Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A451EJ88_LEIDO

TriTrypDb:

LdBPK_010320.1 , LdCL_010008200 , LDHU3_01.0350

Length:

143

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A451EJ88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJ88

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.362
CLV_NRD_NRD_1	17	19	PF00675	0.459
CLV_PCSK_KEX2_1	127	129	PF00082	0.451
CLV_PCSK_KEX2_1	135	137	PF00082	0.325
CLV_PCSK_KEX2_1	17	19	PF00082	0.459
CLV_PCSK_PC1ET2_1	127	129	PF00082	0.451
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.325
DEG_Nend_Nbox_1	1	3	PF02207	0.671
DOC_CDC14_PxL_1	120	128	PF14671	0.546
DOC_CKS1_1	110	115	PF01111	0.360
DOC_CYCLIN_yCln2_LP_2	110	116	PF00134	0.306
DOC_WW_Pin1_4	109	114	PF00397	0.361
LIG_14-3-3_CanoR_1	17	22	PF00244	0.710
LIG_CSL_BTD_1	110	113	PF09270	0.360
LIG_FHA_1	37	43	PF00498	0.308
LIG_FHA_1	46	52	PF00498	0.276
LIG_GBD_Chelix_1	43	51	PF00786	0.360
LIG_LIR_Gen_1	105	114	PF02991	0.360
LIG_LIR_Gen_1	71	79	PF02991	0.410
LIG_LIR_Gen_1	83	92	PF02991	0.390
LIG_LIR_Nem_3	105	110	PF02991	0.306
LIG_LIR_Nem_3	122	126	PF02991	0.561
LIG_LIR_Nem_3	33	38	PF02991	0.433
LIG_LIR_Nem_3	59	65	PF02991	0.372
LIG_LIR_Nem_3	71	76	PF02991	0.405
LIG_LIR_Nem_3	83	87	PF02991	0.409
LIG_LYPXL_yS_3	123	126	PF13949	0.639
LIG_NRBOX	42	48	PF00104	0.376
LIG_PCNA_PIPBox_1	58	67	PF02747	0.443
LIG_PCNA_yPIPBox_3	58	72	PF02747	0.440
LIG_Pex14_2	107	111	PF04695	0.360
LIG_SH2_PTP2	73	76	PF00017	0.429
LIG_SH2_STAT3	55	58	PF00017	0.454
LIG_SH2_STAT5	36	39	PF00017	0.340
LIG_SH2_STAT5	55	58	PF00017	0.471
LIG_SH2_STAT5	73	76	PF00017	0.330
LIG_SH3_3	111	117	PF00018	0.467
LIG_SH3_3	136	142	PF00018	0.661
LIG_SH3_3	5	11	PF00018	0.635
LIG_UBA3_1	61	66	PF00899	0.438
MOD_CK1_1	109	115	PF00069	0.360
MOD_CK1_1	20	26	PF00069	0.738
MOD_GlcNHglycan	93	96	PF01048	0.659
MOD_GSK3_1	102	109	PF00069	0.360
MOD_GSK3_1	13	20	PF00069	0.762
MOD_GSK3_1	64	71	PF00069	0.426
MOD_LATS_1	125	131	PF00433	0.552
MOD_LATS_1	15	21	PF00433	0.648
MOD_N-GLC_1	99	104	PF02516	0.620
MOD_NEK2_1	106	111	PF00069	0.258
MOD_NEK2_1	3	8	PF00069	0.669
MOD_NEK2_1	64	69	PF00069	0.503
MOD_NEK2_1	91	96	PF00069	0.483
MOD_PIKK_1	127	133	PF00454	0.618
MOD_PKA_1	127	133	PF00069	0.621
MOD_PKA_1	17	23	PF00069	0.653
MOD_PKA_2	127	133	PF00069	0.621
MOD_PKA_2	17	23	PF00069	0.655
MOD_PKA_2	3	9	PF00069	0.735
MOD_Plk_2-3	75	81	PF00069	0.509
MOD_Plk_4	102	108	PF00069	0.376
MOD_Plk_4	30	36	PF00069	0.499
MOD_ProDKin_1	109	115	PF00069	0.355
MOD_SUMO_rev_2	75	83	PF00179	0.421
TRG_ENDOCYTIC_2	123	126	PF00928	0.639
TRG_ENDOCYTIC_2	35	38	PF00928	0.333
TRG_ENDOCYTIC_2	53	56	PF00928	0.396
TRG_ENDOCYTIC_2	73	76	PF00928	0.450
TRG_ER_diArg_1	133	136	PF00400	0.564
TRG_ER_diArg_1	17	19	PF00400	0.665

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IR53	Bodo saltans	42%	74%
A4H356	Leishmania braziliensis	73%	100%
E9AC21	Leishmania major	94%	100%
E9AG17	Leishmania infantum	100%	100%
E9AJB8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5DDB3	Trypanosoma cruzi	31%	96%