NUC153 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XCB2_LEIDO

TriTrypDb:

LdBPK_366810.1 , LdCL_360080600 , LDHU3_36.9080

Length:

622

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XCB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XCB2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	278	282	PF00656	0.500
CLV_C14_Caspase3-7	303	307	PF00656	0.703
CLV_C14_Caspase3-7	593	597	PF00656	0.663
CLV_NRD_NRD_1	182	184	PF00675	0.412
CLV_NRD_NRD_1	320	322	PF00675	0.498
CLV_NRD_NRD_1	324	326	PF00675	0.523
CLV_NRD_NRD_1	444	446	PF00675	0.505
CLV_NRD_NRD_1	496	498	PF00675	0.540
CLV_NRD_NRD_1	534	536	PF00675	0.608
CLV_NRD_NRD_1	54	56	PF00675	0.435
CLV_PCSK_FUR_1	317	321	PF00082	0.642
CLV_PCSK_KEX2_1	182	184	PF00082	0.495
CLV_PCSK_KEX2_1	319	321	PF00082	0.564
CLV_PCSK_KEX2_1	323	325	PF00082	0.565
CLV_PCSK_KEX2_1	444	446	PF00082	0.505
CLV_PCSK_KEX2_1	496	498	PF00082	0.540
CLV_PCSK_KEX2_1	53	55	PF00082	0.430
CLV_PCSK_KEX2_1	534	536	PF00082	0.604
CLV_PCSK_KEX2_1	569	571	PF00082	0.589
CLV_PCSK_KEX2_1	589	591	PF00082	0.626
CLV_PCSK_KEX2_1	97	99	PF00082	0.511
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.586
CLV_PCSK_PC1ET2_1	569	571	PF00082	0.608
CLV_PCSK_PC1ET2_1	589	591	PF00082	0.662
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.511
CLV_PCSK_PC7_1	320	326	PF00082	0.626
CLV_PCSK_SKI1_1	164	168	PF00082	0.620
CLV_PCSK_SKI1_1	446	450	PF00082	0.531
CLV_PCSK_SKI1_1	453	457	PF00082	0.508
CLV_PCSK_SKI1_1	502	506	PF00082	0.535
CLV_PCSK_SKI1_1	512	516	PF00082	0.528
CLV_PCSK_SKI1_1	618	622	PF00082	0.565
CLV_PCSK_SKI1_1	97	101	PF00082	0.456
DEG_APCC_DBOX_1	474	482	PF00400	0.642
DOC_ANK_TNKS_1	591	598	PF00023	0.725
DOC_MAPK_gen_1	515	526	PF00069	0.531
DOC_MAPK_MEF2A_6	104	112	PF00069	0.504
DOC_PP1_RVXF_1	263	269	PF00149	0.466
DOC_PP4_FxxP_1	234	237	PF00568	0.484
DOC_USP7_MATH_1	298	302	PF00917	0.611
DOC_USP7_MATH_1	602	606	PF00917	0.672
DOC_USP7_UBL2_3	315	319	PF12436	0.644
DOC_USP7_UBL2_3	442	446	PF12436	0.538
DOC_USP7_UBL2_3	449	453	PF12436	0.525
DOC_USP7_UBL2_3	494	498	PF12436	0.557
DOC_USP7_UBL2_3	618	622	PF12436	0.579
DOC_WW_Pin1_4	233	238	PF00397	0.636
LIG_14-3-3_CanoR_1	265	269	PF00244	0.500
LIG_14-3-3_CanoR_1	275	280	PF00244	0.505
LIG_14-3-3_CanoR_1	374	380	PF00244	0.623
LIG_14-3-3_CanoR_1	590	599	PF00244	0.720
LIG_BIR_II_1	1	5	PF00653	0.650
LIG_CaM_IQ_9	415	431	PF13499	0.628
LIG_CaM_IQ_9	527	543	PF13499	0.647
LIG_CSL_BTD_1	41	44	PF09270	0.663
LIG_FHA_1	486	492	PF00498	0.503
LIG_FHA_1	525	531	PF00498	0.680
LIG_FHA_2	14	20	PF00498	0.697
LIG_FHA_2	284	290	PF00498	0.549
LIG_FHA_2	531	537	PF00498	0.687
LIG_LIR_Apic_2	231	237	PF02991	0.492
LIG_LIR_Gen_1	62	71	PF02991	0.385
LIG_LIR_Nem_3	178	184	PF02991	0.536
LIG_LIR_Nem_3	62	66	PF02991	0.395
LIG_LIR_Nem_3	70	75	PF02991	0.375
LIG_Pex14_2	264	268	PF04695	0.447
LIG_REV1ctd_RIR_1	610	621	PF16727	0.666
LIG_SH2_CRK	326	330	PF00017	0.533
LIG_SH2_CRK	72	76	PF00017	0.407
LIG_SH2_NCK_1	193	197	PF00017	0.375
LIG_SH2_NCK_1	599	603	PF00017	0.534
LIG_SH2_STAP1	326	330	PF00017	0.498
LIG_SH2_STAP1	72	76	PF00017	0.407
LIG_SH2_STAT5	227	230	PF00017	0.423
LIG_SH2_STAT5	295	298	PF00017	0.582
LIG_SH2_STAT5	599	602	PF00017	0.626
LIG_SH3_3	147	153	PF00018	0.773
LIG_SUMO_SIM_par_1	84	89	PF11976	0.507
LIG_TRAF2_1	28	31	PF00917	0.721
LIG_TRAF2_1	286	289	PF00917	0.693
LIG_WRC_WIRS_1	195	200	PF05994	0.381
MOD_CDK_SPxxK_3	233	240	PF00069	0.630
MOD_CK1_1	2	8	PF00069	0.731
MOD_CK1_1	200	206	PF00069	0.412
MOD_CK1_1	236	242	PF00069	0.621
MOD_CK1_1	257	263	PF00069	0.546
MOD_CK1_1	9	15	PF00069	0.682
MOD_CK2_1	122	128	PF00069	0.703
MOD_CK2_1	13	19	PF00069	0.659
MOD_CK2_1	283	289	PF00069	0.657
MOD_CK2_1	298	304	PF00069	0.528
MOD_CK2_1	373	379	PF00069	0.661
MOD_CK2_1	489	495	PF00069	0.573
MOD_CK2_1	530	536	PF00069	0.692
MOD_Cter_Amidation	587	590	PF01082	0.661
MOD_Cter_Amidation	95	98	PF01082	0.441
MOD_GlcNHglycan	124	127	PF01048	0.757
MOD_GlcNHglycan	199	202	PF01048	0.418
MOD_GlcNHglycan	217	221	PF01048	0.423
MOD_GlcNHglycan	256	259	PF01048	0.506
MOD_GlcNHglycan	365	368	PF01048	0.545
MOD_GlcNHglycan	491	494	PF01048	0.570
MOD_GlcNHglycan	6	9	PF01048	0.753
MOD_GSK3_1	148	155	PF00069	0.744
MOD_GSK3_1	2	9	PF00069	0.693
MOD_GSK3_1	275	282	PF00069	0.492
MOD_GSK3_1	410	417	PF00069	0.675
MOD_GSK3_1	481	488	PF00069	0.494
MOD_GSK3_1	602	609	PF00069	0.652
MOD_GSK3_1	86	93	PF00069	0.518
MOD_N-GLC_1	9	14	PF02516	0.602
MOD_NEK2_1	254	259	PF00069	0.445
MOD_NEK2_1	279	284	PF00069	0.654
MOD_NEK2_1	448	453	PF00069	0.628
MOD_NEK2_1	524	529	PF00069	0.622
MOD_NEK2_1	562	567	PF00069	0.683
MOD_NEK2_1	578	583	PF00069	0.397
MOD_NEK2_1	86	91	PF00069	0.528
MOD_PIKK_1	257	263	PF00454	0.458
MOD_PIKK_1	524	530	PF00454	0.718
MOD_PIKK_1	562	568	PF00454	0.725
MOD_PKA_2	264	270	PF00069	0.461
MOD_PKA_2	373	379	PF00069	0.605
MOD_PKA_2	489	495	PF00069	0.699
MOD_Plk_1	368	374	PF00069	0.642
MOD_Plk_1	403	409	PF00069	0.609
MOD_Plk_1	606	612	PF00069	0.638
MOD_Plk_1	86	92	PF00069	0.516
MOD_Plk_2-3	143	149	PF00069	0.734
MOD_Plk_4	395	401	PF00069	0.779
MOD_Plk_4	86	92	PF00069	0.508
MOD_ProDKin_1	233	239	PF00069	0.632
MOD_SUMO_rev_2	116	125	PF00179	0.630
MOD_SUMO_rev_2	307	316	PF00179	0.678
MOD_SUMO_rev_2	408	416	PF00179	0.564
MOD_SUMO_rev_2	593	600	PF00179	0.701
TRG_DiLeu_BaEn_4	30	36	PF01217	0.665
TRG_ENDOCYTIC_2	192	195	PF00928	0.393
TRG_ENDOCYTIC_2	208	211	PF00928	0.404
TRG_ENDOCYTIC_2	326	329	PF00928	0.495
TRG_ENDOCYTIC_2	72	75	PF00928	0.398
TRG_ER_diArg_1	181	183	PF00400	0.498
TRG_ER_diArg_1	320	323	PF00400	0.516
TRG_ER_diArg_1	324	326	PF00400	0.542
TRG_ER_diArg_1	443	445	PF00400	0.515
TRG_ER_diArg_1	53	55	PF00400	0.467
TRG_ER_diLys_1	617	622	PF00400	0.587
TRG_NES_CRM1_1	370	384	PF08389	0.757
TRG_NES_CRM1_1	70	84	PF08389	0.406
TRG_NLS_Bipartite_1	497	519	PF00514	0.543
TRG_NLS_MonoCore_2	615	620	PF00514	0.557
TRG_NLS_MonoExtC_3	448	453	PF00514	0.523
TRG_NLS_MonoExtC_3	514	519	PF00514	0.564
TRG_NLS_MonoExtC_3	588	594	PF00514	0.762
TRG_NLS_MonoExtN_4	446	453	PF00514	0.540
TRG_NLS_MonoExtN_4	512	519	PF00514	0.529
TRG_NLS_MonoExtN_4	586	593	PF00514	0.749
TRG_NLS_MonoExtN_4	616	621	PF00514	0.544
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.741
TRG_Pf-PMV_PEXEL_1	98	103	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Z4	Leptomonas seymouri	72%	85%
A0A0S4IQI8	Bodo saltans	48%	85%
A0A1X0NN45	Trypanosomatidae	54%	84%
A0A3S5IRC1	Trypanosoma rangeli	54%	91%
A4HQH3	Leishmania braziliensis	82%	100%
A4ICA9	Leishmania infantum	98%	100%
D0A3M2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	87%
E9AU86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q0A5	Leishmania major	91%	100%
V5AXL9	Trypanosoma cruzi	54%	91%