LeishMANIAdb
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Nuclease-related domain containing protein, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Nuclease-related domain containing protein, putative
Gene product:
Nuclease-related domain containing protein, putative
Species:
Leishmania donovani
UniProt:
A0A3S7XC13_LEIDO
TriTrypDb:
LdCL_360066000 , LDHU3_36.7760
Length:
518

Annotations

LeishMANIAdb annotations

A conserved signal-anchored protein family of obscure function also found in plants and bacteria.. Some of the Leishmaniid proteins might have 3 TM segments instead of 1

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

A0A3S7XC13
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XC13

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 245 249 PF00656 0.525
CLV_NRD_NRD_1 127 129 PF00675 0.433
CLV_NRD_NRD_1 153 155 PF00675 0.266
CLV_NRD_NRD_1 165 167 PF00675 0.202
CLV_NRD_NRD_1 211 213 PF00675 0.363
CLV_NRD_NRD_1 235 237 PF00675 0.236
CLV_NRD_NRD_1 242 244 PF00675 0.236
CLV_NRD_NRD_1 33 35 PF00675 0.559
CLV_NRD_NRD_1 412 414 PF00675 0.295
CLV_NRD_NRD_1 455 457 PF00675 0.451
CLV_PCSK_KEX2_1 127 129 PF00082 0.457
CLV_PCSK_KEX2_1 164 166 PF00082 0.237
CLV_PCSK_KEX2_1 213 215 PF00082 0.311
CLV_PCSK_KEX2_1 235 237 PF00082 0.236
CLV_PCSK_KEX2_1 242 244 PF00082 0.236
CLV_PCSK_KEX2_1 268 270 PF00082 0.289
CLV_PCSK_KEX2_1 33 35 PF00082 0.559
CLV_PCSK_KEX2_1 450 452 PF00082 0.394
CLV_PCSK_KEX2_1 455 457 PF00082 0.441
CLV_PCSK_PC1ET2_1 213 215 PF00082 0.309
CLV_PCSK_PC1ET2_1 268 270 PF00082 0.350
CLV_PCSK_PC1ET2_1 450 452 PF00082 0.415
CLV_PCSK_PC1ET2_1 455 457 PF00082 0.470
CLV_PCSK_PC7_1 123 129 PF00082 0.458
CLV_PCSK_PC7_1 451 457 PF00082 0.442
CLV_PCSK_SKI1_1 268 272 PF00082 0.289
CLV_PCSK_SKI1_1 308 312 PF00082 0.360
CLV_PCSK_SKI1_1 353 357 PF00082 0.334
CLV_PCSK_SKI1_1 393 397 PF00082 0.325
CLV_PCSK_SKI1_1 414 418 PF00082 0.296
CLV_PCSK_SKI1_1 432 436 PF00082 0.441
CLV_PCSK_SKI1_1 451 455 PF00082 0.320
CLV_PCSK_SKI1_1 56 60 PF00082 0.521
DEG_APCC_DBOX_1 412 420 PF00400 0.540
DEG_APCC_KENBOX_2 477 481 PF00400 0.594
DEG_COP1_1 398 407 PF00400 0.494
DOC_CKS1_1 354 359 PF01111 0.543
DOC_CYCLIN_RxL_1 429 438 PF00134 0.560
DOC_CYCLIN_RxL_1 53 64 PF00134 0.309
DOC_CYCLIN_yCln2_LP_2 59 62 PF00134 0.337
DOC_MAPK_DCC_7 284 292 PF00069 0.539
DOC_MAPK_gen_1 210 220 PF00069 0.539
DOC_MAPK_gen_1 413 421 PF00069 0.487
DOC_MAPK_gen_1 422 430 PF00069 0.542
DOC_MAPK_MEF2A_6 284 292 PF00069 0.471
DOC_MAPK_MEF2A_6 413 421 PF00069 0.482
DOC_MAPK_RevD_3 295 308 PF00069 0.606
DOC_MAPK_RevD_3 442 456 PF00069 0.584
DOC_PP1_RVXF_1 44 50 PF00149 0.323
DOC_PP2B_LxvP_1 58 61 PF13499 0.346
DOC_PP2B_PxIxI_1 184 190 PF00149 0.539
DOC_PP4_FxxP_1 292 295 PF00568 0.494
DOC_USP7_MATH_1 337 341 PF00917 0.668
DOC_USP7_MATH_1 67 71 PF00917 0.406
DOC_USP7_UBL2_3 276 280 PF12436 0.563
DOC_USP7_UBL2_3 450 454 PF12436 0.621
DOC_USP7_UBL2_3 455 459 PF12436 0.671
DOC_WW_Pin1_4 32 37 PF00397 0.356
DOC_WW_Pin1_4 353 358 PF00397 0.602
LIG_14-3-3_CanoR_1 269 273 PF00244 0.498
LIG_BIR_II_1 1 5 PF00653 0.354
LIG_BRCT_BRCA1_1 1 5 PF00533 0.364
LIG_CaM_IQ_9 140 156 PF13499 0.539
LIG_eIF4E_1 411 417 PF01652 0.539
LIG_FHA_1 18 24 PF00498 0.330
LIG_FHA_1 313 319 PF00498 0.568
LIG_FHA_1 381 387 PF00498 0.535
LIG_FHA_1 394 400 PF00498 0.523
LIG_FHA_1 434 440 PF00498 0.558
LIG_FHA_1 488 494 PF00498 0.529
LIG_FHA_1 88 94 PF00498 0.267
LIG_FHA_1 96 102 PF00498 0.279
LIG_GBD_Chelix_1 386 394 PF00786 0.384
LIG_LIR_Apic_2 37 42 PF02991 0.329
LIG_LIR_Gen_1 217 228 PF02991 0.539
LIG_LIR_Gen_1 383 390 PF02991 0.464
LIG_LIR_Gen_1 479 488 PF02991 0.564
LIG_LIR_Gen_1 8 19 PF02991 0.167
LIG_LIR_Gen_1 89 100 PF02991 0.332
LIG_LIR_Nem_3 2 7 PF02991 0.172
LIG_LIR_Nem_3 217 223 PF02991 0.525
LIG_LIR_Nem_3 314 319 PF02991 0.497
LIG_LIR_Nem_3 343 348 PF02991 0.644
LIG_LIR_Nem_3 383 387 PF02991 0.488
LIG_LIR_Nem_3 406 411 PF02991 0.587
LIG_LIR_Nem_3 8 14 PF02991 0.162
LIG_LIR_Nem_3 89 95 PF02991 0.332
LIG_MLH1_MIPbox_1 1 5 PF16413 0.354
LIG_NRBOX 385 391 PF00104 0.574
LIG_Pex14_1 158 162 PF04695 0.447
LIG_Pex14_1 384 388 PF04695 0.502
LIG_REV1ctd_RIR_1 29 35 PF16727 0.338
LIG_RPA_C_Fungi 160 172 PF08784 0.416
LIG_SH2_CRK 39 43 PF00017 0.403
LIG_SH2_PTP2 92 95 PF00017 0.320
LIG_SH2_STAT5 237 240 PF00017 0.416
LIG_SH2_STAT5 309 312 PF00017 0.439
LIG_SH2_STAT5 388 391 PF00017 0.355
LIG_SH2_STAT5 482 485 PF00017 0.427
LIG_SH2_STAT5 92 95 PF00017 0.367
LIG_SH3_2 471 476 PF14604 0.546
LIG_SH3_3 241 247 PF00018 0.375
LIG_SH3_3 348 354 PF00018 0.713
LIG_SH3_3 468 474 PF00018 0.411
LIG_SUMO_SIM_anti_2 177 182 PF11976 0.273
LIG_SUMO_SIM_anti_2 441 448 PF11976 0.477
LIG_SUMO_SIM_par_1 185 191 PF11976 0.277
LIG_SUMO_SIM_par_1 287 293 PF11976 0.288
LIG_SUMO_SIM_par_1 494 500 PF11976 0.357
LIG_SUMO_SIM_par_1 82 90 PF11976 0.554
LIG_WRC_WIRS_1 313 318 PF05994 0.367
MOD_CDK_SPxK_1 32 38 PF00069 0.449
MOD_CK1_1 274 280 PF00069 0.442
MOD_CK1_1 340 346 PF00069 0.616
MOD_CK1_1 438 444 PF00069 0.518
MOD_CK1_1 70 76 PF00069 0.409
MOD_CMANNOS 342 345 PF00535 0.648
MOD_Cter_Amidation 266 269 PF01082 0.347
MOD_DYRK1A_RPxSP_1 353 357 PF00069 0.428
MOD_GlcNHglycan 24 27 PF01048 0.435
MOD_GlcNHglycan 358 361 PF01048 0.607
MOD_GlcNHglycan 405 408 PF01048 0.465
MOD_GlcNHglycan 72 75 PF01048 0.550
MOD_GSK3_1 337 344 PF00069 0.554
MOD_GSK3_1 349 356 PF00069 0.532
MOD_GSK3_1 66 73 PF00069 0.428
MOD_NEK2_1 107 112 PF00069 0.379
MOD_NEK2_1 139 144 PF00069 0.427
MOD_NEK2_1 198 203 PF00069 0.347
MOD_NEK2_1 349 354 PF00069 0.519
MOD_NEK2_1 430 435 PF00069 0.398
MOD_NEK2_1 444 449 PF00069 0.368
MOD_NEK2_1 487 492 PF00069 0.511
MOD_NEK2_1 5 10 PF00069 0.182
MOD_NEK2_1 87 92 PF00069 0.508
MOD_NEK2_1 95 100 PF00069 0.367
MOD_NEK2_2 114 119 PF00069 0.410
MOD_PIKK_1 121 127 PF00454 0.479
MOD_PKA_1 268 274 PF00069 0.347
MOD_PKA_2 114 120 PF00069 0.446
MOD_PKA_2 268 274 PF00069 0.411
MOD_PKA_2 349 355 PF00069 0.462
MOD_PKB_1 212 220 PF00069 0.347
MOD_Plk_1 274 280 PF00069 0.225
MOD_Plk_1 67 73 PF00069 0.427
MOD_Plk_1 87 93 PF00069 0.348
MOD_Plk_4 268 274 PF00069 0.305
MOD_Plk_4 337 343 PF00069 0.539
MOD_Plk_4 430 436 PF00069 0.492
MOD_Plk_4 492 498 PF00069 0.474
MOD_Plk_4 82 88 PF00069 0.478
MOD_Plk_4 96 102 PF00069 0.189
MOD_ProDKin_1 32 38 PF00069 0.438
MOD_ProDKin_1 353 359 PF00069 0.504
MOD_SUMO_rev_2 142 149 PF00179 0.409
TRG_DiLeu_BaEn_1 479 484 PF01217 0.447
TRG_DiLeu_BaEn_2 134 140 PF01217 0.544
TRG_DiLeu_BaLyEn_6 390 395 PF01217 0.488
TRG_ENDOCYTIC_2 482 485 PF00928 0.427
TRG_ENDOCYTIC_2 55 58 PF00928 0.435
TRG_ENDOCYTIC_2 92 95 PF00928 0.367
TRG_ER_diArg_1 126 128 PF00400 0.533
TRG_ER_diArg_1 163 166 PF00400 0.273
TRG_ER_diArg_1 212 215 PF00400 0.456
TRG_ER_diArg_1 234 236 PF00400 0.273
TRG_ER_diArg_1 242 244 PF00400 0.273
TRG_ER_diArg_1 32 34 PF00400 0.450
TRG_Pf-PMV_PEXEL_1 508 512 PF00026 0.462

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDN0 Leptomonas seymouri 73% 100%
A0A0S4J7E4 Bodo saltans 36% 100%
A0A1X0P0I4 Trypanosomatidae 43% 100%
A0A3R7R7J3 Trypanosoma rangeli 43% 100%
A4HQ77 Leishmania braziliensis 87% 100%
A4IDX5 Leishmania infantum 99% 100%
D0A437 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
E9ATZ5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4Q0K0 Leishmania major 92% 100%
V5B3M2 Trypanosoma cruzi 42% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS