Dienelactone hydrolase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

similarity to endo-1-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7XCB3_LEIDO

TriTrypDb:

LdBPK_366850.1 , LdCL_360081000 , LDHU3_36.9130

Length:

240

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XCB3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XCB3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016787	hydrolase activity	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	197	199	PF00082	0.285
CLV_PCSK_KEX2_1	54	56	PF00082	0.300
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.285
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.343
CLV_PCSK_SKI1_1	162	166	PF00082	0.330
DOC_CYCLIN_RxL_1	222	233	PF00134	0.581
DOC_MAPK_gen_1	162	171	PF00069	0.530
DOC_MAPK_MEF2A_6	162	171	PF00069	0.513
DOC_PP2B_LxvP_1	169	172	PF13499	0.581
DOC_PP4_FxxP_1	72	75	PF00568	0.498
DOC_USP7_MATH_1	151	155	PF00917	0.493
DOC_USP7_MATH_1	185	189	PF00917	0.565
DOC_USP7_MATH_1	33	37	PF00917	0.530
DOC_WW_Pin1_4	163	168	PF00397	0.507
DOC_WW_Pin1_4	19	24	PF00397	0.600
LIG_BIR_II_1	1	5	PF00653	0.655
LIG_BRCT_BRCA1_1	52	56	PF00533	0.551
LIG_deltaCOP1_diTrp_1	80	87	PF00928	0.531
LIG_FHA_1	164	170	PF00498	0.507
LIG_FHA_1	88	94	PF00498	0.530
LIG_FHA_2	215	221	PF00498	0.530
LIG_FHA_2	98	104	PF00498	0.526
LIG_GBD_Chelix_1	42	50	PF00786	0.330
LIG_LIR_Apic_2	71	75	PF02991	0.498
LIG_LIR_Gen_1	100	109	PF02991	0.533
LIG_LIR_Gen_1	53	61	PF02991	0.556
LIG_LIR_Gen_1	62	73	PF02991	0.500
LIG_LIR_Nem_3	100	105	PF02991	0.487
LIG_LIR_Nem_3	45	50	PF02991	0.532
LIG_LIR_Nem_3	53	59	PF02991	0.533
LIG_LIR_Nem_3	62	68	PF02991	0.544
LIG_LIR_Nem_3	71	76	PF02991	0.394
LIG_LIR_Nem_3	89	95	PF02991	0.483
LIG_OCRL_FandH_1	198	210	PF00620	0.498
LIG_Pex14_1	83	87	PF04695	0.492
LIG_REV1ctd_RIR_1	204	212	PF16727	0.530
LIG_REV1ctd_RIR_1	232	240	PF16727	0.530
LIG_SH2_NCK_1	21	25	PF00017	0.691
LIG_SH2_STAP1	95	99	PF00017	0.429
LIG_SH2_STAT5	216	219	PF00017	0.530
LIG_SH2_STAT5	29	32	PF00017	0.460
LIG_SH3_3	17	23	PF00018	0.500
LIG_SH3_3	187	193	PF00018	0.516
LIG_SH3_3	27	33	PF00018	0.303
LIG_SH3_3	64	70	PF00018	0.500
LIG_Sin3_3	112	119	PF02671	0.554
LIG_SUMO_SIM_anti_2	166	173	PF11976	0.507
LIG_SUMO_SIM_par_1	166	173	PF11976	0.556
LIG_SUMO_SIM_par_1	39	45	PF11976	0.470
LIG_TRAF2_1	217	220	PF00917	0.524
LIG_TRFH_1	47	51	PF08558	0.526
LIG_UBA3_1	115	123	PF00899	0.484
LIG_UBA3_1	46	54	PF00899	0.581
LIG_WRC_WIRS_1	102	107	PF05994	0.521
MOD_CK1_1	154	160	PF00069	0.511
MOD_CK2_1	170	176	PF00069	0.467
MOD_CK2_1	214	220	PF00069	0.530
MOD_GSK3_1	147	154	PF00069	0.422
MOD_GSK3_1	97	104	PF00069	0.509
MOD_LATS_1	196	202	PF00433	0.429
MOD_N-GLC_2	7	9	PF02516	0.700
MOD_NEK2_1	235	240	PF00069	0.569
MOD_NEK2_1	87	92	PF00069	0.456
MOD_PIKK_1	97	103	PF00454	0.516
MOD_Plk_4	101	107	PF00069	0.488
MOD_Plk_4	151	157	PF00069	0.513
MOD_ProDKin_1	163	169	PF00069	0.507
MOD_ProDKin_1	19	25	PF00069	0.596
MOD_SUMO_rev_2	214	224	PF00179	0.505
TRG_DiLeu_BaEn_1	62	67	PF01217	0.526
TRG_ER_diLys_1	236	240	PF00400	0.569
TRG_Pf-PMV_PEXEL_1	228	233	PF00026	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P241	Leptomonas seymouri	62%	99%
A0A0S4KTD2	Bodo saltans	37%	100%
A0A2V5GSC6	Aspergillus violaceofuscus (strain CBS 115571)	31%	98%
A4HQH7	Leishmania braziliensis	74%	100%
A4ICB3	Leishmania infantum	100%	100%
B8M9K0	Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)	27%	94%
E9AU90	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
O14359	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	96%
Q4Q0A1	Leishmania major	93%	100%
Q5RBU3	Pongo abelii	26%	98%
Q5XH09	Xenopus laevis	27%	98%
Q6P7K0	Xenopus tropicalis	29%	98%
Q7TP52	Rattus norvegicus	26%	98%
Q8R1G2	Mus musculus	28%	98%
Q96DG6	Homo sapiens	26%	98%
Q9P7U1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	97%
Q9ZT66	Zea mays	28%	79%
W7MAD3	Gibberella moniliformis (strain M3125 / FGSC 7600)	30%	92%