LeishMANIAdb
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CG1104 protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
CG1104 protein-like protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7XCH5_LEIDO
TriTrypDb:
LdBPK_367120.1 , LdCL_360083800 , LDHU3_36.9490
Length:
737

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005789 endoplasmic reticulum membrane 4 1
GO:0016020 membrane 2 1
GO:0031090 organelle membrane 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3S7XCH5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XCH5

Function

Biological processes
Term Name Level Count
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0019538 protein metabolic process 3 12
GO:0032446 protein modification by small protein conjugation 6 12
GO:0036211 protein modification process 4 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043412 macromolecule modification 4 12
GO:0044238 primary metabolic process 2 12
GO:0070647 protein modification by small protein conjugation or removal 5 12
GO:0071569 protein ufmylation 7 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:0006950 response to stress 2 1
GO:0009894 regulation of catabolic process 4 1
GO:0009987 cellular process 1 1
GO:0019222 regulation of metabolic process 3 1
GO:0030162 regulation of proteolysis 6 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031329 regulation of cellular catabolic process 5 1
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 7 1
GO:0033554 cellular response to stress 3 1
GO:0034976 response to endoplasmic reticulum stress 4 1
GO:0042176 regulation of protein catabolic process 5 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0050896 response to stimulus 1 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051246 regulation of protein metabolic process 5 1
GO:0051716 cellular response to stimulus 2 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0061136 regulation of proteasomal protein catabolic process 6 1
GO:0065007 biological regulation 1 1
GO:0080090 regulation of primary metabolic process 4 1
GO:1903050 regulation of proteolysis involved in protein catabolic process 7 1
GO:1990564 protein polyufmylation 8 1
GO:1990592 protein K69-linked ufmylation 9 1
GO:2000058 regulation of ubiquitin-dependent protein catabolic process 6 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0016740 transferase activity 2 12
GO:0019787 ubiquitin-like protein transferase activity 3 12
GO:0061659 ubiquitin-like protein ligase activity 4 12
GO:0061666 UFM1 ligase activity 5 12
GO:0071568 UFM1 transferase activity 4 12
GO:0140096 catalytic activity, acting on a protein 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 520 524 PF00656 0.337
CLV_NRD_NRD_1 304 306 PF00675 0.613
CLV_NRD_NRD_1 308 310 PF00675 0.593
CLV_NRD_NRD_1 585 587 PF00675 0.437
CLV_PCSK_KEX2_1 11 13 PF00082 0.417
CLV_PCSK_KEX2_1 204 206 PF00082 0.370
CLV_PCSK_KEX2_1 242 244 PF00082 0.370
CLV_PCSK_KEX2_1 308 310 PF00082 0.538
CLV_PCSK_KEX2_1 585 587 PF00082 0.428
CLV_PCSK_KEX2_1 61 63 PF00082 0.314
CLV_PCSK_PC1ET2_1 11 13 PF00082 0.417
CLV_PCSK_PC1ET2_1 204 206 PF00082 0.241
CLV_PCSK_PC1ET2_1 242 244 PF00082 0.350
CLV_PCSK_PC1ET2_1 61 63 PF00082 0.434
CLV_PCSK_SKI1_1 152 156 PF00082 0.409
CLV_PCSK_SKI1_1 364 368 PF00082 0.379
CLV_PCSK_SKI1_1 420 424 PF00082 0.507
CLV_PCSK_SKI1_1 494 498 PF00082 0.566
CLV_PCSK_SKI1_1 576 580 PF00082 0.431
CLV_PCSK_SKI1_1 730 734 PF00082 0.469
CLV_Separin_Metazoa 195 199 PF03568 0.350
CLV_Separin_Metazoa 458 462 PF03568 0.519
DEG_APCC_DBOX_1 585 593 PF00400 0.369
DEG_Nend_UBRbox_2 1 3 PF02207 0.609
DOC_CDC14_PxL_1 352 360 PF14671 0.466
DOC_CYCLIN_RxL_1 573 583 PF00134 0.446
DOC_CYCLIN_yClb5_NLxxxL_5 37 46 PF00134 0.302
DOC_MAPK_gen_1 39 47 PF00069 0.310
DOC_MAPK_gen_1 431 437 PF00069 0.625
DOC_MAPK_gen_1 585 592 PF00069 0.517
DOC_MAPK_gen_1 627 637 PF00069 0.422
DOC_MAPK_MEF2A_6 321 329 PF00069 0.653
DOC_MAPK_MEF2A_6 364 371 PF00069 0.404
DOC_MAPK_MEF2A_6 39 47 PF00069 0.369
DOC_MAPK_MEF2A_6 628 637 PF00069 0.419
DOC_MAPK_NFAT4_5 40 48 PF00069 0.394
DOC_MIT_MIM_1 8 16 PF04212 0.417
DOC_PP1_RVXF_1 511 518 PF00149 0.353
DOC_PP2B_LxvP_1 208 211 PF13499 0.289
DOC_PP2B_LxvP_1 449 452 PF13499 0.516
DOC_PP2B_LxvP_1 552 555 PF13499 0.465
DOC_PP4_FxxP_1 622 625 PF00568 0.424
DOC_USP7_MATH_1 211 215 PF00917 0.431
DOC_USP7_MATH_1 292 296 PF00917 0.684
DOC_USP7_MATH_1 357 361 PF00917 0.524
DOC_USP7_MATH_1 430 434 PF00917 0.581
DOC_USP7_MATH_1 618 622 PF00917 0.423
DOC_USP7_MATH_1 648 652 PF00917 0.602
DOC_USP7_MATH_1 94 98 PF00917 0.299
DOC_USP7_UBL2_3 306 310 PF12436 0.674
LIG_14-3-3_CanoR_1 12 17 PF00244 0.436
LIG_14-3-3_CanoR_1 326 330 PF00244 0.617
LIG_14-3-3_CanoR_1 504 510 PF00244 0.449
LIG_14-3-3_CanoR_1 532 542 PF00244 0.412
LIG_14-3-3_CanoR_1 585 590 PF00244 0.455
LIG_14-3-3_CanoR_1 691 699 PF00244 0.491
LIG_14-3-3_CanoR_1 730 735 PF00244 0.466
LIG_APCC_ABBA_1 375 380 PF00400 0.524
LIG_BRCT_BRCA1_1 146 150 PF00533 0.375
LIG_BRCT_BRCA1_2 146 152 PF00533 0.350
LIG_eIF4E_1 203 209 PF01652 0.417
LIG_FHA_1 174 180 PF00498 0.279
LIG_FHA_1 242 248 PF00498 0.431
LIG_FHA_1 406 412 PF00498 0.534
LIG_FHA_1 665 671 PF00498 0.456
LIG_FHA_1 729 735 PF00498 0.564
LIG_FHA_1 86 92 PF00498 0.425
LIG_FHA_2 54 60 PF00498 0.435
LIG_FHA_2 578 584 PF00498 0.441
LIG_FHA_2 605 611 PF00498 0.510
LIG_FHA_2 723 729 PF00498 0.532
LIG_GBD_Chelix_1 470 478 PF00786 0.477
LIG_LIR_Apic_2 276 281 PF02991 0.524
LIG_LIR_Apic_2 621 625 PF02991 0.418
LIG_LIR_Gen_1 138 146 PF02991 0.318
LIG_LIR_Gen_1 175 186 PF02991 0.412
LIG_LIR_Gen_1 503 512 PF02991 0.435
LIG_LIR_Gen_1 56 65 PF02991 0.303
LIG_LIR_Gen_1 632 642 PF02991 0.481
LIG_LIR_Nem_3 175 181 PF02991 0.369
LIG_LIR_Nem_3 207 212 PF02991 0.431
LIG_LIR_Nem_3 231 237 PF02991 0.459
LIG_LIR_Nem_3 258 262 PF02991 0.291
LIG_LIR_Nem_3 382 388 PF02991 0.490
LIG_LIR_Nem_3 394 399 PF02991 0.444
LIG_LIR_Nem_3 454 459 PF02991 0.455
LIG_LIR_Nem_3 465 470 PF02991 0.359
LIG_LIR_Nem_3 503 508 PF02991 0.442
LIG_LIR_Nem_3 56 60 PF02991 0.303
LIG_LIR_Nem_3 632 637 PF02991 0.539
LIG_LYPXL_S_1 395 399 PF13949 0.551
LIG_LYPXL_yS_3 396 399 PF13949 0.552
LIG_NRBOX 41 47 PF00104 0.261
LIG_NRBOX 664 670 PF00104 0.405
LIG_PCNA_PIPBox_1 143 152 PF02747 0.302
LIG_SH2_CRK 259 263 PF00017 0.274
LIG_SH2_NCK_1 278 282 PF00017 0.596
LIG_SH2_PTP2 234 237 PF00017 0.350
LIG_SH2_PTP2 634 637 PF00017 0.410
LIG_SH2_SRC 117 120 PF00017 0.274
LIG_SH2_STAP1 174 178 PF00017 0.334
LIG_SH2_STAT3 174 177 PF00017 0.334
LIG_SH2_STAT5 117 120 PF00017 0.274
LIG_SH2_STAT5 174 177 PF00017 0.289
LIG_SH2_STAT5 234 237 PF00017 0.274
LIG_SH2_STAT5 273 276 PF00017 0.502
LIG_SH2_STAT5 351 354 PF00017 0.423
LIG_SH2_STAT5 54 57 PF00017 0.297
LIG_SH2_STAT5 634 637 PF00017 0.508
LIG_SH3_3 565 571 PF00018 0.524
LIG_SH3_3 675 681 PF00018 0.356
LIG_SH3_3 75 81 PF00018 0.289
LIG_SUMO_SIM_par_1 103 108 PF11976 0.400
LIG_SUMO_SIM_par_1 407 412 PF11976 0.551
LIG_SUMO_SIM_par_1 614 621 PF11976 0.540
LIG_SUMO_SIM_par_1 731 737 PF11976 0.395
LIG_SUMO_SIM_par_1 82 88 PF11976 0.348
LIG_TRAF2_1 192 195 PF00917 0.350
LIG_TRAF2_1 414 417 PF00917 0.473
LIG_TRAF2_1 496 499 PF00917 0.401
LIG_TRAF2_1 725 728 PF00917 0.467
LIG_TYR_ITIM 257 262 PF00017 0.274
LIG_UBA3_1 377 383 PF00899 0.578
LIG_UBA3_1 589 597 PF00899 0.430
LIG_WRC_WIRS_1 578 583 PF05994 0.316
LIG_WRC_WIRS_1 619 624 PF05994 0.451
LIG_WRC_WIRS_1 86 91 PF05994 0.410
MOD_CK1_1 172 178 PF00069 0.391
MOD_CK1_1 296 302 PF00069 0.735
MOD_CK1_1 664 670 PF00069 0.433
MOD_CK1_1 85 91 PF00069 0.388
MOD_CK2_1 53 59 PF00069 0.435
MOD_CK2_1 577 583 PF00069 0.433
MOD_CK2_1 604 610 PF00069 0.477
MOD_CK2_1 697 703 PF00069 0.575
MOD_CK2_1 714 720 PF00069 0.501
MOD_CK2_1 722 728 PF00069 0.435
MOD_CK2_1 94 100 PF00069 0.332
MOD_Cter_Amidation 306 309 PF01082 0.617
MOD_GlcNHglycan 298 301 PF01048 0.749
MOD_GlcNHglycan 331 334 PF01048 0.607
MOD_GlcNHglycan 400 403 PF01048 0.609
MOD_GlcNHglycan 411 414 PF01048 0.477
MOD_GlcNHglycan 480 483 PF01048 0.562
MOD_GlcNHglycan 526 529 PF01048 0.483
MOD_GlcNHglycan 610 614 PF01048 0.435
MOD_GlcNHglycan 699 702 PF01048 0.402
MOD_GSK3_1 131 138 PF00069 0.341
MOD_GSK3_1 169 176 PF00069 0.251
MOD_GSK3_1 288 295 PF00069 0.594
MOD_GSK3_1 325 332 PF00069 0.571
MOD_GSK3_1 405 412 PF00069 0.441
MOD_GSK3_1 431 438 PF00069 0.596
MOD_GSK3_1 577 584 PF00069 0.464
MOD_GSK3_1 660 667 PF00069 0.489
MOD_GSK3_1 714 721 PF00069 0.446
MOD_GSK3_1 730 737 PF00069 0.549
MOD_N-GLC_1 548 553 PF02516 0.392
MOD_N-GLC_2 254 256 PF02516 0.278
MOD_NEK2_1 135 140 PF00069 0.356
MOD_NEK2_1 150 155 PF00069 0.252
MOD_NEK2_1 173 178 PF00069 0.255
MOD_NEK2_1 212 217 PF00069 0.346
MOD_NEK2_1 228 233 PF00069 0.395
MOD_NEK2_1 250 255 PF00069 0.374
MOD_NEK2_1 293 298 PF00069 0.635
MOD_NEK2_1 478 483 PF00069 0.523
MOD_NEK2_1 508 513 PF00069 0.442
MOD_NEK2_1 581 586 PF00069 0.512
MOD_NEK2_1 604 609 PF00069 0.392
MOD_NEK2_1 611 616 PF00069 0.372
MOD_NEK2_1 661 666 PF00069 0.373
MOD_NEK2_2 618 623 PF00069 0.422
MOD_NEK2_2 82 87 PF00069 0.346
MOD_PIKK_1 135 141 PF00454 0.400
MOD_PIKK_1 173 179 PF00454 0.254
MOD_PIKK_1 566 572 PF00454 0.540
MOD_PK_1 431 437 PF00069 0.395
MOD_PK_1 597 603 PF00069 0.459
MOD_PK_1 646 652 PF00069 0.465
MOD_PKA_1 431 437 PF00069 0.497
MOD_PKA_1 585 591 PF00069 0.460
MOD_PKA_2 325 331 PF00069 0.632
MOD_PKA_2 503 509 PF00069 0.457
MOD_PKA_2 585 591 PF00069 0.476
MOD_PKA_2 714 720 PF00069 0.559
MOD_Plk_1 169 175 PF00069 0.403
MOD_Plk_1 548 554 PF00069 0.400
MOD_Plk_1 597 603 PF00069 0.523
MOD_Plk_2-3 53 59 PF00069 0.274
MOD_Plk_2-3 722 728 PF00069 0.468
MOD_Plk_4 145 151 PF00069 0.312
MOD_Plk_4 169 175 PF00069 0.437
MOD_Plk_4 212 218 PF00069 0.326
MOD_Plk_4 229 235 PF00069 0.351
MOD_Plk_4 357 363 PF00069 0.461
MOD_Plk_4 400 406 PF00069 0.482
MOD_Plk_4 444 450 PF00069 0.479
MOD_Plk_4 585 591 PF00069 0.553
MOD_Plk_4 664 670 PF00069 0.345
MOD_Plk_4 94 100 PF00069 0.385
MOD_SUMO_for_1 60 63 PF00179 0.417
MOD_SUMO_for_1 692 695 PF00179 0.480
MOD_SUMO_rev_2 412 422 PF00179 0.427
MOD_SUMO_rev_2 639 648 PF00179 0.523
TRG_DiLeu_BaEn_1 108 113 PF01217 0.289
TRG_DiLeu_BaEn_1 400 405 PF01217 0.556
TRG_DiLeu_BaEn_1 5 10 PF01217 0.279
TRG_DiLeu_BaEn_4 100 106 PF01217 0.302
TRG_DiLeu_BaEn_4 194 200 PF01217 0.350
TRG_DiLeu_BaLyEn_6 383 388 PF01217 0.412
TRG_DiLeu_BaLyEn_6 588 593 PF01217 0.503
TRG_DiLeu_LyEn_5 258 263 PF01217 0.217
TRG_ENDOCYTIC_2 234 237 PF00928 0.451
TRG_ENDOCYTIC_2 259 262 PF00928 0.274
TRG_ENDOCYTIC_2 396 399 PF00928 0.552
TRG_ENDOCYTIC_2 456 459 PF00928 0.466
TRG_ENDOCYTIC_2 634 637 PF00928 0.525
TRG_ER_diArg_1 161 164 PF00400 0.350
TRG_NES_CRM1_1 365 380 PF08389 0.477
TRG_NLS_MonoExtC_3 304 309 PF00514 0.625
TRG_Pf-PMV_PEXEL_1 461 465 PF00026 0.492
TRG_Pf-PMV_PEXEL_1 62 66 PF00026 0.396

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IM39 Leptomonas seymouri 67% 100%
A0A0S4JTJ6 Bodo saltans 35% 95%
A0A1X0NLV8 Trypanosomatidae 41% 98%
A0A422NVV8 Trypanosoma rangeli 41% 99%
A4HQK2 Leishmania braziliensis 82% 100%
A4ICC0 Leishmania infantum 99% 100%
D0A3Q3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
E9AUB5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 99%
Q4Q075 Leishmania major 91% 100%
V5AXN4 Trypanosoma cruzi 40% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS