Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XCF7_LEIDO

TriTrypDb:

LdBPK_366990.1 , LdCL_360082500 , LDHU3_36.9330

Length:

162

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XCF7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XCF7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.526
CLV_NRD_NRD_1	157	159	PF00675	0.520
CLV_NRD_NRD_1	19	21	PF00675	0.579
CLV_NRD_NRD_1	56	58	PF00675	0.518
CLV_NRD_NRD_1	93	95	PF00675	0.512
CLV_PCSK_KEX2_1	121	123	PF00082	0.550
CLV_PCSK_KEX2_1	157	159	PF00082	0.637
CLV_PCSK_KEX2_1	19	21	PF00082	0.410
CLV_PCSK_KEX2_1	56	58	PF00082	0.531
CLV_PCSK_KEX2_1	93	95	PF00082	0.512
CLV_PCSK_SKI1_1	158	162	PF00082	0.583
CLV_PCSK_SKI1_1	4	8	PF00082	0.652
CLV_PCSK_SKI1_1	77	81	PF00082	0.527
DEG_APCC_DBOX_1	19	27	PF00400	0.405
DOC_MAPK_gen_1	19	25	PF00069	0.533
DOC_MAPK_MEF2A_6	70	78	PF00069	0.490
DOC_PP1_RVXF_1	141	148	PF00149	0.565
DOC_PP1_RVXF_1	20	26	PF00149	0.435
DOC_WW_Pin1_4	8	13	PF00397	0.619
LIG_14-3-3_CterR_2	157	162	PF00244	0.555
LIG_EVH1_2	2	6	PF00568	0.768
LIG_FHA_1	82	88	PF00498	0.535
LIG_FHA_2	63	69	PF00498	0.505
LIG_FHA_2	98	104	PF00498	0.592
LIG_SUMO_SIM_par_1	34	42	PF11976	0.509
LIG_TRAF2_1	11	14	PF00917	0.609
LIG_TRAF2_1	65	68	PF00917	0.523
MOD_CK1_1	38	44	PF00069	0.509
MOD_CK1_1	8	14	PF00069	0.603
MOD_CK2_1	62	68	PF00069	0.510
MOD_CK2_1	8	14	PF00069	0.632
MOD_CK2_1	97	103	PF00069	0.578
MOD_GSK3_1	58	65	PF00069	0.580
MOD_GSK3_1	77	84	PF00069	0.402
MOD_N-GLC_1	8	13	PF02516	0.630
MOD_NEK2_1	151	156	PF00069	0.548
MOD_NEK2_1	97	102	PF00069	0.650
MOD_PIKK_1	24	30	PF00454	0.541
MOD_PK_1	35	41	PF00069	0.516
MOD_Plk_2-3	62	68	PF00069	0.580
MOD_ProDKin_1	8	14	PF00069	0.614
MOD_SUMO_for_1	131	134	PF00179	0.619
MOD_SUMO_rev_2	125	133	PF00179	0.514
MOD_SUMO_rev_2	68	76	PF00179	0.491
TRG_DiLeu_BaEn_1	135	140	PF01217	0.557
TRG_DiLeu_BaEn_2	20	26	PF01217	0.435
TRG_ENDOCYTIC_2	159	162	PF00928	0.614
TRG_ER_diArg_1	157	159	PF00400	0.520
TRG_ER_diArg_1	56	58	PF00400	0.566
TRG_ER_diArg_1	93	95	PF00400	0.523
TRG_Pf-PMV_PEXEL_1	137	142	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	56	60	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	93	98	PF00026	0.633

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM37	Leptomonas seymouri	64%	99%
A0A1X0NL82	Trypanosomatidae	32%	100%
A0A3R7NY60	Trypanosoma rangeli	30%	100%
A4HQJ1	Leishmania braziliensis	84%	100%
E9AI00	Leishmania infantum	100%	100%
E9AUA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
Q4Q087	Leishmania major	91%	100%
V5AXM4	Trypanosoma cruzi	28%	80%