Sperm tail/Sperm tail C-terminal domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sperm tail/Sperm tail C-terminal domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XCE4_LEIDO

TriTrypDb:

LdBPK_366900.1 , LdCL_360081500 , LDHU3_36.9200

Length:

648

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005858	axonemal dynein complex	4	12
GO:0005875	microtubule associated complex	2	12
GO:0030286	dynein complex	3	12
GO:0032991	protein-containing complex	1	12
GO:1902494	catalytic complex	2	12
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XCE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XCE4

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0043933	protein-containing complex organization	4	12
GO:0065003	protein-containing complex assembly	5	12
GO:0070286	axonemal dynein complex assembly	6	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0003352	regulation of cilium movement	6	1
GO:0032886	regulation of microtubule-based process	4	1
GO:0048870	cell motility	2	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0060285	cilium-dependent cell motility	4	1
GO:0060632	regulation of microtubule-based movement	5	1
GO:0065007	biological regulation	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.452
CLV_NRD_NRD_1	132	134	PF00675	0.252
CLV_NRD_NRD_1	205	207	PF00675	0.391
CLV_NRD_NRD_1	223	225	PF00675	0.293
CLV_NRD_NRD_1	230	232	PF00675	0.403
CLV_NRD_NRD_1	260	262	PF00675	0.579
CLV_NRD_NRD_1	557	559	PF00675	0.456
CLV_NRD_NRD_1	596	598	PF00675	0.217
CLV_NRD_NRD_1	82	84	PF00675	0.224
CLV_PCSK_KEX2_1	205	207	PF00082	0.450
CLV_PCSK_KEX2_1	223	225	PF00082	0.329
CLV_PCSK_KEX2_1	260	262	PF00082	0.394
CLV_PCSK_KEX2_1	332	334	PF00082	0.445
CLV_PCSK_KEX2_1	556	558	PF00082	0.512
CLV_PCSK_KEX2_1	82	84	PF00082	0.224
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.394
CLV_PCSK_PC1ET2_1	332	334	PF00082	0.445
CLV_PCSK_PC1ET2_1	556	558	PF00082	0.607
CLV_PCSK_PC7_1	552	558	PF00082	0.511
CLV_PCSK_SKI1_1	145	149	PF00082	0.219
CLV_PCSK_SKI1_1	358	362	PF00082	0.584
CLV_PCSK_SKI1_1	48	52	PF00082	0.393
CLV_PCSK_SKI1_1	612	616	PF00082	0.241
CLV_PCSK_SKI1_1	635	639	PF00082	0.564
DEG_APCC_KENBOX_2	299	303	PF00400	0.442
DOC_CYCLIN_yCln2_LP_2	400	406	PF00134	0.420
DOC_MAPK_gen_1	143	150	PF00069	0.416
DOC_MAPK_gen_1	364	373	PF00069	0.492
DOC_MAPK_MEF2A_6	143	150	PF00069	0.416
DOC_MAPK_NFAT4_5	143	151	PF00069	0.366
DOC_PP1_SILK_1	446	451	PF00149	0.500
DOC_PP2B_LxvP_1	119	122	PF13499	0.473
DOC_PP2B_LxvP_1	400	403	PF13499	0.419
DOC_PP2B_LxvP_1	630	633	PF13499	0.440
DOC_USP7_MATH_1	430	434	PF00917	0.616
DOC_USP7_MATH_1	464	468	PF00917	0.502
DOC_USP7_MATH_1	63	67	PF00917	0.394
DOC_USP7_UBL2_3	217	221	PF12436	0.462
DOC_USP7_UBL2_3	365	369	PF12436	0.447
DOC_WW_Pin1_4	2	7	PF00397	0.617
DOC_WW_Pin1_4	642	647	PF00397	0.559
LIG_14-3-3_CanoR_1	180	187	PF00244	0.396
LIG_14-3-3_CanoR_1	261	270	PF00244	0.402
LIG_14-3-3_CanoR_1	287	291	PF00244	0.452
LIG_14-3-3_CanoR_1	489	497	PF00244	0.524
LIG_14-3-3_CanoR_1	635	643	PF00244	0.481
LIG_APCC_ABBA_1	109	114	PF00400	0.510
LIG_BIR_II_1	1	5	PF00653	0.568
LIG_BIR_III_2	3	7	PF00653	0.493
LIG_BIR_III_3	1	5	PF00653	0.568
LIG_CaM_IQ_9	191	207	PF13499	0.378
LIG_eIF4E_1	631	637	PF01652	0.486
LIG_FHA_1	189	195	PF00498	0.412
LIG_FHA_1	287	293	PF00498	0.612
LIG_FHA_1	340	346	PF00498	0.426
LIG_FHA_1	366	372	PF00498	0.563
LIG_FHA_1	482	488	PF00498	0.404
LIG_FHA_1	506	512	PF00498	0.449
LIG_FHA_1	602	608	PF00498	0.379
LIG_FHA_2	335	341	PF00498	0.478
LIG_FHA_2	469	475	PF00498	0.543
LIG_FHA_2	51	57	PF00498	0.538
LIG_FHA_2	536	542	PF00498	0.643
LIG_LIR_Apic_2	629	634	PF02991	0.489
LIG_LIR_Apic_2	642	646	PF02991	0.448
LIG_LIR_Gen_1	250	259	PF02991	0.408
LIG_LIR_Gen_1	368	376	PF02991	0.422
LIG_LIR_Nem_3	158	164	PF02991	0.510
LIG_LIR_Nem_3	250	256	PF02991	0.412
LIG_LIR_Nem_3	368	373	PF02991	0.394
LIG_LIR_Nem_3	498	502	PF02991	0.477
LIG_NRBOX	319	325	PF00104	0.510
LIG_PCNA_yPIPBox_3	310	324	PF02747	0.415
LIG_PCNA_yPIPBox_3	608	618	PF02747	0.417
LIG_SH2_CRK	631	635	PF00017	0.633
LIG_SH2_GRB2like	621	624	PF00017	0.485
LIG_SH2_NCK_1	643	647	PF00017	0.562
LIG_SH2_PTP2	161	164	PF00017	0.510
LIG_SH2_SRC	327	330	PF00017	0.417
LIG_SH2_SRC	631	634	PF00017	0.496
LIG_SH2_STAP1	190	194	PF00017	0.356
LIG_SH2_STAP1	396	400	PF00017	0.478
LIG_SH2_STAP1	55	59	PF00017	0.491
LIG_SH2_STAP1	628	632	PF00017	0.457
LIG_SH2_STAT3	186	189	PF00017	0.440
LIG_SH2_STAT3	230	233	PF00017	0.450
LIG_SH2_STAT3	290	293	PF00017	0.420
LIG_SH2_STAT3	590	593	PF00017	0.417
LIG_SH2_STAT5	161	164	PF00017	0.473
LIG_SH2_STAT5	186	189	PF00017	0.376
LIG_SH2_STAT5	190	193	PF00017	0.361
LIG_SH2_STAT5	208	211	PF00017	0.447
LIG_SH2_STAT5	281	284	PF00017	0.533
LIG_SH2_STAT5	352	355	PF00017	0.529
LIG_SH2_STAT5	370	373	PF00017	0.509
LIG_SH2_STAT5	499	502	PF00017	0.422
LIG_SH2_STAT5	524	527	PF00017	0.471
LIG_SH2_STAT5	590	593	PF00017	0.452
LIG_SH3_3	400	406	PF00018	0.420
LIG_SUMO_SIM_anti_2	505	513	PF11976	0.585
LIG_SUMO_SIM_par_1	146	152	PF11976	0.431
LIG_TRAF2_1	128	131	PF00917	0.484
LIG_TRAF2_1	413	416	PF00917	0.561
LIG_TRAF2_1	530	533	PF00917	0.483
LIG_TRAF2_1	6	9	PF00917	0.528
LIG_TYR_ITIM	394	399	PF00017	0.507
LIG_TYR_ITIM	497	502	PF00017	0.422
LIG_UBA3_1	444	450	PF00899	0.417
LIG_WRC_WIRS_1	359	364	PF05994	0.396
LIG_WW_3	632	636	PF00397	0.564
MOD_CK1_1	451	457	PF00069	0.384
MOD_CK1_1	642	648	PF00069	0.611
MOD_CK1_1	66	72	PF00069	0.333
MOD_CK2_1	248	254	PF00069	0.456
MOD_CK2_1	39	45	PF00069	0.586
MOD_CK2_1	468	474	PF00069	0.546
MOD_CK2_1	488	494	PF00069	0.268
MOD_CK2_1	50	56	PF00069	0.406
MOD_CK2_1	535	541	PF00069	0.581
MOD_CK2_1	641	647	PF00069	0.504
MOD_GlcNHglycan	250	253	PF01048	0.524
MOD_GlcNHglycan	623	626	PF01048	0.343
MOD_GlcNHglycan	65	68	PF01048	0.334
MOD_GlcNHglycan	98	102	PF01048	0.221
MOD_GSK3_1	175	182	PF00069	0.590
MOD_GSK3_1	444	451	PF00069	0.422
MOD_GSK3_1	464	471	PF00069	0.330
MOD_GSK3_1	535	542	PF00069	0.569
MOD_GSK3_1	599	606	PF00069	0.510
MOD_GSK3_1	635	642	PF00069	0.494
MOD_N-GLC_1	29	34	PF02516	0.582
MOD_N-GLC_1	487	492	PF02516	0.531
MOD_N-GLC_1	548	553	PF02516	0.557
MOD_N-GLC_1	63	68	PF02516	0.523
MOD_NEK2_1	175	180	PF00069	0.498
MOD_NEK2_1	219	224	PF00069	0.513
MOD_NEK2_1	274	279	PF00069	0.595
MOD_NEK2_1	316	321	PF00069	0.388
MOD_NEK2_1	334	339	PF00069	0.353
MOD_NEK2_1	444	449	PF00069	0.415
MOD_NEK2_1	456	461	PF00069	0.343
MOD_NEK2_1	568	573	PF00069	0.431
MOD_NEK2_1	641	646	PF00069	0.531
MOD_NEK2_1	96	101	PF00069	0.421
MOD_PIKK_1	352	358	PF00454	0.519
MOD_PIKK_1	448	454	PF00454	0.494
MOD_PIKK_1	585	591	PF00454	0.479
MOD_PIKK_1	635	641	PF00454	0.669
MOD_PIKK_1	77	83	PF00454	0.452
MOD_PKA_2	179	185	PF00069	0.451
MOD_PKA_2	222	228	PF00069	0.352
MOD_PKA_2	286	292	PF00069	0.456
MOD_PKA_2	488	494	PF00069	0.538
MOD_PKB_1	16	24	PF00069	0.491
MOD_Plk_1	170	176	PF00069	0.510
MOD_Plk_1	197	203	PF00069	0.409
MOD_Plk_1	505	511	PF00069	0.489
MOD_Plk_4	319	325	PF00069	0.382
MOD_Plk_4	451	457	PF00069	0.384
MOD_ProDKin_1	2	8	PF00069	0.612
MOD_ProDKin_1	642	648	PF00069	0.567
MOD_SUMO_rev_2	210	219	PF00179	0.442
MOD_SUMO_rev_2	229	239	PF00179	0.287
MOD_SUMO_rev_2	42	51	PF00179	0.553
MOD_SUMO_rev_2	526	536	PF00179	0.521
TRG_DiLeu_BaEn_1	135	140	PF01217	0.421
TRG_DiLeu_BaEn_1	160	165	PF01217	0.510
TRG_DiLeu_BaEn_1	171	176	PF01217	0.598
TRG_DiLeu_BaEn_1	215	220	PF01217	0.375
TRG_DiLeu_BaEn_1	507	512	PF01217	0.545
TRG_DiLeu_BaEn_1	613	618	PF01217	0.417
TRG_ENDOCYTIC_2	161	164	PF00928	0.510
TRG_ENDOCYTIC_2	253	256	PF00928	0.415
TRG_ENDOCYTIC_2	370	373	PF00928	0.486
TRG_ENDOCYTIC_2	396	399	PF00928	0.517
TRG_ENDOCYTIC_2	499	502	PF00928	0.422
TRG_ER_diArg_1	16	19	PF00400	0.473
TRG_NES_CRM1_1	137	152	PF08389	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAH6	Leptomonas seymouri	70%	100%
A0A0S4J8E8	Bodo saltans	41%	100%
A0A1X0NL92	Trypanosomatidae	48%	100%
A0A3R7KG47	Trypanosoma rangeli	44%	99%
A4HQI2	Leishmania braziliensis	82%	100%
D0A3N0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AHZ1	Leishmania infantum	100%	100%
E9AU95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
F1QRC1	Danio rerio	26%	97%
P0DL09	Chlamydomonas reinhardtii	27%	93%
Q32KY1	Bos taurus	25%	91%
Q3USS3	Mus musculus	26%	86%
Q4Q096	Leishmania major	95%	100%
Q7T0Y4	Xenopus laevis	29%	94%
V5BD07	Trypanosoma cruzi	51%	100%