Hypothetical_protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S7XC53_LEIDO

TriTrypDb:

LdCL_360075100 , LDHU3_36.8890

Length:

150

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XC53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XC53

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	6	8	PF00675	0.482
CLV_PCSK_FUR_1	4	8	PF00082	0.510
CLV_PCSK_KEX2_1	6	8	PF00082	0.512
CLV_PCSK_KEX2_1	68	70	PF00082	0.432
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.432
CLV_PCSK_SKI1_1	139	143	PF00082	0.442
CLV_PCSK_SKI1_1	65	69	PF00082	0.528
DEG_Nend_Nbox_1	1	3	PF02207	0.472
DEG_SIAH_1	31	39	PF03145	0.474
DOC_USP7_MATH_1	103	107	PF00917	0.522
DOC_USP7_MATH_1	41	45	PF00917	0.584
DOC_USP7_MATH_1	91	95	PF00917	0.583
DOC_WW_Pin1_4	101	106	PF00397	0.545
DOC_WW_Pin1_4	13	18	PF00397	0.583
DOC_WW_Pin1_4	19	24	PF00397	0.382
DOC_WW_Pin1_4	77	82	PF00397	0.564
LIG_14-3-3_CanoR_1	27	32	PF00244	0.448
LIG_14-3-3_CanoR_1	6	15	PF00244	0.524
LIG_Actin_WH2_2	50	67	PF00022	0.399
LIG_EH1_1	131	139	PF00400	0.357
LIG_FHA_1	140	146	PF00498	0.344
LIG_FHA_2	70	76	PF00498	0.500
LIG_IRF3_LxIS_1	45	51	PF10401	0.471
LIG_LIR_Apic_2	22	28	PF02991	0.468
LIG_LIR_Gen_1	140	148	PF02991	0.430
LIG_LIR_Nem_3	140	144	PF02991	0.419
LIG_LIR_Nem_3	95	101	PF02991	0.540
LIG_LYPXL_yS_3	98	101	PF13949	0.493
LIG_PCNA_yPIPBox_3	125	138	PF02747	0.348
LIG_REV1ctd_RIR_1	144	150	PF16727	0.370
LIG_SH2_NCK_1	25	29	PF00017	0.552
LIG_SH3_3	17	23	PF00018	0.615
LIG_SH3_3	35	41	PF00018	0.601
LIG_SH3_3	43	49	PF00018	0.584
LIG_SH3_3	78	84	PF00018	0.590
LIG_SH3_3	93	99	PF00018	0.450
LIG_WRC_WIRS_1	118	123	PF05994	0.483
MOD_CDK_SPK_2	13	18	PF00069	0.499
MOD_CDK_SPK_2	80	85	PF00069	0.501
MOD_CK1_1	5	11	PF00069	0.605
MOD_CK1_1	94	100	PF00069	0.569
MOD_CK2_1	94	100	PF00069	0.488
MOD_GlcNHglycan	10	13	PF01048	0.480
MOD_GlcNHglycan	29	32	PF01048	0.450
MOD_GlcNHglycan	50	53	PF01048	0.535
MOD_GSK3_1	101	108	PF00069	0.519
MOD_GSK3_1	2	9	PF00069	0.575
MOD_GSK3_1	90	97	PF00069	0.701
MOD_N-GLC_1	101	106	PF02516	0.432
MOD_N-GLC_1	69	74	PF02516	0.696
MOD_NEK2_1	2	7	PF00069	0.545
MOD_PKA_1	6	12	PF00069	0.506
MOD_PKA_2	26	32	PF00069	0.504
MOD_PKA_2	5	11	PF00069	0.576
MOD_PKB_1	4	12	PF00069	0.524
MOD_ProDKin_1	101	107	PF00069	0.543
MOD_ProDKin_1	13	19	PF00069	0.583
MOD_ProDKin_1	77	83	PF00069	0.557
MOD_SUMO_for_1	127	130	PF00179	0.411
TRG_ENDOCYTIC_2	118	121	PF00928	0.425
TRG_ENDOCYTIC_2	98	101	PF00928	0.493
TRG_ER_diArg_1	3	6	PF00400	0.479
TRG_ER_diArg_1	63	66	PF00400	0.478
TRG_NLS_MonoExtN_4	65	72	PF00514	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEF4	Leptomonas seymouri	42%	86%
A0A1X0NLZ0	Trypanosomatidae	36%	100%
A0A422NKD6	Trypanosoma rangeli	30%	100%
D0A3L1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%