Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2763), putative

Species:

Leishmania donovani

UniProt:

A0A3S7XC28_LEIDO

TriTrypDb:

LdCL_360071200 , LDHU3_36.8460

Length:

117

Annotations

LeishMANIAdb annotations

The outer portions of this protein are very Gly-rich, possibly aggregation-prone and have an unpaired Cys as well. Structurally similar to other selenoproteins.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XC28

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XC28

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	75	77	PF00675	0.735
CLV_NRD_NRD_1	97	99	PF00675	0.680
CLV_PCSK_KEX2_1	75	77	PF00082	0.735
CLV_PCSK_KEX2_1	97	99	PF00082	0.680
CLV_PCSK_SKI1_1	13	17	PF00082	0.309
CLV_PCSK_SKI1_1	18	22	PF00082	0.372
CLV_PCSK_SKI1_1	70	74	PF00082	0.648
DEG_APCC_DBOX_1	17	25	PF00400	0.360
LIG_BIR_II_1	1	5	PF00653	0.700
LIG_Integrin_isoDGR_2	6	8	PF01839	0.444
LIG_NBox_RRM_1	20	30	PF00076	0.360
LIG_SH2_STAT5	3	6	PF00017	0.637
LIG_SH3_3	103	109	PF00018	0.541
LIG_SUMO_SIM_par_1	20	26	PF11976	0.360
MOD_GlcNHglycan	110	113	PF01048	0.649
MOD_GlcNHglycan	88	91	PF01048	0.728
MOD_GSK3_1	31	38	PF00069	0.456
MOD_NEK2_1	31	36	PF00069	0.317
MOD_Plk_4	26	32	PF00069	0.361

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9B7	Leptomonas seymouri	63%	98%