Bilobe protein, conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hook complex protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XBZ6_LEIDO

TriTrypDb:

LdBPK_366250.1 , LdCL_360069900 , LDHU3_36.8290

Length:

657

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XBZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBZ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	603	607	PF00656	0.713
CLV_NRD_NRD_1	237	239	PF00675	0.675
CLV_NRD_NRD_1	252	254	PF00675	0.320
CLV_NRD_NRD_1	390	392	PF00675	0.735
CLV_NRD_NRD_1	539	541	PF00675	0.561
CLV_NRD_NRD_1	554	556	PF00675	0.476
CLV_NRD_NRD_1	614	616	PF00675	0.724
CLV_NRD_NRD_1	643	645	PF00675	0.727
CLV_NRD_NRD_1	647	649	PF00675	0.733
CLV_PCSK_KEX2_1	237	239	PF00082	0.675
CLV_PCSK_KEX2_1	252	254	PF00082	0.320
CLV_PCSK_KEX2_1	334	336	PF00082	0.560
CLV_PCSK_KEX2_1	390	392	PF00082	0.681
CLV_PCSK_KEX2_1	539	541	PF00082	0.561
CLV_PCSK_KEX2_1	554	556	PF00082	0.476
CLV_PCSK_KEX2_1	614	616	PF00082	0.724
CLV_PCSK_KEX2_1	642	644	PF00082	0.736
CLV_PCSK_KEX2_1	647	649	PF00082	0.734
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.529
CLV_PCSK_PC7_1	233	239	PF00082	0.642
CLV_PCSK_PC7_1	643	649	PF00082	0.581
CLV_PCSK_SKI1_1	116	120	PF00082	0.513
CLV_PCSK_SKI1_1	127	131	PF00082	0.293
CLV_PCSK_SKI1_1	146	150	PF00082	0.339
CLV_PCSK_SKI1_1	369	373	PF00082	0.483
CLV_PCSK_SKI1_1	54	58	PF00082	0.516
CLV_PCSK_SKI1_1	614	618	PF00082	0.686
CLV_Separin_Metazoa	551	555	PF03568	0.546
DEG_APCC_DBOX_1	53	61	PF00400	0.484
DEG_SCF_FBW7_1	198	205	PF00400	0.666
DEG_SCF_FBW7_1	617	622	PF00400	0.694
DEG_SCF_FBW7_1	633	639	PF00400	0.569
DEG_SCF_TRCP1_1	382	388	PF00400	0.587
DEG_SPOP_SBC_1	47	51	PF00917	0.593
DEG_SPOP_SBC_1	593	597	PF00917	0.650
DOC_CKS1_1	199	204	PF01111	0.669
DOC_CKS1_1	630	635	PF01111	0.714
DOC_CYCLIN_RxL_1	143	150	PF00134	0.317
DOC_CYCLIN_yCln2_LP_2	270	276	PF00134	0.488
DOC_MAPK_gen_1	127	136	PF00069	0.314
DOC_MAPK_gen_1	246	256	PF00069	0.560
DOC_MAPK_MEF2A_6	249	258	PF00069	0.502
DOC_MAPK_MEF2A_6	369	376	PF00069	0.430
DOC_PP1_RVXF_1	144	150	PF00149	0.314
DOC_PP1_RVXF_1	302	309	PF00149	0.530
DOC_PP1_RVXF_1	323	329	PF00149	0.415
DOC_PP4_FxxP_1	125	128	PF00568	0.542
DOC_PP4_FxxP_1	448	451	PF00568	0.671
DOC_PP4_FxxP_1	630	633	PF00568	0.678
DOC_USP7_MATH_1	231	235	PF00917	0.676
DOC_USP7_MATH_1	400	404	PF00917	0.641
DOC_USP7_MATH_1	42	46	PF00917	0.550
DOC_USP7_MATH_1	47	51	PF00917	0.697
DOC_USP7_MATH_1	527	531	PF00917	0.718
DOC_USP7_MATH_1	593	597	PF00917	0.694
DOC_USP7_MATH_1	621	625	PF00917	0.690
DOC_USP7_MATH_1	626	630	PF00917	0.714
DOC_USP7_MATH_1	636	640	PF00917	0.655
DOC_WW_Pin1_4	173	178	PF00397	0.767
DOC_WW_Pin1_4	198	203	PF00397	0.631
DOC_WW_Pin1_4	383	388	PF00397	0.645
DOC_WW_Pin1_4	389	394	PF00397	0.680
DOC_WW_Pin1_4	441	446	PF00397	0.762
DOC_WW_Pin1_4	477	482	PF00397	0.713
DOC_WW_Pin1_4	499	504	PF00397	0.628
DOC_WW_Pin1_4	516	521	PF00397	0.689
DOC_WW_Pin1_4	615	620	PF00397	0.632
DOC_WW_Pin1_4	629	634	PF00397	0.609
DOC_WW_Pin1_4	646	651	PF00397	0.593
LIG_14-3-3_CanoR_1	165	170	PF00244	0.699
LIG_14-3-3_CanoR_1	184	190	PF00244	0.512
LIG_14-3-3_CanoR_1	218	224	PF00244	0.705
LIG_14-3-3_CanoR_1	227	236	PF00244	0.594
LIG_14-3-3_CanoR_1	314	318	PF00244	0.484
LIG_14-3-3_CanoR_1	327	331	PF00244	0.359
LIG_14-3-3_CanoR_1	499	503	PF00244	0.677
LIG_14-3-3_CanoR_1	564	570	PF00244	0.617
LIG_14-3-3_CanoR_1	594	599	PF00244	0.625
LIG_14-3-3_CanoR_1	642	650	PF00244	0.691
LIG_BIR_III_4	138	142	PF00653	0.406
LIG_BIR_III_4	25	29	PF00653	0.480
LIG_DCNL_PONY_1	1	4	PF03556	0.390
LIG_deltaCOP1_diTrp_1	353	361	PF00928	0.534
LIG_deltaCOP1_diTrp_1	571	576	PF00928	0.541
LIG_eIF4E_1	455	461	PF01652	0.633
LIG_EVH1_2	481	485	PF00568	0.487
LIG_FHA_1	142	148	PF00498	0.378
LIG_FHA_1	263	269	PF00498	0.581
LIG_FHA_1	294	300	PF00498	0.431
LIG_FHA_1	527	533	PF00498	0.692
LIG_FHA_1	565	571	PF00498	0.626
LIG_FHA_1	607	613	PF00498	0.702
LIG_FHA_1	82	88	PF00498	0.444
LIG_FHA_1	95	101	PF00498	0.349
LIG_LIR_Apic_2	356	360	PF02991	0.420
LIG_LIR_Apic_2	627	633	PF02991	0.761
LIG_LIR_Nem_3	157	163	PF02991	0.463
LIG_LIR_Nem_3	17	21	PF02991	0.394
LIG_LIR_Nem_3	353	357	PF02991	0.477
LIG_Pex14_2	18	22	PF04695	0.425
LIG_Pex14_2	37	41	PF04695	0.254
LIG_Pex14_2	630	634	PF04695	0.681
LIG_SH2_CRK	357	361	PF00017	0.410
LIG_SH2_CRK	455	459	PF00017	0.666
LIG_SH2_NCK_1	105	109	PF00017	0.552
LIG_SH2_NCK_1	357	361	PF00017	0.410
LIG_SH2_NCK_1	455	459	PF00017	0.666
LIG_SH2_SRC	357	360	PF00017	0.506
LIG_SH2_STAP1	132	136	PF00017	0.314
LIG_SH2_STAP1	282	286	PF00017	0.435
LIG_SH2_STAT5	124	127	PF00017	0.489
LIG_SH2_STAT5	291	294	PF00017	0.548
LIG_SH2_STAT5	548	551	PF00017	0.579
LIG_SH3_1	390	396	PF00018	0.653
LIG_SH3_3	390	396	PF00018	0.716
LIG_SH3_3	448	454	PF00018	0.668
LIG_SH3_3	488	494	PF00018	0.627
LIG_SH3_3	560	566	PF00018	0.664
LIG_SH3_3	630	636	PF00018	0.620
LIG_SH3_3	649	655	PF00018	0.576
LIG_TRFH_1	340	344	PF08558	0.416
LIG_WRC_WIRS_1	15	20	PF05994	0.413
LIG_WRC_WIRS_1	95	100	PF05994	0.453
LIG_WW_3	176	180	PF00397	0.621
LIG_WW_3	201	205	PF00397	0.658
MOD_CDC14_SPxK_1	176	179	PF00782	0.751
MOD_CDC14_SPxK_1	181	184	PF00782	0.705
MOD_CDK_SPK_2	615	620	PF00069	0.683
MOD_CDK_SPxK_1	173	179	PF00069	0.752
MOD_CDK_SPxK_1	198	204	PF00069	0.804
MOD_CDK_SPxK_1	441	447	PF00069	0.675
MOD_CDK_SPxK_1	499	505	PF00069	0.630
MOD_CDK_SPxxK_3	383	390	PF00069	0.653
MOD_CDK_SPxxK_3	446	453	PF00069	0.700
MOD_CK1_1	103	109	PF00069	0.542
MOD_CK1_1	171	177	PF00069	0.668
MOD_CK1_1	383	389	PF00069	0.626
MOD_CK1_1	394	400	PF00069	0.718
MOD_CK1_1	52	58	PF00069	0.665
MOD_CK1_1	587	593	PF00069	0.671
MOD_CK1_1	597	603	PF00069	0.575
MOD_CK1_1	607	613	PF00069	0.466
MOD_CK1_1	629	635	PF00069	0.666
MOD_CK1_1	646	652	PF00069	0.565
MOD_CK2_1	326	332	PF00069	0.414
MOD_CK2_1	565	571	PF00069	0.647
MOD_CK2_1	621	627	PF00069	0.568
MOD_CMANNOS	573	576	PF00535	0.534
MOD_DYRK1A_RPxSP_1	615	619	PF00069	0.640
MOD_DYRK1A_RPxSP_1	648	652	PF00069	0.684
MOD_GlcNHglycan	105	108	PF01048	0.551
MOD_GlcNHglycan	382	385	PF01048	0.625
MOD_GlcNHglycan	396	399	PF01048	0.692
MOD_GlcNHglycan	403	406	PF01048	0.691
MOD_GlcNHglycan	488	491	PF01048	0.690
MOD_GlcNHglycan	51	54	PF01048	0.694
MOD_GlcNHglycan	599	602	PF01048	0.793
MOD_GlcNHglycan	637	641	PF01048	0.687
MOD_GSK3_1	165	172	PF00069	0.768
MOD_GSK3_1	173	180	PF00069	0.670
MOD_GSK3_1	198	205	PF00069	0.668
MOD_GSK3_1	227	234	PF00069	0.708
MOD_GSK3_1	289	296	PF00069	0.460
MOD_GSK3_1	33	40	PF00069	0.488
MOD_GSK3_1	382	389	PF00069	0.721
MOD_GSK3_1	42	49	PF00069	0.491
MOD_GSK3_1	437	444	PF00069	0.772
MOD_GSK3_1	467	474	PF00069	0.776
MOD_GSK3_1	477	484	PF00069	0.633
MOD_GSK3_1	580	587	PF00069	0.614
MOD_GSK3_1	593	600	PF00069	0.634
MOD_GSK3_1	606	613	PF00069	0.620
MOD_GSK3_1	615	622	PF00069	0.612
MOD_GSK3_1	632	639	PF00069	0.722
MOD_GSK3_1	642	649	PF00069	0.623
MOD_LATS_1	469	475	PF00433	0.660
MOD_LATS_1	641	647	PF00433	0.586
MOD_N-GLC_1	400	405	PF02516	0.609
MOD_N-GLC_1	497	502	PF02516	0.674
MOD_NEK2_1	147	152	PF00069	0.406
MOD_NEK2_1	326	331	PF00069	0.423
MOD_NEK2_1	37	42	PF00069	0.434
MOD_NEK2_1	467	472	PF00069	0.658
MOD_NEK2_2	280	285	PF00069	0.451
MOD_PIKK_1	100	106	PF00454	0.491
MOD_PIKK_1	293	299	PF00454	0.493
MOD_PK_1	264	270	PF00069	0.599
MOD_PK_1	594	600	PF00069	0.659
MOD_PKA_1	642	648	PF00069	0.680
MOD_PKA_2	100	106	PF00069	0.490
MOD_PKA_2	190	196	PF00069	0.664
MOD_PKA_2	245	251	PF00069	0.647
MOD_PKA_2	259	265	PF00069	0.363
MOD_PKA_2	293	299	PF00069	0.584
MOD_PKA_2	313	319	PF00069	0.329
MOD_PKA_2	326	332	PF00069	0.355
MOD_PKA_2	42	48	PF00069	0.502
MOD_PKA_2	470	476	PF00069	0.725
MOD_PKA_2	498	504	PF00069	0.673
MOD_PKA_2	593	599	PF00069	0.643
MOD_PKA_2	619	625	PF00069	0.684
MOD_PKA_2	642	648	PF00069	0.694
MOD_Plk_1	280	286	PF00069	0.436
MOD_Plk_1	626	632	PF00069	0.721
MOD_Plk_4	219	225	PF00069	0.727
MOD_Plk_4	481	487	PF00069	0.684
MOD_Plk_4	565	571	PF00069	0.603
MOD_Plk_4	587	593	PF00069	0.679
MOD_Plk_4	607	613	PF00069	0.529
MOD_Plk_4	626	632	PF00069	0.476
MOD_ProDKin_1	173	179	PF00069	0.768
MOD_ProDKin_1	198	204	PF00069	0.632
MOD_ProDKin_1	383	389	PF00069	0.648
MOD_ProDKin_1	441	447	PF00069	0.761
MOD_ProDKin_1	477	483	PF00069	0.715
MOD_ProDKin_1	499	505	PF00069	0.630
MOD_ProDKin_1	516	522	PF00069	0.687
MOD_ProDKin_1	615	621	PF00069	0.631
MOD_ProDKin_1	629	635	PF00069	0.607
MOD_ProDKin_1	646	652	PF00069	0.585
MOD_SUMO_for_1	308	311	PF00179	0.370
TRG_DiLeu_BaLyEn_6	194	199	PF01217	0.626
TRG_DiLeu_BaLyEn_6	272	277	PF01217	0.453
TRG_DiLeu_BaLyEn_6	652	657	PF01217	0.658
TRG_ENDOCYTIC_2	455	458	PF00928	0.729
TRG_ER_diArg_1	236	238	PF00400	0.671
TRG_ER_diArg_1	251	253	PF00400	0.350
TRG_ER_diArg_1	539	541	PF00400	0.567
TRG_ER_diArg_1	553	555	PF00400	0.486
TRG_ER_diArg_1	642	644	PF00400	0.701
TRG_ER_FFAT_2	624	635	PF00635	0.602
TRG_Pf-PMV_PEXEL_1	242	247	PF00026	0.680
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	554	559	PF00026	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMS1	Leptomonas seymouri	46%	94%
A0A1X0NLG6	Trypanosomatidae	33%	74%
A0A3R7KCV9	Trypanosoma rangeli	37%	83%
A4HQB8	Leishmania braziliensis	61%	100%
A4IE12	Leishmania infantum	99%	100%
E9AU34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	97%
Q4Q0G1	Leishmania major	92%	100%