TYR_PHOSPHATASE_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XC30_LEIDO

TriTrypDb:

LdBPK_366400.1 , LdCL_360071500 , LDHU3_36.8490

Length:

765

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XC30

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XC30

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.646
CLV_C14_Caspase3-7	161	165	PF00656	0.816
CLV_NRD_NRD_1	200	202	PF00675	0.647
CLV_NRD_NRD_1	252	254	PF00675	0.756
CLV_NRD_NRD_1	275	277	PF00675	0.707
CLV_NRD_NRD_1	284	286	PF00675	0.622
CLV_NRD_NRD_1	389	391	PF00675	0.723
CLV_NRD_NRD_1	469	471	PF00675	0.782
CLV_NRD_NRD_1	662	664	PF00675	0.694
CLV_NRD_NRD_1	75	77	PF00675	0.701
CLV_PCSK_FUR_1	658	662	PF00082	0.647
CLV_PCSK_KEX2_1	200	202	PF00082	0.647
CLV_PCSK_KEX2_1	252	254	PF00082	0.756
CLV_PCSK_KEX2_1	284	286	PF00082	0.726
CLV_PCSK_KEX2_1	469	471	PF00082	0.753
CLV_PCSK_KEX2_1	513	515	PF00082	0.644
CLV_PCSK_KEX2_1	660	662	PF00082	0.700
CLV_PCSK_KEX2_1	75	77	PF00082	0.701
CLV_PCSK_KEX2_1	758	760	PF00082	0.759
CLV_PCSK_PC1ET2_1	513	515	PF00082	0.625
CLV_PCSK_PC1ET2_1	660	662	PF00082	0.686
CLV_PCSK_PC1ET2_1	758	760	PF00082	0.759
CLV_PCSK_PC7_1	658	664	PF00082	0.742
CLV_PCSK_SKI1_1	566	570	PF00082	0.620
CLV_PCSK_SKI1_1	591	595	PF00082	0.566
CLV_PCSK_SKI1_1	628	632	PF00082	0.730
DEG_APCC_DBOX_1	565	573	PF00400	0.618
DEG_MDM2_SWIB_1	209	217	PF02201	0.578
DEG_SCF_FBW7_1	183	189	PF00400	0.704
DEG_SPOP_SBC_1	422	426	PF00917	0.765
DEG_SPOP_SBC_1	486	490	PF00917	0.656
DEG_SPOP_SBC_1	582	586	PF00917	0.748
DOC_CKS1_1	183	188	PF01111	0.703
DOC_MAPK_gen_1	513	521	PF00069	0.580
DOC_PP2B_LxvP_1	634	637	PF13499	0.715
DOC_PP4_FxxP_1	180	183	PF00568	0.688
DOC_PP4_FxxP_1	649	652	PF00568	0.750
DOC_USP7_MATH_1	108	112	PF00917	0.630
DOC_USP7_MATH_1	11	15	PF00917	0.732
DOC_USP7_MATH_1	126	130	PF00917	0.688
DOC_USP7_MATH_1	158	162	PF00917	0.749
DOC_USP7_MATH_1	186	190	PF00917	0.669
DOC_USP7_MATH_1	191	195	PF00917	0.627
DOC_USP7_MATH_1	27	31	PF00917	0.611
DOC_USP7_MATH_1	384	388	PF00917	0.732
DOC_USP7_MATH_1	416	420	PF00917	0.821
DOC_USP7_MATH_1	422	426	PF00917	0.830
DOC_USP7_MATH_1	442	446	PF00917	0.740
DOC_USP7_MATH_1	452	456	PF00917	0.817
DOC_USP7_MATH_1	486	490	PF00917	0.642
DOC_USP7_MATH_1	500	504	PF00917	0.557
DOC_USP7_MATH_1	548	552	PF00917	0.777
DOC_USP7_MATH_1	560	564	PF00917	0.655
DOC_USP7_MATH_1	582	586	PF00917	0.803
DOC_USP7_MATH_1	61	65	PF00917	0.578
DOC_USP7_MATH_1	656	660	PF00917	0.666
DOC_USP7_MATH_1	701	705	PF00917	0.797
DOC_USP7_MATH_1	71	75	PF00917	0.596
DOC_USP7_MATH_1	743	747	PF00917	0.767
DOC_WW_Pin1_4	122	127	PF00397	0.698
DOC_WW_Pin1_4	142	147	PF00397	0.653
DOC_WW_Pin1_4	179	184	PF00397	0.749
DOC_WW_Pin1_4	285	290	PF00397	0.710
DOC_WW_Pin1_4	292	297	PF00397	0.732
DOC_WW_Pin1_4	355	360	PF00397	0.793
DOC_WW_Pin1_4	361	366	PF00397	0.715
DOC_WW_Pin1_4	373	378	PF00397	0.640
DOC_WW_Pin1_4	489	494	PF00397	0.804
DOC_WW_Pin1_4	498	503	PF00397	0.801
DOC_WW_Pin1_4	514	519	PF00397	0.667
DOC_WW_Pin1_4	555	560	PF00397	0.713
DOC_WW_Pin1_4	578	583	PF00397	0.766
DOC_WW_Pin1_4	604	609	PF00397	0.721
DOC_WW_Pin1_4	612	617	PF00397	0.739
DOC_WW_Pin1_4	632	637	PF00397	0.824
DOC_WW_Pin1_4	648	653	PF00397	0.596
DOC_WW_Pin1_4	723	728	PF00397	0.738
LIG_14-3-3_CanoR_1	138	144	PF00244	0.783
LIG_14-3-3_CanoR_1	192	197	PF00244	0.587
LIG_14-3-3_CanoR_1	276	281	PF00244	0.774
LIG_14-3-3_CanoR_1	284	289	PF00244	0.701
LIG_14-3-3_CanoR_1	309	316	PF00244	0.707
LIG_14-3-3_CanoR_1	34	38	PF00244	0.703
LIG_14-3-3_CanoR_1	393	402	PF00244	0.786
LIG_14-3-3_CanoR_1	430	439	PF00244	0.829
LIG_14-3-3_CanoR_1	577	581	PF00244	0.843
LIG_14-3-3_CanoR_1	602	606	PF00244	0.690
LIG_14-3-3_CanoR_1	661	671	PF00244	0.607
LIG_14-3-3_CanoR_1	703	712	PF00244	0.639
LIG_14-3-3_CanoR_1	75	80	PF00244	0.708
LIG_Actin_WH2_2	99	117	PF00022	0.622
LIG_BIR_II_1	1	5	PF00653	0.692
LIG_BRCT_BRCA1_1	35	39	PF00533	0.598
LIG_deltaCOP1_diTrp_1	32	39	PF00928	0.607
LIG_FHA_1	107	113	PF00498	0.732
LIG_FHA_1	394	400	PF00498	0.709
LIG_FHA_1	402	408	PF00498	0.722
LIG_FHA_1	410	416	PF00498	0.762
LIG_FHA_1	663	669	PF00498	0.605
LIG_FHA_2	33	39	PF00498	0.654
LIG_FHA_2	60	66	PF00498	0.666
LIG_FHA_2	633	639	PF00498	0.761
LIG_FHA_2	68	74	PF00498	0.591
LIG_IBAR_NPY_1	80	82	PF08397	0.609
LIG_Integrin_RGD_1	368	370	PF01839	0.629
LIG_Integrin_RGD_1	8	10	PF01839	0.586
LIG_LIR_Apic_2	140	146	PF02991	0.707
LIG_LIR_Gen_1	102	108	PF02991	0.628
LIG_LIR_Gen_1	307	318	PF02991	0.593
LIG_LIR_Gen_1	395	406	PF02991	0.601
LIG_LIR_Nem_3	194	199	PF02991	0.739
LIG_LIR_Nem_3	307	313	PF02991	0.591
LIG_LIR_Nem_3	395	401	PF02991	0.606
LIG_LIR_Nem_3	77	82	PF02991	0.613
LIG_Pex14_2	209	213	PF04695	0.581
LIG_PTAP_UEV_1	711	716	PF05743	0.761
LIG_SH2_CRK	82	86	PF00017	0.597
LIG_SH2_SRC	398	401	PF00017	0.607
LIG_SH2_STAP1	664	668	PF00017	0.566
LIG_SH2_STAT3	664	667	PF00017	0.564
LIG_SH2_STAT5	113	116	PF00017	0.675
LIG_SH2_STAT5	398	401	PF00017	0.607
LIG_SH2_STAT5	664	667	PF00017	0.564
LIG_SH3_1	709	715	PF00018	0.763
LIG_SH3_2	81	86	PF14604	0.624
LIG_SH3_3	143	149	PF00018	0.740
LIG_SH3_3	180	186	PF00018	0.679
LIG_SH3_3	213	219	PF00018	0.576
LIG_SH3_3	315	321	PF00018	0.690
LIG_SH3_3	602	608	PF00018	0.741
LIG_SH3_3	634	640	PF00018	0.828
LIG_SH3_3	691	697	PF00018	0.716
LIG_SH3_3	709	715	PF00018	0.618
LIG_SH3_3	754	760	PF00018	0.720
LIG_SH3_3	78	84	PF00018	0.619
LIG_SUMO_SIM_anti_2	166	173	PF11976	0.725
LIG_SUMO_SIM_anti_2	334	342	PF11976	0.732
LIG_SUMO_SIM_anti_2	344	350	PF11976	0.626
LIG_SUMO_SIM_anti_2	517	523	PF11976	0.717
LIG_SUMO_SIM_par_1	595	601	PF11976	0.657
LIG_SxIP_EBH_1	610	622	PF03271	0.725
LIG_TRAF2_1	165	168	PF00917	0.776
LIG_TRAF2_2	296	301	PF00917	0.741
LIG_TYR_ITSM	394	401	PF00017	0.606
LIG_UBA3_1	474	480	PF00899	0.690
LIG_WRC_WIRS_1	246	251	PF05994	0.825
MOD_CDC14_SPxK_1	501	504	PF00782	0.747
MOD_CDK_SPxK_1	498	504	PF00069	0.745
MOD_CDK_SPxxK_3	292	299	PF00069	0.749
MOD_CDK_SPxxK_3	361	368	PF00069	0.797
MOD_CDK_SPxxK_3	555	562	PF00069	0.793
MOD_CDK_SPxxK_3	612	619	PF00069	0.729
MOD_CK1_1	137	143	PF00069	0.704
MOD_CK1_1	145	151	PF00069	0.772
MOD_CK1_1	182	188	PF00069	0.776
MOD_CK1_1	245	251	PF00069	0.734
MOD_CK1_1	287	293	PF00069	0.814
MOD_CK1_1	339	345	PF00069	0.702
MOD_CK1_1	355	361	PF00069	0.731
MOD_CK1_1	373	379	PF00069	0.560
MOD_CK1_1	423	429	PF00069	0.771
MOD_CK1_1	433	439	PF00069	0.642
MOD_CK1_1	455	461	PF00069	0.613
MOD_CK1_1	489	495	PF00069	0.744
MOD_CK1_1	538	544	PF00069	0.847
MOD_CK1_1	581	587	PF00069	0.801
MOD_CK1_1	601	607	PF00069	0.500
MOD_CK1_1	74	80	PF00069	0.606
MOD_CK2_1	301	307	PF00069	0.584
MOD_CK2_1	465	471	PF00069	0.714
MOD_CK2_1	59	65	PF00069	0.662
MOD_CK2_1	632	638	PF00069	0.745
MOD_CK2_1	67	73	PF00069	0.587
MOD_Cter_Amidation	511	514	PF01082	0.628
MOD_DYRK1A_RPxSP_1	285	289	PF00069	0.765
MOD_DYRK1A_RPxSP_1	514	518	PF00069	0.711
MOD_DYRK1A_RPxSP_1	612	616	PF00069	0.627
MOD_GlcNHglycan	10	14	PF01048	0.693
MOD_GlcNHglycan	175	178	PF01048	0.690
MOD_GlcNHglycan	229	232	PF01048	0.669
MOD_GlcNHglycan	242	245	PF01048	0.679
MOD_GlcNHglycan	260	264	PF01048	0.621
MOD_GlcNHglycan	290	293	PF01048	0.759
MOD_GlcNHglycan	310	313	PF01048	0.577
MOD_GlcNHglycan	322	325	PF01048	0.723
MOD_GlcNHglycan	370	375	PF01048	0.788
MOD_GlcNHglycan	385	389	PF01048	0.620
MOD_GlcNHglycan	432	435	PF01048	0.719
MOD_GlcNHglycan	445	448	PF01048	0.782
MOD_GlcNHglycan	449	452	PF01048	0.813
MOD_GlcNHglycan	454	457	PF01048	0.739
MOD_GlcNHglycan	537	540	PF01048	0.775
MOD_GlcNHglycan	55	58	PF01048	0.584
MOD_GlcNHglycan	550	553	PF01048	0.666
MOD_GlcNHglycan	562	565	PF01048	0.683
MOD_GlcNHglycan	588	591	PF01048	0.699
MOD_GlcNHglycan	628	631	PF01048	0.828
MOD_GlcNHglycan	703	706	PF01048	0.827
MOD_GlcNHglycan	753	756	PF01048	0.734
MOD_GSK3_1	122	129	PF00069	0.662
MOD_GSK3_1	145	152	PF00069	0.696
MOD_GSK3_1	181	188	PF00069	0.703
MOD_GSK3_1	259	266	PF00069	0.718
MOD_GSK3_1	28	35	PF00069	0.633
MOD_GSK3_1	283	290	PF00069	0.801
MOD_GSK3_1	308	315	PF00069	0.719
MOD_GSK3_1	320	327	PF00069	0.690
MOD_GSK3_1	351	358	PF00069	0.824
MOD_GSK3_1	416	423	PF00069	0.857
MOD_GSK3_1	443	450	PF00069	0.781
MOD_GSK3_1	485	492	PF00069	0.771
MOD_GSK3_1	560	567	PF00069	0.721
MOD_GSK3_1	576	583	PF00069	0.843
MOD_GSK3_1	67	74	PF00069	0.688
MOD_GSK3_1	710	717	PF00069	0.804
MOD_GSK3_1	9	16	PF00069	0.791
MOD_N-GLC_1	27	32	PF02516	0.405
MOD_N-GLC_1	292	297	PF02516	0.732
MOD_N-GLC_1	586	591	PF02516	0.703
MOD_N-GLC_1	721	726	PF02516	0.789
MOD_N-GLC_1	730	735	PF02516	0.722
MOD_NEK2_1	132	137	PF00069	0.765
MOD_NEK2_1	435	440	PF00069	0.613
MOD_NEK2_1	475	480	PF00069	0.728
MOD_NEK2_1	610	615	PF00069	0.627
MOD_NEK2_1	684	689	PF00069	0.661
MOD_NEK2_2	108	113	PF00069	0.637
MOD_NEK2_2	128	133	PF00069	0.458
MOD_NEK2_2	312	317	PF00069	0.622
MOD_PIKK_1	237	243	PF00454	0.675
MOD_PIKK_1	424	430	PF00454	0.837
MOD_PIKK_1	689	695	PF00454	0.744
MOD_PKA_1	276	282	PF00069	0.722
MOD_PKA_1	284	290	PF00069	0.630
MOD_PKA_1	662	668	PF00069	0.605
MOD_PKA_1	75	81	PF00069	0.636
MOD_PKA_1	758	764	PF00069	0.758
MOD_PKA_2	132	138	PF00069	0.779
MOD_PKA_2	191	197	PF00069	0.643
MOD_PKA_2	283	289	PF00069	0.802
MOD_PKA_2	308	314	PF00069	0.700
MOD_PKA_2	33	39	PF00069	0.606
MOD_PKA_2	392	398	PF00069	0.717
MOD_PKA_2	546	552	PF00069	0.837
MOD_PKA_2	576	582	PF00069	0.755
MOD_PKA_2	601	607	PF00069	0.707
MOD_PKA_2	621	627	PF00069	0.591
MOD_PKA_2	662	668	PF00069	0.605
MOD_PKA_2	710	716	PF00069	0.742
MOD_PKA_2	74	80	PF00069	0.699
MOD_PKA_2	744	750	PF00069	0.797
MOD_PKA_2	758	764	PF00069	0.721
MOD_Plk_1	339	345	PF00069	0.702
MOD_Plk_1	575	581	PF00069	0.841
MOD_Plk_1	730	736	PF00069	0.836
MOD_Plk_2-3	301	307	PF00069	0.584
MOD_Plk_2-3	336	342	PF00069	0.700
MOD_Plk_4	108	114	PF00069	0.637
MOD_Plk_4	139	145	PF00069	0.784
MOD_Plk_4	192	198	PF00069	0.656
MOD_Plk_4	242	248	PF00069	0.751
MOD_Plk_4	684	690	PF00069	0.698
MOD_ProDKin_1	122	128	PF00069	0.702
MOD_ProDKin_1	142	148	PF00069	0.656
MOD_ProDKin_1	179	185	PF00069	0.746
MOD_ProDKin_1	285	291	PF00069	0.711
MOD_ProDKin_1	292	298	PF00069	0.731
MOD_ProDKin_1	355	361	PF00069	0.795
MOD_ProDKin_1	373	379	PF00069	0.638
MOD_ProDKin_1	489	495	PF00069	0.801
MOD_ProDKin_1	498	504	PF00069	0.804
MOD_ProDKin_1	514	520	PF00069	0.667
MOD_ProDKin_1	555	561	PF00069	0.712
MOD_ProDKin_1	578	584	PF00069	0.763
MOD_ProDKin_1	604	610	PF00069	0.722
MOD_ProDKin_1	612	618	PF00069	0.738
MOD_ProDKin_1	632	638	PF00069	0.825
MOD_ProDKin_1	648	654	PF00069	0.594
MOD_ProDKin_1	723	729	PF00069	0.739
MOD_SUMO_for_1	45	48	PF00179	0.576
MOD_SUMO_for_1	630	633	PF00179	0.774
MOD_SUMO_for_1	91	94	PF00179	0.737
MOD_SUMO_rev_2	344	354	PF00179	0.776
MOD_SUMO_rev_2	38	47	PF00179	0.600
TRG_AP2beta_CARGO_1	307	317	PF09066	0.596
TRG_DiLeu_BaEn_1	166	171	PF01217	0.687
TRG_ENDOCYTIC_2	221	224	PF00928	0.710
TRG_ENDOCYTIC_2	398	401	PF00928	0.607
TRG_ENDOCYTIC_2	82	85	PF00928	0.594
TRG_ER_diArg_1	199	201	PF00400	0.651
TRG_ER_diArg_1	251	253	PF00400	0.758
TRG_ER_diArg_1	661	663	PF00400	0.696
TRG_ER_diArg_1	709	712	PF00400	0.851
TRG_NLS_MonoCore_2	659	664	PF00514	0.644
TRG_NLS_MonoExtC_3	389	394	PF00514	0.760
TRG_NLS_MonoExtN_4	658	664	PF00514	0.644
TRG_Pf-PMV_PEXEL_1	669	673	PF00026	0.744

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMJ9	Leptomonas seymouri	34%	86%
A4HQD3	Leishmania braziliensis	58%	100%
A4IE25	Leishmania infantum	97%	97%
E9AU49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q0E6	Leishmania major	90%	100%