Plus3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A451EJ64_LEIDO

TriTrypDb:

LdBPK_010060.1 , LdCL_010005600 , LDHU3_01.0080

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A451EJ64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJ64

PDB structure(s): 7aih_As , 7am2_As , 7ane_As

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	155	157	PF00675	0.494
CLV_NRD_NRD_1	183	185	PF00675	0.574
CLV_NRD_NRD_1	197	199	PF00675	0.551
CLV_NRD_NRD_1	2	4	PF00675	0.580
CLV_NRD_NRD_1	57	59	PF00675	0.436
CLV_NRD_NRD_1	9	11	PF00675	0.590
CLV_PCSK_FUR_1	156	160	PF00082	0.483
CLV_PCSK_KEX2_1	158	160	PF00082	0.472
CLV_PCSK_KEX2_1	178	180	PF00082	0.296
CLV_PCSK_KEX2_1	2	4	PF00082	0.561

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6N8	Leptomonas seymouri	76%	100%
A0A0S4JMA4	Bodo saltans	62%	100%
A0A3R7NZX6	Trypanosoma rangeli	81%	100%
A4H340	Leishmania braziliensis	75%	95%
A4HRC7	Leishmania infantum	100%	100%
C9ZXG9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
E9ABZ5	Leishmania major	94%	100%
E9AJ92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%

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