RING-type E3 ubiquitin transferase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XBY8_LEIDO

TriTrypDb:

LdBPK_365570.1 , LdCL_360063000 , LDHU3_36.7400

Length:

863

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XBY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBY8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	483	487	PF00656	0.489
CLV_C14_Caspase3-7	777	781	PF00656	0.557
CLV_NRD_NRD_1	124	126	PF00675	0.426
CLV_NRD_NRD_1	158	160	PF00675	0.665
CLV_NRD_NRD_1	251	253	PF00675	0.493
CLV_NRD_NRD_1	297	299	PF00675	0.509
CLV_NRD_NRD_1	429	431	PF00675	0.555
CLV_NRD_NRD_1	525	527	PF00675	0.508
CLV_NRD_NRD_1	53	55	PF00675	0.480
CLV_NRD_NRD_1	560	562	PF00675	0.486
CLV_NRD_NRD_1	607	609	PF00675	0.552
CLV_NRD_NRD_1	720	722	PF00675	0.561
CLV_NRD_NRD_1	727	729	PF00675	0.574
CLV_NRD_NRD_1	75	77	PF00675	0.466
CLV_PCSK_KEX2_1	124	126	PF00082	0.466
CLV_PCSK_KEX2_1	277	279	PF00082	0.451
CLV_PCSK_KEX2_1	285	287	PF00082	0.448
CLV_PCSK_KEX2_1	297	299	PF00082	0.318
CLV_PCSK_KEX2_1	494	496	PF00082	0.509
CLV_PCSK_KEX2_1	560	562	PF00082	0.508
CLV_PCSK_KEX2_1	607	609	PF00082	0.485
CLV_PCSK_KEX2_1	649	651	PF00082	0.446
CLV_PCSK_KEX2_1	720	722	PF00082	0.552
CLV_PCSK_KEX2_1	727	729	PF00082	0.559
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.451
CLV_PCSK_PC1ET2_1	285	287	PF00082	0.448
CLV_PCSK_PC1ET2_1	494	496	PF00082	0.463
CLV_PCSK_PC1ET2_1	649	651	PF00082	0.446
CLV_PCSK_PC7_1	273	279	PF00082	0.446
CLV_PCSK_SKI1_1	407	411	PF00082	0.588
CLV_PCSK_SKI1_1	433	437	PF00082	0.511
CLV_PCSK_SKI1_1	478	482	PF00082	0.502
CLV_PCSK_SKI1_1	54	58	PF00082	0.446
CLV_PCSK_SKI1_1	666	670	PF00082	0.562
CLV_Separin_Metazoa	27	31	PF03568	0.589
DEG_APCC_DBOX_1	481	489	PF00400	0.572
DEG_APCC_DBOX_1	67	75	PF00400	0.504
DOC_CYCLIN_RxL_1	320	330	PF00134	0.548
DOC_CYCLIN_yCln2_LP_2	731	737	PF00134	0.556
DOC_MAPK_gen_1	386	393	PF00069	0.595
DOC_MAPK_gen_1	4	15	PF00069	0.565
DOC_MAPK_gen_1	639	647	PF00069	0.531
DOC_MAPK_gen_1	690	698	PF00069	0.552
DOC_MAPK_gen_1	727	735	PF00069	0.600
DOC_MAPK_MEF2A_6	257	264	PF00069	0.471
DOC_MAPK_MEF2A_6	323	331	PF00069	0.435
DOC_MAPK_MEF2A_6	386	393	PF00069	0.591
DOC_MAPK_MEF2A_6	690	698	PF00069	0.552
DOC_MAPK_MEF2A_6	727	735	PF00069	0.540
DOC_MIT_MIM_1	415	424	PF04212	0.490
DOC_PP2B_LxvP_1	731	734	PF13499	0.542
DOC_USP7_MATH_1	209	213	PF00917	0.642
DOC_USP7_MATH_1	303	307	PF00917	0.611
DOC_USP7_MATH_1	822	826	PF00917	0.618
DOC_USP7_MATH_1	9	13	PF00917	0.566
DOC_USP7_UBL2_3	253	257	PF12436	0.532
DOC_USP7_UBL2_3	403	407	PF12436	0.711
DOC_WW_Pin1_4	810	815	PF00397	0.589
LIG_14-3-3_CanoR_1	139	147	PF00244	0.580
LIG_14-3-3_CanoR_1	208	218	PF00244	0.623
LIG_14-3-3_CanoR_1	236	244	PF00244	0.672
LIG_14-3-3_CanoR_1	304	311	PF00244	0.595
LIG_14-3-3_CanoR_1	509	517	PF00244	0.509
LIG_14-3-3_CanoR_1	560	567	PF00244	0.491
LIG_14-3-3_CanoR_1	666	675	PF00244	0.571
LIG_14-3-3_CanoR_1	68	72	PF00244	0.457
LIG_14-3-3_CanoR_1	684	690	PF00244	0.564
LIG_14-3-3_CanoR_1	721	731	PF00244	0.475
LIG_14-3-3_CanoR_1	764	769	PF00244	0.645
LIG_14-3-3_CanoR_1	8	14	PF00244	0.607
LIG_Actin_WH2_2	126	141	PF00022	0.637
LIG_CaM_IQ_9	676	692	PF13499	0.511
LIG_FHA_1	102	108	PF00498	0.592
LIG_FHA_1	128	134	PF00498	0.490
LIG_FHA_1	221	227	PF00498	0.604
LIG_FHA_1	310	316	PF00498	0.405
LIG_FHA_1	436	442	PF00498	0.479
LIG_FHA_1	462	468	PF00498	0.487
LIG_FHA_1	533	539	PF00498	0.574
LIG_FHA_1	562	568	PF00498	0.547
LIG_FHA_1	572	578	PF00498	0.469
LIG_FHA_1	580	586	PF00498	0.444
LIG_FHA_1	674	680	PF00498	0.586
LIG_FHA_1	691	697	PF00498	0.624
LIG_FHA_1	764	770	PF00498	0.589
LIG_FHA_1	791	797	PF00498	0.760
LIG_FHA_1	800	806	PF00498	0.452
LIG_FHA_2	238	244	PF00498	0.678
LIG_FHA_2	265	271	PF00498	0.496
LIG_FHA_2	396	402	PF00498	0.567
LIG_FHA_2	408	414	PF00498	0.618
LIG_FHA_2	470	476	PF00498	0.605
LIG_FHA_2	510	516	PF00498	0.555
LIG_FHA_2	68	74	PF00498	0.460
LIG_FHA_2	686	692	PF00498	0.546
LIG_FHA_2	845	851	PF00498	0.595
LIG_GBD_Chelix_1	261	269	PF00786	0.462
LIG_LIR_Apic_2	749	753	PF02991	0.572
LIG_LIR_Gen_1	162	171	PF02991	0.546
LIG_LIR_Gen_1	176	187	PF02991	0.546
LIG_LIR_Gen_1	434	444	PF02991	0.443
LIG_LIR_Gen_1	498	508	PF02991	0.468
LIG_LIR_Gen_1	754	762	PF02991	0.495
LIG_LIR_Nem_3	162	168	PF02991	0.546
LIG_LIR_Nem_3	176	182	PF02991	0.498
LIG_LIR_Nem_3	434	439	PF02991	0.450
LIG_LIR_Nem_3	498	503	PF02991	0.468
LIG_LIR_Nem_3	50	56	PF02991	0.440
LIG_LIR_Nem_3	726	732	PF02991	0.546
LIG_LIR_Nem_3	754	759	PF02991	0.576
LIG_LIR_Nem_3	850	854	PF02991	0.664
LIG_PDZ_Class_1	858	863	PF00595	0.597
LIG_Pex14_1	161	165	PF04695	0.523
LIG_PTB_Apo_2	531	538	PF02174	0.422
LIG_PTB_Phospho_1	531	537	PF10480	0.449
LIG_SH2_CRK	165	169	PF00017	0.584
LIG_SH2_CRK	665	669	PF00017	0.472
LIG_SH2_CRK	729	733	PF00017	0.550
LIG_SH2_CRK	756	760	PF00017	0.531
LIG_SH2_CRK	854	858	PF00017	0.590
LIG_SH2_GRB2like	537	540	PF00017	0.441
LIG_SH2_PTP2	750	753	PF00017	0.490
LIG_SH2_SRC	537	540	PF00017	0.441
LIG_SH2_SRC	750	753	PF00017	0.625
LIG_SH2_STAT3	762	765	PF00017	0.558
LIG_SH2_STAT5	531	534	PF00017	0.543
LIG_SH2_STAT5	537	540	PF00017	0.530
LIG_SH2_STAT5	746	749	PF00017	0.667
LIG_SH2_STAT5	750	753	PF00017	0.631
LIG_SH3_3	816	822	PF00018	0.672
LIG_SUMO_SIM_anti_2	219	228	PF11976	0.582
LIG_SUMO_SIM_anti_2	437	443	PF11976	0.442
LIG_TRAF2_1	153	156	PF00917	0.543
LIG_TRAF2_1	171	174	PF00917	0.659
LIG_TRAF2_1	201	204	PF00917	0.777
LIG_TRAF2_1	346	349	PF00917	0.454
LIG_TRAF2_1	447	450	PF00917	0.547
LIG_TRAF2_1	487	490	PF00917	0.462
LIG_TRAF2_1	513	516	PF00917	0.555
LIG_TRAF2_1	711	714	PF00917	0.603
LIG_TRAF2_1	804	807	PF00917	0.628
LIG_TYR_ITAM	162	182	PF00017	0.481
MOD_CK1_1	306	312	PF00069	0.581
MOD_CK1_1	416	422	PF00069	0.635
MOD_CK1_1	579	585	PF00069	0.480
MOD_CK1_1	824	830	PF00069	0.687
MOD_CK1_1	837	843	PF00069	0.684
MOD_CK2_1	188	194	PF00069	0.616
MOD_CK2_1	237	243	PF00069	0.632
MOD_CK2_1	264	270	PF00069	0.424
MOD_CK2_1	407	413	PF00069	0.608
MOD_CK2_1	469	475	PF00069	0.540
MOD_CK2_1	484	490	PF00069	0.410
MOD_CK2_1	509	515	PF00069	0.531
MOD_CK2_1	67	73	PF00069	0.453
MOD_GlcNHglycan	120	123	PF01048	0.433
MOD_GlcNHglycan	190	193	PF01048	0.745
MOD_GlcNHglycan	211	214	PF01048	0.710
MOD_GlcNHglycan	305	308	PF01048	0.476
MOD_GlcNHglycan	315	318	PF01048	0.402
MOD_GlcNHglycan	450	453	PF01048	0.592
MOD_GlcNHglycan	589	592	PF01048	0.477
MOD_GSK3_1	264	271	PF00069	0.507
MOD_GSK3_1	309	316	PF00069	0.532
MOD_GSK3_1	367	374	PF00069	0.627
MOD_GSK3_1	466	473	PF00069	0.561
MOD_GSK3_1	480	487	PF00069	0.521
MOD_GSK3_1	504	511	PF00069	0.627
MOD_GSK3_1	550	557	PF00069	0.564
MOD_GSK3_1	787	794	PF00069	0.718
MOD_GSK3_1	820	827	PF00069	0.653
MOD_GSK3_1	834	841	PF00069	0.711
MOD_N-GLC_1	684	689	PF02516	0.494
MOD_N-GLC_1	771	776	PF02516	0.703
MOD_N-GLC_1	834	839	PF02516	0.750
MOD_NEK2_1	133	138	PF00069	0.590
MOD_NEK2_1	488	493	PF00069	0.623
MOD_NEK2_1	552	557	PF00069	0.529
MOD_NEK2_1	771	776	PF00069	0.507
MOD_PIKK_1	133	139	PF00454	0.515
MOD_PIKK_1	140	146	PF00454	0.467
MOD_PIKK_1	264	270	PF00454	0.424
MOD_PIKK_1	309	315	PF00454	0.378
MOD_PIKK_1	466	472	PF00454	0.603
MOD_PIKK_1	554	560	PF00454	0.561
MOD_PIKK_1	584	590	PF00454	0.424
MOD_PK_1	834	840	PF00069	0.624
MOD_PKA_1	526	532	PF00069	0.503
MOD_PKA_2	138	144	PF00069	0.585
MOD_PKA_2	303	309	PF00069	0.515
MOD_PKA_2	508	514	PF00069	0.469
MOD_PKA_2	559	565	PF00069	0.545
MOD_PKA_2	579	585	PF00069	0.337
MOD_PKA_2	620	626	PF00069	0.631
MOD_PKA_2	67	73	PF00069	0.561
MOD_PKA_2	763	769	PF00069	0.537
MOD_PKA_2	820	826	PF00069	0.699
MOD_PKA_2	838	844	PF00069	0.706
MOD_PKB_1	519	527	PF00069	0.466
MOD_Plk_1	133	139	PF00069	0.515
MOD_Plk_1	220	226	PF00069	0.665
MOD_Plk_1	355	361	PF00069	0.565
MOD_Plk_1	684	690	PF00069	0.497
MOD_Plk_1	834	840	PF00069	0.624
MOD_Plk_2-3	484	490	PF00069	0.437
MOD_Plk_4	220	226	PF00069	0.724
MOD_Plk_4	532	538	PF00069	0.537
MOD_Plk_4	746	752	PF00069	0.561
MOD_Plk_4	764	770	PF00069	0.404
MOD_Plk_4	838	844	PF00069	0.697
MOD_ProDKin_1	810	816	PF00069	0.590
MOD_SUMO_for_1	353	356	PF00179	0.523
MOD_SUMO_for_1	447	450	PF00179	0.511
MOD_SUMO_rev_2	174	180	PF00179	0.584
MOD_SUMO_rev_2	249	258	PF00179	0.462
MOD_SUMO_rev_2	270	279	PF00179	0.439
MOD_SUMO_rev_2	397	404	PF00179	0.525
MOD_SUMO_rev_2	73	78	PF00179	0.505
TRG_DiLeu_BaEn_1	222	227	PF01217	0.557
TRG_DiLeu_BaEn_1	256	261	PF01217	0.561
TRG_DiLeu_BaEn_1	44	49	PF01217	0.468
TRG_DiLeu_BaEn_1	52	57	PF01217	0.431
TRG_DiLeu_BaEn_1	713	718	PF01217	0.560
TRG_DiLeu_BaEn_4	515	521	PF01217	0.513
TRG_DiLeu_BaLyEn_6	727	732	PF01217	0.549
TRG_ENDOCYTIC_2	165	168	PF00928	0.564
TRG_ENDOCYTIC_2	179	182	PF00928	0.546
TRG_ENDOCYTIC_2	500	503	PF00928	0.540
TRG_ENDOCYTIC_2	665	668	PF00928	0.478
TRG_ENDOCYTIC_2	729	732	PF00928	0.590
TRG_ENDOCYTIC_2	756	759	PF00928	0.530
TRG_ENDOCYTIC_2	854	857	PF00928	0.599
TRG_ER_diArg_1	123	125	PF00400	0.428
TRG_ER_diArg_1	296	298	PF00400	0.537
TRG_ER_diArg_1	606	608	PF00400	0.556
TRG_ER_diArg_1	720	722	PF00400	0.562
TRG_ER_diArg_1	727	729	PF00400	0.574
TRG_Pf-PMV_PEXEL_1	277	281	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	323	328	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.597
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	607	611	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	639	644	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	666	670	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	720	724	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	740	744	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ64	Leptomonas seymouri	53%	100%
A0A1X0P393	Trypanosomatidae	34%	100%
A0A422NT20	Trypanosoma rangeli	35%	100%
A4HQ48	Leishmania braziliensis	78%	99%
A4IC76	Leishmania infantum	100%	100%
D0A8R1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ATW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q0M8	Leishmania major	93%	100%