DNA excision/repair protein SNF2, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA excision/repair protein SNF2, putative

Species:

Leishmania donovani

UniProt:

A0A451EJ80_LEIDO

TriTrypDb:

LdBPK_010240.1 , LdCL_010007400 , LDHU3_01.0270

Length:

922

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A451EJ80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJ80

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0008094	ATP-dependent activity, acting on DNA	2	10
GO:0016491	oxidoreductase activity	2	10
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0051213	dioxygenase activity	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:0140097	catalytic activity, acting on DNA	3	10
GO:0140640	catalytic activity, acting on a nucleic acid	2	10
GO:0140657	ATP-dependent activity	1	10
GO:0140658	ATP-dependent chromatin remodeler activity	3	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10
GO:0015616	DNA translocase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	523	527	PF00656	0.569
CLV_C14_Caspase3-7	700	704	PF00656	0.434
CLV_C14_Caspase3-7	710	714	PF00656	0.621
CLV_C14_Caspase3-7	760	764	PF00656	0.707
CLV_NRD_NRD_1	206	208	PF00675	0.317
CLV_NRD_NRD_1	214	216	PF00675	0.303
CLV_NRD_NRD_1	348	350	PF00675	0.279
CLV_NRD_NRD_1	489	491	PF00675	0.277
CLV_NRD_NRD_1	495	497	PF00675	0.261
CLV_NRD_NRD_1	505	507	PF00675	0.254
CLV_NRD_NRD_1	533	535	PF00675	0.369
CLV_NRD_NRD_1	594	596	PF00675	0.501
CLV_NRD_NRD_1	638	640	PF00675	0.681
CLV_NRD_NRD_1	693	695	PF00675	0.543
CLV_NRD_NRD_1	775	777	PF00675	0.783
CLV_PCSK_FUR_1	207	211	PF00082	0.317
CLV_PCSK_FUR_1	503	507	PF00082	0.261
CLV_PCSK_FUR_1	773	777	PF00082	0.718
CLV_PCSK_KEX2_1	209	211	PF00082	0.269
CLV_PCSK_KEX2_1	348	350	PF00082	0.268
CLV_PCSK_KEX2_1	489	491	PF00082	0.326
CLV_PCSK_KEX2_1	505	507	PF00082	0.224
CLV_PCSK_KEX2_1	533	535	PF00082	0.369
CLV_PCSK_KEX2_1	594	596	PF00082	0.501
CLV_PCSK_KEX2_1	619	621	PF00082	0.533
CLV_PCSK_KEX2_1	638	640	PF00082	0.681
CLV_PCSK_KEX2_1	693	695	PF00082	0.543
CLV_PCSK_KEX2_1	773	775	PF00082	0.801
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.269
CLV_PCSK_PC1ET2_1	619	621	PF00082	0.533
CLV_PCSK_PC7_1	590	596	PF00082	0.388
CLV_PCSK_PC7_1	689	695	PF00082	0.503
CLV_PCSK_SKI1_1	264	268	PF00082	0.335
CLV_PCSK_SKI1_1	274	278	PF00082	0.346
CLV_PCSK_SKI1_1	505	509	PF00082	0.268
CLV_PCSK_SKI1_1	601	605	PF00082	0.356
CLV_PCSK_SKI1_1	651	655	PF00082	0.485
CLV_PCSK_SKI1_1	659	663	PF00082	0.449
DEG_APCC_DBOX_1	217	225	PF00400	0.569
DEG_APCC_DBOX_1	504	512	PF00400	0.486
DEG_APCC_DBOX_1	654	662	PF00400	0.460
DEG_APCC_DBOX_1	688	696	PF00400	0.442
DEG_COP1_1	870	878	PF00400	0.550
DEG_Nend_UBRbox_2	1	3	PF02207	0.695
DEG_SPOP_SBC_1	32	36	PF00917	0.658
DEG_SPOP_SBC_1	358	362	PF00917	0.521
DEG_SPOP_SBC_1	840	844	PF00917	0.544
DOC_CKS1_1	640	645	PF01111	0.586
DOC_CYCLIN_RxL_1	494	504	PF00134	0.482
DOC_MAPK_DCC_7	216	226	PF00069	0.539
DOC_MAPK_gen_1	503	513	PF00069	0.471
DOC_MAPK_gen_1	594	600	PF00069	0.454
DOC_MAPK_gen_1	773	779	PF00069	0.673
DOC_MAPK_MEF2A_6	218	226	PF00069	0.509
DOC_MAPK_MEF2A_6	363	372	PF00069	0.468
DOC_MAPK_MEF2A_6	430	439	PF00069	0.478
DOC_MAPK_MEF2A_6	480	487	PF00069	0.353
DOC_PP1_RVXF_1	495	502	PF00149	0.468
DOC_PP2B_LxvP_1	173	176	PF13499	0.539
DOC_PP2B_LxvP_1	858	861	PF13499	0.683
DOC_PP4_FxxP_1	110	113	PF00568	0.478
DOC_USP7_MATH_1	23	27	PF00917	0.679
DOC_USP7_MATH_1	237	241	PF00917	0.535
DOC_USP7_MATH_1	33	37	PF00917	0.641
DOC_USP7_MATH_1	330	334	PF00917	0.539
DOC_USP7_MATH_1	623	627	PF00917	0.503
DOC_USP7_MATH_1	830	834	PF00917	0.739
DOC_USP7_MATH_1	845	849	PF00917	0.751
DOC_WW_Pin1_4	11	16	PF00397	0.684
DOC_WW_Pin1_4	277	282	PF00397	0.468
DOC_WW_Pin1_4	35	40	PF00397	0.751
DOC_WW_Pin1_4	526	531	PF00397	0.570
DOC_WW_Pin1_4	639	644	PF00397	0.726
DOC_WW_Pin1_4	724	729	PF00397	0.800
DOC_WW_Pin1_4	739	744	PF00397	0.688
DOC_WW_Pin1_4	812	817	PF00397	0.739
DOC_WW_Pin1_4	826	831	PF00397	0.700
DOC_WW_Pin1_4	841	846	PF00397	0.708
DOC_WW_Pin1_4	874	879	PF00397	0.699
DOC_WW_Pin1_4	97	102	PF00397	0.761
LIG_14-3-3_CanoR_1	371	379	PF00244	0.553
LIG_14-3-3_CanoR_1	489	499	PF00244	0.489
LIG_14-3-3_CanoR_1	519	525	PF00244	0.528
LIG_14-3-3_CanoR_1	601	608	PF00244	0.358
LIG_14-3-3_CanoR_1	670	678	PF00244	0.551
LIG_14-3-3_CanoR_1	839	845	PF00244	0.644
LIG_14-3-3_CterR_2	919	922	PF00244	0.622
LIG_BIR_III_4	644	648	PF00653	0.723
LIG_BIR_III_4	715	719	PF00653	0.658
LIG_BRCT_BRCA1_1	503	507	PF00533	0.509
LIG_BRCT_BRCA1_1	911	915	PF00533	0.654
LIG_deltaCOP1_diTrp_1	287	295	PF00928	0.468
LIG_FHA_1	150	156	PF00498	0.468
LIG_FHA_1	168	174	PF00498	0.468
LIG_FHA_1	194	200	PF00498	0.444
LIG_FHA_1	226	232	PF00498	0.487
LIG_FHA_1	429	435	PF00498	0.517
LIG_FHA_1	551	557	PF00498	0.484
LIG_FHA_1	707	713	PF00498	0.637
LIG_FHA_1	783	789	PF00498	0.667
LIG_FHA_1	812	818	PF00498	0.686
LIG_FHA_1	841	847	PF00498	0.671
LIG_FHA_2	240	246	PF00498	0.569
LIG_FHA_2	283	289	PF00498	0.580
LIG_FHA_2	403	409	PF00498	0.569
LIG_FHA_2	51	57	PF00498	0.516
LIG_FHA_2	521	527	PF00498	0.532
LIG_FHA_2	605	611	PF00498	0.361
LIG_FHA_2	865	871	PF00498	0.749
LIG_IBAR_NPY_1	463	465	PF08397	0.587
LIG_IRF3_LxIS_1	569	575	PF10401	0.416
LIG_LIR_Gen_1	245	254	PF02991	0.468
LIG_LIR_Gen_1	285	293	PF02991	0.472
LIG_LIR_Gen_1	306	316	PF02991	0.518
LIG_LIR_Gen_1	504	515	PF02991	0.476
LIG_LIR_LC3C_4	170	175	PF02991	0.569
LIG_LIR_Nem_3	227	232	PF02991	0.456
LIG_LIR_Nem_3	245	249	PF02991	0.468
LIG_LIR_Nem_3	287	293	PF02991	0.468
LIG_LIR_Nem_3	306	311	PF02991	0.468
LIG_LIR_Nem_3	504	510	PF02991	0.509
LIG_LIR_Nem_3	648	653	PF02991	0.519
LIG_LIR_Nem_3	829	834	PF02991	0.549
LIG_NRBOX	510	516	PF00104	0.495
LIG_NRBOX	6	12	PF00104	0.694
LIG_PCNA_PIPBox_1	289	298	PF02747	0.539
LIG_PDZ_Class_1	917	922	PF00595	0.619
LIG_Pex14_1	183	187	PF04695	0.569
LIG_Pex14_2	286	290	PF04695	0.468
LIG_PTAP_UEV_1	14	19	PF05743	0.576
LIG_PTB_Apo_2	612	619	PF02174	0.402
LIG_RPA_C_Fungi	590	602	PF08784	0.457
LIG_SH2_CRK	219	223	PF00017	0.362
LIG_SH2_CRK	229	233	PF00017	0.274
LIG_SH2_CRK	465	469	PF00017	0.542
LIG_SH2_PTP2	246	249	PF00017	0.422
LIG_SH2_STAP1	163	167	PF00017	0.464
LIG_SH2_STAP1	380	384	PF00017	0.422
LIG_SH2_STAT3	121	124	PF00017	0.496
LIG_SH2_STAT3	163	166	PF00017	0.422
LIG_SH2_STAT3	613	616	PF00017	0.396
LIG_SH2_STAT5	246	249	PF00017	0.323
LIG_SH2_STAT5	652	655	PF00017	0.472
LIG_SH3_3	12	18	PF00018	0.641
LIG_SH3_3	171	177	PF00018	0.422
LIG_SH3_3	36	42	PF00018	0.665
LIG_SH3_3	637	643	PF00018	0.743
LIG_SH3_3	738	744	PF00018	0.803
LIG_SH3_3	872	878	PF00018	0.678
LIG_SH3_3	98	104	PF00018	0.700
LIG_SUMO_SIM_anti_2	170	176	PF11976	0.326
LIG_SUMO_SIM_anti_2	240	245	PF11976	0.347
LIG_SUMO_SIM_anti_2	567	573	PF11976	0.324
LIG_SUMO_SIM_anti_2	674	680	PF11976	0.591
LIG_SUMO_SIM_anti_2	814	821	PF11976	0.693
LIG_SUMO_SIM_anti_2	877	885	PF11976	0.537
LIG_SUMO_SIM_par_1	178	184	PF11976	0.409
LIG_SUMO_SIM_par_1	431	438	PF11976	0.326
LIG_SUMO_SIM_par_1	567	573	PF11976	0.377
LIG_TRAF2_1	53	56	PF00917	0.713
LIG_TRAF2_1	607	610	PF00917	0.360
LIG_TRFH_1	110	114	PF08558	0.486
LIG_TYR_ITIM	244	249	PF00017	0.422
LIG_UBA3_1	300	305	PF00899	0.386
LIG_WRC_WIRS_1	283	288	PF05994	0.407
LIG_WRC_WIRS_1	510	515	PF05994	0.464
MOD_CDC14_SPxK_1	731	734	PF00782	0.714
MOD_CDK_SPxK_1	728	734	PF00069	0.717
MOD_CDK_SPxxK_3	526	533	PF00069	0.464
MOD_CK1_1	181	187	PF00069	0.327
MOD_CK1_1	265	271	PF00069	0.438
MOD_CK1_1	37	43	PF00069	0.683
MOD_CK1_1	746	752	PF00069	0.686
MOD_CK1_1	833	839	PF00069	0.656
MOD_CK1_1	877	883	PF00069	0.741
MOD_CK1_1	94	100	PF00069	0.716
MOD_CK2_1	358	364	PF00069	0.464
MOD_CK2_1	388	394	PF00069	0.397
MOD_CK2_1	402	408	PF00069	0.275
MOD_CK2_1	50	56	PF00069	0.723
MOD_CK2_1	526	532	PF00069	0.387
MOD_CK2_1	604	610	PF00069	0.358
MOD_CK2_1	668	674	PF00069	0.578
MOD_CK2_1	80	86	PF00069	0.667
MOD_CK2_1	845	851	PF00069	0.536
MOD_Cter_Amidation	636	639	PF01082	0.685
MOD_DYRK1A_RPxSP_1	639	643	PF00069	0.597
MOD_DYRK1A_RPxSP_1	826	830	PF00069	0.543
MOD_GlcNHglycan	105	108	PF01048	0.658
MOD_GlcNHglycan	15	18	PF01048	0.578
MOD_GlcNHglycan	264	267	PF01048	0.347
MOD_GlcNHglycan	311	314	PF01048	0.464
MOD_GlcNHglycan	322	326	PF01048	0.282
MOD_GlcNHglycan	390	393	PF01048	0.427
MOD_GlcNHglycan	422	426	PF01048	0.393
MOD_GlcNHglycan	566	569	PF01048	0.319
MOD_GlcNHglycan	578	581	PF01048	0.276
MOD_GlcNHglycan	71	74	PF01048	0.620
MOD_GlcNHglycan	728	731	PF01048	0.729
MOD_GlcNHglycan	737	740	PF01048	0.697
MOD_GlcNHglycan	795	798	PF01048	0.669
MOD_GlcNHglycan	835	838	PF01048	0.718
MOD_GlcNHglycan	854	857	PF01048	0.665
MOD_GlcNHglycan	894	897	PF01048	0.645
MOD_GlcNHglycan	911	914	PF01048	0.482
MOD_GlcNHglycan	93	96	PF01048	0.680
MOD_GSK3_1	23	30	PF00069	0.575
MOD_GSK3_1	31	38	PF00069	0.716
MOD_GSK3_1	399	406	PF00069	0.384
MOD_GSK3_1	421	428	PF00069	0.458
MOD_GSK3_1	495	502	PF00069	0.379
MOD_GSK3_1	50	57	PF00069	0.523
MOD_GSK3_1	572	579	PF00069	0.340
MOD_GSK3_1	58	65	PF00069	0.659
MOD_GSK3_1	724	731	PF00069	0.690
MOD_GSK3_1	735	742	PF00069	0.674
MOD_GSK3_1	820	827	PF00069	0.708
MOD_GSK3_1	835	842	PF00069	0.487
MOD_GSK3_1	9	16	PF00069	0.605
MOD_GSK3_1	904	911	PF00069	0.681
MOD_GSK3_1	914	921	PF00069	0.629
MOD_N-GLC_1	69	74	PF02516	0.692
MOD_N-GLC_1	78	83	PF02516	0.548
MOD_N-GLC_2	259	261	PF02516	0.386
MOD_N-GLC_2	704	706	PF02516	0.450
MOD_NEK2_1	149	154	PF00069	0.323
MOD_NEK2_1	167	172	PF00069	0.323
MOD_NEK2_1	225	230	PF00069	0.325
MOD_NEK2_1	239	244	PF00069	0.330
MOD_NEK2_1	296	301	PF00069	0.362
MOD_NEK2_1	303	308	PF00069	0.328
MOD_NEK2_1	413	418	PF00069	0.347
MOD_NEK2_1	435	440	PF00069	0.326
MOD_NEK2_1	499	504	PF00069	0.323
MOD_NEK2_1	520	525	PF00069	0.464
MOD_NEK2_1	54	59	PF00069	0.670
MOD_NEK2_1	551	556	PF00069	0.347
MOD_NEK2_1	572	577	PF00069	0.432
MOD_NEK2_1	820	825	PF00069	0.747
MOD_NEK2_1	835	840	PF00069	0.631
MOD_NEK2_1	882	887	PF00069	0.535
MOD_NEK2_1	96	101	PF00069	0.506
MOD_NEK2_2	425	430	PF00069	0.250
MOD_NEK2_2	623	628	PF00069	0.606
MOD_PIKK_1	438	444	PF00454	0.407
MOD_PIKK_1	520	526	PF00454	0.464
MOD_PIKK_1	551	557	PF00454	0.323
MOD_PIKK_1	743	749	PF00454	0.748
MOD_PIKK_1	820	826	PF00454	0.710
MOD_PIKK_1	845	851	PF00454	0.666
MOD_PK_1	737	743	PF00069	0.720
MOD_PKA_2	370	376	PF00069	0.422
MOD_PKA_2	495	501	PF00069	0.329
MOD_PKA_2	518	524	PF00069	0.465
MOD_PKA_2	669	675	PF00069	0.578
MOD_PKA_2	820	826	PF00069	0.593
MOD_PKA_2	838	844	PF00069	0.432
MOD_PKA_2	861	867	PF00069	0.696
MOD_PKA_2	904	910	PF00069	0.728
MOD_PKB_1	757	765	PF00069	0.712
MOD_Plk_1	237	243	PF00069	0.407
MOD_Plk_1	413	419	PF00069	0.289
MOD_Plk_1	572	578	PF00069	0.250
MOD_Plk_1	732	738	PF00069	0.721
MOD_Plk_1	779	785	PF00069	0.666
MOD_Plk_2-3	403	409	PF00069	0.250
MOD_Plk_4	168	174	PF00069	0.383
MOD_Plk_4	175	181	PF00069	0.311
MOD_Plk_4	239	245	PF00069	0.464
MOD_Plk_4	296	302	PF00069	0.323
MOD_Plk_4	311	317	PF00069	0.323
MOD_Plk_4	435	441	PF00069	0.356
MOD_Plk_4	447	453	PF00069	0.438
MOD_Plk_4	495	501	PF00069	0.323
MOD_Plk_4	509	515	PF00069	0.323
MOD_Plk_4	830	836	PF00069	0.696
MOD_Plk_4	877	883	PF00069	0.576
MOD_ProDKin_1	11	17	PF00069	0.682
MOD_ProDKin_1	277	283	PF00069	0.323
MOD_ProDKin_1	35	41	PF00069	0.753
MOD_ProDKin_1	526	532	PF00069	0.465
MOD_ProDKin_1	639	645	PF00069	0.722
MOD_ProDKin_1	724	730	PF00069	0.799
MOD_ProDKin_1	739	745	PF00069	0.684
MOD_ProDKin_1	812	818	PF00069	0.742
MOD_ProDKin_1	826	832	PF00069	0.696
MOD_ProDKin_1	841	847	PF00069	0.672
MOD_ProDKin_1	874	880	PF00069	0.698
MOD_ProDKin_1	97	103	PF00069	0.758
TRG_DiLeu_BaEn_1	2	7	PF01217	0.634
TRG_DiLeu_BaEn_1	674	679	PF01217	0.542
TRG_DiLeu_BaLyEn_6	430	435	PF01217	0.422
TRG_ENDOCYTIC_2	229	232	PF00928	0.323
TRG_ENDOCYTIC_2	246	249	PF00928	0.323
TRG_ENDOCYTIC_2	380	383	PF00928	0.347
TRG_ENDOCYTIC_2	650	653	PF00928	0.486
TRG_ER_diArg_1	347	349	PF00400	0.323
TRG_ER_diArg_1	488	490	PF00400	0.274
TRG_ER_diArg_1	503	506	PF00400	0.260
TRG_ER_diArg_1	638	640	PF00400	0.681
TRG_ER_diArg_1	692	694	PF00400	0.539
TRG_ER_diArg_1	758	761	PF00400	0.750
TRG_ER_diArg_1	772	775	PF00400	0.778
TRG_NES_CRM1_1	238	251	PF08389	0.374
TRG_NES_CRM1_1	778	791	PF08389	0.548
TRG_NLS_MonoCore_2	206	211	PF00514	0.407
TRG_NLS_MonoExtN_4	206	212	PF00514	0.417
TRG_NLS_MonoExtN_4	213	219	PF00514	0.428
TRG_PTS1	919	922	PF00515	0.622

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYE0	Leptomonas seymouri	61%	94%
A0A1X0P3S9	Trypanosomatidae	49%	100%
A0A3R7MS90	Trypanosoma rangeli	49%	100%
A4H349	Leishmania braziliensis	79%	100%
A4HGB7	Leishmania braziliensis	23%	100%
A4HRE5	Leishmania infantum	100%	100%
A6QQR4	Bos taurus	31%	74%
A6ZL17	Saccharomyces cerevisiae (strain YJM789)	24%	100%
B3LN76	Saccharomyces cerevisiae (strain RM11-1a)	24%	100%
B4JCS7	Drosophila grimshawi	26%	100%
B4M9A8	Drosophila virilis	26%	100%
B5VE38	Saccharomyces cerevisiae (strain AWRI1631)	24%	100%
C7GQI8	Saccharomyces cerevisiae (strain JAY291)	25%	100%
E9AC13	Leishmania major	89%	100%
E9AJB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
P31244	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P34739	Drosophila melanogaster	22%	87%
P38086	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	96%
P40352	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	85%
Q2NKX8	Homo sapiens	30%	74%
Q7F2E4	Oryza sativa subsp. japonica	28%	78%
Q8BHK9	Mus musculus	30%	74%
Q8W103	Arabidopsis thaliana	32%	85%
Q9M297	Arabidopsis thaliana	22%	73%
Q9UNY4	Homo sapiens	25%	79%
Q9ZV43	Arabidopsis thaliana	29%	78%
V5B5G3	Trypanosoma cruzi	49%	100%
V5BR43	Trypanosoma cruzi	25%	83%