LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Flagellum attachment zone protein 5
Species:
Leishmania donovani
UniProt:
A0A3S7XC04_LEIDO
TriTrypDb:
LdBPK_366230.1 * , LdCL_360069700 , LDHU3_36.8270
Length:
623

Annotations

LeishMANIAdb annotations

Very tentatively might be a transmembrane chaperone for some unknown protein secretion process. Not unique to kinetoplastids, also found in fungi and other Eukaryotes.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8
GO:0005856 cytoskeleton 5 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1

Expansion

Sequence features

A0A3S7XC04
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XC04

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 403 407 PF00656 0.805
CLV_C14_Caspase3-7 421 425 PF00656 0.673
CLV_C14_Caspase3-7 479 483 PF00656 0.778
CLV_NRD_NRD_1 221 223 PF00675 0.381
CLV_NRD_NRD_1 33 35 PF00675 0.387
CLV_NRD_NRD_1 373 375 PF00675 0.404
CLV_NRD_NRD_1 379 381 PF00675 0.466
CLV_NRD_NRD_1 464 466 PF00675 0.597
CLV_NRD_NRD_1 508 510 PF00675 0.613
CLV_NRD_NRD_1 517 519 PF00675 0.600
CLV_NRD_NRD_1 53 55 PF00675 0.201
CLV_NRD_NRD_1 557 559 PF00675 0.540
CLV_NRD_NRD_1 620 622 PF00675 0.483
CLV_NRD_NRD_1 7 9 PF00675 0.449
CLV_PCSK_KEX2_1 221 223 PF00082 0.381
CLV_PCSK_KEX2_1 372 374 PF00082 0.435
CLV_PCSK_KEX2_1 379 381 PF00082 0.486
CLV_PCSK_KEX2_1 464 466 PF00082 0.589
CLV_PCSK_KEX2_1 508 510 PF00082 0.613
CLV_PCSK_KEX2_1 517 519 PF00082 0.600
CLV_PCSK_KEX2_1 9 11 PF00082 0.420
CLV_PCSK_PC1ET2_1 9 11 PF00082 0.420
CLV_PCSK_SKI1_1 27 31 PF00082 0.373
CLV_PCSK_SKI1_1 34 38 PF00082 0.384
CLV_PCSK_SKI1_1 411 415 PF00082 0.609
DEG_APCC_DBOX_1 281 289 PF00400 0.410
DEG_Nend_UBRbox_4 1 3 PF02207 0.697
DEG_SCF_FBW7_1 459 466 PF00400 0.753
DOC_CKS1_1 146 151 PF01111 0.634
DOC_CKS1_1 384 389 PF01111 0.711
DOC_CKS1_1 460 465 PF01111 0.843
DOC_MAPK_DCC_7 341 351 PF00069 0.389
DOC_MAPK_gen_1 221 229 PF00069 0.536
DOC_MAPK_gen_1 267 277 PF00069 0.319
DOC_MAPK_gen_1 332 342 PF00069 0.381
DOC_MAPK_gen_1 8 20 PF00069 0.615
DOC_MAPK_HePTP_8 215 227 PF00069 0.442
DOC_MAPK_MEF2A_6 218 227 PF00069 0.539
DOC_MAPK_MEF2A_6 270 279 PF00069 0.345
DOC_MAPK_MEF2A_6 303 310 PF00069 0.549
DOC_MAPK_RevD_3 358 373 PF00069 0.422
DOC_PP1_RVXF_1 25 32 PF00149 0.556
DOC_PP4_FxxP_1 175 178 PF00568 0.492
DOC_USP7_MATH_1 23 27 PF00917 0.657
DOC_USP7_MATH_1 463 467 PF00917 0.781
DOC_USP7_MATH_1 615 619 PF00917 0.729
DOC_USP7_MATH_1 83 87 PF00917 0.415
DOC_WW_Pin1_4 145 150 PF00397 0.677
DOC_WW_Pin1_4 160 165 PF00397 0.568
DOC_WW_Pin1_4 19 24 PF00397 0.622
DOC_WW_Pin1_4 232 237 PF00397 0.618
DOC_WW_Pin1_4 383 388 PF00397 0.665
DOC_WW_Pin1_4 459 464 PF00397 0.770
DOC_WW_Pin1_4 469 474 PF00397 0.717
DOC_WW_Pin1_4 483 488 PF00397 0.810
DOC_WW_Pin1_4 517 522 PF00397 0.836
LIG_14-3-3_CanoR_1 267 273 PF00244 0.386
LIG_14-3-3_CanoR_1 34 39 PF00244 0.606
LIG_14-3-3_CanoR_1 464 470 PF00244 0.788
LIG_14-3-3_CanoR_1 485 495 PF00244 0.700
LIG_14-3-3_CanoR_1 565 570 PF00244 0.774
LIG_14-3-3_CanoR_1 595 600 PF00244 0.819
LIG_BIR_III_4 64 68 PF00653 0.585
LIG_BRCT_BRCA1_1 324 328 PF00533 0.378
LIG_BRCT_BRCA1_1 426 430 PF00533 0.683
LIG_DLG_GKlike_1 595 602 PF00625 0.734
LIG_eIF4E_1 15 21 PF01652 0.616
LIG_eIF4E_1 210 216 PF01652 0.391
LIG_eIF4E_1 42 48 PF01652 0.614
LIG_eIF4E_1 90 96 PF01652 0.438
LIG_FHA_1 210 216 PF00498 0.441
LIG_FHA_1 297 303 PF00498 0.548
LIG_FHA_1 361 367 PF00498 0.422
LIG_FHA_1 573 579 PF00498 0.771
LIG_FHA_2 149 155 PF00498 0.636
LIG_FHA_2 449 455 PF00498 0.731
LIG_FHA_2 523 529 PF00498 0.783
LIG_FHA_2 574 580 PF00498 0.781
LIG_LIR_Apic_2 173 178 PF02991 0.415
LIG_LIR_Apic_2 214 220 PF02991 0.419
LIG_LIR_Gen_1 112 123 PF02991 0.382
LIG_LIR_Gen_1 198 205 PF02991 0.304
LIG_LIR_Gen_1 271 281 PF02991 0.358
LIG_LIR_Gen_1 352 362 PF02991 0.438
LIG_LIR_Gen_1 417 426 PF02991 0.661
LIG_LIR_Gen_1 427 437 PF02991 0.687
LIG_LIR_Gen_1 444 453 PF02991 0.693
LIG_LIR_Gen_1 540 550 PF02991 0.785
LIG_LIR_Gen_1 596 605 PF02991 0.775
LIG_LIR_Nem_3 112 118 PF02991 0.387
LIG_LIR_Nem_3 119 123 PF02991 0.340
LIG_LIR_Nem_3 173 177 PF02991 0.429
LIG_LIR_Nem_3 269 275 PF02991 0.301
LIG_LIR_Nem_3 352 358 PF02991 0.438
LIG_LIR_Nem_3 417 423 PF02991 0.662
LIG_LIR_Nem_3 427 433 PF02991 0.683
LIG_LIR_Nem_3 444 449 PF02991 0.692
LIG_LIR_Nem_3 540 546 PF02991 0.763
LIG_LIR_Nem_3 596 602 PF02991 0.777
LIG_LIR_Nem_3 63 69 PF02991 0.565
LIG_LIR_Nem_3 71 77 PF02991 0.577
LIG_MLH1_MIPbox_1 324 328 PF16413 0.378
LIG_NRBOX 13 19 PF00104 0.550
LIG_NRP_CendR_1 621 623 PF00754 0.613
LIG_Pex14_1 12 16 PF04695 0.639
LIG_Pex14_1 272 276 PF04695 0.357
LIG_Pex14_2 175 179 PF04695 0.492
LIG_Pex14_2 243 247 PF04695 0.361
LIG_PTB_Apo_2 237 244 PF02174 0.422
LIG_SH2_CRK 182 186 PF00017 0.454
LIG_SH2_CRK 239 243 PF00017 0.416
LIG_SH2_CRK 470 474 PF00017 0.763
LIG_SH2_CRK 58 62 PF00017 0.550
LIG_SH2_CRK 599 603 PF00017 0.776
LIG_SH2_CRK 66 70 PF00017 0.540
LIG_SH2_CRK 90 94 PF00017 0.438
LIG_SH2_GRB2like 549 552 PF00017 0.774
LIG_SH2_NCK_1 392 396 PF00017 0.637
LIG_SH2_NCK_1 543 547 PF00017 0.783
LIG_SH2_NCK_1 58 62 PF00017 0.638
LIG_SH2_PTP2 115 118 PF00017 0.389
LIG_SH2_SRC 152 155 PF00017 0.712
LIG_SH2_SRC 392 395 PF00017 0.635
LIG_SH2_STAP1 211 215 PF00017 0.438
LIG_SH2_STAP1 392 396 PF00017 0.665
LIG_SH2_STAP1 569 573 PF00017 0.735
LIG_SH2_STAP1 90 94 PF00017 0.492
LIG_SH2_STAT3 571 574 PF00017 0.822
LIG_SH2_STAT3 584 587 PF00017 0.753
LIG_SH2_STAT5 115 118 PF00017 0.445
LIG_SH2_STAT5 16 19 PF00017 0.661
LIG_SH2_STAT5 174 177 PF00017 0.427
LIG_SH2_STAT5 182 185 PF00017 0.395
LIG_SH2_STAT5 196 199 PF00017 0.354
LIG_SH2_STAT5 211 214 PF00017 0.282
LIG_SH2_STAT5 273 276 PF00017 0.362
LIG_SH2_STAT5 298 301 PF00017 0.604
LIG_SH2_STAT5 327 330 PF00017 0.418
LIG_SH2_STAT5 350 353 PF00017 0.350
LIG_SH2_STAT5 46 49 PF00017 0.537
LIG_SH2_STAT5 524 527 PF00017 0.784
LIG_SH2_STAT5 543 546 PF00017 0.740
LIG_SH2_STAT5 56 59 PF00017 0.533
LIG_SH2_STAT5 571 574 PF00017 0.779
LIG_SH2_STAT5 577 580 PF00017 0.784
LIG_SH2_STAT5 584 587 PF00017 0.775
LIG_SH3_3 453 459 PF00018 0.775
LIG_SH3_3 73 79 PF00018 0.603
LIG_SUMO_SIM_anti_2 363 369 PF11976 0.415
LIG_SUMO_SIM_anti_2 91 97 PF11976 0.492
LIG_SUMO_SIM_par_1 16 22 PF11976 0.617
LIG_SUMO_SIM_par_1 91 97 PF11976 0.434
LIG_TRAF2_1 151 154 PF00917 0.631
LIG_TRAF2_1 375 378 PF00917 0.644
LIG_TRAF2_1 451 454 PF00917 0.803
LIG_TRAF2_1 525 528 PF00917 0.761
LIG_TYR_ITIM 172 177 PF00017 0.438
LIG_TYR_ITIM 180 185 PF00017 0.544
LIG_TYR_ITIM 237 242 PF00017 0.410
LIG_TYR_ITIM 88 93 PF00017 0.438
LIG_WRC_WIRS_1 313 318 PF05994 0.391
LIG_WW_3 5 9 PF00397 0.660
MOD_CDC14_SPxK_1 520 523 PF00782 0.783
MOD_CDK_SPK_2 145 150 PF00069 0.626
MOD_CDK_SPK_2 459 464 PF00069 0.775
MOD_CDK_SPK_2 469 474 PF00069 0.712
MOD_CDK_SPxK_1 459 465 PF00069 0.754
MOD_CDK_SPxK_1 517 523 PF00069 0.838
MOD_CK1_1 22 28 PF00069 0.604
MOD_CK1_1 315 321 PF00069 0.422
MOD_CK1_1 425 431 PF00069 0.753
MOD_CK1_1 512 518 PF00069 0.839
MOD_CK1_1 530 536 PF00069 0.660
MOD_CK1_1 567 573 PF00069 0.767
MOD_CK1_1 588 594 PF00069 0.744
MOD_CK1_1 597 603 PF00069 0.722
MOD_CK1_1 604 610 PF00069 0.668
MOD_CK2_1 148 154 PF00069 0.628
MOD_CK2_1 372 378 PF00069 0.606
MOD_CK2_1 448 454 PF00069 0.731
MOD_CK2_1 522 528 PF00069 0.769
MOD_CK2_1 57 63 PF00069 0.597
MOD_GlcNHglycan 406 409 PF01048 0.608
MOD_GlcNHglycan 511 514 PF01048 0.602
MOD_GlcNHglycan 527 532 PF01048 0.607
MOD_GlcNHglycan 603 606 PF01048 0.524
MOD_GlcNHglycan 613 616 PF01048 0.574
MOD_GlcNHglycan 617 620 PF01048 0.482
MOD_GlcNHglycan 70 73 PF01048 0.360
MOD_GSK3_1 180 187 PF00069 0.574
MOD_GSK3_1 19 26 PF00069 0.610
MOD_GSK3_1 422 429 PF00069 0.740
MOD_GSK3_1 459 466 PF00069 0.780
MOD_GSK3_1 486 493 PF00069 0.773
MOD_GSK3_1 509 516 PF00069 0.802
MOD_GSK3_1 541 548 PF00069 0.804
MOD_GSK3_1 561 568 PF00069 0.582
MOD_GSK3_1 569 576 PF00069 0.701
MOD_GSK3_1 587 594 PF00069 0.632
MOD_GSK3_1 597 604 PF00069 0.678
MOD_GSK3_1 611 618 PF00069 0.723
MOD_LATS_1 593 599 PF00433 0.793
MOD_N-GLC_1 50 55 PF02516 0.412
MOD_NEK2_1 195 200 PF00069 0.430
MOD_NEK2_1 209 214 PF00069 0.393
MOD_NEK2_1 268 273 PF00069 0.407
MOD_NEK2_1 296 301 PF00069 0.534
MOD_NEK2_1 321 326 PF00069 0.358
MOD_NEK2_1 360 365 PF00069 0.354
MOD_NEK2_1 563 568 PF00069 0.728
MOD_NEK2_1 57 62 PF00069 0.567
MOD_NEK2_1 68 73 PF00069 0.517
MOD_PIKK_1 180 186 PF00454 0.528
MOD_PIKK_1 463 469 PF00454 0.779
MOD_PIKK_1 585 591 PF00454 0.770
MOD_PKA_1 34 40 PF00069 0.605
MOD_PKA_1 372 378 PF00069 0.632
MOD_PKA_2 266 272 PF00069 0.310
MOD_PKA_2 372 378 PF00069 0.632
MOD_PKA_2 463 469 PF00069 0.737
MOD_PKA_2 497 503 PF00069 0.784
MOD_PKA_2 564 570 PF00069 0.790
MOD_PKA_2 594 600 PF00069 0.791
MOD_Plk_1 544 550 PF00069 0.786
MOD_Plk_2-3 154 160 PF00069 0.641
MOD_Plk_2-3 448 454 PF00069 0.720
MOD_Plk_4 154 160 PF00069 0.609
MOD_Plk_4 170 176 PF00069 0.282
MOD_Plk_4 195 201 PF00069 0.360
MOD_Plk_4 211 217 PF00069 0.355
MOD_Plk_4 312 318 PF00069 0.379
MOD_Plk_4 322 328 PF00069 0.298
MOD_Plk_4 349 355 PF00069 0.400
MOD_Plk_4 360 366 PF00069 0.378
MOD_Plk_4 545 551 PF00069 0.781
MOD_Plk_4 573 579 PF00069 0.761
MOD_Plk_4 83 89 PF00069 0.381
MOD_ProDKin_1 145 151 PF00069 0.676
MOD_ProDKin_1 160 166 PF00069 0.564
MOD_ProDKin_1 19 25 PF00069 0.615
MOD_ProDKin_1 232 238 PF00069 0.610
MOD_ProDKin_1 383 389 PF00069 0.670
MOD_ProDKin_1 459 465 PF00069 0.771
MOD_ProDKin_1 469 475 PF00069 0.718
MOD_ProDKin_1 483 489 PF00069 0.808
MOD_ProDKin_1 517 523 PF00069 0.838
TRG_DiLeu_BaEn_1 97 102 PF01217 0.438
TRG_DiLeu_BaEn_4 453 459 PF01217 0.678
TRG_DiLeu_BaLyEn_6 76 81 PF01217 0.606
TRG_ENDOCYTIC_2 115 118 PF00928 0.417
TRG_ENDOCYTIC_2 15 18 PF00928 0.549
TRG_ENDOCYTIC_2 174 177 PF00928 0.357
TRG_ENDOCYTIC_2 182 185 PF00928 0.378
TRG_ENDOCYTIC_2 199 202 PF00928 0.269
TRG_ENDOCYTIC_2 239 242 PF00928 0.388
TRG_ENDOCYTIC_2 273 276 PF00928 0.324
TRG_ENDOCYTIC_2 350 353 PF00928 0.363
TRG_ENDOCYTIC_2 446 449 PF00928 0.714
TRG_ENDOCYTIC_2 46 49 PF00928 0.537
TRG_ENDOCYTIC_2 543 546 PF00928 0.773
TRG_ENDOCYTIC_2 58 61 PF00928 0.545
TRG_ENDOCYTIC_2 599 602 PF00928 0.778
TRG_ENDOCYTIC_2 66 69 PF00928 0.412
TRG_ENDOCYTIC_2 90 93 PF00928 0.438
TRG_ER_diArg_1 220 222 PF00400 0.582
TRG_ER_diArg_1 339 342 PF00400 0.416
TRG_ER_diArg_1 371 374 PF00400 0.638
TRG_ER_diArg_1 379 381 PF00400 0.688
TRG_ER_diArg_1 463 465 PF00400 0.771
TRG_ER_diArg_1 507 509 PF00400 0.687
TRG_ER_diArg_1 7 10 PF00400 0.647
TRG_NLS_MonoExtN_4 6 12 PF00514 0.631

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IAE8 Leptomonas seymouri 60% 99%
A0A422NJ92 Trypanosoma rangeli 44% 100%
A4HQB6 Leishmania braziliensis 65% 100%
A4IE10 Leishmania infantum 100% 100%
E9AU32 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
Q4Q0G3 Leishmania major 90% 100%
V5DK11 Trypanosoma cruzi 40% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS