Galactose oxidase, central domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XC07_LEIDO

TriTrypDb:

LdBPK_366430.1 , LdCL_360071800 , LDHU3_36.8530

Length:

485

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XC07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XC07

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	38	42	PF00656	0.393
CLV_NRD_NRD_1	123	125	PF00675	0.719
CLV_NRD_NRD_1	479	481	PF00675	0.602
CLV_PCSK_KEX2_1	123	125	PF00082	0.581
CLV_PCSK_KEX2_1	22	24	PF00082	0.637
CLV_PCSK_KEX2_1	478	480	PF00082	0.667
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.637
CLV_PCSK_PC1ET2_1	478	480	PF00082	0.667
CLV_PCSK_SKI1_1	37	41	PF00082	0.399
CLV_PCSK_SKI1_1	442	446	PF00082	0.448
DOC_CKS1_1	263	268	PF01111	0.383
DOC_CYCLIN_RxL_1	439	449	PF00134	0.498
DOC_MAPK_DCC_7	134	142	PF00069	0.641
DOC_MAPK_MEF2A_6	134	142	PF00069	0.641
DOC_MAPK_MEF2A_6	461	469	PF00069	0.623
DOC_PP1_RVXF_1	440	447	PF00149	0.490
DOC_USP7_MATH_1	159	163	PF00917	0.579
DOC_USP7_MATH_1	16	20	PF00917	0.505
DOC_USP7_MATH_1	199	203	PF00917	0.743
DOC_USP7_MATH_1	211	215	PF00917	0.601
DOC_USP7_MATH_1	376	380	PF00917	0.650
DOC_USP7_MATH_1	4	8	PF00917	0.597
DOC_USP7_MATH_1	415	419	PF00917	0.619
DOC_USP7_MATH_1	434	438	PF00917	0.336
DOC_USP7_MATH_1	481	485	PF00917	0.642
DOC_USP7_MATH_1	89	93	PF00917	0.446
DOC_USP7_MATH_1	98	102	PF00917	0.403
DOC_USP7_UBL2_3	18	22	PF12436	0.630
DOC_WW_Pin1_4	133	138	PF00397	0.663
DOC_WW_Pin1_4	146	151	PF00397	0.821
DOC_WW_Pin1_4	203	208	PF00397	0.674
DOC_WW_Pin1_4	233	238	PF00397	0.579
DOC_WW_Pin1_4	262	267	PF00397	0.381
DOC_WW_Pin1_4	278	283	PF00397	0.336
DOC_WW_Pin1_4	332	337	PF00397	0.423
LIG_14-3-3_CanoR_1	158	168	PF00244	0.648
LIG_14-3-3_CanoR_1	178	184	PF00244	0.508
LIG_14-3-3_CanoR_1	23	33	PF00244	0.593
LIG_14-3-3_CanoR_1	392	401	PF00244	0.441
LIG_14-3-3_CanoR_1	414	420	PF00244	0.626
LIG_14-3-3_CanoR_1	433	443	PF00244	0.342
LIG_Actin_WH2_2	265	281	PF00022	0.439
LIG_BIR_II_1	1	5	PF00653	0.575
LIG_BIR_III_1	1	5	PF00653	0.596
LIG_BIR_III_3	1	5	PF00653	0.596
LIG_CSL_BTD_1	333	336	PF09270	0.433
LIG_CtBP_PxDLS_1	137	141	PF00389	0.668
LIG_deltaCOP1_diTrp_1	258	263	PF00928	0.408
LIG_FHA_1	251	257	PF00498	0.495
LIG_FHA_1	263	269	PF00498	0.462
LIG_FHA_1	279	285	PF00498	0.350
LIG_FHA_1	310	316	PF00498	0.552
LIG_FHA_1	34	40	PF00498	0.519
LIG_FHA_1	59	65	PF00498	0.464
LIG_FHA_2	128	134	PF00498	0.748
LIG_FHA_2	236	242	PF00498	0.525
LIG_FHA_2	449	455	PF00498	0.514
LIG_Integrin_isoDGR_2	385	387	PF01839	0.545
LIG_LIR_Gen_1	367	376	PF02991	0.451
LIG_LIR_Nem_3	333	337	PF02991	0.454
LIG_LIR_Nem_3	367	372	PF02991	0.367
LIG_LIR_Nem_3	430	435	PF02991	0.516
LIG_LYPXL_SIV_4	12	20	PF13949	0.597
LIG_NRP_CendR_1	483	485	PF00754	0.688
LIG_Pex14_1	334	338	PF04695	0.435
LIG_SH2_NCK_1	13	17	PF00017	0.626
LIG_SH2_SRC	13	16	PF00017	0.628
LIG_SH2_STAP1	13	17	PF00017	0.626
LIG_SH2_STAP1	67	71	PF00017	0.429
LIG_SH2_STAT5	245	248	PF00017	0.396
LIG_SH2_STAT5	369	372	PF00017	0.374
LIG_SH3_2	82	87	PF14604	0.457
LIG_SH3_3	132	138	PF00018	0.671
LIG_SH3_3	192	198	PF00018	0.454
LIG_SH3_3	204	210	PF00018	0.593
LIG_SH3_3	28	34	PF00018	0.525
LIG_SH3_3	333	339	PF00018	0.401
LIG_SH3_3	79	85	PF00018	0.402
LIG_TRAF2_1	406	409	PF00917	0.531
LIG_TYR_ITIM	65	70	PF00017	0.424
MOD_CK1_1	136	142	PF00069	0.731
MOD_CK1_1	206	212	PF00069	0.612
MOD_CK1_1	25	31	PF00069	0.514
MOD_CK1_1	309	315	PF00069	0.429
MOD_CK1_1	327	333	PF00069	0.476
MOD_CK1_1	413	419	PF00069	0.647
MOD_CK2_1	159	165	PF00069	0.608
MOD_CK2_1	235	241	PF00069	0.548
MOD_CK2_1	4	10	PF00069	0.626
MOD_CK2_1	401	407	PF00069	0.460
MOD_CK2_1	448	454	PF00069	0.528
MOD_CMANNOS	260	263	PF00535	0.407
MOD_GlcNHglycan	142	145	PF01048	0.643
MOD_GlcNHglycan	179	182	PF01048	0.504
MOD_GlcNHglycan	195	198	PF01048	0.367
MOD_GlcNHglycan	231	234	PF01048	0.579
MOD_GlcNHglycan	309	312	PF01048	0.481
MOD_GlcNHglycan	329	332	PF01048	0.464
MOD_GlcNHglycan	91	94	PF01048	0.437
MOD_GSK3_1	136	143	PF00069	0.707
MOD_GSK3_1	146	153	PF00069	0.627
MOD_GSK3_1	199	206	PF00069	0.763
MOD_GSK3_1	211	218	PF00069	0.587
MOD_GSK3_1	229	236	PF00069	0.496
MOD_GSK3_1	33	40	PF00069	0.511
MOD_GSK3_1	399	406	PF00069	0.472
MOD_GSK3_1	409	416	PF00069	0.590
MOD_GSK3_1	453	460	PF00069	0.650
MOD_N-GLC_1	249	254	PF02516	0.437
MOD_N-GLC_1	350	355	PF02516	0.563
MOD_NEK2_1	140	145	PF00069	0.650
MOD_NEK2_1	193	198	PF00069	0.476
MOD_NEK2_1	296	301	PF00069	0.341
MOD_NEK2_1	393	398	PF00069	0.431
MOD_NEK2_1	401	406	PF00069	0.548
MOD_NEK2_1	419	424	PF00069	0.498
MOD_NEK2_1	447	452	PF00069	0.567
MOD_NEK2_1	471	476	PF00069	0.636
MOD_NEK2_2	226	231	PF00069	0.629
MOD_NEK2_2	415	420	PF00069	0.644
MOD_PIKK_1	199	205	PF00454	0.616
MOD_PIKK_1	25	31	PF00454	0.542
MOD_PIKK_1	455	461	PF00454	0.658
MOD_PIKK_1	58	64	PF00454	0.433
MOD_PKA_1	22	28	PF00069	0.585
MOD_PKA_2	157	163	PF00069	0.628
MOD_PKA_2	177	183	PF00069	0.520
MOD_PKA_2	22	28	PF00069	0.585
MOD_PKA_2	413	419	PF00069	0.629
MOD_Plk_1	325	331	PF00069	0.437
MOD_Plk_1	40	46	PF00069	0.453
MOD_Plk_4	226	232	PF00069	0.685
MOD_Plk_4	319	325	PF00069	0.474
MOD_Plk_4	364	370	PF00069	0.508
MOD_Plk_4	98	104	PF00069	0.461
MOD_ProDKin_1	133	139	PF00069	0.662
MOD_ProDKin_1	146	152	PF00069	0.820
MOD_ProDKin_1	203	209	PF00069	0.675
MOD_ProDKin_1	233	239	PF00069	0.565
MOD_ProDKin_1	262	268	PF00069	0.383
MOD_ProDKin_1	278	284	PF00069	0.337
MOD_ProDKin_1	332	338	PF00069	0.433
MOD_SUMO_rev_2	42	52	PF00179	0.389
TRG_DiLeu_BaEn_2	47	53	PF01217	0.471
TRG_ENDOCYTIC_2	369	372	PF00928	0.368
TRG_ENDOCYTIC_2	67	70	PF00928	0.428
TRG_ER_diArg_1	122	124	PF00400	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4IE28	Leishmania infantum	100%	100%
D0A3W0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AU52	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q0E3	Leishmania major	89%	100%