SWIM-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XBY1_LEIDO

TriTrypDb:

LdBPK_365880.1 , LdCL_360066200 , LDHU3_36.7790

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	1
GO:0097196	Shu complex	2	1

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Expansion

Sequence features

A0A3S7XBY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBY1

Function

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Biological processes
Term	Name	Level	Count
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	3
GO:0008270	zinc ion binding	6	3
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3
GO:0046914	transition metal ion binding	5	3

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.750
CLV_PCSK_FUR_1	121	125	PF00082	0.657
CLV_PCSK_KEX2_1	123	125	PF00082	0.657
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.540
CLV_PCSK_SKI1_1	196	200	PF00082	0.363
CLV_PCSK_SKI1_1	21	25	PF00082	0.545
CLV_PCSK_SKI1_1	71	75	PF00082	0.436
DEG_SPOP_SBC_1	129	133	PF00917	0.754
DOC_MAPK_MEF2A_6	196	205	PF00069	0.364
DOC_MAPK_NFAT4_5	196	204	PF00069	0.362

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I274	Leptomonas seymouri	53%	95%
A0A1X0P068	Trypanosomatidae	36%	100%
A0A3R7L646	Trypanosoma rangeli	37%	100%
A4HQ79	Leishmania braziliensis	68%	100%
A4IDX7	Leishmania infantum	99%	100%
D0A433	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9ATZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q0J8	Leishmania major	90%	100%
V5BTC7	Trypanosoma cruzi	38%	100%

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