Replication factor C C-terminal domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

replication factor C subunit 3, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XCG1_LEIDO

TriTrypDb:

LdBPK_367020.1 , LdCL_360082800 , LDHU3_36.9370

Length:

351

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005663	DNA replication factor C complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XCG1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XCG1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006259	DNA metabolic process	4	11
GO:0006260	DNA replication	5	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0006261	DNA-templated DNA replication	6	1
GO:0006281	DNA repair	5	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0033554	cellular response to stress	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	299	303	PF00656	0.474
CLV_NRD_NRD_1	126	128	PF00675	0.379
CLV_NRD_NRD_1	152	154	PF00675	0.312
CLV_NRD_NRD_1	228	230	PF00675	0.388
CLV_PCSK_KEX2_1	152	154	PF00082	0.312
CLV_PCSK_KEX2_1	228	230	PF00082	0.388
CLV_PCSK_SKI1_1	10	14	PF00082	0.558
CLV_PCSK_SKI1_1	163	167	PF00082	0.312
CLV_PCSK_SKI1_1	22	26	PF00082	0.350
CLV_PCSK_SKI1_1	229	233	PF00082	0.398
CLV_PCSK_SKI1_1	257	261	PF00082	0.449
CLV_PCSK_SKI1_1	332	336	PF00082	0.424
CLV_PCSK_SKI1_1	346	350	PF00082	0.442
DEG_APCC_DBOX_1	227	235	PF00400	0.395
DEG_Nend_Nbox_1	1	3	PF02207	0.418
DEG_SCF_SKP2-CKS1_1	268	275	PF00560	0.326
DOC_CYCLIN_RxL_1	226	235	PF00134	0.394
DOC_CYCLIN_yCln2_LP_2	174	177	PF00134	0.410
DOC_MAPK_DCC_7	30	39	PF00069	0.456
DOC_MAPK_gen_1	179	187	PF00069	0.312
DOC_MAPK_gen_1	228	234	PF00069	0.377
DOC_MAPK_gen_1	274	281	PF00069	0.498
DOC_MAPK_gen_1	8	17	PF00069	0.415
DOC_MAPK_MEF2A_6	179	187	PF00069	0.312
DOC_MAPK_MEF2A_6	192	199	PF00069	0.409
DOC_MAPK_MEF2A_6	274	283	PF00069	0.490
DOC_MAPK_MEF2A_6	30	39	PF00069	0.428
DOC_MAPK_MEF2A_6	328	337	PF00069	0.436
DOC_MAPK_NFAT4_5	192	200	PF00069	0.523
DOC_PP1_RVXF_1	239	245	PF00149	0.478
DOC_PP1_RVXF_1	278	284	PF00149	0.483
DOC_PP2B_LxvP_1	174	177	PF13499	0.288
DOC_PP4_FxxP_1	39	42	PF00568	0.423
DOC_USP7_MATH_1	177	181	PF00917	0.312
DOC_USP7_MATH_1	188	192	PF00917	0.406
DOC_USP7_MATH_1	209	213	PF00917	0.533
DOC_USP7_MATH_1	220	224	PF00917	0.510
DOC_USP7_MATH_1	42	46	PF00917	0.423
DOC_USP7_UBL2_3	192	196	PF12436	0.525
DOC_USP7_UBL2_3	328	332	PF12436	0.423
DOC_WW_Pin1_4	269	274	PF00397	0.421
DOC_WW_Pin1_4	85	90	PF00397	0.312
LIG_14-3-3_CanoR_1	152	156	PF00244	0.312
LIG_14-3-3_CanoR_1	186	195	PF00244	0.470
LIG_14-3-3_CanoR_1	8	13	PF00244	0.400
LIG_Actin_WH2_2	136	154	PF00022	0.312
LIG_Actin_WH2_2	180	198	PF00022	0.517
LIG_Actin_WH2_2	212	230	PF00022	0.394
LIG_APCC_ABBA_1	15	20	PF00400	0.449
LIG_APCC_ABBAyCdc20_2	332	338	PF00400	0.371
LIG_BRCT_BRCA1_1	211	215	PF00533	0.389
LIG_Clathr_ClatBox_1	231	235	PF01394	0.387
LIG_deltaCOP1_diTrp_1	255	259	PF00928	0.394
LIG_FHA_1	115	121	PF00498	0.312
LIG_FHA_1	159	165	PF00498	0.300
LIG_FHA_1	169	175	PF00498	0.289
LIG_FHA_1	329	335	PF00498	0.399
LIG_FHA_2	297	303	PF00498	0.475
LIG_FHA_2	9	15	PF00498	0.519
LIG_LIR_Nem_3	16	21	PF02991	0.448
LIG_LIR_Nem_3	255	259	PF02991	0.392
LIG_LYPXL_S_1	17	21	PF13949	0.446
LIG_LYPXL_yS_3	18	21	PF13949	0.448
LIG_Pex14_1	3	7	PF04695	0.390
LIG_SH2_CRK	132	136	PF00017	0.331
LIG_SH2_CRK	284	288	PF00017	0.379
LIG_SH2_GRB2like	158	161	PF00017	0.379
LIG_SH2_STAP1	102	106	PF00017	0.331
LIG_SH2_STAP1	284	288	PF00017	0.484
LIG_SH2_STAP1	323	327	PF00017	0.378
LIG_SH2_STAP1	64	68	PF00017	0.281
LIG_SUMO_SIM_par_1	133	139	PF11976	0.370
LIG_SUMO_SIM_par_1	230	235	PF11976	0.385
LIG_SUMO_SIM_par_1	76	85	PF11976	0.331
LIG_TYR_ITIM	130	135	PF00017	0.355
LIG_UBA3_1	316	322	PF00899	0.499
MOD_CDK_SPK_2	269	274	PF00069	0.421
MOD_CDK_SPxK_1	269	275	PF00069	0.413
MOD_CK1_1	292	298	PF00069	0.476
MOD_CK1_1	303	309	PF00069	0.496
MOD_CK1_1	62	68	PF00069	0.331
MOD_Cter_Amidation	45	48	PF01082	0.312
MOD_GlcNHglycan	145	148	PF01048	0.380
MOD_GlcNHglycan	211	214	PF01048	0.424
MOD_GlcNHglycan	222	225	PF01048	0.469
MOD_GlcNHglycan	235	239	PF01048	0.409
MOD_GlcNHglycan	243	247	PF01048	0.435
MOD_GlcNHglycan	291	294	PF01048	0.384
MOD_GlcNHglycan	42	45	PF01048	0.312
MOD_GSK3_1	292	299	PF00069	0.473
MOD_GSK3_1	42	49	PF00069	0.312
MOD_GSK3_1	69	76	PF00069	0.312
MOD_N-GLC_1	168	173	PF02516	0.305
MOD_N-GLC_2	160	162	PF02516	0.379
MOD_NEK2_1	120	125	PF00069	0.355
MOD_NEK2_1	143	148	PF00069	0.423
MOD_NEK2_1	167	172	PF00069	0.456
MOD_NEK2_1	215	220	PF00069	0.369
MOD_NEK2_1	234	239	PF00069	0.458
MOD_NEK2_1	300	305	PF00069	0.440
MOD_NEK2_2	158	163	PF00069	0.312
MOD_PKA_2	151	157	PF00069	0.312
MOD_PKA_2	26	32	PF00069	0.456
MOD_PKB_1	6	14	PF00069	0.517
MOD_Plk_1	234	240	PF00069	0.457
MOD_Plk_4	292	298	PF00069	0.476
MOD_Plk_4	300	306	PF00069	0.483
MOD_Plk_4	59	65	PF00069	0.331
MOD_ProDKin_1	269	275	PF00069	0.413
MOD_ProDKin_1	85	91	PF00069	0.312
MOD_SUMO_rev_2	14	24	PF00179	0.502
MOD_SUMO_rev_2	65	73	PF00179	0.325
MOD_SUMO_rev_2	76	81	PF00179	0.288
TRG_DiLeu_BaLyEn_6	170	175	PF01217	0.331
TRG_DiLeu_BaLyEn_6	312	317	PF01217	0.490
TRG_ENDOCYTIC_2	132	135	PF00928	0.331
TRG_ENDOCYTIC_2	18	21	PF00928	0.448
TRG_ENDOCYTIC_2	284	287	PF00928	0.371
TRG_ER_diArg_1	151	153	PF00400	0.312
TRG_ER_diArg_1	178	181	PF00400	0.312
TRG_ER_diArg_1	227	229	PF00400	0.395
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.312
TRG_Pf-PMV_PEXEL_1	274	278	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P564	Leptomonas seymouri	31%	96%
A0A0N0P777	Leptomonas seymouri	28%	97%
A0A0N1IAI3	Leptomonas seymouri	88%	100%
A0A0N1PCT2	Leptomonas seymouri	27%	99%
A0A0S4IM83	Bodo saltans	29%	100%
A0A0S4JFI8	Bodo saltans	29%	99%
A0A0S4JGB9	Bodo saltans	32%	93%
A0A1X0NN25	Trypanosomatidae	70%	100%
A0A1X0P333	Trypanosomatidae	28%	100%
A0A1X0P5L7	Trypanosomatidae	34%	98%
A0A3Q8IDA5	Leishmania donovani	27%	100%
A0A3Q8IVD9	Leishmania donovani	32%	100%
A0A3R7KCC2	Trypanosoma rangeli	31%	99%
A0A3R7KEM0	Trypanosoma rangeli	30%	100%
A0A3R7KKZ5	Trypanosoma rangeli	73%	100%
A0A3R7LYZ3	Trypanosoma rangeli	27%	100%
A0A3S7X3R0	Leishmania donovani	33%	100%
A0B6D7	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	24%	75%
A1RSA2	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	29%	100%
A1RV38	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	29%	100%
A1RWU7	Thermofilum pendens (strain DSM 2475 / Hrk 5)	32%	100%
A2SQT3	Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)	28%	100%
A3CUX9	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	29%	100%
A3DNV9	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	32%	100%
A3MS28	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	29%	100%
A4FZ74	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	30%	100%
A4HFI1	Leishmania braziliensis	28%	100%
A4HIJ5	Leishmania braziliensis	29%	100%
A4HMZ2	Leishmania braziliensis	33%	100%
A4HQJ4	Leishmania braziliensis	93%	100%
A4I5T9	Leishmania infantum	33%	100%
A4IBL6	Leishmania infantum	32%	100%
A4WGV2	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	29%	100%
A4WLY0	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	29%	100%
A5UMF3	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	24%	100%
A6US36	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	26%	100%
A6VJ61	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	30%	100%
A7I8Y0	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	26%	100%
A9A6K6	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	30%	100%
B0R7H7	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	26%	100%
C9ZR59	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZZ23	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	98%
D0A3P3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
D0A8F2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AD32	Leishmania major	27%	100%
E9AFE9	Leishmania major	32%	100%
E9AHC5	Leishmania infantum	27%	100%
E9AI03	Leishmania infantum	100%	100%
E9AUA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9AYV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B134	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B6K4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
O14003	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
O26343	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	26%	100%
O28219	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	29%	100%
O74111	Blastobotrys adeninivorans	33%	100%
O94449	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
O94697	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	98%
P0C7N7	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	31%	85%
P34429	Caenorhabditis elegans	28%	95%
P35249	Homo sapiens	33%	97%
P35250	Homo sapiens	26%	99%
P38251	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	99%
P38629	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P40339	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
P40348	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	99%
P40937	Homo sapiens	30%	100%
P40938	Homo sapiens	46%	99%
P53016	Caenorhabditis elegans	33%	100%
P53033	Gallus gallus	26%	98%
P53034	Drosophila melanogaster	26%	100%
P60374	Nanoarchaeum equitans (strain Kin4-M)	31%	100%
Q05B83	Bos taurus	25%	100%
Q09843	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
Q0W037	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	27%	100%
Q2FQT9	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	26%	100%
Q2NH89	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	26%	100%
Q2TBV1	Bos taurus	46%	99%
Q3ITJ2	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	25%	100%
Q46C63	Methanosarcina barkeri (strain Fusaro / DSM 804)	28%	100%
Q4JAB0	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	28%	100%
Q4Q084	Leishmania major	96%	100%
Q4Q732	Leishmania major	33%	100%
Q54BN3	Dictyostelium discoideum	42%	100%
Q54E21	Dictyostelium discoideum	27%	100%
Q54MD4	Dictyostelium discoideum	28%	100%
Q54ST4	Dictyostelium discoideum	30%	100%
Q5UP47	Acanthamoeba polyphaga mimivirus	26%	100%
Q5UQ72	Acanthamoeba polyphaga mimivirus	27%	97%
Q5UQE8	Acanthamoeba polyphaga mimivirus	29%	95%
Q5UZE5	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	29%	100%
Q641W4	Rattus norvegicus	26%	100%
Q6L1I0	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	29%	100%
Q6M044	Methanococcus maripaludis (strain S2 / LL)	26%	100%
Q6YZ54	Oryza sativa subsp. japonica	30%	97%
Q7XRX1	Oryza sativa subsp. japonica	31%	100%
Q852K3	Oryza sativa subsp. japonica	45%	99%
Q8PVY4	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	28%	100%
Q8R323	Mus musculus	46%	99%
Q8SQM0	Encephalitozoon cuniculi (strain GB-M1)	26%	100%
Q8TSX5	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	28%	100%
Q8TZC5	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	26%	69%
Q8VXX4	Arabidopsis thaliana	45%	99%
Q8X082	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	42%	100%
Q8ZWS2	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	30%	100%
Q8ZYK4	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	27%	100%
Q93ZX1	Arabidopsis thaliana	31%	100%
Q975D3	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	31%	100%
Q977Z9	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	28%	100%
Q99J62	Mus musculus	32%	96%
Q9CAM7	Arabidopsis thaliana	28%	100%
Q9CAQ8	Arabidopsis thaliana	32%	95%
Q9D0F6	Mus musculus	29%	100%
Q9FXM3	Oryza sativa subsp. japonica	33%	100%
Q9HI47	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	27%	100%
Q9HN27	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	26%	100%
Q9UXF5	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	31%	100%
Q9WUK4	Mus musculus	26%	100%
Q9YBS7	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	30%	100%
V5BM57	Trypanosoma cruzi	73%	100%
V5BMW7	Trypanosoma cruzi	32%	100%
V5C2V9	Trypanosoma cruzi	31%	99%