Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XCE6_LEIDO

TriTrypDb:

LdBPK_366930.1 , LdCL_360081800 , LDHU3_36.9250

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S7XCE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XCE6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	327	329	PF00675	0.412
CLV_NRD_NRD_1	388	390	PF00675	0.450
CLV_NRD_NRD_1	74	76	PF00675	0.416
CLV_PCSK_KEX2_1	327	329	PF00082	0.412
CLV_PCSK_KEX2_1	388	390	PF00082	0.450
CLV_PCSK_KEX2_1	74	76	PF00082	0.416
DOC_CDC14_PxL_1	359	367	PF14671	0.504
DOC_CYCLIN_yCln2_LP_2	148	154	PF00134	0.313
DOC_MAPK_gen_1	191	198	PF00069	0.630
DOC_MAPK_gen_1	74	82	PF00069	0.640
DOC_MAPK_HePTP_8	72	84	PF00069	0.483
DOC_MAPK_MEF2A_6	341	348	PF00069	0.266
DOC_MAPK_MEF2A_6	74	82	PF00069	0.630
DOC_MAPK_RevD_3	374	389	PF00069	0.357
DOC_PP4_FxxP_1	142	145	PF00568	0.433
DOC_WW_Pin1_4	228	233	PF00397	0.477
LIG_14-3-3_CanoR_1	191	196	PF00244	0.632
LIG_14-3-3_CanoR_1	23	29	PF00244	0.665
LIG_14-3-3_CanoR_1	327	336	PF00244	0.709
LIG_14-3-3_CanoR_1	341	347	PF00244	0.255
LIG_14-3-3_CanoR_1	54	64	PF00244	0.295
LIG_14-3-3_CanoR_1	91	97	PF00244	0.644
LIG_Actin_WH2_2	283	298	PF00022	0.500
LIG_Actin_WH2_2	58	76	PF00022	0.365
LIG_BRCT_BRCA1_1	198	202	PF00533	0.357
LIG_EH_1	180	184	PF12763	0.660
LIG_EH1_1	107	115	PF00400	0.236
LIG_EH1_1	211	219	PF00400	0.313
LIG_FHA_1	110	116	PF00498	0.351
LIG_FHA_1	203	209	PF00498	0.276
LIG_FHA_1	300	306	PF00498	0.397
LIG_FHA_1	312	318	PF00498	0.343
LIG_FHA_1	341	347	PF00498	0.409
LIG_FHA_1	400	406	PF00498	0.659
LIG_FHA_1	57	63	PF00498	0.360
LIG_FHA_1	9	15	PF00498	0.668
LIG_FHA_1	95	101	PF00498	0.654
LIG_GBD_Chelix_1	365	373	PF00786	0.483
LIG_LIR_Gen_1	194	203	PF02991	0.477
LIG_LIR_Gen_1	255	263	PF02991	0.375
LIG_LIR_Gen_1	284	295	PF02991	0.544
LIG_LIR_Gen_1	3	12	PF02991	0.667
LIG_LIR_Gen_1	354	364	PF02991	0.397
LIG_LIR_LC3C_4	112	115	PF02991	0.313
LIG_LIR_Nem_3	106	110	PF02991	0.482
LIG_LIR_Nem_3	194	198	PF02991	0.632
LIG_LIR_Nem_3	199	204	PF02991	0.332
LIG_LIR_Nem_3	20	25	PF02991	0.641
LIG_LIR_Nem_3	255	259	PF02991	0.408
LIG_LIR_Nem_3	273	279	PF02991	0.566
LIG_LIR_Nem_3	284	290	PF02991	0.488
LIG_LIR_Nem_3	3	7	PF02991	0.671
LIG_LIR_Nem_3	354	359	PF02991	0.397
LIG_NRBOX	368	374	PF00104	0.350
LIG_PDZ_Class_2	403	408	PF00595	0.628
LIG_Pex14_2	243	247	PF04695	0.302
LIG_SH2_NCK_1	89	93	PF00017	0.646
LIG_SH2_PTP2	41	44	PF00017	0.357
LIG_SH2_SRC	41	44	PF00017	0.416
LIG_SH2_STAP1	137	141	PF00017	0.442
LIG_SH2_STAT5	125	128	PF00017	0.349
LIG_SH2_STAT5	130	133	PF00017	0.446
LIG_SH2_STAT5	234	237	PF00017	0.515
LIG_SH2_STAT5	24	27	PF00017	0.638
LIG_SH2_STAT5	311	314	PF00017	0.448
LIG_SH2_STAT5	41	44	PF00017	0.504
LIG_SH3_3	115	121	PF00018	0.351
LIG_SH3_3	170	176	PF00018	0.322
LIG_SH3_3	182	188	PF00018	0.638
LIG_SUMO_SIM_anti_2	112	117	PF11976	0.316
LIG_SUMO_SIM_anti_2	205	210	PF11976	0.282
LIG_SUMO_SIM_anti_2	345	350	PF11976	0.293
LIG_SUMO_SIM_par_1	301	307	PF11976	0.336
LIG_SUMO_SIM_par_1	343	350	PF11976	0.405
LIG_TRFH_1	277	281	PF08558	0.648
LIG_TYR_ITIM	274	279	PF00017	0.650
LIG_TYR_ITIM	39	44	PF00017	0.434
LIG_WRC_WIRS_1	1	6	PF05994	0.676
MOD_CK1_1	255	261	PF00069	0.313
MOD_CK1_1	3	9	PF00069	0.723
MOD_CK1_1	358	364	PF00069	0.499
MOD_CK1_1	399	405	PF00069	0.631
MOD_GlcNHglycan	19	22	PF01048	0.387
MOD_GlcNHglycan	237	240	PF01048	0.644
MOD_GlcNHglycan	396	399	PF01048	0.513
MOD_GlcNHglycan	92	95	PF01048	0.427
MOD_GSK3_1	223	230	PF00069	0.463
MOD_GSK3_1	24	31	PF00069	0.589
MOD_GSK3_1	295	302	PF00069	0.415
MOD_GSK3_1	347	354	PF00069	0.299
MOD_GSK3_1	8	15	PF00069	0.602
MOD_GSK3_1	90	97	PF00069	0.629
MOD_N-GLC_1	56	61	PF02516	0.313
MOD_NEK2_1	295	300	PF00069	0.328
MOD_NEK2_1	304	309	PF00069	0.289
MOD_NEK2_1	322	327	PF00069	0.197
MOD_NEK2_1	394	399	PF00069	0.628
MOD_NEK2_1	68	73	PF00069	0.315
MOD_NEK2_2	351	356	PF00069	0.338
MOD_PKA_1	327	333	PF00069	0.608
MOD_PKA_2	327	333	PF00069	0.697
MOD_PKA_2	340	346	PF00069	0.466
MOD_PKA_2	90	96	PF00069	0.672
MOD_Plk_1	56	62	PF00069	0.313
MOD_Plk_4	103	109	PF00069	0.564
MOD_Plk_4	144	150	PF00069	0.332
MOD_Plk_4	197	203	PF00069	0.297
MOD_Plk_4	252	258	PF00069	0.351
MOD_Plk_4	28	34	PF00069	0.448
MOD_Plk_4	299	305	PF00069	0.356
MOD_Plk_4	342	348	PF00069	0.274
MOD_Plk_4	68	74	PF00069	0.313
MOD_ProDKin_1	228	234	PF00069	0.477
TRG_DiLeu_BaLyEn_6	213	218	PF01217	0.444
TRG_DiLeu_BaLyEn_6	264	269	PF01217	0.609
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.658
TRG_ENDOCYTIC_2	180	183	PF00928	0.685
TRG_ENDOCYTIC_2	276	279	PF00928	0.647
TRG_ENDOCYTIC_2	41	44	PF00928	0.443
TRG_ENDOCYTIC_2	89	92	PF00928	0.639
TRG_ER_diArg_1	326	328	PF00400	0.607
TRG_ER_diArg_1	388	390	PF00400	0.653
TRG_ER_diArg_1	73	75	PF00400	0.513
TRG_Pf-PMV_PEXEL_1	216	221	PF00026	0.635

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I240	Leptomonas seymouri	49%	100%
A0A1X0NN35	Trypanosomatidae	23%	100%
A4HQI5	Leishmania braziliensis	74%	100%
E9AHZ4	Leishmania infantum	100%	100%
E9AU98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q093	Leishmania major	91%	100%