LeishMANIAdb
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EF-hand domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
EF-hand domain-containing protein
Gene product:
Protein of unknown function (DUF2453), putative
Species:
Leishmania donovani
UniProt:
A0A3S7XCB7_LEIDO
TriTrypDb:
LdBPK_367160.1 , LdCL_360084200 , LDHU3_36.9530
Length:
349

Annotations

LeishMANIAdb annotations

These Kinetoplastid proteins share considerable homology with the animal TMEM65 proteins at their membrane domains, with a unique EF-hand at the N-terminus.. While the animal orthologs have a mitochondrial transit signal, it seems to be absent from the Kinetoplastid proteins. The latter have an alanine-rich segment of unclear function.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0016020 membrane 2 14
GO:0110165 cellular anatomical entity 1 14
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A0A3S7XCB7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XCB7

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 11
GO:0005509 calcium ion binding 5 11
GO:0043167 ion binding 2 11
GO:0043169 cation binding 3 11
GO:0046872 metal ion binding 4 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 185 189 PF00656 0.287
CLV_C14_Caspase3-7 340 344 PF00656 0.469
CLV_C14_Caspase3-7 89 93 PF00656 0.640
CLV_NRD_NRD_1 114 116 PF00675 0.408
CLV_NRD_NRD_1 243 245 PF00675 0.308
CLV_NRD_NRD_1 67 69 PF00675 0.386
CLV_PCSK_KEX2_1 113 115 PF00082 0.395
CLV_PCSK_KEX2_1 121 123 PF00082 0.451
CLV_PCSK_KEX2_1 243 245 PF00082 0.308
CLV_PCSK_KEX2_1 66 68 PF00082 0.384
CLV_PCSK_PC1ET2_1 113 115 PF00082 0.430
CLV_PCSK_PC1ET2_1 121 123 PF00082 0.481
CLV_PCSK_SKI1_1 121 125 PF00082 0.531
CLV_PCSK_SKI1_1 127 131 PF00082 0.572
CLV_PCSK_SKI1_1 243 247 PF00082 0.308
CLV_PCSK_SKI1_1 345 349 PF00082 0.657
DEG_SPOP_SBC_1 29 33 PF00917 0.694
DOC_CDC14_PxL_1 263 271 PF14671 0.397
DOC_CKS1_1 230 235 PF01111 0.540
DOC_CYCLIN_RxL_1 302 313 PF00134 0.454
DOC_PP1_RVXF_1 225 231 PF00149 0.489
DOC_PP1_RVXF_1 326 332 PF00149 0.417
DOC_PP4_FxxP_1 230 233 PF00568 0.488
DOC_USP7_MATH_1 147 151 PF00917 0.711
DOC_USP7_MATH_1 23 27 PF00917 0.742
DOC_USP7_MATH_1 29 33 PF00917 0.747
DOC_USP7_UBL2_3 223 227 PF12436 0.500
DOC_WW_Pin1_4 141 146 PF00397 0.781
DOC_WW_Pin1_4 229 234 PF00397 0.515
DOC_WW_Pin1_4 97 102 PF00397 0.610
LIG_14-3-3_CanoR_1 122 129 PF00244 0.694
LIG_BIR_II_1 1 5 PF00653 0.724
LIG_BRCT_BRCA1_1 189 193 PF00533 0.361
LIG_Clathr_ClatBox_1 268 272 PF01394 0.397
LIG_FHA_1 12 18 PF00498 0.717
LIG_FHA_1 150 156 PF00498 0.670
LIG_FHA_1 177 183 PF00498 0.309
LIG_FHA_1 230 236 PF00498 0.528
LIG_FHA_1 252 258 PF00498 0.346
LIG_FHA_2 128 134 PF00498 0.765
LIG_FHA_2 34 40 PF00498 0.639
LIG_LIR_Gen_1 279 289 PF02991 0.428
LIG_LIR_Gen_1 292 300 PF02991 0.286
LIG_LIR_Gen_1 330 339 PF02991 0.410
LIG_LIR_Nem_3 279 284 PF02991 0.435
LIG_LIR_Nem_3 292 297 PF02991 0.289
LIG_LIR_Nem_3 299 303 PF02991 0.375
LIG_LIR_Nem_3 330 334 PF02991 0.364
LIG_Pex14_2 104 108 PF04695 0.607
LIG_PTB_Apo_2 288 295 PF02174 0.415
LIG_SH2_GRB2like 194 197 PF00017 0.397
LIG_SH2_STAT5 194 197 PF00017 0.376
LIG_SH2_STAT5 281 284 PF00017 0.434
LIG_SH3_3 292 298 PF00018 0.434
LIG_SUMO_SIM_par_1 159 164 PF11976 0.417
LIG_TRAF2_1 84 87 PF00917 0.643
MOD_CDK_SPK_2 97 102 PF00069 0.611
MOD_CK1_1 134 140 PF00069 0.731
MOD_CK1_1 28 34 PF00069 0.730
MOD_CK2_1 127 133 PF00069 0.784
MOD_CK2_1 33 39 PF00069 0.652
MOD_GlcNHglycan 109 112 PF01048 0.408
MOD_GlcNHglycan 133 136 PF01048 0.569
MOD_GlcNHglycan 201 204 PF01048 0.350
MOD_GlcNHglycan 209 212 PF01048 0.273
MOD_GlcNHglycan 25 28 PF01048 0.489
MOD_GlcNHglycan 291 294 PF01048 0.601
MOD_GlcNHglycan 82 85 PF01048 0.425
MOD_GSK3_1 127 134 PF00069 0.714
MOD_GSK3_1 195 202 PF00069 0.414
MOD_GSK3_1 21 28 PF00069 0.714
MOD_GSK3_1 229 236 PF00069 0.524
MOD_GSK3_1 272 279 PF00069 0.414
MOD_GSK3_1 29 36 PF00069 0.667
MOD_N-GLC_1 176 181 PF02516 0.538
MOD_N-GLC_1 195 200 PF02516 0.192
MOD_N-GLC_1 289 294 PF02516 0.626
MOD_N-GLC_2 207 209 PF02516 0.451
MOD_NEK2_1 1 6 PF00069 0.740
MOD_NEK2_1 175 180 PF00069 0.379
MOD_NEK2_1 195 200 PF00069 0.138
MOD_NEK2_1 251 256 PF00069 0.381
MOD_NEK2_1 69 74 PF00069 0.630
MOD_PIKK_1 332 338 PF00454 0.409
MOD_PKA_1 121 127 PF00069 0.754
MOD_PKA_2 121 127 PF00069 0.723
MOD_Plk_1 175 181 PF00069 0.334
MOD_Plk_1 195 201 PF00069 0.138
MOD_Plk_4 176 182 PF00069 0.285
MOD_Plk_4 195 201 PF00069 0.197
MOD_Plk_4 30 36 PF00069 0.747
MOD_ProDKin_1 141 147 PF00069 0.779
MOD_ProDKin_1 229 235 PF00069 0.515
MOD_ProDKin_1 97 103 PF00069 0.604
MOD_SUMO_rev_2 340 347 PF00179 0.474
TRG_DiLeu_BaLyEn_6 264 269 PF01217 0.318
TRG_ENDOCYTIC_2 281 284 PF00928 0.427
TRG_ER_diArg_1 243 245 PF00400 0.508
TRG_ER_diArg_1 66 68 PF00400 0.584
TRG_NLS_MonoExtC_3 119 125 PF00514 0.727
TRG_Pf-PMV_PEXEL_1 302 306 PF00026 0.612
TRG_Pf-PMV_PEXEL_1 317 321 PF00026 0.411
TRG_Pf-PMV_PEXEL_1 5 9 PF00026 0.577
TRG_Pf-PMV_PEXEL_1 52 56 PF00026 0.463

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P806 Leptomonas seymouri 80% 99%
A0A0S4J8V3 Bodo saltans 34% 100%
A0A0S4JY67 Bodo saltans 55% 100%
A0A1X0NL71 Trypanosomatidae 56% 100%
A0A3R7NFF7 Trypanosoma rangeli 30% 90%
A4HQK4 Leishmania braziliensis 85% 100%
A4ICC4 Leishmania infantum 96% 100%
C9ZPD7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 81%
E9AUB9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4Q071 Leishmania major 95% 100%
V5BGX0 Trypanosoma cruzi 34% 84%
V5BHN9 Trypanosoma cruzi 55% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS