Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XCD6_LEIDO

TriTrypDb:

LdBPK_366830.1 , LdCL_360080800 , LDHU3_36.9110

Length:

590

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XCD6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XCD6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	264	268	PF00656	0.701
CLV_C14_Caspase3-7	405	409	PF00656	0.598
CLV_NRD_NRD_1	422	424	PF00675	0.593
CLV_NRD_NRD_1	470	472	PF00675	0.558
CLV_NRD_NRD_1	577	579	PF00675	0.675
CLV_PCSK_KEX2_1	168	170	PF00082	0.538
CLV_PCSK_KEX2_1	422	424	PF00082	0.561
CLV_PCSK_KEX2_1	470	472	PF00082	0.563
CLV_PCSK_KEX2_1	518	520	PF00082	0.630
CLV_PCSK_KEX2_1	577	579	PF00082	0.514
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.591
CLV_PCSK_PC1ET2_1	518	520	PF00082	0.630
CLV_PCSK_SKI1_1	155	159	PF00082	0.700
CLV_PCSK_SKI1_1	169	173	PF00082	0.395
CLV_PCSK_SKI1_1	410	414	PF00082	0.604
CLV_PCSK_SKI1_1	434	438	PF00082	0.523
DEG_APCC_DBOX_1	409	417	PF00400	0.628
DEG_SPOP_SBC_1	332	336	PF00917	0.416
DOC_CDC14_PxL_1	385	393	PF14671	0.550
DOC_CKS1_1	530	535	PF01111	0.739
DOC_CYCLIN_yCln2_LP_2	212	218	PF00134	0.414
DOC_CYCLIN_yCln2_LP_2	531	537	PF00134	0.609
DOC_MAPK_DCC_7	501	511	PF00069	0.641
DOC_MAPK_gen_1	518	524	PF00069	0.578
DOC_MAPK_gen_1	577	584	PF00069	0.528
DOC_PP1_RVXF_1	153	159	PF00149	0.609
DOC_PP2B_LxvP_1	212	215	PF13499	0.481
DOC_PP2B_LxvP_1	282	285	PF13499	0.452
DOC_PP2B_LxvP_1	531	534	PF13499	0.594
DOC_PP4_FxxP_1	111	114	PF00568	0.550
DOC_PP4_FxxP_1	236	239	PF00568	0.596
DOC_PP4_FxxP_1	357	360	PF00568	0.628
DOC_SPAK_OSR1_1	356	360	PF12202	0.565
DOC_USP7_MATH_1	112	116	PF00917	0.642
DOC_USP7_MATH_1	261	265	PF00917	0.722
DOC_USP7_MATH_1	332	336	PF00917	0.419
DOC_USP7_MATH_1	536	540	PF00917	0.676
DOC_WW_Pin1_4	110	115	PF00397	0.615
DOC_WW_Pin1_4	118	123	PF00397	0.744
DOC_WW_Pin1_4	150	155	PF00397	0.615
DOC_WW_Pin1_4	259	264	PF00397	0.510
DOC_WW_Pin1_4	313	318	PF00397	0.486
DOC_WW_Pin1_4	529	534	PF00397	0.610
DOC_WW_Pin1_4	547	552	PF00397	0.718
LIG_14-3-3_CanoR_1	169	177	PF00244	0.500
LIG_14-3-3_CanoR_1	204	213	PF00244	0.600
LIG_14-3-3_CanoR_1	298	303	PF00244	0.686
LIG_14-3-3_CanoR_1	33	38	PF00244	0.565
LIG_14-3-3_CanoR_1	394	398	PF00244	0.618
LIG_14-3-3_CanoR_1	422	426	PF00244	0.675
LIG_14-3-3_CanoR_1	428	434	PF00244	0.629
LIG_14-3-3_CanoR_1	51	59	PF00244	0.412
LIG_14-3-3_CanoR_1	519	523	PF00244	0.732
LIG_BRCT_BRCA1_1	142	146	PF00533	0.629
LIG_BRCT_BRCA1_1	353	357	PF00533	0.507
LIG_deltaCOP1_diTrp_1	352	357	PF00928	0.561
LIG_DLG_GKlike_1	33	41	PF00625	0.455
LIG_FHA_1	131	137	PF00498	0.697
LIG_FHA_1	305	311	PF00498	0.541
LIG_FHA_1	33	39	PF00498	0.541
LIG_FHA_1	332	338	PF00498	0.410
LIG_FHA_1	530	536	PF00498	0.715
LIG_FHA_1	542	548	PF00498	0.585
LIG_FHA_1	558	564	PF00498	0.668
LIG_FHA_2	170	176	PF00498	0.495
LIG_FHA_2	43	49	PF00498	0.489
LIG_FHA_2	430	436	PF00498	0.579
LIG_FHA_2	439	445	PF00498	0.432
LIG_FHA_2	453	459	PF00498	0.427
LIG_LIR_Apic_2	108	114	PF02991	0.553
LIG_LIR_Apic_2	233	239	PF02991	0.689
LIG_LIR_Apic_2	354	360	PF02991	0.546
LIG_LIR_Gen_1	172	182	PF02991	0.460
LIG_LIR_Gen_1	228	239	PF02991	0.544
LIG_LIR_Gen_1	343	351	PF02991	0.433
LIG_LIR_Nem_3	172	177	PF02991	0.490
LIG_LIR_Nem_3	180	185	PF02991	0.408
LIG_LIR_Nem_3	228	234	PF02991	0.650
LIG_NRBOX	54	60	PF00104	0.545
LIG_PCNA_PIPBox_1	430	439	PF02747	0.549
LIG_Pex14_1	353	357	PF04695	0.562
LIG_SH2_STAP1	346	350	PF00017	0.509
LIG_SH2_STAT5	138	141	PF00017	0.579
LIG_SH2_STAT5	231	234	PF00017	0.503
LIG_SH2_STAT5	30	33	PF00017	0.554
LIG_SH2_STAT5	358	361	PF00017	0.714
LIG_SH3_1	423	429	PF00018	0.568
LIG_SH3_3	148	154	PF00018	0.626
LIG_SH3_3	314	320	PF00018	0.455
LIG_SH3_3	423	429	PF00018	0.568
LIG_SH3_3	501	507	PF00018	0.677
LIG_SH3_3	527	533	PF00018	0.722
LIG_SH3_3	552	558	PF00018	0.651
LIG_SH3_CIN85_PxpxPR_1	150	155	PF14604	0.502
LIG_SUMO_SIM_anti_2	306	312	PF11976	0.410
LIG_SUMO_SIM_anti_2	566	572	PF11976	0.524
LIG_SUMO_SIM_par_1	389	396	PF11976	0.551
LIG_TRAF2_1	514	517	PF00917	0.546
LIG_TRAF2_1	65	68	PF00917	0.446
LIG_WRC_WIRS_1	337	342	PF05994	0.427
LIG_WRC_WIRS_1	82	87	PF05994	0.600
MOD_CDK_SPK_2	150	155	PF00069	0.555
MOD_CDK_SPxxK_3	110	117	PF00069	0.548
MOD_CK1_1	110	116	PF00069	0.728
MOD_CK1_1	142	148	PF00069	0.621
MOD_CK1_1	22	28	PF00069	0.615
MOD_CK1_1	268	274	PF00069	0.641
MOD_CK1_1	32	38	PF00069	0.552
MOD_CK1_1	401	407	PF00069	0.694
MOD_CK1_1	489	495	PF00069	0.641
MOD_CK1_1	86	92	PF00069	0.694
MOD_CK2_1	205	211	PF00069	0.554
MOD_CK2_1	341	347	PF00069	0.363
MOD_CK2_1	438	444	PF00069	0.482
MOD_CK2_1	446	452	PF00069	0.467
MOD_CK2_1	584	590	PF00069	0.578
MOD_CK2_1	9	15	PF00069	0.570
MOD_GlcNHglycan	122	125	PF01048	0.634
MOD_GlcNHglycan	177	180	PF01048	0.441
MOD_GlcNHglycan	227	230	PF01048	0.537
MOD_GlcNHglycan	263	266	PF01048	0.608
MOD_GlcNHglycan	400	403	PF01048	0.681
MOD_GlcNHglycan	404	407	PF01048	0.636
MOD_GlcNHglycan	423	426	PF01048	0.697
MOD_GlcNHglycan	448	451	PF01048	0.588
MOD_GlcNHglycan	487	491	PF01048	0.682
MOD_GSK3_1	140	147	PF00069	0.543
MOD_GSK3_1	221	228	PF00069	0.625
MOD_GSK3_1	230	237	PF00069	0.611
MOD_GSK3_1	257	264	PF00069	0.706
MOD_GSK3_1	29	36	PF00069	0.475
MOD_GSK3_1	294	301	PF00069	0.708
MOD_GSK3_1	332	339	PF00069	0.388
MOD_GSK3_1	341	348	PF00069	0.353
MOD_GSK3_1	359	366	PF00069	0.477
MOD_GSK3_1	38	45	PF00069	0.483
MOD_GSK3_1	398	405	PF00069	0.592
MOD_GSK3_1	438	445	PF00069	0.539
MOD_GSK3_1	482	489	PF00069	0.567
MOD_GSK3_1	5	12	PF00069	0.595
MOD_GSK3_1	536	543	PF00069	0.585
MOD_GSK3_1	81	88	PF00069	0.756
MOD_N-GLC_1	205	210	PF02516	0.635
MOD_N-GLC_1	398	403	PF02516	0.662
MOD_NEK2_1	130	135	PF00069	0.704
MOD_NEK2_1	141	146	PF00069	0.531
MOD_NEK2_1	158	163	PF00069	0.496
MOD_NEK2_1	184	189	PF00069	0.401
MOD_NEK2_1	225	230	PF00069	0.498
MOD_NEK2_1	257	262	PF00069	0.541
MOD_NEK2_1	274	279	PF00069	0.512
MOD_NEK2_1	31	36	PF00069	0.522
MOD_NEK2_1	340	345	PF00069	0.433
MOD_NEK2_1	363	368	PF00069	0.547
MOD_NEK2_1	38	43	PF00069	0.528
MOD_NEK2_1	392	397	PF00069	0.707
MOD_NEK2_1	5	10	PF00069	0.540
MOD_NEK2_1	85	90	PF00069	0.738
MOD_NEK2_2	429	434	PF00069	0.570
MOD_PIKK_1	414	420	PF00454	0.545
MOD_PIKK_1	50	56	PF00454	0.506
MOD_PKA_1	518	524	PF00069	0.624
MOD_PKA_2	297	303	PF00069	0.694
MOD_PKA_2	32	38	PF00069	0.574
MOD_PKA_2	393	399	PF00069	0.707
MOD_PKA_2	421	427	PF00069	0.630
MOD_PKA_2	485	491	PF00069	0.697
MOD_PKA_2	494	500	PF00069	0.700
MOD_PKA_2	50	56	PF00069	0.449
MOD_PKA_2	518	524	PF00069	0.734
MOD_Plk_1	220	226	PF00069	0.603
MOD_Plk_1	234	240	PF00069	0.510
MOD_Plk_1	457	463	PF00069	0.537
MOD_Plk_1	584	590	PF00069	0.643
MOD_Plk_4	177	183	PF00069	0.404
MOD_Plk_4	265	271	PF00069	0.566
MOD_Plk_4	33	39	PF00069	0.502
MOD_Plk_4	333	339	PF00069	0.383
MOD_Plk_4	341	347	PF00069	0.346
MOD_Plk_4	584	590	PF00069	0.597
MOD_ProDKin_1	110	116	PF00069	0.615
MOD_ProDKin_1	118	124	PF00069	0.743
MOD_ProDKin_1	150	156	PF00069	0.616
MOD_ProDKin_1	259	265	PF00069	0.507
MOD_ProDKin_1	313	319	PF00069	0.494
MOD_ProDKin_1	529	535	PF00069	0.612
MOD_ProDKin_1	547	553	PF00069	0.717
MOD_SUMO_rev_2	374	382	PF00179	0.637
MOD_SUMO_rev_2	494	503	PF00179	0.647
TRG_DiLeu_BaEn_1	68	73	PF01217	0.472
TRG_DiLeu_BaEn_4	68	74	PF01217	0.580
TRG_DiLeu_BaLyEn_6	386	391	PF01217	0.655
TRG_ENDOCYTIC_2	138	141	PF00928	0.694
TRG_ENDOCYTIC_2	182	185	PF00928	0.388
TRG_ENDOCYTIC_2	231	234	PF00928	0.636
TRG_ENDOCYTIC_2	346	349	PF00928	0.400
TRG_ER_diArg_1	201	204	PF00400	0.465
TRG_ER_diArg_1	469	471	PF00400	0.566
TRG_ER_diArg_1	576	578	PF00400	0.531
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	471	475	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	577	581	PF00026	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2K6	Leptomonas seymouri	53%	97%
A0A1X0NLK5	Trypanosomatidae	35%	100%
A0A3R7NFJ5	Trypanosoma rangeli	35%	100%
A4HQH5	Leishmania braziliensis	77%	100%
A4ICB1	Leishmania infantum	100%	100%
D0A3M4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AU88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q0A3	Leishmania major	93%	100%
V5DDT5	Trypanosoma cruzi	34%	100%