Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XCG4_LEIDO

TriTrypDb:

LdBPK_366790.1 , LdCL_360080400 , LDHU3_36.9060

Length:

652

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3S7XCG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XCG4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	338	342	PF00656	0.656
CLV_NRD_NRD_1	172	174	PF00675	0.621
CLV_NRD_NRD_1	297	299	PF00675	0.460
CLV_NRD_NRD_1	36	38	PF00675	0.505
CLV_NRD_NRD_1	42	44	PF00675	0.467
CLV_NRD_NRD_1	448	450	PF00675	0.526
CLV_NRD_NRD_1	554	556	PF00675	0.660
CLV_NRD_NRD_1	582	584	PF00675	0.640
CLV_NRD_NRD_1	640	642	PF00675	0.644
CLV_NRD_NRD_1	90	92	PF00675	0.608
CLV_PCSK_FUR_1	580	584	PF00082	0.637
CLV_PCSK_KEX2_1	172	174	PF00082	0.548
CLV_PCSK_KEX2_1	272	274	PF00082	0.461
CLV_PCSK_KEX2_1	35	37	PF00082	0.505
CLV_PCSK_KEX2_1	42	44	PF00082	0.468
CLV_PCSK_KEX2_1	448	450	PF00082	0.526
CLV_PCSK_KEX2_1	554	556	PF00082	0.660
CLV_PCSK_KEX2_1	582	584	PF00082	0.597
CLV_PCSK_KEX2_1	640	642	PF00082	0.656
CLV_PCSK_KEX2_1	90	92	PF00082	0.604
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.461
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.499
CLV_PCSK_SKI1_1	141	145	PF00082	0.571
CLV_PCSK_SKI1_1	299	303	PF00082	0.460
CLV_PCSK_SKI1_1	38	42	PF00082	0.467
CLV_PCSK_SKI1_1	494	498	PF00082	0.697
CLV_PCSK_SKI1_1	70	74	PF00082	0.471
CLV_Separin_Metazoa	237	241	PF03568	0.667
CLV_Separin_Metazoa	39	43	PF03568	0.601
DEG_APCC_DBOX_1	69	77	PF00400	0.692
DEG_Nend_UBRbox_2	1	3	PF02207	0.528
DEG_SCF_FBW7_1	204	209	PF00400	0.636
DEG_SCF_FBW7_1	413	420	PF00400	0.695
DEG_SCF_FBW7_1	98	104	PF00400	0.734
DEG_SPOP_SBC_1	149	153	PF00917	0.759
DEG_SPOP_SBC_1	78	82	PF00917	0.749
DOC_CKS1_1	414	419	PF01111	0.696
DOC_CKS1_1	575	580	PF01111	0.442
DOC_CKS1_1	98	103	PF01111	0.761
DOC_CYCLIN_yCln2_LP_2	484	490	PF00134	0.507
DOC_MAPK_gen_1	448	455	PF00069	0.646
DOC_MAPK_MEF2A_6	388	396	PF00069	0.541
DOC_PP2B_LxvP_1	484	487	PF13499	0.493
DOC_PP2B_LxvP_1	517	520	PF13499	0.499
DOC_PP4_FxxP_1	575	578	PF00568	0.423
DOC_USP7_MATH_1	168	172	PF00917	0.776
DOC_USP7_MATH_1	408	412	PF00917	0.722
DOC_USP7_MATH_1	417	421	PF00917	0.746
DOC_USP7_MATH_1	531	535	PF00917	0.491
DOC_USP7_MATH_1	581	585	PF00917	0.492
DOC_USP7_MATH_1	72	76	PF00917	0.691
DOC_USP7_MATH_1	78	82	PF00917	0.753
DOC_USP7_UBL2_3	286	290	PF12436	0.647
DOC_WW_Pin1_4	171	176	PF00397	0.750
DOC_WW_Pin1_4	182	187	PF00397	0.773
DOC_WW_Pin1_4	202	207	PF00397	0.712
DOC_WW_Pin1_4	27	32	PF00397	0.703
DOC_WW_Pin1_4	313	318	PF00397	0.662
DOC_WW_Pin1_4	413	418	PF00397	0.710
DOC_WW_Pin1_4	46	51	PF00397	0.554
DOC_WW_Pin1_4	477	482	PF00397	0.583
DOC_WW_Pin1_4	56	61	PF00397	0.614
DOC_WW_Pin1_4	574	579	PF00397	0.436
DOC_WW_Pin1_4	598	603	PF00397	0.500
DOC_WW_Pin1_4	85	90	PF00397	0.795
DOC_WW_Pin1_4	94	99	PF00397	0.835
LIG_14-3-3_CanoR_1	129	134	PF00244	0.829
LIG_14-3-3_CanoR_1	150	155	PF00244	0.763
LIG_14-3-3_CanoR_1	199	205	PF00244	0.771
LIG_14-3-3_CanoR_1	298	308	PF00244	0.661
LIG_14-3-3_CanoR_1	580	586	PF00244	0.438
LIG_Clathr_ClatBox_1	548	552	PF01394	0.467
LIG_deltaCOP1_diTrp_1	616	624	PF00928	0.413
LIG_deltaCOP1_diTrp_1	8	11	PF00928	0.479
LIG_DLG_GKlike_1	129	137	PF00625	0.828
LIG_EVH1_2	519	523	PF00568	0.546
LIG_FHA_1	150	156	PF00498	0.813
LIG_FHA_1	207	213	PF00498	0.780
LIG_FHA_1	264	270	PF00498	0.686
LIG_FHA_1	331	337	PF00498	0.617
LIG_FHA_1	429	435	PF00498	0.656
LIG_FHA_1	512	518	PF00498	0.469
LIG_FHA_1	535	541	PF00498	0.483
LIG_FHA_1	571	577	PF00498	0.432
LIG_FHA_1	604	610	PF00498	0.434
LIG_FHA_2	114	120	PF00498	0.732
LIG_FHA_2	301	307	PF00498	0.613
LIG_FHA_2	336	342	PF00498	0.708
LIG_FHA_2	495	501	PF00498	0.538
LIG_FHA_2	542	548	PF00498	0.483
LIG_HCF-1_HBM_1	529	532	PF13415	0.564
LIG_LIR_Apic_2	229	235	PF02991	0.656
LIG_LIR_Apic_2	572	578	PF02991	0.421
LIG_LIR_Gen_1	306	315	PF02991	0.601
LIG_LIR_Gen_1	521	531	PF02991	0.499
LIG_LIR_Gen_1	565	576	PF02991	0.423
LIG_LIR_Gen_1	616	627	PF02991	0.411
LIG_LIR_Gen_1	8	19	PF02991	0.324
LIG_LIR_LC3C_4	108	112	PF02991	0.653
LIG_LIR_Nem_3	104	110	PF02991	0.709
LIG_LIR_Nem_3	287	291	PF02991	0.568
LIG_LIR_Nem_3	306	311	PF02991	0.550
LIG_LIR_Nem_3	521	526	PF02991	0.522
LIG_LIR_Nem_3	565	571	PF02991	0.374
LIG_LIR_Nem_3	616	622	PF02991	0.363
LIG_LIR_Nem_3	8	14	PF02991	0.401
LIG_MYND_1	482	486	PF01753	0.549
LIG_NRBOX	346	352	PF00104	0.665
LIG_PTAP_UEV_1	402	407	PF05743	0.664
LIG_SH2_CRK	312	316	PF00017	0.685
LIG_SH2_GRB2like	308	311	PF00017	0.624
LIG_SH2_PTP2	308	311	PF00017	0.624
LIG_SH2_SRC	308	311	PF00017	0.624
LIG_SH2_STAP1	332	336	PF00017	0.639
LIG_SH2_STAP1	343	347	PF00017	0.678
LIG_SH2_STAP1	532	536	PF00017	0.535
LIG_SH2_STAT3	332	335	PF00017	0.602
LIG_SH2_STAT3	352	355	PF00017	0.507
LIG_SH2_STAT3	379	382	PF00017	0.658
LIG_SH2_STAT3	610	613	PF00017	0.448
LIG_SH2_STAT5	23	26	PF00017	0.430
LIG_SH2_STAT5	270	273	PF00017	0.620
LIG_SH2_STAT5	288	291	PF00017	0.512
LIG_SH2_STAT5	308	311	PF00017	0.439
LIG_SH2_STAT5	324	327	PF00017	0.582
LIG_SH2_STAT5	332	335	PF00017	0.617
LIG_SH2_STAT5	352	355	PF00017	0.507
LIG_SH2_STAT5	390	393	PF00017	0.628
LIG_SH2_STAT5	468	471	PF00017	0.352
LIG_SH2_STAT5	570	573	PF00017	0.433
LIG_SH3_2	578	583	PF14604	0.441
LIG_SH3_3	389	395	PF00018	0.695
LIG_SH3_3	397	403	PF00018	0.651
LIG_SH3_3	479	485	PF00018	0.528
LIG_SH3_3	575	581	PF00018	0.436
LIG_SH3_3	95	101	PF00018	0.800
LIG_SUMO_SIM_anti_2	247	255	PF11976	0.608
LIG_SUMO_SIM_anti_2	49	55	PF11976	0.665
LIG_SUMO_SIM_par_1	108	114	PF11976	0.742
LIG_TRAF2_1	342	345	PF00917	0.675
LIG_UBA3_1	51	55	PF00899	0.585
LIG_WW_2	482	485	PF00397	0.545
MOD_CDC14_SPxK_1	174	177	PF00782	0.679
MOD_CDC14_SPxK_1	601	604	PF00782	0.464
MOD_CDK_SPK_2	85	90	PF00069	0.798
MOD_CDK_SPxK_1	171	177	PF00069	0.678
MOD_CDK_SPxK_1	413	419	PF00069	0.618
MOD_CDK_SPxK_1	574	580	PF00069	0.438
MOD_CDK_SPxK_1	598	604	PF00069	0.447
MOD_CDK_SPxK_1	85	91	PF00069	0.799
MOD_CK1_1	132	138	PF00069	0.825
MOD_CK1_1	156	162	PF00069	0.759
MOD_CK1_1	171	177	PF00069	0.784
MOD_CK1_1	226	232	PF00069	0.666
MOD_CK1_1	247	253	PF00069	0.642
MOD_CK1_1	534	540	PF00069	0.481
MOD_CK1_1	542	548	PF00069	0.437
MOD_CK1_1	82	88	PF00069	0.770
MOD_CK1_1	97	103	PF00069	0.756
MOD_CK2_1	300	306	PF00069	0.612
MOD_CK2_1	541	547	PF00069	0.508
MOD_CK2_1	56	62	PF00069	0.660
MOD_CK2_1	566	572	PF00069	0.423
MOD_CK2_1	626	632	PF00069	0.484
MOD_GlcNHglycan	155	158	PF01048	0.461
MOD_GlcNHglycan	162	165	PF01048	0.470
MOD_GlcNHglycan	200	203	PF01048	0.598
MOD_GlcNHglycan	217	220	PF01048	0.430
MOD_GlcNHglycan	225	228	PF01048	0.513
MOD_GlcNHglycan	355	358	PF01048	0.455
MOD_GlcNHglycan	419	422	PF01048	0.499
MOD_GlcNHglycan	503	506	PF01048	0.733
MOD_GlcNHglycan	509	512	PF01048	0.776
MOD_GlcNHglycan	544	547	PF01048	0.686
MOD_GlcNHglycan	628	631	PF01048	0.625
MOD_GSK3_1	127	134	PF00069	0.813
MOD_GSK3_1	141	148	PF00069	0.700
MOD_GSK3_1	149	156	PF00069	0.735
MOD_GSK3_1	198	205	PF00069	0.755
MOD_GSK3_1	23	30	PF00069	0.675
MOD_GSK3_1	254	261	PF00069	0.664
MOD_GSK3_1	300	307	PF00069	0.630
MOD_GSK3_1	413	420	PF00069	0.722
MOD_GSK3_1	503	510	PF00069	0.525
MOD_GSK3_1	534	541	PF00069	0.502
MOD_GSK3_1	566	573	PF00069	0.447
MOD_GSK3_1	598	605	PF00069	0.453
MOD_GSK3_1	78	85	PF00069	0.743
MOD_GSK3_1	97	104	PF00069	0.617
MOD_N-GLC_1	168	173	PF02516	0.527
MOD_N-GLC_1	428	433	PF02516	0.408
MOD_NEK2_1	133	138	PF00069	0.828
MOD_NEK2_1	217	222	PF00069	0.683
MOD_NEK2_1	350	355	PF00069	0.665
MOD_NEK2_1	503	508	PF00069	0.558
MOD_NEK2_1	538	543	PF00069	0.493
MOD_NEK2_1	643	648	PF00069	0.440
MOD_NEK2_2	113	118	PF00069	0.731
MOD_NEK2_2	206	211	PF00069	0.705
MOD_NEK2_2	23	28	PF00069	0.447
MOD_NEK2_2	570	575	PF00069	0.404
MOD_NEK2_2	72	77	PF00069	0.696
MOD_PIKK_1	83	89	PF00454	0.752
MOD_PKA_1	554	560	PF00069	0.451
MOD_PKA_2	149	155	PF00069	0.792
MOD_PKA_2	198	204	PF00069	0.794
MOD_PKA_2	247	253	PF00069	0.642
MOD_PKA_2	554	560	PF00069	0.451
MOD_PKA_2	581	587	PF00069	0.498
MOD_PKB_1	129	137	PF00069	0.760
MOD_PKB_1	94	102	PF00069	0.745
MOD_Plk_1	254	260	PF00069	0.692
MOD_Plk_1	428	434	PF00069	0.551
MOD_Plk_1	511	517	PF00069	0.570
MOD_Plk_1	532	538	PF00069	0.496
MOD_Plk_1	560	566	PF00069	0.488
MOD_Plk_2-3	193	199	PF00069	0.749
MOD_Plk_4	150	156	PF00069	0.763
MOD_Plk_4	247	253	PF00069	0.642
MOD_Plk_4	284	290	PF00069	0.638
MOD_Plk_4	300	306	PF00069	0.644
MOD_Plk_4	503	509	PF00069	0.493
MOD_Plk_4	511	517	PF00069	0.475
MOD_Plk_4	522	528	PF00069	0.302
MOD_Plk_4	534	540	PF00069	0.459
MOD_Plk_4	570	576	PF00069	0.427
MOD_Plk_4	603	609	PF00069	0.406
MOD_Plk_4	643	649	PF00069	0.426
MOD_Plk_4	79	85	PF00069	0.755
MOD_ProDKin_1	171	177	PF00069	0.752
MOD_ProDKin_1	182	188	PF00069	0.771
MOD_ProDKin_1	202	208	PF00069	0.712
MOD_ProDKin_1	27	33	PF00069	0.701
MOD_ProDKin_1	313	319	PF00069	0.655
MOD_ProDKin_1	413	419	PF00069	0.715
MOD_ProDKin_1	46	52	PF00069	0.556
MOD_ProDKin_1	477	483	PF00069	0.582
MOD_ProDKin_1	56	62	PF00069	0.611
MOD_ProDKin_1	574	580	PF00069	0.438
MOD_ProDKin_1	598	604	PF00069	0.502
MOD_ProDKin_1	85	91	PF00069	0.796
MOD_ProDKin_1	94	100	PF00069	0.833
MOD_SUMO_rev_2	283	287	PF00179	0.594
TRG_DiLeu_BaEn_1	616	621	PF01217	0.417
TRG_DiLeu_BaEn_1	8	13	PF01217	0.379
TRG_DiLeu_BaEn_2	236	242	PF01217	0.677
TRG_DiLeu_BaLyEn_6	451	456	PF01217	0.611
TRG_ENDOCYTIC_2	107	110	PF00928	0.703
TRG_ENDOCYTIC_2	288	291	PF00928	0.582
TRG_ENDOCYTIC_2	308	311	PF00928	0.439
TRG_ER_diArg_1	128	131	PF00400	0.740
TRG_ER_diArg_1	210	213	PF00400	0.754
TRG_ER_diArg_1	41	43	PF00400	0.686
TRG_ER_diArg_1	553	555	PF00400	0.461
TRG_ER_diArg_1	580	583	PF00400	0.437
TRG_ER_diArg_1	639	641	PF00400	0.434
TRG_ER_diArg_1	89	91	PF00400	0.801
TRG_ER_FFAT_1	185	196	PF00635	0.722
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHH7	Leptomonas seymouri	42%	100%
A0A422NKE7	Trypanosoma rangeli	28%	100%
A4HQH1	Leishmania braziliensis	69%	100%
A4ICA7	Leishmania infantum	100%	100%
E9AU84	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q0A7	Leishmania major	91%	100%