Disgorgin, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Disgorgin, putative

Gene product:

rab-like GTPase activating protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XC15_LEIDO

TriTrypDb:

LdBPK_366330.1 , LdCL_360070700 , LDHU3_36.8390

Length:

498

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0000331	contractile vacuole	6	1
GO:0005773	vacuole	5	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S7XC15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XC15

Function

Biological processes
Term	Name	Level	Count
GO:0043085	positive regulation of catalytic activity	4	2
GO:0043087	regulation of GTPase activity	5	2
GO:0043547	positive regulation of GTPase activity	6	2
GO:0044093	positive regulation of molecular function	3	2
GO:0050790	regulation of catalytic activity	3	2
GO:0051336	regulation of hydrolase activity	4	2
GO:0051345	positive regulation of hydrolase activity	5	2
GO:0065007	biological regulation	1	2
GO:0065009	regulation of molecular function	2	2
GO:0090630	activation of GTPase activity	7	2

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	2
GO:0008047	enzyme activator activity	3	2
GO:0030234	enzyme regulator activity	2	2
GO:0030695	GTPase regulator activity	4	2
GO:0060589	nucleoside-triphosphatase regulator activity	3	2
GO:0098772	molecular function regulator activity	1	2
GO:0140677	molecular function activator activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	162	166	PF00656	0.585
CLV_C14_Caspase3-7	460	464	PF00656	0.475
CLV_NRD_NRD_1	200	202	PF00675	0.377
CLV_NRD_NRD_1	227	229	PF00675	0.393
CLV_NRD_NRD_1	469	471	PF00675	0.317
CLV_PCSK_KEX2_1	200	202	PF00082	0.385
CLV_PCSK_KEX2_1	371	373	PF00082	0.273
CLV_PCSK_KEX2_1	383	385	PF00082	0.259
CLV_PCSK_KEX2_1	469	471	PF00082	0.382
CLV_PCSK_PC1ET2_1	371	373	PF00082	0.273
CLV_PCSK_PC1ET2_1	383	385	PF00082	0.259
CLV_PCSK_PC7_1	196	202	PF00082	0.383
CLV_PCSK_SKI1_1	140	144	PF00082	0.576
CLV_PCSK_SKI1_1	201	205	PF00082	0.376
CLV_PCSK_SKI1_1	302	306	PF00082	0.294
CLV_PCSK_SKI1_1	353	357	PF00082	0.389
CLV_PCSK_SKI1_1	411	415	PF00082	0.253
CLV_PCSK_SKI1_1	426	430	PF00082	0.353
CLV_Separin_Metazoa	466	470	PF03568	0.390
DEG_MDM2_SWIB_1	395	403	PF02201	0.383
DEG_MDM2_SWIB_1	421	428	PF02201	0.327
DEG_SCF_FBW7_1	21	28	PF00400	0.502
DOC_CKS1_1	141	146	PF01111	0.599
DOC_CYCLIN_RxL_1	407	418	PF00134	0.267
DOC_MAPK_gen_1	380	390	PF00069	0.327
DOC_MAPK_gen_1	469	476	PF00069	0.309
DOC_PP1_RVXF_1	199	206	PF00149	0.350
DOC_PP1_RVXF_1	234	241	PF00149	0.266
DOC_PP1_RVXF_1	424	430	PF00149	0.267
DOC_PP1_RVXF_1	471	477	PF00149	0.412
DOC_PP2B_LxvP_1	444	447	PF13499	0.361
DOC_PP2B_LxvP_1	55	58	PF13499	0.670
DOC_PP4_FxxP_1	290	293	PF00568	0.229
DOC_PP4_FxxP_1	71	74	PF00568	0.499
DOC_USP7_MATH_1	32	36	PF00917	0.715
DOC_USP7_UBL2_3	214	218	PF12436	0.382
DOC_USP7_UBL2_3	266	270	PF12436	0.383
DOC_WW_Pin1_4	140	145	PF00397	0.748
DOC_WW_Pin1_4	21	26	PF00397	0.721
DOC_WW_Pin1_4	48	53	PF00397	0.652
DOC_WW_Pin1_4	66	71	PF00397	0.782
LIG_14-3-3_CanoR_1	27	36	PF00244	0.484
LIG_14-3-3_CanoR_1	7	13	PF00244	0.500
LIG_BIR_III_4	145	149	PF00653	0.542
LIG_BRCT_BRCA1_1	396	400	PF00533	0.250
LIG_BRCT_BRCA1_1	67	71	PF00533	0.545
LIG_deltaCOP1_diTrp_1	202	212	PF00928	0.391
LIG_deltaCOP1_diTrp_1	423	429	PF00928	0.250
LIG_eIF4E_1	350	356	PF01652	0.357
LIG_eIF4E_1	368	374	PF01652	0.226
LIG_FHA_1	270	276	PF00498	0.326
LIG_FHA_1	284	290	PF00498	0.389
LIG_FHA_1	40	46	PF00498	0.563
LIG_FHA_1	400	406	PF00498	0.255
LIG_FHA_1	476	482	PF00498	0.293
LIG_FHA_1	82	88	PF00498	0.608
LIG_FHA_2	130	136	PF00498	0.720
LIG_GBD_Chelix_1	324	332	PF00786	0.250
LIG_LIR_Apic_2	68	74	PF02991	0.503
LIG_LIR_Gen_1	202	210	PF02991	0.397
LIG_LIR_Gen_1	246	254	PF02991	0.298
LIG_LIR_Gen_1	35	43	PF02991	0.597
LIG_LIR_Gen_1	397	408	PF02991	0.243
LIG_LIR_Gen_1	463	471	PF02991	0.501
LIG_LIR_Gen_1	486	495	PF02991	0.463
LIG_LIR_Nem_3	172	177	PF02991	0.411
LIG_LIR_Nem_3	233	238	PF02991	0.346
LIG_LIR_Nem_3	246	250	PF02991	0.271
LIG_LIR_Nem_3	335	341	PF02991	0.278
LIG_LIR_Nem_3	35	39	PF02991	0.604
LIG_LIR_Nem_3	397	403	PF02991	0.291
LIG_LIR_Nem_3	422	428	PF02991	0.266
LIG_LIR_Nem_3	463	468	PF02991	0.513
LIG_LIR_Nem_3	486	492	PF02991	0.422
LIG_OCRL_FandH_1	337	349	PF00620	0.267
LIG_PALB2_WD40_1	395	403	PF16756	0.236
LIG_PAM2_1	390	402	PF00658	0.315
LIG_Pex14_1	417	421	PF04695	0.306
LIG_Pex14_1	425	429	PF04695	0.279
LIG_Pex14_2	356	360	PF04695	0.356
LIG_Pex14_2	395	399	PF04695	0.301
LIG_Pex14_2	400	404	PF04695	0.284
LIG_Pex14_2	421	425	PF04695	0.349
LIG_PTB_Apo_2	344	351	PF02174	0.418
LIG_PTB_Phospho_1	344	350	PF10480	0.418
LIG_SH2_PTP2	259	262	PF00017	0.258
LIG_SH2_STAT3	20	23	PF00017	0.516
LIG_SH2_STAT5	189	192	PF00017	0.439
LIG_SH2_STAT5	259	262	PF00017	0.434
LIG_SH2_STAT5	317	320	PF00017	0.286
LIG_SH3_3	355	361	PF00018	0.275
LIG_SH3_3	46	52	PF00018	0.617
LIG_SH3_3	82	88	PF00018	0.625
LIG_SUMO_SIM_anti_2	431	437	PF11976	0.337
LIG_SUMO_SIM_anti_2	50	57	PF11976	0.540
LIG_TRAF2_1	132	135	PF00917	0.571
LIG_TRAF2_1	333	336	PF00917	0.383
LIG_TRAF2_1	58	61	PF00917	0.577
LIG_UBA3_1	377	383	PF00899	0.334
LIG_UBA3_1	452	456	PF00899	0.411
LIG_WRC_WIRS_1	244	249	PF05994	0.383
LIG_WW_3	24	28	PF00397	0.498
MOD_CDK_SPxK_1	21	27	PF00069	0.536
MOD_CK1_1	28	34	PF00069	0.692
MOD_CK1_1	90	96	PF00069	0.615
MOD_CK2_1	127	133	PF00069	0.671
MOD_CK2_1	154	160	PF00069	0.580
MOD_CK2_1	32	38	PF00069	0.611
MOD_GlcNHglycan	156	159	PF01048	0.687
MOD_GlcNHglycan	27	30	PF01048	0.617
MOD_GSK3_1	125	132	PF00069	0.676
MOD_GSK3_1	136	143	PF00069	0.644
MOD_GSK3_1	21	28	PF00069	0.689
MOD_GSK3_1	390	397	PF00069	0.236
MOD_GSK3_1	438	445	PF00069	0.366
MOD_N-GLC_1	154	159	PF02516	0.671
MOD_N-GLC_1	212	217	PF02516	0.441
MOD_NEK2_1	115	120	PF00069	0.616
MOD_NEK2_1	243	248	PF00069	0.312
MOD_NEK2_1	280	285	PF00069	0.303
MOD_NEK2_1	394	399	PF00069	0.292
MOD_NEK2_1	448	453	PF00069	0.538
MOD_NEK2_2	399	404	PF00069	0.292
MOD_PIKK_1	115	121	PF00454	0.670
MOD_PIKK_1	19	25	PF00454	0.671
MOD_PIKK_1	327	333	PF00454	0.250
MOD_PIKK_1	394	400	PF00454	0.250
MOD_PKA_2	379	385	PF00069	0.308
MOD_PKA_2	6	12	PF00069	0.493
MOD_PKA_2	65	71	PF00069	0.812
MOD_Plk_1	154	160	PF00069	0.736
MOD_Plk_1	334	340	PF00069	0.225
MOD_Plk_1	438	444	PF00069	0.363
MOD_Plk_1	448	454	PF00069	0.425
MOD_Plk_2-3	129	135	PF00069	0.650
MOD_Plk_4	296	302	PF00069	0.265
MOD_Plk_4	334	340	PF00069	0.263
MOD_Plk_4	390	396	PF00069	0.279
MOD_Plk_4	399	405	PF00069	0.291
MOD_Plk_4	448	454	PF00069	0.291
MOD_ProDKin_1	140	146	PF00069	0.746
MOD_ProDKin_1	21	27	PF00069	0.723
MOD_ProDKin_1	48	54	PF00069	0.653
MOD_ProDKin_1	66	72	PF00069	0.780
MOD_SUMO_for_1	436	439	PF00179	0.300
MOD_SUMO_rev_2	180	190	PF00179	0.541
TRG_DiLeu_BaEn_1	439	444	PF01217	0.292
TRG_DiLeu_BaEn_1	490	495	PF01217	0.332
TRG_DiLeu_BaEn_4	439	445	PF01217	0.297
TRG_DiLeu_BaLyEn_6	358	363	PF01217	0.372
TRG_DiLeu_BaLyEn_6	369	374	PF01217	0.312
TRG_DiLeu_BaLyEn_6	49	54	PF01217	0.519
TRG_ENDOCYTIC_2	259	262	PF00928	0.301
TRG_ENDOCYTIC_2	36	39	PF00928	0.583
TRG_ENDOCYTIC_2	465	468	PF00928	0.292
TRG_ENDOCYTIC_2	488	491	PF00928	0.249
TRG_ER_diArg_1	199	201	PF00400	0.363
TRG_ER_diArg_1	468	470	PF00400	0.348
TRG_ER_diArg_1	94	97	PF00400	0.544
TRG_Pf-PMV_PEXEL_1	383	387	PF00026	0.383

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDX9	Leptomonas seymouri	75%	91%
A0A0S4II34	Bodo saltans	53%	100%
A0A1X0NLM2	Trypanosomatidae	39%	100%
A0A1X0NLQ9	Trypanosomatidae	65%	100%
A0A3S7XBZ8	Leishmania donovani	41%	100%
A0A422NJE8	Trypanosoma rangeli	38%	100%
A4HQC6	Leishmania braziliensis	79%	100%
A4HQC7	Leishmania braziliensis	40%	100%
A4IE19	Leishmania infantum	99%	100%
A4IE20	Leishmania infantum	41%	100%
D0A3X9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AU42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9AU43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
P48566	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	79%
P58802	Mus musculus	33%	100%
Q4Q0F2	Leishmania major	35%	93%
Q4Q0F3	Leishmania major	92%	100%
Q9Y7J5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
V5BT66	Trypanosoma cruzi	63%	100%