Poly(A)-specific ribonuclease PARN, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

poly(A)-specific ribonuclease PARN, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XC77_LEIDO

TriTrypDb:

LdBPK_366630.1 , LdCL_360074100 , LDHU3_36.8800

Length:

510

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S7XC77

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XC77

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	21
GO:0005488	binding	1	21
GO:0097159	organic cyclic compound binding	2	21
GO:1901363	heterocyclic compound binding	2	21
GO:0000175	3'-5'-RNA exonuclease activity	7	3
GO:0003824	catalytic activity	1	3
GO:0004518	nuclease activity	4	3
GO:0004527	exonuclease activity	5	3
GO:0004532	RNA exonuclease activity	5	3
GO:0004535	poly(A)-specific ribonuclease activity	8	1
GO:0004540	RNA nuclease activity	4	3
GO:0008408	3'-5' exonuclease activity	6	3
GO:0016787	hydrolase activity	2	3
GO:0016788	hydrolase activity, acting on ester bonds	3	3
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	3
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	3
GO:0140098	catalytic activity, acting on RNA	3	3
GO:0140640	catalytic activity, acting on a nucleic acid	2	3
GO:0003723	RNA binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	178	180	PF00675	0.282
CLV_NRD_NRD_1	186	188	PF00675	0.250
CLV_NRD_NRD_1	225	227	PF00675	0.309
CLV_NRD_NRD_1	249	251	PF00675	0.297
CLV_NRD_NRD_1	321	323	PF00675	0.311
CLV_NRD_NRD_1	481	483	PF00675	0.512
CLV_PCSK_KEX2_1	178	180	PF00082	0.307
CLV_PCSK_KEX2_1	186	188	PF00082	0.307
CLV_PCSK_KEX2_1	224	226	PF00082	0.283
CLV_PCSK_KEX2_1	320	322	PF00082	0.311
CLV_PCSK_KEX2_1	481	483	PF00082	0.451
CLV_PCSK_KEX2_1	54	56	PF00082	0.261
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.299
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.270
CLV_PCSK_SKI1_1	281	285	PF00082	0.324
DEG_APCC_DBOX_1	95	103	PF00400	0.520
DEG_MDM2_SWIB_1	239	247	PF02201	0.417
DEG_Nend_UBRbox_2	1	3	PF02207	0.324
DOC_MAPK_gen_1	186	194	PF00069	0.439
DOC_MAPK_gen_1	231	239	PF00069	0.528
DOC_MAPK_gen_1	469	476	PF00069	0.408
DOC_MAPK_gen_1	54	60	PF00069	0.382
DOC_MIT_MIM_1	477	487	PF04212	0.354
DOC_PP1_RVXF_1	203	209	PF00149	0.566
DOC_PP1_RVXF_1	238	244	PF00149	0.449
DOC_PP2B_LxvP_1	135	138	PF13499	0.357
DOC_PP4_FxxP_1	43	46	PF00568	0.412
DOC_USP7_MATH_1	388	392	PF00917	0.447
DOC_USP7_MATH_1	416	420	PF00917	0.300
DOC_USP7_UBL2_3	349	353	PF12436	0.520
DOC_USP7_UBL2_3	441	445	PF12436	0.486
DOC_WW_Pin1_4	268	273	PF00397	0.387
DOC_WW_Pin1_4	489	494	PF00397	0.633
LIG_14-3-3_CanoR_1	178	184	PF00244	0.465
LIG_14-3-3_CanoR_1	322	330	PF00244	0.555
LIG_14-3-3_CanoR_1	481	487	PF00244	0.430
LIG_14-3-3_CanoR_1	96	102	PF00244	0.527
LIG_BIR_III_2	305	309	PF00653	0.392
LIG_BRCT_BRCA1_1	326	330	PF00533	0.449
LIG_BRCT_BRCA1_1	39	43	PF00533	0.512
LIG_BRCT_BRCA1_1	390	394	PF00533	0.496
LIG_FHA_1	115	121	PF00498	0.526
LIG_FHA_1	406	412	PF00498	0.346
LIG_FHA_1	427	433	PF00498	0.554
LIG_FHA_1	76	82	PF00498	0.491
LIG_FHA_2	209	215	PF00498	0.382
LIG_FHA_2	30	36	PF00498	0.445
LIG_FHA_2	300	306	PF00498	0.473
LIG_FHA_2	308	314	PF00498	0.550
LIG_FHA_2	70	76	PF00498	0.468
LIG_GBD_Chelix_1	176	184	PF00786	0.212
LIG_GBD_Chelix_1	366	374	PF00786	0.281
LIG_IRF3_LxIS_1	451	457	PF10401	0.318
LIG_LIR_Apic_2	331	337	PF02991	0.429
LIG_LIR_Apic_2	40	46	PF02991	0.411
LIG_LIR_Gen_1	23	31	PF02991	0.485
LIG_LIR_Gen_1	274	284	PF02991	0.495
LIG_LIR_Gen_1	4	13	PF02991	0.517
LIG_LIR_Nem_3	182	188	PF02991	0.506
LIG_LIR_Nem_3	23	27	PF02991	0.405
LIG_LIR_Nem_3	274	280	PF02991	0.467
LIG_LIR_Nem_3	356	362	PF02991	0.434
LIG_LIR_Nem_3	391	397	PF02991	0.327
LIG_LIR_Nem_3	4	9	PF02991	0.458
LIG_MAD2	244	252	PF02301	0.520
LIG_MLH1_MIPbox_1	390	394	PF16413	0.256
LIG_PCNA_yPIPBox_3	96	105	PF02747	0.392
LIG_Pex14_2	239	243	PF04695	0.448
LIG_Pex14_2	385	389	PF04695	0.204
LIG_RPA_C_Fungi	182	194	PF08784	0.169
LIG_SH2_CRK	334	338	PF00017	0.379
LIG_SH2_STAP1	131	135	PF00017	0.410
LIG_SH2_STAP1	188	192	PF00017	0.246
LIG_SH2_STAP1	359	363	PF00017	0.295
LIG_SH2_STAT3	201	204	PF00017	0.375
LIG_SH2_STAT5	201	204	PF00017	0.347
LIG_SH2_STAT5	277	280	PF00017	0.419
LIG_SH2_STAT5	393	396	PF00017	0.442
LIG_SH2_STAT5	87	90	PF00017	0.273
LIG_SH3_3	36	42	PF00018	0.310
LIG_SH3_3	7	13	PF00018	0.414
LIG_SUMO_SIM_par_1	498	503	PF11976	0.321
LIG_SUMO_SIM_par_1	8	14	PF11976	0.316
LIG_TRAF2_1	130	133	PF00917	0.314
LIG_TRFH_1	334	338	PF08558	0.397
LIG_WRC_WIRS_1	101	106	PF05994	0.218
LIG_WRC_WIRS_1	180	185	PF05994	0.218
LIG_WRC_WIRS_1	463	468	PF05994	0.409
MOD_CK1_1	100	106	PF00069	0.320
MOD_CK1_1	492	498	PF00069	0.532
MOD_CK2_1	217	223	PF00069	0.382
MOD_CK2_1	307	313	PF00069	0.397
MOD_CK2_1	69	75	PF00069	0.309
MOD_GlcNHglycan	117	120	PF01048	0.297
MOD_GlcNHglycan	345	348	PF01048	0.325
MOD_GlcNHglycan	386	389	PF01048	0.437
MOD_GlcNHglycan	39	42	PF01048	0.398
MOD_GlcNHglycan	390	393	PF01048	0.413
MOD_GlcNHglycan	91	94	PF01048	0.387
MOD_GSK3_1	111	118	PF00069	0.367
MOD_GSK3_1	208	215	PF00069	0.351
MOD_GSK3_1	287	294	PF00069	0.302
MOD_GSK3_1	324	331	PF00069	0.430
MOD_GSK3_1	384	391	PF00069	0.324
MOD_GSK3_1	426	433	PF00069	0.453
MOD_GSK3_1	71	78	PF00069	0.289
MOD_LATS_1	480	486	PF00433	0.314
MOD_N-GLC_1	343	348	PF02516	0.366
MOD_N-GLC_1	461	466	PF02516	0.509
MOD_N-GLC_1	75	80	PF02516	0.218
MOD_N-GLC_1	89	94	PF02516	0.349
MOD_N-GLC_1	97	102	PF02516	0.328
MOD_NEK2_1	1	6	PF00069	0.397
MOD_NEK2_1	208	213	PF00069	0.355
MOD_NEK2_1	246	251	PF00069	0.286
MOD_NEK2_1	284	289	PF00069	0.375
MOD_NEK2_1	97	102	PF00069	0.464
MOD_PIKK_1	271	277	PF00454	0.183
MOD_PIKK_1	328	334	PF00454	0.470
MOD_PKA_1	445	451	PF00069	0.345
MOD_Plk_1	1	7	PF00069	0.367
MOD_Plk_1	343	349	PF00069	0.311
MOD_Plk_1	461	467	PF00069	0.411
MOD_Plk_1	75	81	PF00069	0.383
MOD_Plk_1	97	103	PF00069	0.435
MOD_Plk_2-3	217	223	PF00069	0.246
MOD_Plk_2-3	75	81	PF00069	0.380
MOD_Plk_4	111	117	PF00069	0.204
MOD_Plk_4	179	185	PF00069	0.390
MOD_Plk_4	287	293	PF00069	0.345
MOD_Plk_4	405	411	PF00069	0.382
MOD_Plk_4	97	103	PF00069	0.383
MOD_ProDKin_1	268	274	PF00069	0.211
MOD_ProDKin_1	489	495	PF00069	0.629
MOD_SUMO_rev_2	127	135	PF00179	0.312
MOD_SUMO_rev_2	274	283	PF00179	0.341
MOD_SUMO_rev_2	290	297	PF00179	0.244
MOD_SUMO_rev_2	438	447	PF00179	0.570
TRG_DiLeu_BaEn_2	380	386	PF01217	0.190
TRG_DiLeu_BaLyEn_6	496	501	PF01217	0.550
TRG_ENDOCYTIC_2	277	280	PF00928	0.320
TRG_ENDOCYTIC_2	463	466	PF00928	0.471
TRG_ENDOCYTIC_2	61	64	PF00928	0.277
TRG_ER_diArg_1	178	180	PF00400	0.218
TRG_ER_diArg_1	185	187	PF00400	0.186
TRG_ER_diArg_1	225	227	PF00400	0.365
TRG_ER_diArg_1	320	322	PF00400	0.384
TRG_ER_diArg_1	481	483	PF00400	0.512
TRG_ER_FFAT_2	381	391	PF00635	0.180
TRG_NES_CRM1_1	2	14	PF08389	0.246
TRG_Pf-PMV_PEXEL_1	225	230	PF00026	0.327

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P603	Leptomonas seymouri	56%	99%
A0A0N1ILJ1	Leptomonas seymouri	26%	84%
A0A0S4IJ60	Bodo saltans	23%	100%
A0A0S4IMW3	Bodo saltans	23%	100%
A0A0S4J225	Bodo saltans	35%	70%
A0A1X0NLC6	Trypanosomatidae	33%	99%
A0A1X0NXI3	Trypanosomatidae	26%	84%
A0A3Q8ICI3	Leishmania donovani	26%	100%
A0A3R7K5K5	Trypanosoma rangeli	35%	98%
A0A422N5N5	Trypanosoma rangeli	28%	86%
A4HCS6	Leishmania braziliensis	27%	100%
A4HQF5	Leishmania braziliensis	74%	100%
A4I0A0	Leishmania infantum	26%	100%
A4IC91	Leishmania infantum	99%	100%
B2RXZ1	Mus musculus	23%	96%
C9ZV58	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	87%
C9ZZC3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	82%
D0A3T2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AU71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9AW65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
H9JAQ7	Bombyx mori	24%	96%
O95453	Homo sapiens	24%	80%
P69341	Bos taurus	24%	80%
Q21412	Caenorhabditis elegans	24%	90%
Q4Q0C3	Leishmania major	91%	100%
Q4QBB3	Leishmania major	26%	100%
Q5R6R6	Pongo abelii	23%	98%
Q5RC51	Pongo abelii	24%	80%
Q7ZU92	Danio rerio	26%	77%
Q8NA58	Homo sapiens	23%	98%
Q8VDG3	Mus musculus	25%	82%
Q90ZA1	Xenopus laevis	25%	81%
V5ASU9	Trypanosoma cruzi	35%	99%
V5BCG2	Trypanosoma cruzi	25%	100%