Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD family protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclophilin type peptidyl-prolyl cis-trans isomerase, putative

Species:

Leishmania donovani

UniProt:

A0A451EJ79_LEIDO

TriTrypDb:

LdBPK_010220.1 , LdCL_010007200 , LDHU3_01.0250

Length:

334

Annotations

LeishMANIAdb annotations

A large collection of conserved eukaryotic peptidyl-prolyl cis-trans isomerases. Some members of this group are secreted (into the ER).. Localization: Cytoplasmic (by homology) / ER (by homology)

Annotations by Jardim et al.

Chaperone/Protein Folding, cyclophilin 12 CYP12

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 32

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 25
NetGPI	no	yes: 0, no: 25

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	6
GO:0005737	cytoplasm	2	4
GO:0005930	axoneme	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A0A451EJ79

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJ79

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	26
GO:0006807	nitrogen compound metabolic process	2	26
GO:0008152	metabolic process	1	26
GO:0018193	peptidyl-amino acid modification	5	26
GO:0018208	peptidyl-proline modification	6	26
GO:0019538	protein metabolic process	3	26
GO:0036211	protein modification process	4	26
GO:0043170	macromolecule metabolic process	3	26
GO:0043412	macromolecule modification	4	26
GO:0044238	primary metabolic process	2	26
GO:0071704	organic substance metabolic process	2	26
GO:1901564	organonitrogen compound metabolic process	3	26
GO:0006457	protein folding	2	13
GO:0009987	cellular process	1	13

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	26
GO:0003824	catalytic activity	1	26
GO:0016853	isomerase activity	2	26
GO:0016859	cis-trans isomerase activity	3	26
GO:0140096	catalytic activity, acting on a protein	2	26
GO:0005488	binding	1	3
GO:0016018	cyclosporin A binding	4	3
GO:0033218	amide binding	2	3
GO:0042277	peptide binding	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	220	224	PF00656	0.217
CLV_NRD_NRD_1	51	53	PF00675	0.357
CLV_PCSK_KEX2_1	51	53	PF00082	0.355
CLV_PCSK_SKI1_1	105	109	PF00082	0.431
CLV_PCSK_SKI1_1	140	144	PF00082	0.408
CLV_PCSK_SKI1_1	2	6	PF00082	0.321
CLV_PCSK_SKI1_1	219	223	PF00082	0.368
CLV_Separin_Metazoa	43	47	PF03568	0.345
DEG_Nend_UBRbox_1	1	4	PF02207	0.364
DOC_MAPK_gen_1	146	155	PF00069	0.289
DOC_MAPK_MEF2A_6	148	157	PF00069	0.285
DOC_PP1_RVXF_1	162	168	PF00149	0.270
DOC_PP1_RVXF_1	288	295	PF00149	0.312
DOC_PP2B_LxvP_1	42	45	PF13499	0.330
DOC_PP4_FxxP_1	202	205	PF00568	0.194
DOC_USP7_MATH_1	197	201	PF00917	0.364
DOC_USP7_MATH_1	318	322	PF00917	0.202
DOC_USP7_MATH_1	54	58	PF00917	0.383
LIG_14-3-3_CanoR_1	105	113	PF00244	0.498
LIG_14-3-3_CanoR_1	186	191	PF00244	0.387
LIG_14-3-3_CanoR_1	282	287	PF00244	0.269
LIG_BIR_III_4	258	262	PF00653	0.218
LIG_BRCT_BRCA1_1	198	202	PF00533	0.194
LIG_BRCT_BRCA1_1	273	277	PF00533	0.415
LIG_FHA_1	250	256	PF00498	0.343
LIG_FHA_2	116	122	PF00498	0.463
LIG_FHA_2	12	18	PF00498	0.501
LIG_FHA_2	218	224	PF00498	0.248
LIG_FHA_2	323	329	PF00498	0.291
LIG_LIR_Apic_2	199	205	PF02991	0.202
LIG_LIR_Apic_2	250	256	PF02991	0.277
LIG_LIR_Gen_1	168	176	PF02991	0.304
LIG_LIR_Gen_1	275	284	PF02991	0.258
LIG_LIR_Gen_1	34	44	PF02991	0.318
LIG_LIR_Nem_3	137	142	PF02991	0.305
LIG_LIR_Nem_3	168	173	PF02991	0.365
LIG_LIR_Nem_3	215	221	PF02991	0.241
LIG_LIR_Nem_3	275	281	PF02991	0.399
LIG_LIR_Nem_3	34	39	PF02991	0.308
LIG_LIR_Nem_3	5	10	PF02991	0.372
LIG_PDZ_Class_1	329	334	PF00595	0.353
LIG_Pex14_1	166	170	PF04695	0.321
LIG_REV1ctd_RIR_1	215	223	PF16727	0.207
LIG_SH2_CRK	10	14	PF00017	0.410
LIG_SH2_CRK	170	174	PF00017	0.235
LIG_SH2_CRK	253	257	PF00017	0.235
LIG_SH2_CRK	36	40	PF00017	0.283
LIG_SH2_NCK_1	170	174	PF00017	0.217
LIG_SH2_PTP2	278	281	PF00017	0.298
LIG_SH2_STAP1	170	174	PF00017	0.218
LIG_SH2_STAP1	36	40	PF00017	0.362
LIG_SH2_STAT3	131	134	PF00017	0.312
LIG_SH2_STAT5	131	134	PF00017	0.454
LIG_SH2_STAT5	150	153	PF00017	0.274
LIG_SH2_STAT5	278	281	PF00017	0.218
LIG_SH2_STAT5	291	294	PF00017	0.218
LIG_SH3_3	198	204	PF00018	0.336
LIG_TYR_ITSM	6	13	PF00017	0.380
LIG_WRC_WIRS_1	4	9	PF05994	0.276
MOD_CK2_1	322	328	PF00069	0.174
MOD_CK2_1	68	74	PF00069	0.528
MOD_CK2_1	96	102	PF00069	0.578
MOD_GlcNHglycan	136	139	PF01048	0.298
MOD_GlcNHglycan	235	238	PF01048	0.291
MOD_GlcNHglycan	274	277	PF01048	0.378
MOD_GlcNHglycan	56	59	PF01048	0.437
MOD_GlcNHglycan	74	77	PF01048	0.450
MOD_GlcNHglycan	82	85	PF01048	0.476
MOD_GSK3_1	185	192	PF00069	0.333
MOD_GSK3_1	213	220	PF00069	0.256
MOD_GSK3_1	229	236	PF00069	0.383
MOD_GSK3_1	318	325	PF00069	0.408
MOD_GSK3_1	68	75	PF00069	0.732
MOD_N-GLC_1	272	277	PF02516	0.312
MOD_N-GLC_2	180	182	PF02516	0.272
MOD_NEK2_1	142	147	PF00069	0.492
MOD_NEK2_1	169	174	PF00069	0.257
MOD_NEK2_1	217	222	PF00069	0.290
MOD_NEK2_1	277	282	PF00069	0.291
MOD_NEK2_1	72	77	PF00069	0.763
MOD_NEK2_2	197	202	PF00069	0.202
MOD_NEK2_2	239	244	PF00069	0.303
MOD_PIKK_1	204	210	PF00454	0.349
MOD_PIKK_1	60	66	PF00454	0.458
MOD_PKA_2	185	191	PF00069	0.398
MOD_Plk_1	153	159	PF00069	0.288
MOD_Plk_1	249	255	PF00069	0.284
MOD_Plk_1	272	278	PF00069	0.186
MOD_Plk_1	68	74	PF00069	0.677
MOD_Plk_4	108	114	PF00069	0.299
MOD_Plk_4	197	203	PF00069	0.327
MOD_Plk_4	213	219	PF00069	0.175
MOD_Plk_4	282	288	PF00069	0.236
MOD_Plk_4	318	324	PF00069	0.269
MOD_Plk_4	88	94	PF00069	0.318
MOD_SUMO_for_1	40	43	PF00179	0.495
TRG_DiLeu_BaEn_1	102	107	PF01217	0.368
TRG_DiLeu_LyEn_5	102	107	PF01217	0.348
TRG_ENDOCYTIC_2	10	13	PF00928	0.397
TRG_ENDOCYTIC_2	150	153	PF00928	0.253
TRG_ENDOCYTIC_2	170	173	PF00928	0.218
TRG_ENDOCYTIC_2	278	281	PF00928	0.218
TRG_ENDOCYTIC_2	291	294	PF00928	0.284
TRG_ENDOCYTIC_2	36	39	PF00928	0.301
TRG_Pf-PMV_PEXEL_1	105	110	PF00026	0.332
TRG_Pf-PMV_PEXEL_1	219	223	PF00026	0.333

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL84	Leptomonas seymouri	55%	100%
A0A0N1PDY0	Leptomonas seymouri	24%	100%
A0A0S4IKA5	Bodo saltans	39%	100%
A0A3Q8ICB3	Leishmania donovani	29%	100%
A0A3R7M7E5	Trypanosoma rangeli	43%	100%
A0A3S5H7U6	Leishmania donovani	38%	100%
A0A3S5IQL2	Trypanosoma rangeli	27%	100%
A0A3S7X325	Leishmania donovani	25%	100%
A0A3S7X410	Leishmania donovani	36%	100%
A0A3S7XB52	Leishmania donovani	34%	100%
A4H346	Leishmania braziliensis	83%	100%
A4HCI8	Leishmania braziliensis	28%	100%
A4HHU7	Leishmania braziliensis	24%	100%
A4HIW9	Leishmania braziliensis	35%	100%
A4HRE3	Leishmania infantum	100%	100%
A4I004	Leishmania infantum	29%	100%
A4I4Z7	Leishmania infantum	25%	100%
A4I698	Leishmania infantum	36%	100%
A4I935	Leishmania infantum	38%	100%
A4IDA1	Leishmania infantum	34%	100%
C9ZXF5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AC11	Leishmania major	94%	100%
E9AJA8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9AT91	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AVX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B0C7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B1F3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9B400	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
Q4Q1A6	Leishmania major	34%	100%
Q4Q6Q9	Leishmania major	36%	100%
Q4Q7V7	Leishmania major	26%	100%
Q4QBK2	Leishmania major	29%	100%
Q8IXY8	Homo sapiens	29%	100%
V5B9Y6	Trypanosoma cruzi	42%	100%