DUF4201 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XC33_LEIDO

TriTrypDb:

LdBPK_366270.1 , LdCL_360070100 , LDHU3_36.8320

Length:

670

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XC33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XC33

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	261	265	PF00656	0.509
CLV_C14_Caspase3-7	496	500	PF00656	0.609
CLV_C14_Caspase3-7	65	69	PF00656	0.653
CLV_NRD_NRD_1	133	135	PF00675	0.457
CLV_NRD_NRD_1	173	175	PF00675	0.445
CLV_NRD_NRD_1	21	23	PF00675	0.596
CLV_NRD_NRD_1	329	331	PF00675	0.592
CLV_NRD_NRD_1	342	344	PF00675	0.447
CLV_NRD_NRD_1	375	377	PF00675	0.518
CLV_NRD_NRD_1	434	436	PF00675	0.534
CLV_NRD_NRD_1	466	468	PF00675	0.626
CLV_PCSK_KEX2_1	133	135	PF00082	0.457
CLV_PCSK_KEX2_1	164	166	PF00082	0.485
CLV_PCSK_KEX2_1	173	175	PF00082	0.412
CLV_PCSK_KEX2_1	21	23	PF00082	0.606
CLV_PCSK_KEX2_1	329	331	PF00082	0.592
CLV_PCSK_KEX2_1	342	344	PF00082	0.447
CLV_PCSK_KEX2_1	375	377	PF00082	0.518
CLV_PCSK_KEX2_1	410	412	PF00082	0.509
CLV_PCSK_KEX2_1	440	442	PF00082	0.549
CLV_PCSK_KEX2_1	466	468	PF00082	0.626
CLV_PCSK_KEX2_1	616	618	PF00082	0.443
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.467
CLV_PCSK_PC1ET2_1	410	412	PF00082	0.519
CLV_PCSK_PC1ET2_1	440	442	PF00082	0.528
CLV_PCSK_PC1ET2_1	616	618	PF00082	0.443
CLV_PCSK_PC7_1	325	331	PF00082	0.431
CLV_PCSK_SKI1_1	233	237	PF00082	0.425
CLV_PCSK_SKI1_1	253	257	PF00082	0.307
CLV_PCSK_SKI1_1	269	273	PF00082	0.414
CLV_PCSK_SKI1_1	274	278	PF00082	0.460
CLV_PCSK_SKI1_1	330	334	PF00082	0.441
CLV_PCSK_SKI1_1	36	40	PF00082	0.580
CLV_PCSK_SKI1_1	376	380	PF00082	0.553
CLV_PCSK_SKI1_1	411	415	PF00082	0.570
DEG_COP1_1	507	515	PF00400	0.632
DEG_Nend_UBRbox_3	1	3	PF02207	0.585
DOC_CKS1_1	56	61	PF01111	0.674
DOC_CYCLIN_RxL_1	269	281	PF00134	0.493
DOC_CYCLIN_RxL_1	405	417	PF00134	0.560
DOC_CYCLIN_yClb1_LxF_4	661	667	PF00134	0.525
DOC_CYCLIN_yClb5_NLxxxL_5	36	42	PF00134	0.517
DOC_MAPK_gen_1	329	335	PF00069	0.442
DOC_MAPK_gen_1	607	615	PF00069	0.416
DOC_MAPK_MEF2A_6	607	615	PF00069	0.416
DOC_MAPK_RevD_3	362	376	PF00069	0.522
DOC_PP2B_LxvP_1	406	409	PF13499	0.530
DOC_PP2B_LxvP_1	526	529	PF13499	0.521
DOC_PP4_FxxP_1	56	59	PF00568	0.713
DOC_PP4_FxxP_1	561	564	PF00568	0.580
DOC_USP7_MATH_1	12	16	PF00917	0.645
DOC_USP7_MATH_1	25	29	PF00917	0.559
DOC_USP7_MATH_1	317	321	PF00917	0.450
DOC_USP7_MATH_1	351	355	PF00917	0.492
DOC_USP7_MATH_1	444	448	PF00917	0.575
DOC_USP7_MATH_1	457	461	PF00917	0.738
DOC_USP7_MATH_1	465	469	PF00917	0.577
DOC_USP7_MATH_1	500	504	PF00917	0.600
DOC_USP7_MATH_1	530	534	PF00917	0.620
DOC_USP7_MATH_1	581	585	PF00917	0.646
DOC_USP7_MATH_1	651	655	PF00917	0.549
DOC_USP7_UBL2_3	436	440	PF12436	0.520
DOC_WW_Pin1_4	105	110	PF00397	0.661
DOC_WW_Pin1_4	21	26	PF00397	0.773
DOC_WW_Pin1_4	380	385	PF00397	0.648
DOC_WW_Pin1_4	392	397	PF00397	0.557
DOC_WW_Pin1_4	424	429	PF00397	0.587
DOC_WW_Pin1_4	48	53	PF00397	0.628
DOC_WW_Pin1_4	498	503	PF00397	0.617
DOC_WW_Pin1_4	535	540	PF00397	0.593
DOC_WW_Pin1_4	55	60	PF00397	0.595
DOC_WW_Pin1_4	577	582	PF00397	0.602
DOC_WW_Pin1_4	72	77	PF00397	0.713
LIG_14-3-3_CanoR_1	133	137	PF00244	0.488
LIG_14-3-3_CanoR_1	191	199	PF00244	0.390
LIG_14-3-3_CanoR_1	342	350	PF00244	0.335
LIG_14-3-3_CanoR_1	36	44	PF00244	0.500
LIG_14-3-3_CanoR_1	411	420	PF00244	0.644
LIG_14-3-3_CanoR_1	466	470	PF00244	0.564
LIG_14-3-3_CanoR_1	506	513	PF00244	0.599
LIG_14-3-3_CanoR_1	518	526	PF00244	0.525
LIG_Actin_WH2_2	490	508	PF00022	0.616
LIG_Actin_WH2_2	590	605	PF00022	0.501
LIG_BIR_III_2	499	503	PF00653	0.616
LIG_BIR_III_2	650	654	PF00653	0.539
LIG_BRCT_BRCA1_1	52	56	PF00533	0.662
LIG_BRCT_BRCA1_1	662	666	PF00533	0.584
LIG_Clathr_ClatBox_1	403	407	PF01394	0.566
LIG_EH1_1	397	405	PF00400	0.606
LIG_FHA_1	202	208	PF00498	0.633
LIG_FHA_1	217	223	PF00498	0.379
LIG_FHA_1	37	43	PF00498	0.522
LIG_FHA_1	448	454	PF00498	0.579
LIG_FHA_1	472	478	PF00498	0.709
LIG_FHA_2	133	139	PF00498	0.458
LIG_FHA_2	146	152	PF00498	0.538
LIG_FHA_2	154	160	PF00498	0.461
LIG_FHA_2	192	198	PF00498	0.421
LIG_FHA_2	259	265	PF00498	0.434
LIG_FHA_2	494	500	PF00498	0.612
LIG_FHA_2	536	542	PF00498	0.640
LIG_FHA_2	550	556	PF00498	0.517
LIG_FHA_2	588	594	PF00498	0.465
LIG_LIR_Apic_2	53	59	PF02991	0.702
LIG_LIR_Apic_2	554	560	PF02991	0.618
LIG_LIR_Gen_1	224	235	PF02991	0.433
LIG_LIR_Gen_1	358	367	PF02991	0.496
LIG_LIR_Gen_1	590	599	PF02991	0.511
LIG_LIR_Nem_3	252	257	PF02991	0.460
LIG_LIR_Nem_3	358	364	PF02991	0.492
LIG_LIR_Nem_3	576	582	PF02991	0.682
LIG_LIR_Nem_3	590	594	PF02991	0.405
LIG_PCNA_TLS_4	353	360	PF02747	0.414
LIG_PTAP_UEV_1	585	590	PF05743	0.510
LIG_SH2_CRK	254	258	PF00017	0.415
LIG_SH2_CRK	557	561	PF00017	0.620
LIG_SH2_NCK_1	557	561	PF00017	0.535
LIG_SH2_STAP1	167	171	PF00017	0.401
LIG_SH2_STAP1	203	207	PF00017	0.452
LIG_SH2_STAP1	303	307	PF00017	0.473
LIG_SH2_STAT3	192	195	PF00017	0.388
LIG_SH2_STAT5	203	206	PF00017	0.454
LIG_SH2_STAT5	504	507	PF00017	0.576
LIG_SH3_1	583	589	PF00018	0.508
LIG_SH3_3	492	498	PF00018	0.641
LIG_SH3_3	583	589	PF00018	0.499
LIG_SUMO_SIM_anti_2	68	75	PF11976	0.708
LIG_SUMO_SIM_par_1	493	499	PF11976	0.566
LIG_TRAF2_1	135	138	PF00917	0.444
LIG_TRAF2_1	194	197	PF00917	0.444
LIG_TRAF2_1	363	366	PF00917	0.418
LIG_TRFH_1	546	550	PF08558	0.558
LIG_UBA3_1	403	410	PF00899	0.515
LIG_WRC_WIRS_1	356	361	PF05994	0.491
MOD_CDC14_SPxK_1	580	583	PF00782	0.590
MOD_CDK_SPK_2	380	385	PF00069	0.490
MOD_CDK_SPxK_1	577	583	PF00069	0.602
MOD_CK1_1	103	109	PF00069	0.723
MOD_CK1_1	15	21	PF00069	0.643
MOD_CK1_1	447	453	PF00069	0.641
MOD_CK1_1	460	466	PF00069	0.547
MOD_CK1_1	584	590	PF00069	0.516
MOD_CK1_1	633	639	PF00069	0.582
MOD_CK1_1	654	660	PF00069	0.667
MOD_CK2_1	132	138	PF00069	0.458
MOD_CK2_1	153	159	PF00069	0.538
MOD_CK2_1	191	197	PF00069	0.420
MOD_CK2_1	29	35	PF00069	0.600
MOD_CK2_1	351	357	PF00069	0.433
MOD_CK2_1	505	511	PF00069	0.535
MOD_CK2_1	535	541	PF00069	0.629
MOD_DYRK1A_RPxSP_1	424	428	PF00069	0.547
MOD_GlcNHglycan	111	115	PF01048	0.602
MOD_GlcNHglycan	154	159	PF01048	0.570
MOD_GlcNHglycan	264	268	PF01048	0.403
MOD_GlcNHglycan	27	30	PF01048	0.556
MOD_GlcNHglycan	343	346	PF01048	0.619
MOD_GlcNHglycan	416	419	PF01048	0.540
MOD_GlcNHglycan	460	463	PF01048	0.711
MOD_GlcNHglycan	467	470	PF01048	0.716
MOD_GlcNHglycan	486	489	PF01048	0.563
MOD_GlcNHglycan	532	535	PF01048	0.634
MOD_GlcNHglycan	586	589	PF01048	0.689
MOD_GlcNHglycan	98	101	PF01048	0.693
MOD_GSK3_1	12	19	PF00069	0.654
MOD_GSK3_1	21	28	PF00069	0.752
MOD_GSK3_1	351	358	PF00069	0.521
MOD_GSK3_1	392	399	PF00069	0.573
MOD_GSK3_1	457	464	PF00069	0.741
MOD_GSK3_1	47	54	PF00069	0.604
MOD_GSK3_1	500	507	PF00069	0.559
MOD_GSK3_1	530	537	PF00069	0.553
MOD_GSK3_1	55	62	PF00069	0.665
MOD_GSK3_1	573	580	PF00069	0.601
MOD_GSK3_1	593	600	PF00069	0.369
MOD_GSK3_1	68	75	PF00069	0.585
MOD_GSK3_1	96	103	PF00069	0.658
MOD_LATS_1	180	186	PF00433	0.402
MOD_N-GLC_1	36	41	PF02516	0.546
MOD_NEK2_1	132	137	PF00069	0.468
MOD_NEK2_1	199	204	PF00069	0.588
MOD_NEK2_1	263	268	PF00069	0.503
MOD_NEK2_1	272	277	PF00069	0.443
MOD_NEK2_1	414	419	PF00069	0.623
MOD_NEK2_1	422	427	PF00069	0.585
MOD_NEK2_1	471	476	PF00069	0.531
MOD_NEK2_1	86	91	PF00069	0.717
MOD_PIKK_1	138	144	PF00454	0.467
MOD_PIKK_1	191	197	PF00454	0.390
MOD_PIKK_1	216	222	PF00454	0.495
MOD_PIKK_1	36	42	PF00454	0.493
MOD_PKA_2	132	138	PF00069	0.458
MOD_PKA_2	341	347	PF00069	0.335
MOD_PKA_2	465	471	PF00069	0.696
MOD_PKA_2	505	511	PF00069	0.777
MOD_PKA_2	517	523	PF00069	0.525
MOD_PKB_1	189	197	PF00069	0.390
MOD_Plk_1	238	244	PF00069	0.501
MOD_Plk_1	29	35	PF00069	0.667
MOD_Plk_2-3	593	599	PF00069	0.423
MOD_Plk_4	355	361	PF00069	0.475
MOD_Plk_4	399	405	PF00069	0.639
MOD_Plk_4	500	506	PF00069	0.628
MOD_Plk_4	511	517	PF00069	0.523
MOD_Plk_4	662	668	PF00069	0.578
MOD_Plk_4	68	74	PF00069	0.650
MOD_ProDKin_1	105	111	PF00069	0.659
MOD_ProDKin_1	21	27	PF00069	0.768
MOD_ProDKin_1	380	386	PF00069	0.653
MOD_ProDKin_1	392	398	PF00069	0.553
MOD_ProDKin_1	424	430	PF00069	0.581
MOD_ProDKin_1	48	54	PF00069	0.634
MOD_ProDKin_1	498	504	PF00069	0.619
MOD_ProDKin_1	535	541	PF00069	0.594
MOD_ProDKin_1	55	61	PF00069	0.594
MOD_ProDKin_1	577	583	PF00069	0.597
MOD_ProDKin_1	72	78	PF00069	0.712
MOD_SUMO_rev_2	157	166	PF00179	0.454
MOD_SUMO_rev_2	302	307	PF00179	0.434
MOD_SUMO_rev_2	587	597	PF00179	0.504
TRG_DiLeu_BaEn_1	252	257	PF01217	0.469
TRG_DiLeu_BaEn_1	374	379	PF01217	0.533
TRG_DiLeu_BaEn_1	511	516	PF01217	0.524
TRG_DiLeu_BaLyEn_6	117	122	PF01217	0.472
TRG_ENDOCYTIC_2	247	250	PF00928	0.431
TRG_ENDOCYTIC_2	254	257	PF00928	0.437
TRG_ENDOCYTIC_2	361	364	PF00928	0.416
TRG_ER_diArg_1	132	134	PF00400	0.480
TRG_ER_diArg_1	189	192	PF00400	0.474
TRG_NES_CRM1_1	281	294	PF08389	0.357
TRG_NLS_MonoExtC_3	615	621	PF00514	0.499
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	274	278	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	337	341	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	36	40	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	376	381	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMK1	Leptomonas seymouri	45%	100%
A4HQC0	Leishmania braziliensis	57%	94%
A4IE14	Leishmania infantum	99%	100%
E9AU36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q0F9	Leishmania major	86%	100%