Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XC20_LEIDO

TriTrypDb:

LdBPK_366310.1 , LdCL_360070500 , LDHU3_36.8360

Length:

331

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XC20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XC20

PDB structure(s): 7aih_An , 7am2_An , 7ane_An

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.433
CLV_C14_Caspase3-7	249	253	PF00656	0.558
CLV_NRD_NRD_1	145	147	PF00675	0.465
CLV_NRD_NRD_1	160	162	PF00675	0.502
CLV_NRD_NRD_1	17	19	PF00675	0.596
CLV_NRD_NRD_1	215	217	PF00675	0.551
CLV_NRD_NRD_1	311	313	PF00675	0.502
CLV_PCSK_KEX2_1	145	147	PF00082	0.465
CLV_PCSK_KEX2_1	160	162	PF00082	0.502
CLV_PCSK_KEX2_1	310	312	PF00082	0.528
CLV_PCSK_SKI1_1	14	18	PF00082	0.649
CLV_PCSK_SKI1_1	152	156	PF00082	0.503
CLV_PCSK_SKI1_1	297	301	PF00082	0.522
DEG_APCC_DBOX_1	194	202	PF00400	0.419
DEG_APCC_DBOX_1	281	289	PF00400	0.454
DEG_Kelch_Keap1_1	303	308	PF01344	0.537
DEG_Nend_Nbox_1	1	3	PF02207	0.598
DOC_ANK_TNKS_1	56	63	PF00023	0.513
DOC_MAPK_gen_1	216	223	PF00069	0.398
DOC_MAPK_JIP1_4	217	223	PF00069	0.408
DOC_MAPK_MEF2A_6	216	223	PF00069	0.398
DOC_PP1_RVXF_1	143	150	PF00149	0.465
DOC_PP2B_LxvP_1	221	224	PF13499	0.411
DOC_USP7_UBL2_3	10	14	PF12436	0.678
DOC_WW_Pin1_4	93	98	PF00397	0.588
LIG_14-3-3_CanoR_1	282	288	PF00244	0.496
LIG_14-3-3_CanoR_1	67	76	PF00244	0.451
LIG_AP_GAE_1	106	112	PF02883	0.515
LIG_CSL_BTD_1	82	85	PF09270	0.495
LIG_deltaCOP1_diTrp_1	265	268	PF00928	0.429
LIG_FHA_1	128	134	PF00498	0.384
LIG_FHA_1	3	9	PF00498	0.684
LIG_FHA_2	135	141	PF00498	0.459
LIG_FHA_2	170	176	PF00498	0.418
LIG_FHA_2	189	195	PF00498	0.309
LIG_FHA_2	39	45	PF00498	0.567
LIG_GBD_Chelix_1	201	209	PF00786	0.446
LIG_LIR_Apic_2	91	95	PF02991	0.557
LIG_LIR_Gen_1	106	116	PF02991	0.436
LIG_LIR_Gen_1	257	264	PF02991	0.451
LIG_LIR_Nem_3	106	112	PF02991	0.445
LIG_LIR_Nem_3	183	189	PF02991	0.554
LIG_LIR_Nem_3	79	84	PF02991	0.506
LIG_LYPXL_yS_3	81	84	PF13949	0.534
LIG_Pex14_1	105	109	PF04695	0.427
LIG_Pex14_1	77	81	PF04695	0.493
LIG_PTB_Apo_2	162	169	PF02174	0.546
LIG_SH2_PTP2	92	95	PF00017	0.575
LIG_SH2_SRC	92	95	PF00017	0.599
LIG_SH2_STAP1	72	76	PF00017	0.581
LIG_SH2_STAT5	124	127	PF00017	0.407
LIG_SH2_STAT5	54	57	PF00017	0.529
LIG_SH2_STAT5	92	95	PF00017	0.599
LIG_SH3_1	232	238	PF00018	0.606
LIG_SH3_3	232	238	PF00018	0.516
LIG_SH3_3	269	275	PF00018	0.470
LIG_SH3_3	79	85	PF00018	0.470
LIG_SH3_3	91	97	PF00018	0.487
LIG_TRAF2_1	117	120	PF00917	0.548
LIG_TRFH_1	186	190	PF08558	0.389
MOD_CDK_SPK_2	93	98	PF00069	0.596
MOD_CK2_1	114	120	PF00069	0.477
MOD_CK2_1	169	175	PF00069	0.414
MOD_CK2_1	38	44	PF00069	0.622
MOD_CMANNOS	74	77	PF00535	0.439
MOD_GlcNHglycan	191	194	PF01048	0.427
MOD_GlcNHglycan	305	308	PF01048	0.489
MOD_GlcNHglycan	69	72	PF01048	0.464
MOD_GSK3_1	323	330	PF00069	0.691
MOD_GSK3_1	63	70	PF00069	0.451
MOD_N-GLC_1	283	288	PF02516	0.473
MOD_NEK2_1	134	139	PF00069	0.423
MOD_NEK2_1	2	7	PF00069	0.568
MOD_NEK2_1	207	212	PF00069	0.458
MOD_PIKK_1	134	140	PF00454	0.427
MOD_PIKK_1	76	82	PF00454	0.446
MOD_PIKK_1	8	14	PF00454	0.615
MOD_PKA_2	66	72	PF00069	0.442
MOD_Plk_1	169	175	PF00069	0.414
MOD_Plk_1	283	289	PF00069	0.475
MOD_Plk_2-3	169	175	PF00069	0.414
MOD_Plk_2-3	274	280	PF00069	0.516
MOD_Plk_4	120	126	PF00069	0.538
MOD_Plk_4	283	289	PF00069	0.452
MOD_ProDKin_1	93	99	PF00069	0.585
MOD_SUMO_rev_2	148	154	PF00179	0.522
MOD_SUMO_rev_2	192	201	PF00179	0.446
TRG_ENDOCYTIC_2	27	30	PF00928	0.479
TRG_ENDOCYTIC_2	81	84	PF00928	0.522
TRG_ER_diArg_1	144	146	PF00400	0.444
TRG_ER_diArg_1	160	162	PF00400	0.500
TRG_ER_diArg_1	310	312	PF00400	0.571
TRG_NLS_MonoExtC_3	17	22	PF00514	0.703
TRG_Pf-PMV_PEXEL_1	145	150	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P900	Leptomonas seymouri	85%	100%
A0A0S4KF76	Bodo saltans	61%	100%
A0A1X0P370	Trypanosomatidae	63%	94%
A0A3R7NW18	Trypanosoma rangeli	68%	98%
A4HQC4	Leishmania braziliensis	90%	100%
A4IE17	Leishmania infantum	100%	100%
D0A8R6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	99%
E9AU40	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q0F5	Leishmania major	97%	100%
V5BRZ1	Trypanosoma cruzi	68%	98%