DUF3456 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XC03_LEIDO

TriTrypDb:

LdBPK_365900.1 , LdCL_360066400 , LDHU3_36.7810

Length:

327

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 11, no: 0
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XC03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XC03

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.533
CLV_C14_Caspase3-7	227	231	PF00656	0.540
CLV_NRD_NRD_1	212	214	PF00675	0.547
CLV_NRD_NRD_1	268	270	PF00675	0.579
CLV_NRD_NRD_1	308	310	PF00675	0.626
CLV_NRD_NRD_1	316	318	PF00675	0.578
CLV_NRD_NRD_1	37	39	PF00675	0.683
CLV_NRD_NRD_1	79	81	PF00675	0.519
CLV_PCSK_FUR_1	314	318	PF00082	0.697
CLV_PCSK_KEX2_1	122	124	PF00082	0.675
CLV_PCSK_KEX2_1	268	270	PF00082	0.579
CLV_PCSK_KEX2_1	316	318	PF00082	0.759
CLV_PCSK_KEX2_1	74	76	PF00082	0.445
CLV_PCSK_KEX2_1	81	83	PF00082	0.475
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.651
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.502
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.584
CLV_PCSK_PC7_1	264	270	PF00082	0.640
CLV_PCSK_SKI1_1	174	178	PF00082	0.529
CLV_PCSK_SKI1_1	207	211	PF00082	0.481
CLV_PCSK_SKI1_1	268	272	PF00082	0.575
DOC_CKS1_1	43	48	PF01111	0.526
DOC_CYCLIN_RxL_1	36	45	PF00134	0.605
DOC_CYCLIN_yCln2_LP_2	43	49	PF00134	0.602
DOC_MAPK_gen_1	147	157	PF00069	0.542
DOC_MAPK_gen_1	213	219	PF00069	0.535
DOC_MAPK_MEF2A_6	134	141	PF00069	0.597
DOC_PP1_RVXF_1	189	196	PF00149	0.579
DOC_PP4_FxxP_1	198	201	PF00568	0.518
DOC_WW_Pin1_4	129	134	PF00397	0.707
DOC_WW_Pin1_4	199	204	PF00397	0.467
DOC_WW_Pin1_4	2	7	PF00397	0.646
DOC_WW_Pin1_4	42	47	PF00397	0.544
LIG_14-3-3_CanoR_1	134	140	PF00244	0.576
LIG_14-3-3_CanoR_1	14	24	PF00244	0.616
LIG_Actin_WH2_2	212	228	PF00022	0.595
LIG_FHA_1	11	17	PF00498	0.662
LIG_FHA_1	152	158	PF00498	0.474
LIG_FHA_2	286	292	PF00498	0.642
LIG_FHA_2	297	303	PF00498	0.644
LIG_G3BP_FGDF_1	193	198	PF02136	0.349
LIG_GBD_Chelix_1	24	32	PF00786	0.522
LIG_LIR_Apic_2	197	201	PF02991	0.542
LIG_LIR_Gen_1	294	304	PF02991	0.543
LIG_LIR_Gen_1	61	69	PF02991	0.460
LIG_LIR_Nem_3	192	198	PF02991	0.570
LIG_LIR_Nem_3	294	300	PF02991	0.537
LIG_LIR_Nem_3	45	50	PF02991	0.499
LIG_LIR_Nem_3	61	65	PF02991	0.426
LIG_LYPXL_yS_3	47	50	PF13949	0.561
LIG_PDZ_Class_3	322	327	PF00595	0.743
LIG_PTAP_UEV_1	317	322	PF05743	0.704
LIG_PTB_Apo_2	63	70	PF02174	0.452
LIG_PTB_Phospho_1	63	69	PF10480	0.451
LIG_SH3_3	315	321	PF00018	0.749
LIG_SH3_3	43	49	PF00018	0.546
LIG_SH3_3	9	15	PF00018	0.626
LIG_SUMO_SIM_anti_2	153	161	PF11976	0.553
LIG_SUMO_SIM_anti_2	18	25	PF11976	0.551
LIG_TYR_ITSM	43	50	PF00017	0.518
LIG_WRC_WIRS_1	195	200	PF05994	0.479
LIG_WRC_WIRS_1	59	64	PF05994	0.446
MOD_CDK_SPK_2	129	134	PF00069	0.624
MOD_CDK_SPxxK_3	199	206	PF00069	0.357
MOD_CK1_1	319	325	PF00069	0.784
MOD_CK1_1	5	11	PF00069	0.696
MOD_CK2_1	260	266	PF00069	0.557
MOD_CK2_1	290	296	PF00069	0.565
MOD_GlcNHglycan	164	167	PF01048	0.525
MOD_GlcNHglycan	18	21	PF01048	0.510
MOD_GlcNHglycan	257	260	PF01048	0.677
MOD_GlcNHglycan	318	321	PF01048	0.763
MOD_GlcNHglycan	35	38	PF01048	0.557
MOD_N-GLC_1	183	188	PF02516	0.525
MOD_N-GLC_2	96	98	PF02516	0.537
MOD_NEK2_1	16	21	PF00069	0.524
MOD_PKA_1	316	322	PF00069	0.703
MOD_PKA_2	225	231	PF00069	0.636
MOD_PKA_2	249	255	PF00069	0.629
MOD_PKA_2	316	322	PF00069	0.775
MOD_PKB_1	314	322	PF00069	0.699
MOD_Plk_1	295	301	PF00069	0.607
MOD_Plk_2-3	236	242	PF00069	0.644
MOD_Plk_2-3	296	302	PF00069	0.570
MOD_Plk_4	207	213	PF00069	0.569
MOD_Plk_4	243	249	PF00069	0.613
MOD_Plk_4	58	64	PF00069	0.415
MOD_ProDKin_1	129	135	PF00069	0.694
MOD_ProDKin_1	199	205	PF00069	0.465
MOD_ProDKin_1	2	8	PF00069	0.647
MOD_ProDKin_1	42	48	PF00069	0.537
MOD_SUMO_for_1	73	76	PF00179	0.489
MOD_SUMO_rev_2	172	181	PF00179	0.365
TRG_ENDOCYTIC_2	47	50	PF00928	0.561
TRG_ER_diArg_1	267	269	PF00400	0.588
TRG_ER_diArg_1	314	317	PF00400	0.766
TRG_ER_diArg_1	80	83	PF00400	0.513
TRG_NES_CRM1_1	89	103	PF08389	0.589
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.617

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P915	Leptomonas seymouri	51%	100%
A0A0S4IVP5	Bodo saltans	26%	100%
A0A1X0P0S9	Trypanosomatidae	31%	100%
A0A3R7NVI0	Trypanosoma rangeli	31%	100%
A4HQ81	Leishmania braziliensis	65%	99%
A4IDX9	Leishmania infantum	100%	100%
D0A431	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ATZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q0J6	Leishmania major	92%	100%
V5DK35	Trypanosoma cruzi	34%	99%