Voltage gated chloride channel family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CLC-type chloride channel, putative

Species:

Leishmania donovani

UniProt:

A0A451EJ75_LEIDO

TriTrypDb:

LdBPK_010180.1 , LdCL_010006800 , LDHU3_01.0200

Length:

770

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005768	endosome	7	1
GO:0005769	early endosome	8	1
GO:0005794	Golgi apparatus	5	1
GO:0005886	plasma membrane	3	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

A0A451EJ75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJ75

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	12
GO:0005216	monoatomic ion channel activity	4	12
GO:0005244	voltage-gated monoatomic ion channel activity	4	12
GO:0005247	voltage-gated chloride channel activity	6	12
GO:0005253	monoatomic anion channel activity	5	12
GO:0005254	chloride channel activity	6	12
GO:0008308	voltage-gated monoatomic anion channel activity	5	12
GO:0008509	monoatomic anion transmembrane transporter activity	4	12
GO:0015075	monoatomic ion transmembrane transporter activity	3	12
GO:0015103	inorganic anion transmembrane transporter activity	4	12
GO:0015108	chloride transmembrane transporter activity	5	12
GO:0015267	channel activity	4	12
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	12
GO:0022803	passive transmembrane transporter activity	3	12
GO:0022832	voltage-gated channel activity	6	12
GO:0022836	gated channel activity	5	12
GO:0022857	transmembrane transporter activity	2	12
GO:0005451	obsolete monoatomic cation:proton antiporter activity	5	1
GO:0008324	monoatomic cation transmembrane transporter activity	4	1
GO:0015078	proton transmembrane transporter activity	5	1
GO:0015291	secondary active transmembrane transporter activity	4	1
GO:0015297	antiporter activity	5	1
GO:0015298	obsolete solute:monoatomic cation antiporter activity	5	1
GO:0015299	obsolete solute:proton antiporter activity	6	1
GO:0022804	active transmembrane transporter activity	3	1
GO:0022853	active monoatomic ion transmembrane transporter activity	4	1
GO:0022890	inorganic cation transmembrane transporter activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	364	366	PF00675	0.207
CLV_NRD_NRD_1	60	62	PF00675	0.350
CLV_PCSK_KEX2_1	202	204	PF00082	0.206
CLV_PCSK_KEX2_1	366	368	PF00082	0.255
CLV_PCSK_KEX2_1	60	62	PF00082	0.361
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.249
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.167
CLV_PCSK_SKI1_1	424	428	PF00082	0.431
CLV_PCSK_SKI1_1	586	590	PF00082	0.300
CLV_PCSK_SKI1_1	663	667	PF00082	0.361
CLV_PCSK_SKI1_1	690	694	PF00082	0.330
DEG_SCF_FBW7_1	390	395	PF00400	0.273
DEG_SPOP_SBC_1	67	71	PF00917	0.565
DOC_AGCK_PIF_1	437	442	PF00069	0.229
DOC_CKS1_1	389	394	PF01111	0.241
DOC_CYCLIN_RxL_1	688	698	PF00134	0.469
DOC_MAPK_gen_1	365	377	PF00069	0.436
DOC_MAPK_gen_1	570	577	PF00069	0.571
DOC_MAPK_gen_1	631	639	PF00069	0.503
DOC_MAPK_gen_1	718	724	PF00069	0.458
DOC_MAPK_MEF2A_6	229	236	PF00069	0.206
DOC_MAPK_MEF2A_6	370	379	PF00069	0.406
DOC_MAPK_MEF2A_6	663	672	PF00069	0.603
DOC_PP1_RVXF_1	318	325	PF00149	0.202
DOC_PP4_FxxP_1	273	276	PF00568	0.241
DOC_PP4_FxxP_1	335	338	PF00568	0.206
DOC_PP4_FxxP_1	389	392	PF00568	0.256
DOC_USP7_MATH_1	112	116	PF00917	0.377
DOC_USP7_MATH_1	182	186	PF00917	0.462
DOC_USP7_MATH_1	247	251	PF00917	0.310
DOC_USP7_MATH_1	392	396	PF00917	0.249
DOC_USP7_MATH_1	642	646	PF00917	0.519
DOC_USP7_MATH_1	659	663	PF00917	0.633
DOC_USP7_MATH_1	66	70	PF00917	0.701
DOC_USP7_MATH_1	685	689	PF00917	0.548
DOC_WW_Pin1_4	388	393	PF00397	0.241
DOC_WW_Pin1_4	407	412	PF00397	0.206
DOC_WW_Pin1_4	615	620	PF00397	0.442
DOC_WW_Pin1_4	655	660	PF00397	0.506
DOC_WW_Pin1_4	77	82	PF00397	0.572
LIG_14-3-3_CanoR_1	424	430	PF00244	0.310
LIG_14-3-3_CanoR_1	643	649	PF00244	0.602
LIG_14-3-3_CanoR_1	654	659	PF00244	0.531
LIG_APCC_ABBA_1	99	104	PF00400	0.252
LIG_BRCT_BRCA1_1	289	293	PF00533	0.510
LIG_BRCT_BRCA1_1	480	484	PF00533	0.232
LIG_Clathr_ClatBox_1	680	684	PF01394	0.580
LIG_eIF4E_1	291	297	PF01652	0.449
LIG_FHA_1	210	216	PF00498	0.300
LIG_FHA_1	27	33	PF00498	0.578
LIG_FHA_1	303	309	PF00498	0.250
LIG_FHA_1	316	322	PF00498	0.192
LIG_FHA_1	351	357	PF00498	0.388
LIG_FHA_1	382	388	PF00498	0.335
LIG_FHA_1	513	519	PF00498	0.249
LIG_FHA_1	524	530	PF00498	0.396
LIG_FHA_1	552	558	PF00498	0.523
LIG_FHA_1	671	677	PF00498	0.489
LIG_FHA_1	699	705	PF00498	0.570
LIG_FHA_1	73	79	PF00498	0.646
LIG_FHA_1	755	761	PF00498	0.663
LIG_FHA_2	664	670	PF00498	0.636
LIG_KLC1_Yacidic_2	572	576	PF13176	0.600
LIG_LIR_Apic_2	528	534	PF02991	0.407
LIG_LIR_Gen_1	164	173	PF02991	0.271
LIG_LIR_Gen_1	230	240	PF02991	0.206
LIG_LIR_Gen_1	352	361	PF02991	0.256
LIG_LIR_Gen_1	37	46	PF02991	0.526
LIG_LIR_Gen_1	434	444	PF02991	0.350
LIG_LIR_Gen_1	572	582	PF02991	0.553
LIG_LIR_Gen_1	651	659	PF02991	0.533
LIG_LIR_Gen_1	664	675	PF02991	0.551
LIG_LIR_Gen_1	720	727	PF02991	0.493
LIG_LIR_Gen_1	84	95	PF02991	0.262
LIG_LIR_LC3C_4	29	33	PF02991	0.590
LIG_LIR_Nem_3	141	145	PF02991	0.249
LIG_LIR_Nem_3	158	162	PF02991	0.241
LIG_LIR_Nem_3	179	183	PF02991	0.470
LIG_LIR_Nem_3	230	236	PF02991	0.206
LIG_LIR_Nem_3	290	296	PF02991	0.410
LIG_LIR_Nem_3	352	357	PF02991	0.252
LIG_LIR_Nem_3	37	43	PF02991	0.552
LIG_LIR_Nem_3	434	440	PF02991	0.350
LIG_LIR_Nem_3	572	577	PF02991	0.559
LIG_LIR_Nem_3	611	616	PF02991	0.476
LIG_LIR_Nem_3	651	655	PF02991	0.514
LIG_LIR_Nem_3	664	670	PF02991	0.575
LIG_LIR_Nem_3	710	715	PF02991	0.450
LIG_LIR_Nem_3	720	724	PF02991	0.463
LIG_LIR_Nem_3	74	79	PF02991	0.650
LIG_MYND_1	565	569	PF01753	0.457
LIG_Pex14_1	109	113	PF04695	0.289
LIG_Pex14_1	142	146	PF04695	0.267
LIG_Pex14_2	467	471	PF04695	0.389
LIG_Pex14_2	573	577	PF04695	0.588
LIG_PTB_Apo_2	582	589	PF02174	0.580
LIG_REV1ctd_RIR_1	143	153	PF16727	0.288
LIG_RPA_C_Fungi	56	68	PF08784	0.437
LIG_SH2_CRK	499	503	PF00017	0.241
LIG_SH2_CRK	531	535	PF00017	0.386
LIG_SH2_NCK_1	499	503	PF00017	0.241
LIG_SH2_SRC	499	502	PF00017	0.241
LIG_SH2_SRC	555	558	PF00017	0.322
LIG_SH2_SRC	566	569	PF00017	0.328
LIG_SH2_SRC	627	630	PF00017	0.309
LIG_SH2_STAP1	478	482	PF00017	0.252
LIG_SH2_STAP1	488	492	PF00017	0.252
LIG_SH2_STAT3	594	597	PF00017	0.459
LIG_SH2_STAT5	162	165	PF00017	0.245
LIG_SH2_STAT5	175	178	PF00017	0.254
LIG_SH2_STAT5	204	207	PF00017	0.241
LIG_SH2_STAT5	442	445	PF00017	0.353
LIG_SH2_STAT5	482	485	PF00017	0.285
LIG_SH2_STAT5	566	569	PF00017	0.425
LIG_SH2_STAT5	574	577	PF00017	0.426
LIG_SH2_STAT5	652	655	PF00017	0.396
LIG_SH2_STAT5	694	697	PF00017	0.353
LIG_SH3_3	30	36	PF00018	0.438
LIG_SH3_3	613	619	PF00018	0.274
LIG_SH3_3	75	81	PF00018	0.460
LIG_SUMO_SIM_anti_2	376	381	PF11976	0.339
LIG_SUMO_SIM_anti_2	397	404	PF11976	0.277
LIG_TRAF2_1	473	476	PF00917	0.275
LIG_UBA3_1	692	697	PF00899	0.341
LIG_Vh1_VBS_1	501	519	PF01044	0.256
LIG_WRC_WIRS_1	162	167	PF05994	0.257
LIG_WRC_WIRS_1	444	449	PF05994	0.275
MOD_CK1_1	164	170	PF00069	0.262
MOD_CK1_1	220	226	PF00069	0.245
MOD_CK1_1	352	358	PF00069	0.386
MOD_CK1_1	47	53	PF00069	0.544
MOD_CK1_1	620	626	PF00069	0.415
MOD_CK1_1	698	704	PF00069	0.361
MOD_CK1_1	77	83	PF00069	0.502
MOD_CK2_1	138	144	PF00069	0.319
MOD_CK2_1	394	400	PF00069	0.249
MOD_CK2_1	45	51	PF00069	0.391
MOD_CK2_1	663	669	PF00069	0.521
MOD_CK2_1	707	713	PF00069	0.360
MOD_GlcNHglycan	110	113	PF01048	0.310
MOD_GlcNHglycan	114	117	PF01048	0.303
MOD_GlcNHglycan	184	187	PF01048	0.275
MOD_GlcNHglycan	196	199	PF01048	0.204
MOD_GlcNHglycan	21	24	PF01048	0.477
MOD_GlcNHglycan	222	225	PF01048	0.241
MOD_GlcNHglycan	244	247	PF01048	0.380
MOD_GlcNHglycan	394	397	PF01048	0.258
MOD_GlcNHglycan	62	65	PF01048	0.454
MOD_GSK3_1	108	115	PF00069	0.319
MOD_GSK3_1	388	395	PF00069	0.299
MOD_GSK3_1	407	414	PF00069	0.162
MOD_GSK3_1	425	432	PF00069	0.256
MOD_GSK3_1	474	481	PF00069	0.275
MOD_GSK3_1	62	69	PF00069	0.497
MOD_GSK3_1	655	662	PF00069	0.418
MOD_LATS_1	661	667	PF00433	0.452
MOD_N-GLC_1	411	416	PF02516	0.318
MOD_N-GLC_1	608	613	PF02516	0.462
MOD_N-GLC_2	127	129	PF02516	0.430
MOD_NEK2_1	1	6	PF00069	0.526
MOD_NEK2_1	161	166	PF00069	0.250
MOD_NEK2_1	176	181	PF00069	0.268
MOD_NEK2_1	217	222	PF00069	0.256
MOD_NEK2_1	308	313	PF00069	0.262
MOD_NEK2_1	315	320	PF00069	0.248
MOD_NEK2_1	349	354	PF00069	0.241
MOD_NEK2_1	429	434	PF00069	0.300
MOD_NEK2_1	440	445	PF00069	0.300
MOD_NEK2_1	474	479	PF00069	0.281
MOD_NEK2_1	523	528	PF00069	0.241
MOD_NEK2_1	608	613	PF00069	0.382
MOD_NEK2_1	695	700	PF00069	0.356
MOD_NEK2_2	685	690	PF00069	0.446
MOD_PKA_1	60	66	PF00069	0.578
MOD_PKA_2	60	66	PF00069	0.475
MOD_PKA_2	642	648	PF00069	0.409
MOD_PKA_2	707	713	PF00069	0.329
MOD_Plk_1	620	626	PF00069	0.355
MOD_Plk_1	663	669	PF00069	0.546
MOD_Plk_1	685	691	PF00069	0.438
MOD_Plk_2-3	138	144	PF00069	0.369
MOD_Plk_2-3	39	45	PF00069	0.401
MOD_Plk_4	191	197	PF00069	0.386
MOD_Plk_4	394	400	PF00069	0.254
MOD_Plk_4	443	449	PF00069	0.275
MOD_Plk_4	478	484	PF00069	0.258
MOD_Plk_4	620	626	PF00069	0.355
MOD_Plk_4	648	654	PF00069	0.386
MOD_Plk_4	663	669	PF00069	0.467
MOD_ProDKin_1	388	394	PF00069	0.241
MOD_ProDKin_1	407	413	PF00069	0.241
MOD_ProDKin_1	615	621	PF00069	0.292
MOD_ProDKin_1	655	661	PF00069	0.391
MOD_ProDKin_1	77	83	PF00069	0.460
MOD_SUMO_for_1	569	572	PF00179	0.369
MOD_SUMO_rev_2	185	195	PF00179	0.300
MOD_SUMO_rev_2	556	565	PF00179	0.383
TRG_ENDOCYTIC_2	162	165	PF00928	0.245
TRG_ENDOCYTIC_2	499	502	PF00928	0.261
TRG_ENDOCYTIC_2	574	577	PF00928	0.485
TRG_ENDOCYTIC_2	652	655	PF00928	0.396
TRG_ENDOCYTIC_2	709	712	PF00928	0.491
TRG_ER_diArg_1	364	367	PF00400	0.305
TRG_ER_diArg_1	59	61	PF00400	0.496
TRG_NLS_MonoExtN_4	363	369	PF00514	0.300
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.185
TRG_Pf-PMV_PEXEL_1	472	476	PF00026	0.256
TRG_Pf-PMV_PEXEL_1	599	603	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6P9	Leptomonas seymouri	79%	100%
A0A0N1IHR6	Leptomonas seymouri	29%	66%
A0A0N1IJL2	Leptomonas seymouri	25%	87%
A0A0S4IKD3	Bodo saltans	59%	100%
A0A0S4IL39	Bodo saltans	54%	100%
A0A0S4JG93	Bodo saltans	23%	91%
A0A0S4JSW7	Bodo saltans	25%	89%
A0A1X0NSH7	Trypanosomatidae	25%	83%
A0A1X0P2R6	Trypanosomatidae	65%	100%
A0A3Q8IH43	Leishmania donovani	24%	87%
A0A3R7KRB4	Trypanosoma rangeli	24%	85%
A0A3S5IRJ9	Trypanosoma rangeli	27%	79%
A0A422NY59	Trypanosoma rangeli	67%	100%
A4H342	Leishmania braziliensis	87%	100%
A4HKY2	Leishmania braziliensis	23%	87%
A4HRD9	Leishmania infantum	100%	100%
C9ZY92	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	82%
D0AAR0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	84%
E9AC07	Leishmania major	96%	100%
E9AHM3	Leishmania infantum	24%	87%
E9AJA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9AK82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	68%
E9B3C0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	87%
O18894	Oryctolagus cuniculus	33%	94%
O60159	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
O70496	Mus musculus	26%	96%
O94287	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
P0C197	Ustilago maydis (strain 521 / FGSC 9021)	33%	68%
P35523	Homo sapiens	28%	78%
P35524	Rattus norvegicus	28%	77%
P35525	Rattus norvegicus	28%	85%
P37020	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	99%
P51788	Homo sapiens	28%	86%
P51789	Oryctolagus cuniculus	28%	86%
P51790	Homo sapiens	33%	94%
P51791	Mus musculus	33%	94%
P51792	Rattus norvegicus	33%	94%
P51793	Homo sapiens	32%	100%
P51794	Rattus norvegicus	32%	100%
P51795	Homo sapiens	33%	94%
P51796	Rattus norvegicus	33%	94%
P51797	Homo sapiens	27%	89%
P51798	Homo sapiens	27%	96%
P51799	Rattus norvegicus	26%	96%
P51800	Homo sapiens	27%	100%
P51801	Homo sapiens	26%	100%
P51802	Rattus norvegicus	27%	100%
P51803	Oryctolagus cuniculus	26%	100%
P51804	Oryctolagus cuniculus	27%	100%
P60300	Arabidopsis thaliana	25%	100%
P92941	Arabidopsis thaliana	27%	99%
P92942	Arabidopsis thaliana	25%	99%
P92943	Arabidopsis thaliana	26%	97%
Q06393	Rattus norvegicus	27%	100%
Q4PKH3	Bos taurus	27%	95%
Q4Q4T5	Leishmania major	25%	88%
Q54AX6	Dictyostelium discoideum	27%	89%
Q5RBK4	Pongo abelii	33%	94%
Q5RDJ7	Pongo abelii	32%	96%
Q61418	Mus musculus	32%	100%
Q64347	Mus musculus	27%	77%
Q75JF3	Dictyostelium discoideum	28%	100%
Q86AZ6	Dictyostelium discoideum	28%	94%
Q96282	Arabidopsis thaliana	26%	99%
Q99P66	Cavia porcellus	33%	100%
Q9BMK9	Caenorhabditis elegans	30%	77%
Q9GKE7	Sus scrofa	33%	94%
Q9MZT1	Canis lupus familiaris	27%	79%
Q9R0A1	Mus musculus	29%	85%
Q9R279	Cavia porcellus	33%	94%
Q9TT16	Oryctolagus cuniculus	27%	89%
Q9TTU3	Oryctolagus cuniculus	31%	94%
Q9W701	Xenopus laevis	26%	100%
Q9WU45	Cavia porcellus	29%	85%
Q9WUB6	Mus musculus	27%	100%
Q9WUB7	Mus musculus	27%	100%
Q9WVD4	Mus musculus	33%	94%
V5AY77	Trypanosoma cruzi	26%	79%
V5BEI7	Trypanosoma cruzi	67%	100%