Cop9 signalosome complex subunit, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cop9 signalosome complex subunit, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XCD5_LEIDO

TriTrypDb:

LdBPK_366800.1 , LdCL_360080500 , LDHU3_36.9070

Length:

399

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XCD5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XCD5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.397
CLV_C14_Caspase3-7	374	378	PF00656	0.558
CLV_PCSK_KEX2_1	380	382	PF00082	0.482
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.482
CLV_PCSK_SKI1_1	230	234	PF00082	0.344
CLV_PCSK_SKI1_1	300	304	PF00082	0.356
CLV_PCSK_SKI1_1	330	334	PF00082	0.446
CLV_PCSK_SKI1_1	34	38	PF00082	0.615
DEG_APCC_DBOX_1	229	237	PF00400	0.344
DOC_CYCLIN_RxL_1	318	329	PF00134	0.419
DOC_MAPK_gen_1	391	399	PF00069	0.633
DOC_MAPK_JIP1_4	393	399	PF00069	0.541
DOC_MAPK_MEF2A_6	391	398	PF00069	0.551
DOC_PP1_RVXF_1	109	116	PF00149	0.375
DOC_PP2B_LxvP_1	261	264	PF13499	0.420
DOC_USP7_MATH_1	211	215	PF00917	0.353
DOC_USP7_MATH_1	4	8	PF00917	0.439
DOC_WW_Pin1_4	129	134	PF00397	0.445
LIG_14-3-3_CanoR_1	210	216	PF00244	0.389
LIG_14-3-3_CanoR_1	34	39	PF00244	0.423
LIG_14-3-3_CanoR_1	79	88	PF00244	0.530
LIG_APCC_ABBA_1	323	328	PF00400	0.396
LIG_BIR_II_1	1	5	PF00653	0.547
LIG_BRCT_BRCA1_1	121	125	PF00533	0.384
LIG_BRCT_BRCA1_1	4	8	PF00533	0.558
LIG_deltaCOP1_diTrp_1	70	78	PF00928	0.407
LIG_FHA_1	356	362	PF00498	0.433
LIG_FHA_2	102	108	PF00498	0.449
LIG_FHA_2	130	136	PF00498	0.367
LIG_FHA_2	16	22	PF00498	0.443
LIG_FHA_2	26	32	PF00498	0.438
LIG_FHA_2	331	337	PF00498	0.402
LIG_FHA_2	372	378	PF00498	0.564
LIG_Integrin_isoDGR_2	39	41	PF01839	0.394
LIG_Integrin_RGD_1	19	21	PF01839	0.372
LIG_LIR_Apic_2	70	76	PF02991	0.406
LIG_LIR_Gen_1	101	109	PF02991	0.363
LIG_LIR_Gen_1	132	141	PF02991	0.383
LIG_LIR_Gen_1	314	323	PF02991	0.408
LIG_LIR_Gen_1	336	345	PF02991	0.391
LIG_LIR_Gen_1	357	367	PF02991	0.446
LIG_LIR_Gen_1	42	53	PF02991	0.389
LIG_LIR_Gen_1	7	17	PF02991	0.417
LIG_LIR_Nem_3	101	106	PF02991	0.431
LIG_LIR_Nem_3	122	128	PF02991	0.386
LIG_LIR_Nem_3	132	137	PF02991	0.361
LIG_LIR_Nem_3	165	170	PF02991	0.447
LIG_LIR_Nem_3	214	218	PF02991	0.427
LIG_LIR_Nem_3	314	318	PF02991	0.409
LIG_LIR_Nem_3	336	341	PF02991	0.401
LIG_LIR_Nem_3	357	363	PF02991	0.405
LIG_LIR_Nem_3	377	382	PF02991	0.443
LIG_LIR_Nem_3	42	48	PF02991	0.391
LIG_MLH1_MIPbox_1	122	126	PF16413	0.463
LIG_NRBOX	336	342	PF00104	0.381
LIG_PDZ_Class_2	394	399	PF00595	0.568
LIG_Pex14_2	212	216	PF04695	0.412
LIG_SH2_CRK	128	132	PF00017	0.364
LIG_SH2_CRK	167	171	PF00017	0.496
LIG_SH2_CRK	266	270	PF00017	0.377
LIG_SH2_CRK	338	342	PF00017	0.370
LIG_SH2_NCK_1	103	107	PF00017	0.450
LIG_SH2_STAP1	338	342	PF00017	0.410
LIG_SH2_STAT3	273	276	PF00017	0.420
LIG_SH2_STAT3	293	296	PF00017	0.264
LIG_SH2_STAT5	103	106	PF00017	0.439
LIG_SH2_STAT5	194	197	PF00017	0.342
LIG_SH2_STAT5	208	211	PF00017	0.357
LIG_SH2_STAT5	268	271	PF00017	0.370
LIG_SH2_STAT5	293	296	PF00017	0.369
LIG_SH3_3	289	295	PF00018	0.389
LIG_SUMO_SIM_par_1	93	98	PF11976	0.281
LIG_TRAF2_1	68	71	PF00917	0.368
LIG_TYR_ITSM	99	106	PF00017	0.427
LIG_UBA3_1	308	313	PF00899	0.352
LIG_WRC_WIRS_1	212	217	PF05994	0.438
MOD_CDK_SPxxK_3	129	136	PF00069	0.457
MOD_CK1_1	147	153	PF00069	0.418
MOD_CK1_1	2	8	PF00069	0.582
MOD_CK1_1	46	52	PF00069	0.389
MOD_CK1_1	80	86	PF00069	0.585
MOD_CK2_1	25	31	PF00069	0.424
MOD_CK2_1	330	336	PF00069	0.424
MOD_GlcNHglycan	122	125	PF01048	0.432
MOD_GlcNHglycan	157	160	PF01048	0.407
MOD_GlcNHglycan	177	180	PF01048	0.388
MOD_GlcNHglycan	256	259	PF01048	0.473
MOD_GlcNHglycan	278	281	PF01048	0.429
MOD_GlcNHglycan	49	52	PF01048	0.364
MOD_GlcNHglycan	83	86	PF01048	0.595
MOD_GSK3_1	120	127	PF00069	0.466
MOD_GSK3_1	2	9	PF00069	0.441
MOD_GSK3_1	250	257	PF00069	0.368
MOD_GSK3_1	340	347	PF00069	0.468
MOD_GSK3_1	43	50	PF00069	0.369
MOD_GSK3_1	77	84	PF00069	0.521
MOD_GSK3_1	98	105	PF00069	0.363
MOD_N-GLC_1	80	85	PF02516	0.601
MOD_NEK2_1	120	125	PF00069	0.455
MOD_NEK2_1	144	149	PF00069	0.388
MOD_NEK2_1	340	345	PF00069	0.444
MOD_NEK2_1	95	100	PF00069	0.272
MOD_NEK2_2	211	216	PF00069	0.409
MOD_PIKK_1	180	186	PF00454	0.541
MOD_PIKK_1	250	256	PF00454	0.389
MOD_PIKK_1	344	350	PF00454	0.389
MOD_PIKK_1	43	49	PF00454	0.378
MOD_PKA_2	144	150	PF00069	0.384
MOD_PKA_2	254	260	PF00069	0.557
MOD_PKB_1	173	181	PF00069	0.605
MOD_Plk_1	20	26	PF00069	0.324
MOD_Plk_4	162	168	PF00069	0.476
MOD_Plk_4	211	217	PF00069	0.354
MOD_Plk_4	340	346	PF00069	0.454
MOD_ProDKin_1	129	135	PF00069	0.441
MOD_SUMO_rev_2	322	332	PF00179	0.428
TRG_DiLeu_BaEn_1	336	341	PF01217	0.384
TRG_ENDOCYTIC_2	103	106	PF00928	0.395
TRG_ENDOCYTIC_2	128	131	PF00928	0.575
TRG_ENDOCYTIC_2	167	170	PF00928	0.409
TRG_ENDOCYTIC_2	266	269	PF00928	0.351
TRG_ENDOCYTIC_2	338	341	PF00928	0.374
TRG_ER_diArg_1	173	176	PF00400	0.551
TRG_NES_CRM1_1	207	220	PF08389	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2K5	Leptomonas seymouri	56%	100%
A4HQH2	Leishmania braziliensis	81%	100%
A4ICA8	Leishmania infantum	99%	100%
E9AU85	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q0A6	Leishmania major	91%	100%