Sugar (And other) transporter family protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glucose transporter 1

Species:

Leishmania donovani

UniProt:

A0A3S7XC27_LEIDO

TriTrypDb:

LdBPK_366560.1 , LdCL_360072900 , LDHU3_36.8650

Length:

567

Annotations

LeishMANIAdb annotations

Publication identifier(s): 30068561 23766511
These proteins are related to other Eukaryotic proton-coupled hexose transporters, but the family has extremely expanded in parazitic species.. Subcellular localization depends on the actual paralogue. In L. mexicana, the GT2 protein (E9AU63) is found on the cell membrane, GT3 (E9AU62) is largely located at the ER while GT1 (E9AU64) is flagellar.. Localization: ER (experimental) / Cell surface (experimental) / Flagellar (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 3

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 40
NetGPI	no	yes: 0, no: 40

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	41
GO:0110165	cellular anatomical entity	1	41
GO:0005886	plasma membrane	3	3
GO:0051286	cell tip	3	3
GO:0060187	cell pole	2	3

Expansion

Sequence features

A0A3S7XC27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XC27

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	16
GO:0008643	carbohydrate transport	5	16
GO:0051179	localization	1	16
GO:0051234	establishment of localization	2	16
GO:0071702	organic substance transport	4	16
GO:0009987	cellular process	1	1
GO:0015749	monosaccharide transmembrane transport	4	1
GO:0034219	carbohydrate transmembrane transport	3	1
GO:0055085	transmembrane transport	2	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	41
GO:0015144	carbohydrate transmembrane transporter activity	3	15
GO:0022857	transmembrane transporter activity	2	41
GO:0015145	monosaccharide transmembrane transporter activity	5	2
GO:0015149	hexose transmembrane transporter activity	6	2
GO:0051119	sugar transmembrane transporter activity	4	2
GO:0005353	fructose transmembrane transporter activity	7	1
GO:0005354	galactose transmembrane transporter activity	7	1
GO:0015578	mannose transmembrane transporter activity	7	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	30	34	PF00656	0.577
CLV_C14_Caspase3-7	539	543	PF00656	0.646
CLV_NRD_NRD_1	10	12	PF00675	0.505
CLV_PCSK_KEX2_1	245	247	PF00082	0.335
CLV_PCSK_KEX2_1	540	542	PF00082	0.464
CLV_PCSK_KEX2_1	545	547	PF00082	0.545
CLV_PCSK_KEX2_1	9	11	PF00082	0.510
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.347
CLV_PCSK_PC1ET2_1	540	542	PF00082	0.464
CLV_PCSK_PC1ET2_1	545	547	PF00082	0.545
CLV_PCSK_PC7_1	541	547	PF00082	0.401
CLV_PCSK_SKI1_1	402	406	PF00082	0.265
CLV_PCSK_SKI1_1	44	48	PF00082	0.338
DEG_ODPH_VHL_1	372	383	PF01847	0.347
DOC_CYCLIN_RxL_1	399	409	PF00134	0.535
DOC_MAPK_gen_1	243	252	PF00069	0.484
DOC_MAPK_HePTP_8	215	227	PF00069	0.436
DOC_MAPK_MEF2A_6	185	193	PF00069	0.483
DOC_MAPK_MEF2A_6	218	227	PF00069	0.322
DOC_MAPK_MEF2A_6	243	252	PF00069	0.494
DOC_MAPK_NFAT4_5	218	226	PF00069	0.390
DOC_PP1_RVXF_1	183	189	PF00149	0.477
DOC_PP4_FxxP_1	174	177	PF00568	0.443
DOC_PP4_FxxP_1	533	536	PF00568	0.351
DOC_SPAK_OSR1_1	218	222	PF12202	0.419
DOC_USP7_MATH_1	177	181	PF00917	0.472
DOC_USP7_MATH_1	36	40	PF00917	0.616
DOC_USP7_MATH_1	426	430	PF00917	0.345
DOC_USP7_UBL2_3	431	435	PF12436	0.362
DOC_USP7_UBL2_3	540	544	PF12436	0.655
LIG_14-3-3_CanoR_1	10	16	PF00244	0.773
LIG_14-3-3_CanoR_1	114	119	PF00244	0.353
LIG_14-3-3_CanoR_1	136	142	PF00244	0.316
LIG_14-3-3_CanoR_1	185	189	PF00244	0.495
LIG_14-3-3_CanoR_1	473	478	PF00244	0.477
LIG_14-3-3_CanoR_1	83	89	PF00244	0.362
LIG_BIR_II_1	1	5	PF00653	0.757
LIG_BIR_III_2	33	37	PF00653	0.561
LIG_BRCT_BRCA1_1	156	160	PF00533	0.285
LIG_BRCT_BRCA1_1	272	276	PF00533	0.305
LIG_BRCT_BRCA1_1	294	298	PF00533	0.455
LIG_BRCT_BRCA1_1	395	399	PF00533	0.421
LIG_BRCT_BRCA1_1	557	561	PF00533	0.545
LIG_BRCT_BRCA1_1	58	62	PF00533	0.351
LIG_BRCT_BRCA1_1	66	70	PF00533	0.288
LIG_deltaCOP1_diTrp_1	210	219	PF00928	0.326
LIG_FHA_1	245	251	PF00498	0.491
LIG_FHA_1	255	261	PF00498	0.252
LIG_FHA_1	300	306	PF00498	0.424
LIG_FHA_1	348	354	PF00498	0.352
LIG_FHA_1	439	445	PF00498	0.372
LIG_FHA_1	479	485	PF00498	0.377
LIG_FHA_1	495	501	PF00498	0.394
LIG_FHA_2	127	133	PF00498	0.351
LIG_GBD_Chelix_1	178	186	PF00786	0.447
LIG_GBD_Chelix_1	47	55	PF00786	0.433
LIG_LIR_Apic_2	172	177	PF02991	0.453
LIG_LIR_Gen_1	187	196	PF02991	0.345
LIG_LIR_Gen_1	210	220	PF02991	0.308
LIG_LIR_Gen_1	295	305	PF02991	0.383
LIG_LIR_Gen_1	331	342	PF02991	0.487
LIG_LIR_Gen_1	476	485	PF02991	0.283
LIG_LIR_Nem_3	187	191	PF02991	0.349
LIG_LIR_Nem_3	208	214	PF02991	0.250
LIG_LIR_Nem_3	295	301	PF02991	0.364
LIG_LIR_Nem_3	331	335	PF02991	0.569
LIG_LIR_Nem_3	476	480	PF02991	0.406
LIG_LIR_Nem_3	59	65	PF02991	0.327
LIG_LYPXL_S_1	424	428	PF13949	0.332
LIG_LYPXL_yS_3	425	428	PF13949	0.269
LIG_NRBOX	185	191	PF00104	0.561
LIG_NRBOX	296	302	PF00104	0.425
LIG_Pex14_2	294	298	PF04695	0.445
LIG_Pex14_2	407	411	PF04695	0.436
LIG_Pex14_2	446	450	PF04695	0.286
LIG_Pex14_2	466	470	PF04695	0.452
LIG_Pex14_2	533	537	PF04695	0.372
LIG_PTB_Apo_2	487	494	PF02174	0.321
LIG_PTB_Phospho_1	487	493	PF10480	0.360
LIG_SH2_CRK	66	70	PF00017	0.284
LIG_SH2_NCK_1	118	122	PF00017	0.276
LIG_SH2_STAP1	66	70	PF00017	0.313
LIG_SH2_STAT3	235	238	PF00017	0.497
LIG_SH2_STAT5	104	107	PF00017	0.324
LIG_SH2_STAT5	116	119	PF00017	0.291
LIG_SH2_STAT5	235	238	PF00017	0.449
LIG_SH2_STAT5	334	337	PF00017	0.601
LIG_SH2_STAT5	397	400	PF00017	0.531
LIG_SH2_STAT5	459	462	PF00017	0.374
LIG_SH3_3	227	233	PF00018	0.311
LIG_SH3_3	420	426	PF00018	0.311
LIG_SH3_3	488	494	PF00018	0.322
LIG_SUMO_SIM_anti_2	299	305	PF11976	0.315
LIG_TRFH_1	532	536	PF08558	0.351
MOD_CK1_1	119	125	PF00069	0.320
MOD_CK1_1	150	156	PF00069	0.314
MOD_CK1_1	299	305	PF00069	0.398
MOD_CK1_1	409	415	PF00069	0.396
MOD_CK1_1	429	435	PF00069	0.336
MOD_CK2_1	11	17	PF00069	0.756
MOD_CK2_1	117	123	PF00069	0.317
MOD_CK2_1	126	132	PF00069	0.361
MOD_CK2_1	139	145	PF00069	0.324
MOD_CK2_1	150	156	PF00069	0.286
MOD_CK2_1	202	208	PF00069	0.421
MOD_Cter_Amidation	542	545	PF01082	0.472
MOD_Cter_Amidation	552	555	PF01082	0.548
MOD_GlcNHglycan	119	122	PF01048	0.485
MOD_GlcNHglycan	141	144	PF01048	0.496
MOD_GlcNHglycan	149	152	PF01048	0.461
MOD_GlcNHglycan	156	159	PF01048	0.431
MOD_GlcNHglycan	38	41	PF01048	0.434
MOD_GlcNHglycan	500	503	PF01048	0.449
MOD_GlcNHglycan	504	507	PF01048	0.448
MOD_GlcNHglycan	556	560	PF01048	0.504
MOD_GSK3_1	108	115	PF00069	0.313
MOD_GSK3_1	147	154	PF00069	0.278
MOD_GSK3_1	292	299	PF00069	0.350
MOD_GSK3_1	347	354	PF00069	0.328
MOD_GSK3_1	362	369	PF00069	0.272
MOD_GSK3_1	385	392	PF00069	0.344
MOD_GSK3_1	393	400	PF00069	0.318
MOD_GSK3_1	406	413	PF00069	0.248
MOD_GSK3_1	494	501	PF00069	0.319
MOD_GSK3_1	9	16	PF00069	0.735
MOD_N-GLC_1	97	102	PF02516	0.514
MOD_N-GLC_2	490	492	PF02516	0.377
MOD_NEK2_1	160	165	PF00069	0.329
MOD_NEK2_1	169	174	PF00069	0.266
MOD_NEK2_1	178	183	PF00069	0.194
MOD_NEK2_1	270	275	PF00069	0.271
MOD_NEK2_1	309	314	PF00069	0.461
MOD_NEK2_1	347	352	PF00069	0.321
MOD_NEK2_1	38	43	PF00069	0.652
MOD_NEK2_1	386	391	PF00069	0.348
MOD_NEK2_1	406	411	PF00069	0.127
MOD_NEK2_1	70	75	PF00069	0.289
MOD_NEK2_2	108	113	PF00069	0.322
MOD_NEK2_2	293	298	PF00069	0.419
MOD_NEK2_2	397	402	PF00069	0.501
MOD_OFUCOSY	105	112	PF10250	0.487
MOD_PIKK_1	126	132	PF00454	0.331
MOD_PIKK_1	459	465	PF00454	0.355
MOD_PIKK_1	475	481	PF00454	0.320
MOD_PKA_1	9	15	PF00069	0.635
MOD_PKA_2	137	143	PF00069	0.340
MOD_PKA_2	184	190	PF00069	0.509
MOD_PKA_2	9	15	PF00069	0.770
MOD_PKB_1	471	479	PF00069	0.477
MOD_PKB_1	9	17	PF00069	0.601
MOD_Plk_4	160	166	PF00069	0.341
MOD_Plk_4	169	175	PF00069	0.292
MOD_Plk_4	184	190	PF00069	0.457
MOD_Plk_4	196	202	PF00069	0.192
MOD_Plk_4	270	276	PF00069	0.327
MOD_Plk_4	293	299	PF00069	0.323
MOD_Plk_4	362	368	PF00069	0.274
MOD_Plk_4	393	399	PF00069	0.335
MOD_Plk_4	406	412	PF00069	0.289
MOD_Plk_4	65	71	PF00069	0.338
MOD_SUMO_rev_2	17	27	PF00179	0.692
TRG_AP2beta_CARGO_1	208	218	PF09066	0.336
TRG_DiLeu_BaEn_1	210	215	PF01217	0.335
TRG_DiLeu_BaLyEn_6	337	342	PF01217	0.514
TRG_ENDOCYTIC_2	332	335	PF00928	0.548
TRG_ENDOCYTIC_2	425	428	PF00928	0.269
TRG_ENDOCYTIC_2	458	461	PF00928	0.410
TRG_ENDOCYTIC_2	66	69	PF00928	0.263
TRG_ER_diArg_1	135	138	PF00400	0.296
TRG_ER_diArg_1	470	473	PF00400	0.483
TRG_ER_diArg_1	9	11	PF00400	0.775
TRG_ER_diLys_1	564	567	PF00400	0.536
TRG_NLS_MonoExtN_4	541	548	PF00514	0.709

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0H2VG78	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	25%	100%
A0A0N0P2E1	Leptomonas seymouri	53%	100%
A0A0N0P3Z7	Leptomonas seymouri	46%	74%
A0A0N0P4D8	Leptomonas seymouri	50%	77%
A0A0N1IG16	Leptomonas seymouri	71%	100%
A0A0N1P9H5	Leptomonas seymouri	47%	100%
A0A0S4J363	Bodo saltans	28%	100%
A0A0S4JDF9	Bodo saltans	39%	100%
A0A0S4JEY7	Bodo saltans	40%	100%
A0A0S4JH90	Bodo saltans	35%	100%
A0A0S4JS00	Bodo saltans	33%	100%
A0A1X0NIR0	Trypanosomatidae	21%	100%
A0A1X0NLE0	Trypanosomatidae	58%	100%
A0A1X0NM05	Trypanosomatidae	57%	100%
A0A1X0NN62	Trypanosomatidae	53%	100%
A0A1X0P9L7	Trypanosomatidae	38%	100%
A0A381N054	Leishmania infantum	98%	100%
A0A3Q8IDK1	Leishmania donovani	43%	100%
A0A3Q8IK60	Leishmania donovani	98%	100%
A0A3Q8IWJ4	Leishmania donovani	95%	100%
A0A3R7KPU3	Trypanosoma rangeli	35%	100%
A0A3S7WY58	Leishmania donovani	22%	100%
A0A422MNQ4	Trypanosoma rangeli	56%	100%
A0A422MRN5	Trypanosoma rangeli	62%	100%
A4HL65	Leishmania braziliensis	42%	100%
A4HQD6	Leishmania braziliensis	86%	100%
A4HQD7	Leishmania braziliensis	88%	100%
A4HQE7	Leishmania braziliensis	91%	100%
A4I0Q6	Leishmania infantum	22%	100%
A4I8N6	Leishmania infantum	43%	100%
A4IC83	Leishmania infantum	95%	100%
C0SPB2	Bacillus subtilis (strain 168)	23%	100%
C7GWV6	Saccharomyces cerevisiae (strain JAY291)	21%	98%
C9ZMM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
D0A3U1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
D0A3U2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
D0A3U3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AU62	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AU63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AU64	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9AWQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9B3K8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
K0E3U9	Aspergillus rugulosus	22%	100%
O04249	Arabidopsis thaliana	24%	100%
O34718	Bacillus subtilis (strain 168)	20%	100%
O52733	Levilactobacillus brevis	22%	100%
O59932	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
O62786	Sus scrofa	24%	100%
O65413	Arabidopsis thaliana	24%	100%
O74849	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
O74969	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
P11166	Homo sapiens	24%	100%
P11167	Rattus norvegicus	24%	100%
P11168	Homo sapiens	22%	100%
P12336	Rattus norvegicus	22%	100%
P13355	Oryctolagus cuniculus	24%	100%
P13865	Leishmania enriettii	83%	100%
P15686	Parachlorella kessleri	24%	100%
P15729	Synechocystis sp. (strain PCC 6803 / Kazusa)	23%	100%
P17809	Mus musculus	23%	100%
P18631	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	20%	100%
P20303	Sus scrofa	23%	100%
P23585	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P23586	Arabidopsis thaliana	25%	100%
P27674	Bos taurus	24%	100%
P38142	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P38695	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	96%
P39003	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	99%
P39004	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	99%
P39924	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P40885	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P43427	Rattus norvegicus	21%	100%
P43581	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	100%
P46333	Bacillus subtilis (strain 168)	23%	100%
P46896	Gallus gallus	22%	100%
P47185	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P49374	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	23%	100%
P53631	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P54723	Bacillus subtilis (strain 168)	20%	100%
P54854	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P54862	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P58351	Bos taurus	24%	100%
P78831	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
P79365	Ovis aries	24%	100%
Q01440	Leishmania donovani	22%	100%
Q01441	Leishmania donovani	43%	100%
Q06221	Trypanosoma brucei brucei	45%	100%
Q06222	Trypanosoma brucei brucei	46%	100%
Q07423	Ricinus communis	24%	100%
Q09037	Trypanosoma brucei brucei	44%	100%
Q10PW9	Oryza sativa subsp. japonica	22%	100%
Q27115	Trypanosoma vivax	47%	100%
Q39524	Parachlorella kessleri	22%	100%
Q39525	Parachlorella kessleri	25%	100%
Q41144	Ricinus communis	22%	100%
Q4Q0D0	Leishmania major	90%	100%
Q4Q0D1	Leishmania major	93%	100%
Q4Q0D2	Leishmania major	94%	100%
Q4Q4J1	Leishmania major	43%	100%
Q4QAR5	Leishmania major	22%	100%
Q6AWX0	Arabidopsis thaliana	23%	100%
Q7EZD7	Oryza sativa subsp. japonica	25%	100%
Q8GW61	Arabidopsis thaliana	23%	100%
Q8L6Z8	Arabidopsis thaliana	24%	100%
Q8TFG1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
Q8WMN1	Ovis aries	23%	100%
Q92253	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	23%	95%
Q92339	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
Q94AZ2	Arabidopsis thaliana	24%	100%
Q94EC3	Oryza sativa subsp. japonica	24%	100%
Q9P3U6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
Q9P3U7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	100%
Q9SX48	Arabidopsis thaliana	22%	100%
Q9XSC2	Oryctolagus cuniculus	23%	100%