ATPase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

ATPase, putative

Gene product:

ATPase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XCB8_LEIDO

TriTrypDb:

LdBPK_367110.1 , LdCL_360083700 , LDHU3_36.9480

Length:

531

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XCB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XCB8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0005488	binding	1	13
GO:0005524	ATP binding	5	13
GO:0016462	pyrophosphatase activity	5	13
GO:0016787	hydrolase activity	2	13
GO:0016817	hydrolase activity, acting on acid anhydrides	3	13
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	13
GO:0016887	ATP hydrolysis activity	7	13
GO:0017076	purine nucleotide binding	4	13
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	13
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	158	160	PF00675	0.273
CLV_NRD_NRD_1	184	186	PF00675	0.346
CLV_NRD_NRD_1	3	5	PF00675	0.647
CLV_NRD_NRD_1	30	32	PF00675	0.424
CLV_NRD_NRD_1	314	316	PF00675	0.322
CLV_NRD_NRD_1	526	528	PF00675	0.587
CLV_NRD_NRD_1	8	10	PF00675	0.540
CLV_NRD_NRD_1	92	94	PF00675	0.459
CLV_PCSK_FUR_1	182	186	PF00082	0.171
CLV_PCSK_KEX2_1	128	130	PF00082	0.339
CLV_PCSK_KEX2_1	157	159	PF00082	0.275
CLV_PCSK_KEX2_1	182	184	PF00082	0.333
CLV_PCSK_KEX2_1	19	21	PF00082	0.353
CLV_PCSK_KEX2_1	193	195	PF00082	0.345
CLV_PCSK_KEX2_1	3	5	PF00082	0.647
CLV_PCSK_KEX2_1	314	316	PF00082	0.327
CLV_PCSK_KEX2_1	8	10	PF00082	0.532
CLV_PCSK_KEX2_1	92	94	PF00082	0.608
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.316
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.275
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.490
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.224
CLV_PCSK_PC7_1	4	10	PF00082	0.546
CLV_PCSK_SKI1_1	104	108	PF00082	0.511
CLV_PCSK_SKI1_1	193	197	PF00082	0.338
CLV_PCSK_SKI1_1	413	417	PF00082	0.235
DEG_APCC_DBOX_1	240	248	PF00400	0.367
DEG_APCC_DBOX_1	490	498	PF00400	0.425
DEG_Nend_Nbox_1	1	3	PF02207	0.643
DOC_CYCLIN_RxL_1	110	121	PF00134	0.546
DOC_MAPK_DCC_7	194	204	PF00069	0.346
DOC_MAPK_gen_1	172	180	PF00069	0.377
DOC_PP1_RVXF_1	411	417	PF00149	0.263
DOC_PP4_FxxP_1	300	303	PF00568	0.235
DOC_USP7_MATH_1	449	453	PF00917	0.645
DOC_USP7_MATH_1	47	51	PF00917	0.305
DOC_USP7_MATH_1	73	77	PF00917	0.574
DOC_USP7_MATH_1	87	91	PF00917	0.491
DOC_WW_Pin1_4	150	155	PF00397	0.273
DOC_WW_Pin1_4	186	191	PF00397	0.429
DOC_WW_Pin1_4	210	215	PF00397	0.277
DOC_WW_Pin1_4	65	70	PF00397	0.514
LIG_14-3-3_CanoR_1	158	166	PF00244	0.314
LIG_14-3-3_CanoR_1	182	190	PF00244	0.386
LIG_14-3-3_CanoR_1	259	265	PF00244	0.255
LIG_14-3-3_CanoR_1	42	51	PF00244	0.281
LIG_BRCT_BRCA1_1	260	264	PF00533	0.267
LIG_BRCT_BRCA1_1	474	478	PF00533	0.494
LIG_deltaCOP1_diTrp_1	326	336	PF00928	0.314
LIG_FHA_1	110	116	PF00498	0.455
LIG_FHA_1	140	146	PF00498	0.250
LIG_FHA_1	211	217	PF00498	0.257
LIG_FHA_1	221	227	PF00498	0.216
LIG_FHA_1	378	384	PF00498	0.279
LIG_FHA_1	415	421	PF00498	0.220
LIG_FHA_1	430	436	PF00498	0.416
LIG_FHA_1	47	53	PF00498	0.296
LIG_FHA_2	19	25	PF00498	0.324
LIG_FHA_2	511	517	PF00498	0.343
LIG_LIR_Apic_2	68	73	PF02991	0.471
LIG_LIR_Gen_1	219	229	PF02991	0.220
LIG_LIR_Gen_1	24	34	PF02991	0.357
LIG_LIR_Gen_1	261	271	PF02991	0.274
LIG_LIR_Gen_1	355	362	PF02991	0.274
LIG_LIR_Gen_1	419	430	PF02991	0.280
LIG_LIR_Gen_1	486	494	PF02991	0.332
LIG_LIR_Gen_1	514	525	PF02991	0.419
LIG_LIR_Gen_1	94	103	PF02991	0.650
LIG_LIR_Nem_3	219	224	PF02991	0.222
LIG_LIR_Nem_3	24	29	PF02991	0.377
LIG_LIR_Nem_3	261	267	PF02991	0.250
LIG_LIR_Nem_3	355	359	PF02991	0.271
LIG_LIR_Nem_3	419	425	PF02991	0.264
LIG_LIR_Nem_3	486	490	PF02991	0.362
LIG_LIR_Nem_3	514	520	PF02991	0.388
LIG_LIR_Nem_3	94	99	PF02991	0.651
LIG_PCNA_yPIPBox_3	200	210	PF02747	0.318
LIG_Rb_pABgroove_1	142	150	PF01858	0.389
LIG_SH2_CRK	70	74	PF00017	0.481
LIG_SH2_GRB2like	408	411	PF00017	0.357
LIG_SH2_STAP1	26	30	PF00017	0.327
LIG_SH2_STAP1	59	63	PF00017	0.391
LIG_SH2_STAT5	132	135	PF00017	0.324
LIG_SH2_STAT5	502	505	PF00017	0.335
LIG_SH2_STAT5	70	73	PF00017	0.649
LIG_SH3_3	339	345	PF00018	0.404
LIG_SUMO_SIM_par_1	142	149	PF11976	0.252
LIG_SUMO_SIM_par_1	379	384	PF11976	0.250
LIG_SUMO_SIM_par_1	400	406	PF11976	0.263
LIG_UBA3_1	298	306	PF00899	0.239
LIG_WRC_WIRS_1	162	167	PF05994	0.233
LIG_WRC_WIRS_1	221	226	PF05994	0.246
LIG_WRC_WIRS_1	484	489	PF05994	0.340
MOD_CDK_SPK_2	186	191	PF00069	0.255
MOD_CDK_SPxxK_3	150	157	PF00069	0.309
MOD_CDK_SPxxK_3	186	193	PF00069	0.255
MOD_CDK_SPxxK_3	65	72	PF00069	0.473
MOD_CK1_1	14	20	PF00069	0.418
MOD_CK1_1	164	170	PF00069	0.250
MOD_CK1_1	186	192	PF00069	0.435
MOD_CK1_1	428	434	PF00069	0.518
MOD_CK1_1	456	462	PF00069	0.521
MOD_CK1_1	68	74	PF00069	0.627
MOD_CK2_1	164	170	PF00069	0.383
MOD_CK2_1	18	24	PF00069	0.350
MOD_CK2_1	186	192	PF00069	0.349
MOD_CK2_1	460	466	PF00069	0.555
MOD_GlcNHglycan	185	188	PF01048	0.353
MOD_GlcNHglycan	260	263	PF01048	0.367
MOD_GlcNHglycan	367	370	PF01048	0.426
MOD_GlcNHglycan	442	445	PF01048	0.610
MOD_GlcNHglycan	451	454	PF01048	0.545
MOD_GlcNHglycan	466	472	PF01048	0.516
MOD_GlcNHglycan	498	501	PF01048	0.422
MOD_GlcNHglycan	75	78	PF01048	0.540
MOD_GSK3_1	10	17	PF00069	0.436
MOD_GSK3_1	107	114	PF00069	0.598
MOD_GSK3_1	157	164	PF00069	0.280
MOD_GSK3_1	377	384	PF00069	0.294
MOD_GSK3_1	416	423	PF00069	0.374
MOD_GSK3_1	42	49	PF00069	0.487
MOD_GSK3_1	425	432	PF00069	0.433
MOD_GSK3_1	449	456	PF00069	0.645
MOD_GSK3_1	87	94	PF00069	0.556
MOD_N-GLC_1	390	395	PF02516	0.382
MOD_NEK2_1	178	183	PF00069	0.284
MOD_NEK2_1	245	250	PF00069	0.292
MOD_NEK2_1	414	419	PF00069	0.330
MOD_NEK2_1	425	430	PF00069	0.292
MOD_NEK2_1	91	96	PF00069	0.593
MOD_NEK2_2	87	92	PF00069	0.470
MOD_PKA_1	157	163	PF00069	0.309
MOD_PKA_1	183	189	PF00069	0.389
MOD_PKA_2	157	163	PF00069	0.280
MOD_PKA_2	183	189	PF00069	0.322
MOD_PKA_2	258	264	PF00069	0.255
MOD_PKA_2	91	97	PF00069	0.467
MOD_PKB_1	40	48	PF00069	0.288
MOD_Plk_1	331	337	PF00069	0.305
MOD_Plk_1	426	432	PF00069	0.485
MOD_Plk_2-3	220	226	PF00069	0.220
MOD_Plk_2-3	460	466	PF00069	0.651
MOD_Plk_4	139	145	PF00069	0.252
MOD_Plk_4	161	167	PF00069	0.233
MOD_Plk_4	331	337	PF00069	0.253
MOD_Plk_4	377	383	PF00069	0.279
MOD_Plk_4	47	53	PF00069	0.293
MOD_Plk_4	498	504	PF00069	0.523
MOD_ProDKin_1	150	156	PF00069	0.273
MOD_ProDKin_1	186	192	PF00069	0.429
MOD_ProDKin_1	210	216	PF00069	0.277
MOD_ProDKin_1	65	71	PF00069	0.525
TRG_DiLeu_BaEn_1	242	247	PF01217	0.186
TRG_ENDOCYTIC_2	26	29	PF00928	0.346
TRG_ER_diArg_1	182	185	PF00400	0.326
TRG_ER_diArg_1	2	4	PF00400	0.659
TRG_ER_diArg_1	313	315	PF00400	0.324
TRG_ER_diArg_1	40	43	PF00400	0.347
TRG_ER_diArg_1	490	493	PF00400	0.443
TRG_ER_diArg_1	91	93	PF00400	0.564
TRG_NLS_MonoExtN_4	154	161	PF00514	0.325
TRG_Pf-PMV_PEXEL_1	436	440	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P494	Leptomonas seymouri	29%	100%
A0A0N1I0J7	Leptomonas seymouri	66%	100%
A0A0S4J9H9	Bodo saltans	27%	100%
A0A0S4JPV5	Bodo saltans	44%	100%
A0A1X0NK74	Trypanosomatidae	27%	100%
A0A1X0NN10	Trypanosomatidae	47%	100%
A0A3R7K771	Trypanosoma rangeli	30%	100%
A0A3R7L848	Trypanosoma rangeli	48%	100%
A0A3S5H5L6	Leishmania donovani	28%	100%
A4H4F1	Leishmania braziliensis	29%	100%
A4HSM8	Leishmania infantum	29%	100%
A4ICB9	Leishmania infantum	100%	100%
C9ZU69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
D0A3Q2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AIY4	Leishmania braziliensis	80%	100%
E9AKL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AUB4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O42895	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
P32317	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
P46441	Haematobia irritans	28%	100%
Q32PX9	Rattus norvegicus	31%	100%
Q3V384	Mus musculus	30%	100%
Q4Q076	Leishmania major	92%	100%
Q4QJ96	Leishmania major	29%	100%
Q5TYS0	Danio rerio	28%	100%
Q8WV93	Homo sapiens	30%	100%
V5BD25	Trypanosoma cruzi	49%	100%
V5D7E6	Trypanosoma cruzi	30%	100%