Hemolysin-III related protein family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Haemolysin-III related, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XC05_LEIDO

TriTrypDb:

LdBPK_365760.1 , LdCL_360065000 , LDHU3_36.7660

Length:

337

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 25
NetGPI	no	yes: 0, no: 25

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	26
GO:0110165	cellular anatomical entity	1	26

Expansion

Sequence features

A0A3S7XC05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XC05

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0038023	signaling receptor activity	2	3
GO:0060089	molecular transducer activity	1	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	232	236	PF00082	0.338
CLV_PCSK_SKI1_1	265	269	PF00082	0.518
CLV_PCSK_SKI1_1	93	97	PF00082	0.262
DOC_CYCLIN_RxL_1	40	48	PF00134	0.639
DOC_MAPK_MEF2A_6	200	209	PF00069	0.257
DOC_PP1_RVXF_1	41	48	PF00149	0.509
DOC_PP4_FxxP_1	185	188	PF00568	0.310
DOC_PP4_FxxP_1	228	231	PF00568	0.528
DOC_PP4_FxxP_1	252	255	PF00568	0.216
DOC_PP4_FxxP_1	283	286	PF00568	0.340
DOC_SPAK_OSR1_1	293	297	PF12202	0.423
DOC_USP7_MATH_1	159	163	PF00917	0.506
DOC_USP7_UBL2_3	89	93	PF12436	0.564
DOC_WW_Pin1_4	45	50	PF00397	0.637
LIG_14-3-3_CanoR_1	43	48	PF00244	0.673
LIG_14-3-3_CanoR_1	83	92	PF00244	0.492
LIG_APCC_ABBA_1	96	101	PF00400	0.422
LIG_deltaCOP1_diTrp_1	287	294	PF00928	0.426
LIG_deltaCOP1_diTrp_1	295	304	PF00928	0.475
LIG_deltaCOP1_diTrp_1	70	77	PF00928	0.539
LIG_EH_1	74	78	PF12763	0.482
LIG_EH1_1	107	115	PF00400	0.376
LIG_EH1_1	174	182	PF00400	0.250
LIG_eIF4E_1	264	270	PF01652	0.231
LIG_FHA_1	100	106	PF00498	0.428
LIG_FHA_1	176	182	PF00498	0.324
LIG_FHA_1	25	31	PF00498	0.659
LIG_FHA_1	258	264	PF00498	0.274
LIG_FHA_1	271	277	PF00498	0.225
LIG_FHA_1	327	333	PF00498	0.468
LIG_FHA_2	4	10	PF00498	0.531
LIG_GBD_Chelix_1	116	124	PF00786	0.407
LIG_LIR_Apic_2	184	188	PF02991	0.308
LIG_LIR_Apic_2	225	231	PF02991	0.546
LIG_LIR_Gen_1	104	114	PF02991	0.422
LIG_LIR_Gen_1	131	142	PF02991	0.268
LIG_LIR_Gen_1	151	159	PF02991	0.229
LIG_LIR_Nem_3	104	109	PF02991	0.460
LIG_LIR_Nem_3	131	137	PF02991	0.250
LIG_LIR_Nem_3	151	157	PF02991	0.297
LIG_LIR_Nem_3	173	177	PF02991	0.328
LIG_LIR_Nem_3	184	189	PF02991	0.305
LIG_LYPXL_S_1	185	189	PF13949	0.395
LIG_LYPXL_yS_3	186	189	PF13949	0.395
LIG_NRBOX	108	114	PF00104	0.205
LIG_NRBOX	119	125	PF00104	0.423
LIG_PDZ_Class_3	332	337	PF00595	0.306
LIG_Pex14_2	219	223	PF04695	0.451
LIG_Pex14_2	92	96	PF04695	0.499
LIG_SH2_CRK	236	240	PF00017	0.288
LIG_SH2_SRC	203	206	PF00017	0.205
LIG_SH2_STAP1	8	12	PF00017	0.584
LIG_SH2_STAT5	134	137	PF00017	0.269
LIG_SH2_STAT5	174	177	PF00017	0.264
LIG_SH2_STAT5	191	194	PF00017	0.264
LIG_SH2_STAT5	203	206	PF00017	0.307
LIG_SH2_STAT5	274	277	PF00017	0.325
LIG_SH2_STAT5	281	284	PF00017	0.295
LIG_SH2_STAT5	316	319	PF00017	0.387
LIG_SH2_STAT5	86	89	PF00017	0.506
LIG_SH3_3	46	52	PF00018	0.600
LIG_SUMO_SIM_anti_2	194	200	PF11976	0.351
LIG_SUMO_SIM_anti_2	206	211	PF11976	0.385
LIG_SUMO_SIM_par_1	101	107	PF11976	0.403
LIG_SUMO_SIM_par_1	113	119	PF11976	0.379
LIG_SUMO_SIM_par_1	203	208	PF11976	0.389
LIG_TYR_ITIM	172	177	PF00017	0.318
LIG_TYR_ITIM	234	239	PF00017	0.342
LIG_WRC_WIRS_1	154	159	PF05994	0.561
LIG_WRC_WIRS_1	182	187	PF05994	0.302
LIG_WRC_WIRS_1	219	224	PF05994	0.478
MOD_CK1_1	104	110	PF00069	0.395
MOD_CK1_1	194	200	PF00069	0.324
MOD_CK1_1	237	243	PF00069	0.379
MOD_CK2_1	26	32	PF00069	0.654
MOD_CK2_1	3	9	PF00069	0.711
MOD_CK2_1	64	70	PF00069	0.536
MOD_GlcNHglycan	157	160	PF01048	0.270
MOD_GSK3_1	149	156	PF00069	0.275
MOD_GSK3_1	218	225	PF00069	0.308
MOD_GSK3_1	234	241	PF00069	0.242
MOD_N-GLC_1	99	104	PF02516	0.241
MOD_NEK2_1	1	6	PF00069	0.540
MOD_NEK2_1	116	121	PF00069	0.310
MOD_NEK2_1	135	140	PF00069	0.329
MOD_NEK2_1	148	153	PF00069	0.233
MOD_NEK2_1	175	180	PF00069	0.262
MOD_NEK2_1	222	227	PF00069	0.510
MOD_NEK2_1	235	240	PF00069	0.302
MOD_NEK2_1	270	275	PF00069	0.376
MOD_NEK2_1	37	42	PF00069	0.539
MOD_NEK2_2	149	154	PF00069	0.264
MOD_NEK2_2	218	223	PF00069	0.395
MOD_NEK2_2	91	96	PF00069	0.448
MOD_PIKK_1	128	134	PF00454	0.201
MOD_PIKK_1	222	228	PF00454	0.485
MOD_Plk_1	257	263	PF00069	0.320
MOD_Plk_1	63	69	PF00069	0.584
MOD_Plk_1	99	105	PF00069	0.469
MOD_Plk_2-3	64	70	PF00069	0.450
MOD_Plk_4	101	107	PF00069	0.531
MOD_Plk_4	141	147	PF00069	0.326
MOD_Plk_4	149	155	PF00069	0.313
MOD_Plk_4	176	182	PF00069	0.308
MOD_Plk_4	194	200	PF00069	0.235
MOD_Plk_4	224	230	PF00069	0.497
MOD_Plk_4	91	97	PF00069	0.541
MOD_ProDKin_1	45	51	PF00069	0.637
TRG_ENDOCYTIC_2	134	137	PF00928	0.315
TRG_ENDOCYTIC_2	154	157	PF00928	0.464
TRG_ENDOCYTIC_2	174	177	PF00928	0.264
TRG_ENDOCYTIC_2	186	189	PF00928	0.319
TRG_ENDOCYTIC_2	236	239	PF00928	0.283
TRG_ENDOCYTIC_2	264	267	PF00928	0.315
TRG_ER_diArg_1	12	15	PF00400	0.632
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.301

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I280	Leptomonas seymouri	34%	94%
A0A0N1I909	Leptomonas seymouri	77%	100%
A0A0S4J7T5	Bodo saltans	37%	91%
A0A0S4J8V2	Bodo saltans	46%	100%
A0A0S4JQM0	Bodo saltans	47%	100%
A0A0S4JWI8	Bodo saltans	37%	100%
A0A0S4KIQ2	Bodo saltans	42%	100%
A0A1X0P1D6	Trypanosomatidae	38%	100%
A0A1X0P1Q2	Trypanosomatidae	35%	97%
A0A3R7L1Y6	Trypanosoma rangeli	37%	99%
A0A3S7XBT4	Leishmania donovani	38%	100%
A0A3S7XBU6	Leishmania donovani	38%	66%
A4HQ63	Leishmania braziliensis	37%	100%
A4HQ67	Leishmania braziliensis	37%	100%
A4HQ68	Leishmania braziliensis	86%	100%
A4IDW4	Leishmania infantum	38%	100%
A4IDW5	Leishmania infantum	38%	66%
A4IDW6	Leishmania infantum	100%	100%
A8WZU4	Caenorhabditis briggsae	28%	80%
D0A450	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
D0A451	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	97%
E9ATY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9ATY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	68%
E9ATY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q03419	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
Q09749	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
Q09910	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	76%
Q12442	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
Q4Q0K9	Leishmania major	96%	100%
Q4Q0L0	Leishmania major	38%	66%
Q4Q0L1	Leishmania major	37%	100%
Q6TCG8	Mus musculus	32%	100%
Q6TCH7	Homo sapiens	32%	100%
Q753H5	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	27%	100%
Q75F81	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	24%	80%
Q7ZVH1	Danio rerio	27%	98%
Q801D8	Cynoscion nebulosus	23%	96%
Q801G2	Danio rerio	25%	95%
Q80ZE4	Mus musculus	27%	98%
Q84N34	Arabidopsis thaliana	28%	94%
Q86V24	Homo sapiens	34%	87%
Q86WK9	Homo sapiens	26%	97%
Q8BQS5	Mus musculus	34%	87%
Q8N4S7	Homo sapiens	29%	100%
Q91VH1	Mus musculus	34%	90%
Q93ZH9	Arabidopsis thaliana	36%	100%
Q94177	Caenorhabditis elegans	35%	78%
Q96A54	Homo sapiens	34%	90%
Q9DCU0	Mus musculus	25%	100%
Q9JJE4	Mus musculus	29%	100%
Q9NXK6	Homo sapiens	25%	100%
Q9VCY8	Drosophila melanogaster	35%	76%
Q9ZUH8	Arabidopsis thaliana	33%	98%
V5BJ57	Trypanosoma cruzi	40%	100%
V5DK49	Trypanosoma cruzi	39%	99%