Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XC64_LEIDO

TriTrypDb:

LdBPK_366730.1 , LdCL_360075600 , LDHU3_36.8940

Length:

197

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XC64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XC64

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.607
CLV_NRD_NRD_1	169	171	PF00675	0.513
CLV_PCSK_SKI1_1	175	179	PF00082	0.550
CLV_PCSK_SKI1_1	184	188	PF00082	0.457
CLV_PCSK_SKI1_1	191	195	PF00082	0.492
DOC_MAPK_gen_1	90	98	PF00069	0.467
DOC_PP4_FxxP_1	154	157	PF00568	0.522
DOC_PP4_FxxP_1	76	79	PF00568	0.565
DOC_USP7_MATH_1	22	26	PF00917	0.585
DOC_USP7_MATH_1	35	39	PF00917	0.337
DOC_USP7_MATH_1	79	83	PF00917	0.575
LIG_14-3-3_CanoR_1	103	109	PF00244	0.524
LIG_14-3-3_CanoR_1	122	126	PF00244	0.478
LIG_14-3-3_CanoR_1	184	192	PF00244	0.547
LIG_14-3-3_CanoR_1	23	27	PF00244	0.452
LIG_14-3-3_CanoR_1	71	77	PF00244	0.458
LIG_Actin_WH2_2	55	73	PF00022	0.551
LIG_APCC_ABBA_1	56	61	PF00400	0.500
LIG_APCC_ABBAyCdc20_2	55	61	PF00400	0.484
LIG_BH_BH3_1	35	51	PF00452	0.526
LIG_BRCT_BRCA1_1	182	186	PF00533	0.530
LIG_deltaCOP1_diTrp_1	172	178	PF00928	0.501
LIG_Dynein_DLC8_1	136	142	PF01221	0.639
LIG_FHA_1	112	118	PF00498	0.524
LIG_FHA_1	140	146	PF00498	0.559
LIG_LIR_Apic_2	151	157	PF02991	0.541
LIG_LIR_Apic_2	75	79	PF02991	0.572
LIG_LIR_Gen_1	94	99	PF02991	0.423
LIG_LIR_Nem_3	94	98	PF02991	0.436
LIG_OCRL_FandH_1	88	100	PF00620	0.479
LIG_SH2_STAP1	74	78	PF00017	0.571
LIG_SH2_STAT3	106	109	PF00017	0.433
LIG_SH2_STAT5	106	109	PF00017	0.433
LIG_SH2_STAT5	74	77	PF00017	0.504
LIG_UBA3_1	165	171	PF00899	0.500
LIG_WRC_WIRS_1	73	78	PF05994	0.443
MOD_Cter_Amidation	101	104	PF01082	0.607
MOD_GlcNHglycan	5	8	PF01048	0.484
MOD_GSK3_1	176	183	PF00069	0.551
MOD_NEK2_1	121	126	PF00069	0.610
MOD_NMyristoyl	1	7	PF02799	0.448
MOD_PIKK_1	137	143	PF00454	0.654
MOD_PKA_2	121	127	PF00069	0.509
MOD_PKA_2	137	143	PF00069	0.598
MOD_PKA_2	22	28	PF00069	0.426
MOD_Plk_4	72	78	PF00069	0.460
MOD_SUMO_rev_2	47	57	PF00179	0.587
TRG_ER_diArg_1	189	192	PF00400	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYZ7	Leptomonas seymouri	87%	100%
A0A0S4IQL1	Bodo saltans	63%	100%
A0A1X0NLH3	Trypanosomatidae	69%	100%
A0A3R7MH65	Trypanosoma rangeli	68%	100%
A4HQG5	Leishmania braziliensis	93%	100%
A4ICA1	Leishmania infantum	100%	100%
D0A3L6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9AU81	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q0B3	Leishmania major	97%	100%