Plus3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A451EJ64_LEIDO

TriTrypDb:

LdBPK_010060.1 , LdCL_010005600 , LDHU3_01.0080

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A451EJ64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJ64

PDB structure(s): 7aih_As , 7am2_As , 7ane_As

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	155	157	PF00675	0.494
CLV_NRD_NRD_1	183	185	PF00675	0.574
CLV_NRD_NRD_1	197	199	PF00675	0.551
CLV_NRD_NRD_1	2	4	PF00675	0.580
CLV_NRD_NRD_1	57	59	PF00675	0.436
CLV_NRD_NRD_1	9	11	PF00675	0.590
CLV_PCSK_FUR_1	156	160	PF00082	0.483
CLV_PCSK_KEX2_1	158	160	PF00082	0.472
CLV_PCSK_KEX2_1	178	180	PF00082	0.296
CLV_PCSK_KEX2_1	2	4	PF00082	0.561
CLV_PCSK_KEX2_1	57	59	PF00082	0.436
CLV_PCSK_KEX2_1	9	11	PF00082	0.571
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.472
CLV_PCSK_PC1ET2_1	178	180	PF00082	0.296
CLV_PCSK_SKI1_1	194	198	PF00082	0.563
DEG_APCC_DBOX_1	57	65	PF00400	0.435
DEG_Nend_UBRbox_1	1	4	PF02207	0.585
DOC_CDC14_PxL_1	1	9	PF14671	0.544
DOC_CKS1_1	131	136	PF01111	0.456
DOC_MAPK_gen_1	57	64	PF00069	0.428
DOC_USP7_MATH_1	17	21	PF00917	0.700
DOC_USP7_MATH_1	173	177	PF00917	0.555
DOC_USP7_MATH_1	212	216	PF00917	0.764
DOC_USP7_MATH_1	34	38	PF00917	0.651
DOC_USP7_UBL2_3	200	204	PF12436	0.492
DOC_WW_Pin1_4	130	135	PF00397	0.446
DOC_WW_Pin1_4	68	73	PF00397	0.410
LIG_14-3-3_CanoR_1	172	176	PF00244	0.619
LIG_Clathr_ClatBox_1	61	65	PF01394	0.445
LIG_FHA_1	85	91	PF00498	0.427
LIG_FHA_2	172	178	PF00498	0.580
LIG_FHA_2	51	57	PF00498	0.450
LIG_Integrin_isoDGR_2	49	51	PF01839	0.544
LIG_LIR_Nem_3	56	62	PF02991	0.428
LIG_SH3_3	30	36	PF00018	0.544
LIG_UBA3_1	131	136	PF00899	0.531
LIG_UBA3_1	152	158	PF00899	0.520
LIG_WW_3	245	249	PF00397	0.793
MOD_CDK_SPxK_1	130	136	PF00069	0.484
MOD_CK1_1	215	221	PF00069	0.813
MOD_CK1_1	22	28	PF00069	0.729
MOD_GlcNHglycan	11	14	PF01048	0.651
MOD_GlcNHglycan	139	143	PF01048	0.573
MOD_GlcNHglycan	19	22	PF01048	0.708
MOD_GlcNHglycan	214	217	PF01048	0.704
MOD_GlcNHglycan	241	244	PF01048	0.724
MOD_GlcNHglycan	25	28	PF01048	0.739
MOD_GSK3_1	143	150	PF00069	0.602
MOD_GSK3_1	15	22	PF00069	0.672
MOD_NEK2_1	186	191	PF00069	0.572
MOD_PIKK_1	143	149	PF00454	0.692
MOD_PKA_1	9	15	PF00069	0.688
MOD_PKA_2	164	170	PF00069	0.576
MOD_PKA_2	171	177	PF00069	0.588
MOD_PKA_2	186	192	PF00069	0.473
MOD_PKA_2	221	227	PF00069	0.716
MOD_PKA_2	239	245	PF00069	0.550
MOD_PKA_2	50	56	PF00069	0.452
MOD_PKA_2	8	14	PF00069	0.629
MOD_Plk_1	179	185	PF00069	0.483
MOD_Plk_2-3	171	177	PF00069	0.620
MOD_Plk_4	164	170	PF00069	0.514
MOD_Plk_4	34	40	PF00069	0.591
MOD_Plk_4	71	77	PF00069	0.415
MOD_ProDKin_1	130	136	PF00069	0.453
MOD_ProDKin_1	68	74	PF00069	0.406
TRG_DiLeu_BaLyEn_6	2	7	PF01217	0.529
TRG_ER_diArg_1	1	3	PF00400	0.589
TRG_ER_diArg_1	57	59	PF00400	0.436
TRG_Pf-PMV_PEXEL_1	159	164	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	88	92	PF00026	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6N8	Leptomonas seymouri	76%	100%
A0A0S4JMA4	Bodo saltans	62%	100%
A0A3R7NZX6	Trypanosoma rangeli	81%	100%
A4H340	Leishmania braziliensis	75%	95%
A4HRC7	Leishmania infantum	100%	100%
C9ZXG9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
E9ABZ5	Leishmania major	94%	100%
E9AJ92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%