Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A451EJ62_LEIDO

TriTrypDb:

LdBPK_010040.1 , LdCL_010005400 , LDHU3_01.0060

Length:

186

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A451EJ62

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A451EJ62

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.571
CLV_NRD_NRD_1	75	77	PF00675	0.565
CLV_PCSK_KEX2_1	120	122	PF00082	0.557
CLV_PCSK_KEX2_1	2	4	PF00082	0.595
CLV_PCSK_KEX2_1	75	77	PF00082	0.503
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.595
CLV_PCSK_SKI1_1	177	181	PF00082	0.616
CLV_PCSK_SKI1_1	51	55	PF00082	0.554
DEG_APCC_DBOX_1	176	184	PF00400	0.517
DEG_APCC_DBOX_1	50	58	PF00400	0.540
DEG_Nend_UBRbox_1	1	4	PF02207	0.605
DEG_SPOP_SBC_1	32	36	PF00917	0.552
DOC_CYCLIN_RxL_1	45	58	PF00134	0.498
DOC_MAPK_DCC_7	121	131	PF00069	0.574
DOC_MAPK_gen_1	105	113	PF00069	0.572
DOC_MAPK_gen_1	174	182	PF00069	0.616
DOC_MAPK_MEF2A_6	174	182	PF00069	0.616
DOC_PP4_FxxP_1	29	32	PF00568	0.505
DOC_USP7_MATH_1	32	36	PF00917	0.630
DOC_WW_Pin1_4	3	8	PF00397	0.605
LIG_14-3-3_CanoR_1	120	130	PF00244	0.550
LIG_14-3-3_CanoR_1	177	183	PF00244	0.616
LIG_14-3-3_CanoR_1	31	39	PF00244	0.595
LIG_Actin_WH2_2	49	67	PF00022	0.524
LIG_BRCT_BRCA1_1	25	29	PF00533	0.495
LIG_FHA_2	95	101	PF00498	0.509
LIG_LIR_Apic_2	26	32	PF02991	0.509
LIG_LIR_Gen_1	100	106	PF02991	0.562
LIG_SH2_STAT5	158	161	PF00017	0.731
LIG_SH3_3	180	186	PF00018	0.522
LIG_SH3_4	137	144	PF00018	0.561
LIG_SUMO_SIM_par_1	52	58	PF11976	0.536
LIG_TRAF2_1	115	118	PF00917	0.708
LIG_TRAF2_1	41	44	PF00917	0.644
MOD_CK1_1	16	22	PF00069	0.626
MOD_CK1_1	34	40	PF00069	0.726
MOD_CK1_1	8	14	PF00069	0.593
MOD_CK2_1	37	43	PF00069	0.600
MOD_CK2_1	52	58	PF00069	0.536
MOD_CK2_1	94	100	PF00069	0.507
MOD_Cter_Amidation	159	162	PF01082	0.619
MOD_DYRK1A_RPxSP_1	3	7	PF00069	0.603
MOD_GlcNHglycan	13	16	PF01048	0.608
MOD_GlcNHglycan	18	21	PF01048	0.587
MOD_GlcNHglycan	25	28	PF01048	0.621
MOD_GlcNHglycan	39	42	PF01048	0.559
MOD_GlcNHglycan	7	10	PF01048	0.644
MOD_GSK3_1	19	26	PF00069	0.716
MOD_GSK3_1	31	38	PF00069	0.518
MOD_GSK3_1	5	12	PF00069	0.618
MOD_NEK2_1	23	28	PF00069	0.657
MOD_NEK2_1	33	38	PF00069	0.545
MOD_PIKK_1	94	100	PF00454	0.552
MOD_PKA_1	120	126	PF00069	0.538
MOD_PKA_1	75	81	PF00069	0.565
MOD_PKA_2	104	110	PF00069	0.575
MOD_PKA_2	119	125	PF00069	0.453
MOD_PKA_2	75	81	PF00069	0.565
MOD_PKB_1	3	11	PF00069	0.586
MOD_Plk_1	9	15	PF00069	0.603
MOD_Plk_4	178	184	PF00069	0.591
MOD_Plk_4	52	58	PF00069	0.527
MOD_ProDKin_1	3	9	PF00069	0.604
TRG_DiLeu_BaLyEn_6	49	54	PF01217	0.534
TRG_ER_diArg_1	74	76	PF00400	0.565
TRG_Pf-PMV_PEXEL_1	114	118	PF00026	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8D7	Leptomonas seymouri	56%	100%
A4H338	Leishmania braziliensis	81%	100%
E9ABZ3	Leishmania major	95%	100%
E9AJ90	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%