PHB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A451EJ66_LEIDO

TriTrypDb:

LdBPK_010080.1 , LdCL_010005800 , LDHU3_01.0100

Length:

237

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A0A451EJ66

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJ66

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	199	201	PF00675	0.593
CLV_NRD_NRD_1	62	64	PF00675	0.596
CLV_NRD_NRD_1	76	78	PF00675	0.588
CLV_PCSK_KEX2_1	199	201	PF00082	0.577
CLV_PCSK_KEX2_1	62	64	PF00082	0.614
CLV_PCSK_KEX2_1	76	78	PF00082	0.621
CLV_PCSK_SKI1_1	119	123	PF00082	0.575
CLV_PCSK_SKI1_1	200	204	PF00082	0.647
CLV_PCSK_SKI1_1	53	57	PF00082	0.595
CLV_PCSK_SKI1_1	64	68	PF00082	0.523
DEG_APCC_DBOX_1	76	84	PF00400	0.490
DOC_CYCLIN_yCln2_LP_2	105	108	PF00134	0.438
DOC_PP2B_LxvP_1	104	107	PF13499	0.394
DOC_PP4_FxxP_1	115	118	PF00568	0.339
DOC_PP4_FxxP_1	203	206	PF00568	0.363
DOC_USP7_MATH_1	187	191	PF00917	0.436
DOC_USP7_MATH_1	2	6	PF00917	0.708
DOC_USP7_MATH_1	227	231	PF00917	0.301
DOC_USP7_MATH_1	81	85	PF00917	0.441
LIG_14-3-3_CanoR_1	53	58	PF00244	0.378
LIG_14-3-3_CanoR_1	62	67	PF00244	0.368
LIG_14-3-3_CanoR_1	82	90	PF00244	0.457
LIG_APCC_ABBA_1	204	209	PF00400	0.428
LIG_BRCT_BRCA1_1	108	112	PF00533	0.414
LIG_BRCT_BRCA1_1	88	92	PF00533	0.491
LIG_eIF4E_1	91	97	PF01652	0.395
LIG_EVH1_2	107	111	PF00568	0.381
LIG_FHA_1	100	106	PF00498	0.401
LIG_FHA_1	210	216	PF00498	0.400
LIG_FHA_1	5	11	PF00498	0.698
LIG_FHA_2	196	202	PF00498	0.464
LIG_FHA_2	67	73	PF00498	0.368
LIG_LIR_Apic_2	148	154	PF02991	0.292
LIG_LIR_Apic_2	201	206	PF02991	0.375
LIG_LIR_Gen_1	152	163	PF02991	0.393
LIG_LIR_Nem_3	109	115	PF02991	0.355
LIG_LIR_Nem_3	148	153	PF02991	0.359
LIG_MLH1_MIPbox_1	108	112	PF16413	0.426
LIG_MLH1_MIPbox_1	88	92	PF16413	0.491
LIG_Pex14_2	111	115	PF04695	0.355
LIG_SH2_CRK	151	155	PF00017	0.294
LIG_SH2_NCK_1	151	155	PF00017	0.377
LIG_SH2_STAT5	151	154	PF00017	0.306
LIG_SH2_STAT5	161	164	PF00017	0.350
LIG_SH2_STAT5	180	183	PF00017	0.269
LIG_SH2_STAT5	91	94	PF00017	0.389
LIG_SH3_3	122	128	PF00018	0.303
LIG_SH3_3	164	170	PF00018	0.357
LIG_SH3_3	22	28	PF00018	0.537
LIG_SH3_3	46	52	PF00018	0.405
LIG_SH3_3	7	13	PF00018	0.694
LIG_SUMO_SIM_anti_2	229	235	PF11976	0.400
LIG_SUMO_SIM_par_1	229	235	PF11976	0.444
LIG_TRAF2_1	132	135	PF00917	0.379
LIG_UBA3_1	36	41	PF00899	0.475
MOD_CK2_1	117	123	PF00069	0.419
MOD_CK2_1	195	201	PF00069	0.442
MOD_GlcNHglycan	188	192	PF01048	0.618
MOD_GlcNHglycan	21	24	PF01048	0.515
MOD_GlcNHglycan	69	72	PF01048	0.607
MOD_GlcNHglycan	93	96	PF01048	0.645
MOD_GSK3_1	113	120	PF00069	0.400
MOD_GSK3_1	145	152	PF00069	0.385
MOD_GSK3_1	210	217	PF00069	0.334
MOD_GSK3_1	58	65	PF00069	0.352
MOD_LATS_1	51	57	PF00433	0.426
MOD_N-GLC_1	86	91	PF02516	0.679
MOD_NEK2_1	145	150	PF00069	0.282
MOD_NEK2_1	19	24	PF00069	0.686
MOD_NEK2_1	195	200	PF00069	0.437
MOD_NEK2_1	86	91	PF00069	0.439
MOD_NEK2_1	97	102	PF00069	0.318
MOD_PK_1	139	145	PF00069	0.356
MOD_PKA_1	62	68	PF00069	0.356
MOD_PKA_1	76	82	PF00069	0.409
MOD_PKA_2	62	68	PF00069	0.356
MOD_PKA_2	76	82	PF00069	0.409
MOD_Plk_1	86	92	PF00069	0.458
MOD_Plk_4	107	113	PF00069	0.400
MOD_Plk_4	145	151	PF00069	0.355
MOD_Plk_4	227	233	PF00069	0.421
MOD_Plk_4	53	59	PF00069	0.326
MOD_Plk_4	62	68	PF00069	0.356
MOD_Plk_4	86	92	PF00069	0.441
TRG_DiLeu_BaEn_1	218	223	PF01217	0.383
TRG_DiLeu_BaEn_1	229	234	PF01217	0.368
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.437
TRG_ER_diArg_1	101	104	PF00400	0.423
TRG_ER_diArg_1	75	77	PF00400	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDU2	Leptomonas seymouri	78%	100%
A0A0S4JQK8	Bodo saltans	35%	90%
A0A1X0P2T1	Trypanosomatidae	48%	99%
A0A3S5ISA4	Trypanosoma rangeli	49%	100%
A4H323	Leishmania braziliensis	88%	100%
A4HRC9	Leishmania infantum	100%	100%
C9ZXG7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	89%
E9ABZ7	Leishmania major	94%	100%
E9AJ94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5B2Q8	Trypanosoma cruzi	48%	91%