EVE domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EVE domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XCF0_LEIDO

TriTrypDb:

LdBPK_367200.1 , LdCL_360084600 , LDHU3_36.9570

Length:

204

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XCF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XCF0

PDB structure(s): 2ar1_A

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	127	129	PF00675	0.384
CLV_NRD_NRD_1	162	164	PF00675	0.435
CLV_NRD_NRD_1	191	193	PF00675	0.527
CLV_NRD_NRD_1	2	4	PF00675	0.543
CLV_PCSK_FUR_1	189	193	PF00082	0.506
CLV_PCSK_KEX2_1	127	129	PF00082	0.433
CLV_PCSK_KEX2_1	188	190	PF00082	0.543
CLV_PCSK_KEX2_1	191	193	PF00082	0.513
CLV_PCSK_KEX2_1	197	199	PF00082	0.445
CLV_PCSK_KEX2_1	4	6	PF00082	0.470
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.511
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.490
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.442
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.470
CLV_PCSK_SKI1_1	132	136	PF00082	0.446
CLV_PCSK_SKI1_1	194	198	PF00082	0.492
CLV_PCSK_SKI1_1	56	60	PF00082	0.289
CLV_Separin_Metazoa	74	78	PF03568	0.384
DEG_APCC_DBOX_1	126	134	PF00400	0.384
DEG_MDM2_SWIB_1	111	119	PF02201	0.402
DOC_MAPK_gen_1	125	135	PF00069	0.296
DOC_MAPK_gen_1	191	201	PF00069	0.490
DOC_PP1_RVXF_1	54	60	PF00149	0.259
DOC_USP7_UBL2_3	101	105	PF12436	0.342
DOC_USP7_UBL2_3	110	114	PF12436	0.255
DOC_USP7_UBL2_3	193	197	PF12436	0.494
DOC_WW_Pin1_4	31	36	PF00397	0.268
LIG_14-3-3_CanoR_1	140	144	PF00244	0.269
LIG_14-3-3_CanoR_1	192	201	PF00244	0.488
LIG_14-3-3_CanoR_1	88	95	PF00244	0.343
LIG_BIR_II_1	1	5	PF00653	0.573
LIG_BRCT_BRCA1_1	89	93	PF00533	0.384
LIG_FHA_2	118	124	PF00498	0.387
LIG_FHA_2	82	88	PF00498	0.266
LIG_LIR_Apic_2	89	95	PF02991	0.402
LIG_LIR_Gen_1	149	157	PF02991	0.302
LIG_LIR_Gen_1	81	87	PF02991	0.402
LIG_LIR_Nem_3	10	16	PF02991	0.422
LIG_LIR_Nem_3	149	154	PF02991	0.302
LIG_LIR_Nem_3	33	39	PF02991	0.270
LIG_LIR_Nem_3	81	86	PF02991	0.406
LIG_MLH1_MIPbox_1	89	93	PF16413	0.384
LIG_Pex14_2	111	115	PF04695	0.266
LIG_SH2_CRK	151	155	PF00017	0.384
LIG_SH2_SRC	151	154	PF00017	0.326
LIG_SH2_STAP1	151	155	PF00017	0.301
LIG_SH2_STAT5	153	156	PF00017	0.384
LIG_SH2_STAT5	92	95	PF00017	0.446
LIG_SUMO_SIM_par_1	116	123	PF11976	0.259
LIG_TYR_ITIM	11	16	PF00017	0.384
MOD_CK1_1	139	145	PF00069	0.358
MOD_CK2_1	117	123	PF00069	0.353
MOD_CK2_1	144	150	PF00069	0.303
MOD_CK2_1	81	87	PF00069	0.209
MOD_GlcNHglycan	146	149	PF01048	0.320
MOD_N-GLC_2	47	49	PF02516	0.241
MOD_NEK2_1	136	141	PF00069	0.304
MOD_NEK2_1	59	64	PF00069	0.267
MOD_PIKK_1	134	140	PF00454	0.358
MOD_PKA_1	192	198	PF00069	0.494
MOD_PKA_2	139	145	PF00069	0.266
MOD_PKA_2	177	183	PF00069	0.489
MOD_PKA_2	197	203	PF00069	0.378
MOD_PKA_2	87	93	PF00069	0.360
MOD_Plk_1	81	87	PF00069	0.301
MOD_Plk_4	114	120	PF00069	0.338
MOD_Plk_4	197	203	PF00069	0.474
MOD_ProDKin_1	31	37	PF00069	0.268
MOD_SUMO_for_1	16	19	PF00179	0.266
MOD_SUMO_rev_2	90	98	PF00179	0.315
TRG_ENDOCYTIC_2	13	16	PF00928	0.307
TRG_ENDOCYTIC_2	151	154	PF00928	0.301
TRG_ENDOCYTIC_2	80	83	PF00928	0.426
TRG_ER_diArg_1	3	6	PF00400	0.514
TRG_NLS_MonoCore_2	190	195	PF00514	0.502
TRG_NLS_MonoExtC_3	187	192	PF00514	0.509
TRG_NLS_MonoExtC_3	2	7	PF00514	0.516
TRG_NLS_MonoExtN_4	188	195	PF00514	0.506
TRG_NLS_MonoExtN_4	3	8	PF00514	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I255	Leptomonas seymouri	78%	100%
A0A0S4JQP8	Bodo saltans	59%	100%
A0A0S4KI49	Bodo saltans	59%	100%
A0A1X0NLS9	Trypanosomatidae	63%	100%
A0A3R7KTV7	Trypanosoma rangeli	65%	100%
A4HQK8	Leishmania braziliensis	88%	100%
A4ICC8	Leishmania infantum	100%	100%
D0A3R0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AUC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O94645	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	85%
Q4Q067	Leishmania major	98%	100%
Q6P3E0	Rattus norvegicus	44%	90%
Q6PFL8	Danio rerio	43%	88%
Q90679	Gallus gallus	40%	84%
Q91YJ3	Mus musculus	43%	90%
Q9P016	Homo sapiens	45%	91%