk_4	251	257	PF00069	0.441
MOD_Plk_4	292	298	PF00069	0.404
MOD_Plk_4	54	60	PF00069	0.438
MOD_Plk_4	653	659	PF00069	0.560
MOD_ProDKin_1	296	302	PF00069	0.391
MOD_ProDKin_1	421	427	PF00069	0.765
MOD_ProDKin_1	7	13	PF00069	0.498
MOD_SUMO_for_1	552	555	PF00179	0.560
MOD_SUMO_for_1	613	616	PF00179	0.434
MOD_SUMO_rev_2	331	340	PF00179	0.421
MOD_SUMO_rev_2	384	392	PF00179	0.500
TRG_DiLeu_BaEn_4	554	560	PF01217	0.502
TRG_DiLeu_BaLyEn_6	297	302	PF01217	0.353
TRG_DiLeu_BaLyEn_6	440	445	PF01217	0.579
TRG_ENDOCYTIC_2	321	324	PF00928	0.416
TRG_ENDOCYTIC_2	326	329	PF00928	0.370
TRG_ER_diArg_1	394	396	PF00400	0.589
TRG_ER_diArg_1	405	407	PF00400	0.721
TRG_ER_diArg_1	44	46	PF00400	0.424
TRG_ER_diArg_1	581	583	PF00400	0.489
TRG_ER_diArg_1	742	744	PF00400	0.717
TRG_NES_CRM1_1	134	149	PF08389	0.434
TRG_Pf-PMV_PEXEL_1	597	602	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6N7	Leptomonas seymouri	60%	100%
A0A1X0P2P6	Trypanosomatidae	37%	100%
A0A422NY96	Trypanosoma rangeli	38%	100%
A4H361	Leishmania braziliensis	76%	99%
A4HRF8	Leishmania infantum	99%	100%
C9ZXI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AC26	Leishmania major	94%	100%
E9AJC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	98%
V5D5U6	Trypanosoma cruzi	37%	100%