Rab-like GTPase activating protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

rab-like GTPase activating protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XBZ8_LEIDO

TriTrypDb:

LdBPK_366340.1 , LdCL_360070800 , LDHU3_36.8400

Length:

413

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0000331	contractile vacuole	6	1
GO:0005773	vacuole	5	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

A0A3S7XBZ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBZ8

Function

Biological processes
Term	Name	Level	Count
GO:0043085	positive regulation of catalytic activity	4	2
GO:0043087	regulation of GTPase activity	5	2
GO:0043547	positive regulation of GTPase activity	6	2
GO:0044093	positive regulation of molecular function	3	2
GO:0050790	regulation of catalytic activity	3	2
GO:0051336	regulation of hydrolase activity	4	2
GO:0051345	positive regulation of hydrolase activity	5	2
GO:0065007	biological regulation	1	2
GO:0065009	regulation of molecular function	2	2
GO:0090630	activation of GTPase activity	7	2

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	2
GO:0008047	enzyme activator activity	3	2
GO:0030234	enzyme regulator activity	2	2
GO:0030695	GTPase regulator activity	4	2
GO:0060589	nucleoside-triphosphatase regulator activity	3	2
GO:0098772	molecular function regulator activity	1	2
GO:0140677	molecular function activator activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	49	53	PF00656	0.490
CLV_NRD_NRD_1	114	116	PF00675	0.476
CLV_NRD_NRD_1	12	14	PF00675	0.535
CLV_NRD_NRD_1	147	149	PF00675	0.366
CLV_NRD_NRD_1	219	221	PF00675	0.402
CLV_NRD_NRD_1	296	298	PF00675	0.281
CLV_NRD_NRD_1	360	362	PF00675	0.364
CLV_NRD_NRD_1	88	90	PF00675	0.571
CLV_PCSK_KEX2_1	114	116	PF00082	0.478
CLV_PCSK_KEX2_1	12	14	PF00082	0.535
CLV_PCSK_KEX2_1	143	145	PF00082	0.354
CLV_PCSK_KEX2_1	147	149	PF00082	0.343
CLV_PCSK_KEX2_1	154	156	PF00082	0.230
CLV_PCSK_KEX2_1	219	221	PF00082	0.400
CLV_PCSK_KEX2_1	360	362	PF00082	0.241
CLV_PCSK_KEX2_1	382	384	PF00082	0.390
CLV_PCSK_KEX2_1	88	90	PF00082	0.580
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.359
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.310
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.473
CLV_PCSK_SKI1_1	219	223	PF00082	0.262
CLV_PCSK_SKI1_1	271	275	PF00082	0.364
CLV_PCSK_SKI1_1	349	353	PF00082	0.328
CLV_PCSK_SKI1_1	360	364	PF00082	0.276
CLV_PCSK_SKI1_1	389	393	PF00082	0.343
CLV_PCSK_SKI1_1	81	85	PF00082	0.489
DEG_APCC_DBOX_1	348	356	PF00400	0.394
DEG_Nend_Nbox_1	1	3	PF02207	0.730
DEG_SPOP_SBC_1	32	36	PF00917	0.695
DOC_CKS1_1	64	69	PF01111	0.484
DOC_MAPK_DCC_7	169	177	PF00069	0.386
DOC_MAPK_MEF2A_6	169	177	PF00069	0.377
DOC_MAPK_MEF2A_6	345	354	PF00069	0.229
DOC_MAPK_MEF2A_6	389	396	PF00069	0.400
DOC_PP1_RVXF_1	391	397	PF00149	0.427
DOC_PP2B_LxvP_1	84	87	PF13499	0.580
DOC_USP7_MATH_1	183	187	PF00917	0.280
DOC_USP7_MATH_1	58	62	PF00917	0.627
DOC_USP7_MATH_1	75	79	PF00917	0.669
DOC_USP7_UBL2_3	267	271	PF12436	0.217
DOC_USP7_UBL2_3	389	393	PF12436	0.392
DOC_WW_Pin1_4	13	18	PF00397	0.769
DOC_WW_Pin1_4	63	68	PF00397	0.666
LIG_14-3-3_CanoR_1	178	183	PF00244	0.321
LIG_14-3-3_CanoR_1	205	210	PF00244	0.224
LIG_14-3-3_CanoR_1	360	366	PF00244	0.468
LIG_14-3-3_CanoR_1	395	404	PF00244	0.425
LIG_14-3-3_CanoR_1	72	80	PF00244	0.673
LIG_AP2alpha_1	94	98	PF02296	0.359
LIG_APCC_ABBA_1	2	7	PF00400	0.683
LIG_Clathr_ClatBox_1	354	358	PF01394	0.337
LIG_deltaCOP1_diTrp_1	125	134	PF00928	0.381
LIG_deltaCOP1_diTrp_1	252	259	PF00928	0.397
LIG_eIF4E_1	286	292	PF01652	0.227
LIG_eIF4E_1	326	332	PF01652	0.371
LIG_FHA_1	201	207	PF00498	0.323
LIG_FHA_1	22	28	PF00498	0.711
LIG_FHA_1	242	248	PF00498	0.311
LIG_FHA_1	367	373	PF00498	0.414
LIG_FHA_2	101	107	PF00498	0.434
LIG_FHA_2	32	38	PF00498	0.540
LIG_FHA_2	365	371	PF00498	0.308
LIG_GBD_Chelix_1	189	197	PF00786	0.323
LIG_LIR_Gen_1	125	135	PF02991	0.387
LIG_LIR_Gen_1	254	263	PF02991	0.313
LIG_LIR_Gen_1	333	340	PF02991	0.384
LIG_LIR_Gen_1	93	102	PF02991	0.319
LIG_LIR_Nem_3	132	137	PF02991	0.349
LIG_LIR_Nem_3	253	259	PF02991	0.268
LIG_LIR_Nem_3	277	281	PF02991	0.352
LIG_LIR_Nem_3	321	326	PF02991	0.304
LIG_LIR_Nem_3	333	339	PF02991	0.351
LIG_LIR_Nem_3	342	347	PF02991	0.292
LIG_LIR_Nem_3	96	101	PF02991	0.358
LIG_PCNA_PIPBox_1	296	305	PF02747	0.394
LIG_Pex14_1	344	348	PF04695	0.262
LIG_Pex14_2	274	278	PF04695	0.365
LIG_Pex14_2	319	323	PF04695	0.269
LIG_Pex14_2	94	98	PF04695	0.339
LIG_PTB_Apo_2	262	269	PF02174	0.422
LIG_PTB_Phospho_1	262	268	PF10480	0.422
LIG_SH2_CRK	176	180	PF00017	0.252
LIG_SH2_GRB2like	225	228	PF00017	0.267
LIG_SH2_GRB2like	326	329	PF00017	0.371
LIG_SH2_GRB2like	400	403	PF00017	0.279
LIG_SH2_NCK_1	119	123	PF00017	0.321
LIG_SH2_STAP1	119	123	PF00017	0.321
LIG_SH2_STAP1	314	318	PF00017	0.229
LIG_SH2_STAT3	408	411	PF00017	0.454
LIG_SH2_STAT5	123	126	PF00017	0.398
LIG_SH2_STAT5	145	148	PF00017	0.513
LIG_SH2_STAT5	234	237	PF00017	0.267
LIG_SH2_STAT5	286	289	PF00017	0.351
LIG_SH2_STAT5	326	329	PF00017	0.274
LIG_SH3_3	147	153	PF00018	0.322
LIG_SH3_3	270	276	PF00018	0.268
LIG_SUMO_SIM_anti_2	367	376	PF11976	0.494
LIG_SUMO_SIM_par_1	361	370	PF11976	0.420
LIG_TRAF2_1	103	106	PF00917	0.423
LIG_TRAF2_1	35	38	PF00917	0.538
LIG_UBA3_1	371	376	PF00899	0.392
MOD_CDK_SPxK_1	63	69	PF00069	0.637
MOD_CDK_SPxxK_3	63	70	PF00069	0.471
MOD_CK1_1	16	22	PF00069	0.611
MOD_CK1_1	208	214	PF00069	0.454
MOD_CK1_1	364	370	PF00069	0.317
MOD_CK1_1	63	69	PF00069	0.610
MOD_CK2_1	100	106	PF00069	0.410
MOD_CK2_1	31	37	PF00069	0.539
MOD_CK2_1	364	370	PF00069	0.393
MOD_GlcNHglycan	210	213	PF01048	0.447
MOD_GlcNHglycan	397	400	PF01048	0.515
MOD_GlcNHglycan	60	63	PF01048	0.618
MOD_GlcNHglycan	84	87	PF01048	0.611
MOD_GSK3_1	12	19	PF00069	0.702
MOD_NEK2_1	162	167	PF00069	0.280
MOD_NEK2_1	197	202	PF00069	0.274
MOD_NEK2_1	241	246	PF00069	0.311
MOD_NEK2_1	387	392	PF00069	0.408
MOD_NEK2_1	73	78	PF00069	0.682
MOD_NEK2_2	318	323	PF00069	0.276
MOD_PIKK_1	178	184	PF00454	0.345
MOD_PIKK_1	41	47	PF00454	0.713
MOD_PK_1	205	211	PF00069	0.202
MOD_PKA_1	12	18	PF00069	0.538
MOD_PKA_2	12	18	PF00069	0.786
MOD_PKA_2	305	311	PF00069	0.251
MOD_Plk_1	197	203	PF00069	0.433
MOD_Plk_2-3	33	39	PF00069	0.544
MOD_Plk_4	241	247	PF00069	0.282
MOD_Plk_4	318	324	PF00069	0.275
MOD_ProDKin_1	13	19	PF00069	0.769
MOD_ProDKin_1	63	69	PF00069	0.667
MOD_SUMO_for_1	355	358	PF00179	0.292
MOD_SUMO_rev_2	104	109	PF00179	0.539
MOD_SUMO_rev_2	181	189	PF00179	0.237
TRG_DiLeu_BaEn_1	358	363	PF01217	0.276
TRG_DiLeu_BaEn_4	358	364	PF01217	0.300
TRG_DiLeu_LyEn_5	358	363	PF01217	0.286
TRG_ENDOCYTIC_2	176	179	PF00928	0.283
TRG_ENDOCYTIC_2	300	303	PF00928	0.264
TRG_ENDOCYTIC_2	326	329	PF00928	0.332
TRG_ER_diArg_1	11	13	PF00400	0.538
TRG_ER_diArg_1	218	220	PF00400	0.389
TRG_ER_diArg_1	360	362	PF00400	0.319
TRG_ER_diArg_1	87	89	PF00400	0.629
TRG_NES_CRM1_1	236	251	PF08389	0.286

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3T4	Leptomonas seymouri	59%	96%
A0A0N1PDX9	Leptomonas seymouri	36%	75%
A0A0S4II34	Bodo saltans	36%	97%
A0A0S4ITU5	Bodo saltans	26%	100%
A0A1X0NLM2	Trypanosomatidae	44%	100%
A0A1X0NLQ9	Trypanosomatidae	43%	97%
A0A1X0P1K5	Trypanosomatidae	26%	100%
A0A3R7MIU7	Trypanosoma rangeli	32%	100%
A0A3S7XC15	Leishmania donovani	41%	83%
A0A422NJ84	Trypanosoma rangeli	41%	99%
A0A422NJE8	Trypanosoma rangeli	42%	100%
A4HQC6	Leishmania braziliensis	40%	84%
A4HQC7	Leishmania braziliensis	72%	100%
A4IE19	Leishmania infantum	41%	83%
A4IE20	Leishmania infantum	100%	100%
D0A3X9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	99%
E9AU42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9AU43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q0F2	Leishmania major	93%	100%
Q4Q0F3	Leishmania major	36%	100%
Q6GLZ0	Xenopus laevis	32%	100%
Q8IV04	Homo sapiens	30%	93%
V5BT66	Trypanosoma cruzi	42%	100%