WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7XBY9_LEIDO

TriTrypDb:

LdBPK_366240.1 , LdCL_360069800 , LDHU3_36.8280

Length:

618

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XBY9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBY9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8
GO:0003723	RNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	318	322	PF00656	0.660
CLV_C14_Caspase3-7	513	517	PF00656	0.636
CLV_NRD_NRD_1	109	111	PF00675	0.749
CLV_NRD_NRD_1	164	166	PF00675	0.534
CLV_NRD_NRD_1	273	275	PF00675	0.563
CLV_NRD_NRD_1	438	440	PF00675	0.490
CLV_NRD_NRD_1	588	590	PF00675	0.593
CLV_PCSK_FUR_1	436	440	PF00082	0.437
CLV_PCSK_KEX2_1	164	166	PF00082	0.534
CLV_PCSK_KEX2_1	273	275	PF00082	0.563
CLV_PCSK_KEX2_1	413	415	PF00082	0.718
CLV_PCSK_KEX2_1	438	440	PF00082	0.488
CLV_PCSK_KEX2_1	588	590	PF00082	0.593
CLV_PCSK_PC1ET2_1	413	415	PF00082	0.531
CLV_PCSK_SKI1_1	201	205	PF00082	0.707
CLV_PCSK_SKI1_1	226	230	PF00082	0.522
CLV_PCSK_SKI1_1	28	32	PF00082	0.541
DEG_SPOP_SBC_1	528	532	PF00917	0.751
DEG_SPOP_SBC_1	71	75	PF00917	0.566
DEG_SPOP_SBC_1	88	92	PF00917	0.679
DOC_CDC14_PxL_1	238	246	PF14671	0.474
DOC_CYCLIN_RxL_1	223	231	PF00134	0.544
DOC_CYCLIN_yCln2_LP_2	405	408	PF00134	0.547
DOC_CYCLIN_yCln2_LP_2	444	450	PF00134	0.543
DOC_MAPK_DCC_7	403	411	PF00069	0.642
DOC_MAPK_gen_1	273	282	PF00069	0.570
DOC_MAPK_gen_1	436	445	PF00069	0.499
DOC_MAPK_MEF2A_6	192	199	PF00069	0.548
DOC_MAPK_MEF2A_6	403	411	PF00069	0.570
DOC_MAPK_NFAT4_5	192	200	PF00069	0.628
DOC_PP2B_LxvP_1	145	148	PF13499	0.572
DOC_PP2B_LxvP_1	404	407	PF13499	0.481
DOC_PP2B_LxvP_1	444	447	PF13499	0.595
DOC_USP7_MATH_1	278	282	PF00917	0.607
DOC_USP7_MATH_1	286	290	PF00917	0.638
DOC_USP7_MATH_1	429	433	PF00917	0.622
DOC_USP7_MATH_1	50	54	PF00917	0.768
DOC_USP7_MATH_1	527	531	PF00917	0.749
DOC_USP7_MATH_1	534	538	PF00917	0.612
DOC_USP7_MATH_1	543	547	PF00917	0.755
DOC_USP7_MATH_1	549	553	PF00917	0.762
DOC_USP7_MATH_1	559	563	PF00917	0.483
DOC_USP7_MATH_1	6	10	PF00917	0.572
DOC_USP7_MATH_1	71	75	PF00917	0.732
DOC_USP7_MATH_1	80	84	PF00917	0.680
DOC_USP7_MATH_1	88	92	PF00917	0.703
DOC_WW_Pin1_4	147	152	PF00397	0.745
DOC_WW_Pin1_4	2	7	PF00397	0.626
DOC_WW_Pin1_4	228	233	PF00397	0.657
DOC_WW_Pin1_4	418	423	PF00397	0.691
DOC_WW_Pin1_4	425	430	PF00397	0.746
DOC_WW_Pin1_4	523	528	PF00397	0.742
LIG_14-3-3_CanoR_1	219	228	PF00244	0.471
LIG_14-3-3_CanoR_1	28	34	PF00244	0.541
LIG_14-3-3_CanoR_1	469	474	PF00244	0.555
LIG_14-3-3_CanoR_1	588	592	PF00244	0.635
LIG_14-3-3_CanoR_1	78	85	PF00244	0.754
LIG_Actin_WH2_2	182	198	PF00022	0.653
LIG_BIR_II_1	1	5	PF00653	0.579
LIG_deltaCOP1_diTrp_1	247	255	PF00928	0.518
LIG_EVH1_1	145	149	PF00568	0.720
LIG_EVH1_1	575	579	PF00568	0.554
LIG_FHA_1	113	119	PF00498	0.736
LIG_FHA_1	126	132	PF00498	0.679
LIG_FHA_1	219	225	PF00498	0.506
LIG_FHA_1	344	350	PF00498	0.557
LIG_FHA_1	419	425	PF00498	0.721
LIG_FHA_1	440	446	PF00498	0.535
LIG_FHA_1	518	524	PF00498	0.660
LIG_FHA_1	71	77	PF00498	0.805
LIG_FHA_2	294	300	PF00498	0.756
LIG_FHA_2	316	322	PF00498	0.662
LIG_FHA_2	366	372	PF00498	0.619
LIG_FHA_2	511	517	PF00498	0.657
LIG_LIR_Apic_2	168	173	PF02991	0.687
LIG_LIR_Apic_2	602	608	PF02991	0.538
LIG_LIR_Gen_1	247	258	PF02991	0.476
LIG_LIR_Gen_1	275	285	PF02991	0.556
LIG_LIR_Gen_1	454	461	PF02991	0.534
LIG_LIR_Nem_3	247	253	PF02991	0.472
LIG_LIR_Nem_3	275	280	PF02991	0.572
LIG_LIR_Nem_3	400	405	PF02991	0.518
LIG_LIR_Nem_3	572	578	PF02991	0.702
LIG_LIR_Nem_3	590	596	PF02991	0.362
LIG_MYND_2	407	411	PF01753	0.637
LIG_MYND_3	241	245	PF01753	0.457
LIG_NRP_CendR_1	615	618	PF00754	0.730
LIG_Pex14_1	250	254	PF04695	0.504
LIG_Pex14_1	463	467	PF04695	0.524
LIG_Pex14_2	457	461	PF04695	0.519
LIG_SH2_CRK	481	485	PF00017	0.506
LIG_SH2_STAT3	594	597	PF00017	0.537
LIG_SH2_STAT5	295	298	PF00017	0.524
LIG_SH2_STAT5	358	361	PF00017	0.525
LIG_SH2_STAT5	594	597	PF00017	0.493
LIG_SH3_1	157	163	PF00018	0.601
LIG_SH3_2	160	165	PF14604	0.535
LIG_SH3_3	103	109	PF00018	0.653
LIG_SH3_3	143	149	PF00018	0.767
LIG_SH3_3	157	163	PF00018	0.732
LIG_SH3_3	171	177	PF00018	0.702
LIG_SH3_3	236	242	PF00018	0.562
LIG_SH3_3	444	450	PF00018	0.557
LIG_SH3_3	568	574	PF00018	0.643
LIG_SUMO_SIM_anti_2	441	447	PF11976	0.600
LIG_SUMO_SIM_par_1	29	34	PF11976	0.622
LIG_SUMO_SIM_par_1	407	412	PF11976	0.571
LIG_SUMO_SIM_par_1	421	428	PF11976	0.550
LIG_TRAF2_1	22	25	PF00917	0.581
LIG_TRAF2_1	296	299	PF00917	0.681
LIG_TYR_ITIM	479	484	PF00017	0.513
LIG_ULM_U2AF65_1	273	278	PF00076	0.575
LIG_WW_2	174	177	PF00397	0.722
LIG_WW_2	576	579	PF00397	0.547
MOD_CK1_1	125	131	PF00069	0.723
MOD_CK1_1	137	143	PF00069	0.707
MOD_CK1_1	2	8	PF00069	0.678
MOD_CK1_1	289	295	PF00069	0.762
MOD_CK1_1	41	47	PF00069	0.698
MOD_CK1_1	48	54	PF00069	0.669
MOD_CK1_1	519	525	PF00069	0.628
MOD_CK1_1	55	61	PF00069	0.550
MOD_CK1_1	560	566	PF00069	0.742
MOD_CK1_1	587	593	PF00069	0.560
MOD_CK1_1	74	80	PF00069	0.679
MOD_CK1_1	81	87	PF00069	0.637
MOD_CK1_1	89	95	PF00069	0.721
MOD_CK2_1	19	25	PF00069	0.627
MOD_CK2_1	219	225	PF00069	0.506
MOD_CK2_1	253	259	PF00069	0.560
MOD_CK2_1	287	293	PF00069	0.702
MOD_CK2_1	31	37	PF00069	0.567
MOD_CK2_1	409	415	PF00069	0.689
MOD_CK2_1	425	431	PF00069	0.577
MOD_CK2_1	527	533	PF00069	0.830
MOD_CK2_1	59	65	PF00069	0.777
MOD_CK2_1	91	97	PF00069	0.846
MOD_Cter_Amidation	271	274	PF01082	0.579
MOD_Cter_Amidation	598	601	PF01082	0.628
MOD_GlcNHglycan	10	13	PF01048	0.612
MOD_GlcNHglycan	139	142	PF01048	0.794
MOD_GlcNHglycan	179	182	PF01048	0.775
MOD_GlcNHglycan	18	22	PF01048	0.500
MOD_GlcNHglycan	256	259	PF01048	0.537
MOD_GlcNHglycan	33	36	PF01048	0.619
MOD_GlcNHglycan	336	339	PF01048	0.611
MOD_GlcNHglycan	352	355	PF01048	0.424
MOD_GlcNHglycan	43	46	PF01048	0.702
MOD_GlcNHglycan	431	434	PF01048	0.642
MOD_GlcNHglycan	490	493	PF01048	0.469
MOD_GlcNHglycan	50	53	PF01048	0.784
MOD_GlcNHglycan	536	539	PF01048	0.746
MOD_GlcNHglycan	55	58	PF01048	0.529
MOD_GlcNHglycan	551	554	PF01048	0.735
MOD_GlcNHglycan	559	562	PF01048	0.656
MOD_GlcNHglycan	597	600	PF01048	0.586
MOD_GlcNHglycan	6	9	PF01048	0.598
MOD_GlcNHglycan	68	71	PF01048	0.709
MOD_GlcNHglycan	78	81	PF01048	0.740
MOD_GlcNHglycan	94	97	PF01048	0.754
MOD_GSK3_1	125	132	PF00069	0.740
MOD_GSK3_1	175	182	PF00069	0.634
MOD_GSK3_1	2	9	PF00069	0.616
MOD_GSK3_1	214	221	PF00069	0.525
MOD_GSK3_1	249	256	PF00069	0.544
MOD_GSK3_1	289	296	PF00069	0.771
MOD_GSK3_1	29	36	PF00069	0.655
MOD_GSK3_1	409	416	PF00069	0.613
MOD_GSK3_1	41	48	PF00069	0.565
MOD_GSK3_1	420	427	PF00069	0.609
MOD_GSK3_1	519	526	PF00069	0.720
MOD_GSK3_1	528	535	PF00069	0.765
MOD_GSK3_1	545	552	PF00069	0.835
MOD_GSK3_1	55	62	PF00069	0.566
MOD_GSK3_1	557	564	PF00069	0.756
MOD_GSK3_1	595	602	PF00069	0.542
MOD_GSK3_1	66	73	PF00069	0.609
MOD_GSK3_1	74	81	PF00069	0.607
MOD_GSK3_1	83	90	PF00069	0.646
MOD_N-GLC_1	365	370	PF02516	0.414
MOD_N-GLC_1	517	522	PF02516	0.681
MOD_N-GLC_1	543	548	PF02516	0.783
MOD_NEK2_1	1	6	PF00069	0.634
MOD_NEK2_1	122	127	PF00069	0.733
MOD_NEK2_1	179	184	PF00069	0.738
MOD_NEK2_1	31	36	PF00069	0.637
MOD_NEK2_1	334	339	PF00069	0.591
MOD_NEK2_1	424	429	PF00069	0.670
MOD_NEK2_1	595	600	PF00069	0.580
MOD_NEK2_1	66	71	PF00069	0.768
MOD_NEK2_2	249	254	PF00069	0.491
MOD_PIKK_1	287	293	PF00454	0.613
MOD_PIKK_1	607	613	PF00454	0.637
MOD_PKA_1	413	419	PF00069	0.634
MOD_PKA_1	439	445	PF00069	0.480
MOD_PKA_1	600	606	PF00069	0.609
MOD_PKA_2	204	210	PF00069	0.514
MOD_PKA_2	218	224	PF00069	0.441
MOD_PKA_2	272	278	PF00069	0.524
MOD_PKA_2	315	321	PF00069	0.725
MOD_PKA_2	413	419	PF00069	0.610
MOD_PKA_2	587	593	PF00069	0.560
MOD_Plk_1	59	65	PF00069	0.589
MOD_Plk_4	140	146	PF00069	0.727
MOD_Plk_4	249	255	PF00069	0.508
MOD_Plk_4	329	335	PF00069	0.577
MOD_Plk_4	420	426	PF00069	0.754
MOD_Plk_4	439	445	PF00069	0.624
MOD_ProDKin_1	147	153	PF00069	0.748
MOD_ProDKin_1	2	8	PF00069	0.628
MOD_ProDKin_1	228	234	PF00069	0.663
MOD_ProDKin_1	418	424	PF00069	0.693
MOD_ProDKin_1	425	431	PF00069	0.732
MOD_ProDKin_1	523	529	PF00069	0.742
MOD_SUMO_rev_2	377	386	PF00179	0.446
TRG_DiLeu_BaEn_1	26	31	PF01217	0.535
TRG_DiLeu_BaEn_1	400	405	PF01217	0.525
TRG_DiLeu_LyEn_5	400	405	PF01217	0.597
TRG_ENDOCYTIC_2	481	484	PF00928	0.508
TRG_ENDOCYTIC_2	593	596	PF00928	0.495
TRG_ER_diArg_1	163	165	PF00400	0.534
TRG_ER_diArg_1	436	439	PF00400	0.443
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC61	Leptomonas seymouri	51%	96%
A0A0S4IPB1	Bodo saltans	33%	100%
A4HQB7	Leishmania braziliensis	75%	100%
A4IE11	Leishmania infantum	100%	100%
E9AU33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q0G2	Leishmania major	93%	100%