Macrocin-O-methyltransferase (TylF)/Methyltransferase domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Macrocin-O-methyltransferase (TylF), putative

Species:

Leishmania donovani

UniProt:

A0A3S7XBX8_LEIDO

TriTrypDb:

LdBPK_365670.1 , LdCL_360064100 , LDHU3_36.7540

Length:

386

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XBX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBX8

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	4
GO:0032259	methylation	2	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0008168	methyltransferase activity	4	4
GO:0016740	transferase activity	2	4
GO:0016741	transferase activity, transferring one-carbon groups	3	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	106	108	PF00675	0.489
CLV_NRD_NRD_1	190	192	PF00675	0.315
CLV_NRD_NRD_1	279	281	PF00675	0.375
CLV_NRD_NRD_1	313	315	PF00675	0.438
CLV_PCSK_KEX2_1	189	191	PF00082	0.371
CLV_PCSK_KEX2_1	279	281	PF00082	0.375
CLV_PCSK_KEX2_1	312	314	PF00082	0.437
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.302
CLV_PCSK_SKI1_1	190	194	PF00082	0.368
CLV_PCSK_SKI1_1	301	305	PF00082	0.285
CLV_PCSK_SKI1_1	97	101	PF00082	0.488
DEG_APCC_DBOX_1	300	308	PF00400	0.340
DEG_Nend_Nbox_1	1	3	PF02207	0.623
DOC_CYCLIN_RxL_1	49	59	PF00134	0.372
DOC_CYCLIN_RxL_1	94	104	PF00134	0.471
DOC_MAPK_MEF2A_6	301	310	PF00069	0.409
DOC_MAPK_NFAT4_5	301	309	PF00069	0.417
DOC_PP1_RVXF_1	50	57	PF00149	0.328
DOC_PP2B_LxvP_1	306	309	PF13499	0.417
DOC_PP2B_LxvP_1	99	102	PF13499	0.390
DOC_PP4_MxPP_1	201	204	PF00568	0.346
DOC_USP7_MATH_1	146	150	PF00917	0.278
DOC_USP7_MATH_1	178	182	PF00917	0.350
DOC_USP7_MATH_1	194	198	PF00917	0.368
DOC_USP7_MATH_1	225	229	PF00917	0.448
DOC_USP7_MATH_1	232	236	PF00917	0.418
DOC_USP7_MATH_1	316	320	PF00917	0.414
DOC_USP7_MATH_1	68	72	PF00917	0.491
DOC_WW_Pin1_4	184	189	PF00397	0.350
DOC_WW_Pin1_4	216	221	PF00397	0.435
DOC_WW_Pin1_4	230	235	PF00397	0.455
DOC_WW_Pin1_4	240	245	PF00397	0.412
DOC_WW_Pin1_4	354	359	PF00397	0.326
LIG_14-3-3_CanoR_1	253	258	PF00244	0.404
LIG_14-3-3_CanoR_1	312	321	PF00244	0.439
LIG_14-3-3_CanoR_1	69	73	PF00244	0.432
LIG_Actin_WH2_2	25	41	PF00022	0.376
LIG_Clathr_ClatBox_1	261	265	PF01394	0.350
LIG_Clathr_ClatBox_1	289	293	PF01394	0.417
LIG_FHA_1	136	142	PF00498	0.352
LIG_FHA_1	2	8	PF00498	0.546
LIG_FHA_1	267	273	PF00498	0.465
LIG_FHA_1	93	99	PF00498	0.510
LIG_FHA_2	203	209	PF00498	0.308
LIG_FHA_2	300	306	PF00498	0.412
LIG_FHA_2	313	319	PF00498	0.459
LIG_LIR_LC3C_4	258	263	PF02991	0.368
LIG_LIR_Nem_3	127	131	PF02991	0.274
LIG_PCNA_yPIPBox_3	107	116	PF02747	0.482
LIG_Pex14_2	113	117	PF04695	0.386
LIG_Rb_pABgroove_1	52	60	PF01858	0.374
LIG_SH2_STAP1	50	54	PF00017	0.413
LIG_SUMO_SIM_anti_2	258	265	PF11976	0.334
LIG_SUMO_SIM_anti_2	285	291	PF11976	0.417
LIG_SUMO_SIM_anti_2	302	308	PF11976	0.417
LIG_SUMO_SIM_par_1	258	265	PF11976	0.350
LIG_WRC_WIRS_1	195	200	PF05994	0.274
MOD_CDC14_SPxK_1	187	190	PF00782	0.350
MOD_CDC14_SPxK_1	224	227	PF00782	0.278
MOD_CDK_SPK_2	184	189	PF00069	0.302
MOD_CDK_SPxK_1	184	190	PF00069	0.350
MOD_CDK_SPxK_1	221	227	PF00069	0.278
MOD_CDK_SPxxK_3	184	191	PF00069	0.350
MOD_CK1_1	148	154	PF00069	0.290
MOD_CK1_1	181	187	PF00069	0.217
MOD_CK1_1	218	224	PF00069	0.390
MOD_CK1_1	299	305	PF00069	0.393
MOD_CK2_1	225	231	PF00069	0.403
MOD_CK2_1	299	305	PF00069	0.410
MOD_CK2_1	68	74	PF00069	0.389
MOD_GlcNHglycan	148	151	PF01048	0.433
MOD_GlcNHglycan	166	169	PF01048	0.230
MOD_GlcNHglycan	181	184	PF01048	0.407
MOD_GlcNHglycan	211	214	PF01048	0.389
MOD_GlcNHglycan	317	321	PF01048	0.418
MOD_GSK3_1	120	127	PF00069	0.391
MOD_GSK3_1	179	186	PF00069	0.489
MOD_GSK3_1	221	228	PF00069	0.341
MOD_GSK3_1	312	319	PF00069	0.360
MOD_N-GLC_1	92	97	PF02516	0.549
MOD_NEK2_1	1	6	PF00069	0.577
MOD_NEK2_1	120	125	PF00069	0.336
MOD_NEK2_1	268	273	PF00069	0.284
MOD_NEK2_2	237	242	PF00069	0.350
MOD_PIKK_1	218	224	PF00454	0.350
MOD_PK_1	253	259	PF00069	0.302
MOD_PKA_1	312	318	PF00069	0.440
MOD_PKA_2	312	318	PF00069	0.445
MOD_PKA_2	68	74	PF00069	0.389
MOD_Plk_1	121	127	PF00069	0.328
MOD_Plk_4	121	127	PF00069	0.334
MOD_Plk_4	68	74	PF00069	0.490
MOD_Plk_4	84	90	PF00069	0.424
MOD_ProDKin_1	184	190	PF00069	0.350
MOD_ProDKin_1	216	222	PF00069	0.435
MOD_ProDKin_1	230	236	PF00069	0.455
MOD_ProDKin_1	240	246	PF00069	0.412
MOD_ProDKin_1	354	360	PF00069	0.326
MOD_SUMO_rev_2	139	149	PF00179	0.413
TRG_DiLeu_BaEn_1	61	66	PF01217	0.401
TRG_DiLeu_BaEn_1	84	89	PF01217	0.472
TRG_DiLeu_BaLyEn_6	127	132	PF01217	0.350
TRG_DiLeu_BaLyEn_6	94	99	PF01217	0.482
TRG_ER_diArg_1	190	192	PF00400	0.367
TRG_ER_diArg_1	226	229	PF00400	0.217
TRG_ER_diArg_1	311	314	PF00400	0.417
TRG_NLS_MonoExtN_4	188	193	PF00514	0.302
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC88	Leptomonas seymouri	59%	99%
A0A0S4JTC1	Bodo saltans	39%	100%
A0A1X0P072	Trypanosomatidae	41%	100%
A0A3S5IRD0	Trypanosoma rangeli	44%	100%
A4HQ58	Leishmania braziliensis	81%	100%
A4IDV7	Leishmania infantum	100%	100%
D0A459	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9ATX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q0L8	Leishmania major	94%	100%
V5DLQ3	Trypanosoma cruzi	42%	100%