Kinesin-like protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin-D

Species:

Leishmania donovani

UniProt:

A0A3S7XBW9_LEIDO

TriTrypDb:

LdBPK_365380.1 , LdCL_360061000 , LDHU3_36.7200

Length:

625

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	no	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0005871	kinesin complex	3	1
GO:0005874	microtubule	6	1
GO:0005875	microtubule associated complex	2	1
GO:0015630	microtubule cytoskeleton	6	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XBW9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBW9

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	12
GO:0007018	microtubule-based movement	3	12
GO:0009987	cellular process	1	12
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0000902	cell morphogenesis	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0009653	anatomical structure morphogenesis	2	1
GO:0016043	cellular component organization	3	1
GO:0030865	cortical cytoskeleton organization	6	1
GO:0031122	cytoplasmic microtubule organization	4	1
GO:0032502	developmental process	1	1
GO:0043622	cortical microtubule organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0097435	supramolecular fiber organization	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003774	cytoskeletal motor activity	1	12
GO:0003777	microtubule motor activity	2	12
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0005524	ATP binding	5	12
GO:0008017	microtubule binding	5	12
GO:0008092	cytoskeletal protein binding	3	12
GO:0015631	tubulin binding	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003824	catalytic activity	1	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.376
CLV_NRD_NRD_1	265	267	PF00675	0.302
CLV_NRD_NRD_1	367	369	PF00675	0.535
CLV_NRD_NRD_1	380	382	PF00675	0.520
CLV_NRD_NRD_1	439	441	PF00675	0.530
CLV_NRD_NRD_1	510	512	PF00675	0.538
CLV_NRD_NRD_1	528	530	PF00675	0.523
CLV_NRD_NRD_1	58	60	PF00675	0.371
CLV_NRD_NRD_1	607	609	PF00675	0.464
CLV_PCSK_KEX2_1	234	236	PF00082	0.376
CLV_PCSK_KEX2_1	265	267	PF00082	0.302
CLV_PCSK_KEX2_1	367	369	PF00082	0.549
CLV_PCSK_KEX2_1	450	452	PF00082	0.466
CLV_PCSK_KEX2_1	469	471	PF00082	0.483
CLV_PCSK_KEX2_1	528	530	PF00082	0.576
CLV_PCSK_KEX2_1	58	60	PF00082	0.500
CLV_PCSK_KEX2_1	607	609	PF00082	0.473
CLV_PCSK_KEX2_1	86	88	PF00082	0.363
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.391
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.525
CLV_PCSK_PC1ET2_1	469	471	PF00082	0.518
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.363
CLV_PCSK_PC7_1	230	236	PF00082	0.352
CLV_PCSK_SKI1_1	138	142	PF00082	0.267
CLV_PCSK_SKI1_1	17	21	PF00082	0.377
CLV_PCSK_SKI1_1	349	353	PF00082	0.395
CLV_PCSK_SKI1_1	35	39	PF00082	0.242
CLV_PCSK_SKI1_1	420	424	PF00082	0.481
CLV_PCSK_SKI1_1	528	532	PF00082	0.565
CLV_PCSK_SKI1_1	87	91	PF00082	0.306
DOC_CKS1_1	199	204	PF01111	0.378
DOC_MAPK_gen_1	263	272	PF00069	0.316
DOC_MAPK_gen_1	381	389	PF00069	0.545
DOC_MAPK_MEF2A_6	263	271	PF00069	0.330
DOC_MAPK_RevD_3	219	235	PF00069	0.323
DOC_PP4_FxxP_1	251	254	PF00568	0.403
DOC_PP4_FxxP_1	72	75	PF00568	0.501
DOC_USP7_MATH_1	117	121	PF00917	0.315
DOC_USP7_MATH_1	28	32	PF00917	0.558
DOC_USP7_MATH_1	433	437	PF00917	0.549
DOC_USP7_MATH_1	579	583	PF00917	0.626
DOC_USP7_MATH_1	79	83	PF00917	0.651
DOC_USP7_UBL2_3	81	85	PF12436	0.591
DOC_WW_Pin1_4	198	203	PF00397	0.395
DOC_WW_Pin1_4	215	220	PF00397	0.395
DOC_WW_Pin1_4	326	331	PF00397	0.291
DOC_WW_Pin1_4	520	525	PF00397	0.568
LIG_14-3-3_CanoR_1	124	129	PF00244	0.285
LIG_14-3-3_CanoR_1	17	26	PF00244	0.305
LIG_14-3-3_CanoR_1	235	243	PF00244	0.362
LIG_14-3-3_CanoR_1	244	251	PF00244	0.396
LIG_14-3-3_CanoR_1	381	389	PF00244	0.502
LIG_14-3-3_CanoR_1	511	519	PF00244	0.508
LIG_14-3-3_CanoR_1	552	558	PF00244	0.689
LIG_14-3-3_CanoR_1	87	95	PF00244	0.394
LIG_APCC_ABBA_1	328	333	PF00400	0.315
LIG_BRCT_BRCA1_1	121	125	PF00533	0.327
LIG_BRCT_BRCA1_1	241	245	PF00533	0.404
LIG_CaM_IQ_9	222	237	PF13499	0.365
LIG_CaM_IQ_9	339	354	PF13499	0.488
LIG_deltaCOP1_diTrp_1	67	72	PF00928	0.381
LIG_FHA_1	216	222	PF00498	0.448
LIG_FHA_1	236	242	PF00498	0.244
LIG_FHA_1	410	416	PF00498	0.375
LIG_FHA_1	511	517	PF00498	0.579
LIG_FHA_2	173	179	PF00498	0.286
LIG_FHA_2	18	24	PF00498	0.370
LIG_FHA_2	189	195	PF00498	0.311
LIG_FHA_2	409	415	PF00498	0.519
LIG_FHA_2	552	558	PF00498	0.745
LIG_FHA_2	600	606	PF00498	0.446
LIG_FHA_2	88	94	PF00498	0.290
LIG_KLC1_Yacidic_2	174	178	PF13176	0.312
LIG_LIR_Apic_2	248	254	PF02991	0.380
LIG_LIR_Apic_2	71	75	PF02991	0.491
LIG_LIR_Gen_1	12	21	PF02991	0.396
LIG_LIR_Gen_1	174	181	PF02991	0.285
LIG_LIR_Gen_1	305	316	PF02991	0.316
LIG_LIR_Gen_1	329	339	PF02991	0.403
LIG_LIR_Gen_1	360	370	PF02991	0.616
LIG_LIR_Gen_1	456	464	PF02991	0.470
LIG_LIR_Gen_1	93	103	PF02991	0.267
LIG_LIR_Nem_3	12	16	PF02991	0.377
LIG_LIR_Nem_3	122	128	PF02991	0.372
LIG_LIR_Nem_3	174	179	PF02991	0.292
LIG_LIR_Nem_3	305	311	PF02991	0.339
LIG_LIR_Nem_3	93	98	PF02991	0.273
LIG_NRBOX	269	275	PF00104	0.298
LIG_Pex14_2	245	249	PF04695	0.346
LIG_Pex14_2	308	312	PF04695	0.392
LIG_SH2_CRK	95	99	PF00017	0.257
LIG_SH2_NCK_1	110	114	PF00017	0.267
LIG_SH2_NCK_1	572	576	PF00017	0.505
LIG_SH2_PTP2	176	179	PF00017	0.286
LIG_SH2_SRC	572	575	PF00017	0.470
LIG_SH2_STAP1	499	503	PF00017	0.620
LIG_SH2_STAP1	572	576	PF00017	0.530
LIG_SH2_STAP1	595	599	PF00017	0.502
LIG_SH2_STAT5	126	129	PF00017	0.395
LIG_SH2_STAT5	176	179	PF00017	0.286
LIG_SH2_STAT5	54	57	PF00017	0.377
LIG_SH3_3	199	205	PF00018	0.313
LIG_SH3_3	45	51	PF00018	0.447
LIG_SH3_3	518	524	PF00018	0.529
LIG_SH3_3	95	101	PF00018	0.266
LIG_SUMO_SIM_anti_2	174	182	PF11976	0.273
LIG_SUMO_SIM_anti_2	385	391	PF11976	0.503
LIG_SUMO_SIM_anti_2	398	403	PF11976	0.336
LIG_SUMO_SIM_par_1	44	50	PF11976	0.326
LIG_TRAF2_1	71	74	PF00917	0.462
LIG_TRAF2_1	75	78	PF00917	0.562
LIG_WRC_WIRS_1	149	154	PF05994	0.400
LIG_WRC_WIRS_1	69	74	PF05994	0.323
MOD_CK1_1	160	166	PF00069	0.294
MOD_CK1_1	172	178	PF00069	0.302
MOD_CK1_1	188	194	PF00069	0.321
MOD_CK1_1	200	206	PF00069	0.409
MOD_CK1_1	237	243	PF00069	0.357
MOD_CK1_1	306	312	PF00069	0.431
MOD_CK1_1	326	332	PF00069	0.378
MOD_CK1_1	4	10	PF00069	0.541
MOD_CK2_1	17	23	PF00069	0.351
MOD_CK2_1	214	220	PF00069	0.351
MOD_CK2_1	359	365	PF00069	0.539
MOD_CK2_1	408	414	PF00069	0.469
MOD_CK2_1	520	526	PF00069	0.509
MOD_CK2_1	551	557	PF00069	0.549
MOD_CK2_1	599	605	PF00069	0.589
MOD_CK2_1	68	74	PF00069	0.403
MOD_GlcNHglycan	121	124	PF01048	0.302
MOD_GlcNHglycan	170	174	PF01048	0.328
MOD_GlcNHglycan	191	194	PF01048	0.451
MOD_GlcNHglycan	202	205	PF01048	0.378
MOD_GlcNHglycan	278	281	PF01048	0.413
MOD_GlcNHglycan	29	33	PF01048	0.543
MOD_GlcNHglycan	292	295	PF01048	0.304
MOD_GlcNHglycan	305	308	PF01048	0.444
MOD_GSK3_1	1	8	PF00069	0.668
MOD_GSK3_1	185	192	PF00069	0.356
MOD_GSK3_1	235	242	PF00069	0.353
MOD_GSK3_1	257	264	PF00069	0.502
MOD_GSK3_1	338	345	PF00069	0.442
MOD_GSK3_1	409	416	PF00069	0.428
MOD_GSK3_1	597	604	PF00069	0.363
MOD_N-GLC_1	158	163	PF02516	0.294
MOD_N-GLC_1	235	240	PF02516	0.466
MOD_N-GLC_1	257	262	PF02516	0.563
MOD_N-GLC_1	408	413	PF02516	0.501
MOD_NEK2_1	1	6	PF00069	0.639
MOD_NEK2_1	179	184	PF00069	0.409
MOD_NEK2_1	342	347	PF00069	0.429
MOD_NEK2_1	80	85	PF00069	0.649
MOD_PIKK_1	599	605	PF00454	0.421
MOD_PIKK_1	615	621	PF00454	0.593
MOD_PIKK_1	87	93	PF00454	0.286
MOD_PK_1	512	518	PF00069	0.466
MOD_PKA_1	234	240	PF00069	0.355
MOD_PKA_1	615	621	PF00069	0.585
MOD_PKA_2	234	240	PF00069	0.363
MOD_PKA_2	243	249	PF00069	0.362
MOD_PKA_2	303	309	PF00069	0.315
MOD_PKA_2	380	386	PF00069	0.522
MOD_PKA_2	510	516	PF00069	0.456
MOD_PKA_2	551	557	PF00069	0.666
MOD_PKB_1	15	23	PF00069	0.288
MOD_Plk_1	158	164	PF00069	0.266
MOD_Plk_1	257	263	PF00069	0.559
MOD_Plk_1	28	34	PF00069	0.510
MOD_Plk_1	359	365	PF00069	0.508
MOD_Plk_4	124	130	PF00069	0.286
MOD_Plk_4	172	178	PF00069	0.270
MOD_Plk_4	311	317	PF00069	0.408
MOD_Plk_4	359	365	PF00069	0.508
MOD_Plk_4	385	391	PF00069	0.433
MOD_Plk_4	484	490	PF00069	0.366
MOD_ProDKin_1	198	204	PF00069	0.395
MOD_ProDKin_1	215	221	PF00069	0.395
MOD_ProDKin_1	326	332	PF00069	0.297
MOD_ProDKin_1	520	526	PF00069	0.565
MOD_SUMO_for_1	402	405	PF00179	0.441
MOD_SUMO_for_1	593	596	PF00179	0.534
MOD_SUMO_rev_2	22	26	PF00179	0.463
MOD_SUMO_rev_2	371	376	PF00179	0.427
MOD_SUMO_rev_2	379	383	PF00179	0.425
MOD_SUMO_rev_2	474	480	PF00179	0.522
MOD_SUMO_rev_2	505	513	PF00179	0.603
MOD_SUMO_rev_2	533	541	PF00179	0.655
MOD_SUMO_rev_2	611	618	PF00179	0.567
TRG_ENDOCYTIC_2	176	179	PF00928	0.292
TRG_ENDOCYTIC_2	229	232	PF00928	0.277
TRG_ENDOCYTIC_2	332	335	PF00928	0.479
TRG_ENDOCYTIC_2	54	57	PF00928	0.377
TRG_ENDOCYTIC_2	95	98	PF00928	0.252
TRG_ER_diArg_1	14	17	PF00400	0.293
TRG_ER_diArg_1	265	267	PF00400	0.304
TRG_ER_diArg_1	366	368	PF00400	0.535
TRG_ER_diArg_1	528	530	PF00400	0.543
TRG_ER_diArg_1	57	59	PF00400	0.470
TRG_ER_diArg_1	606	608	PF00400	0.507
TRG_NES_CRM1_1	385	400	PF08389	0.337
TRG_NES_CRM1_1	453	465	PF08389	0.384
TRG_NLS_MonoExtN_4	347	353	PF00514	0.494
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	529	534	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	607	611	PF00026	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1K9	Leptomonas seymouri	69%	100%
A0A0S4IR67	Bodo saltans	23%	80%
A0A0S4J0Q2	Bodo saltans	22%	75%
A0A0S4JPE8	Bodo saltans	33%	69%
A0A0S4JRN9	Bodo saltans	23%	95%
A0A1X0NPH9	Trypanosomatidae	21%	68%
A0A1X0P435	Trypanosomatidae	43%	100%
A0A3R7KHX7	Trypanosoma rangeli	21%	85%
A0A422NMD1	Trypanosoma rangeli	45%	100%
A4HQ31	Leishmania braziliensis	75%	100%
A4IDT7	Leishmania infantum	100%	100%
C9ZV26	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	83%
D0A8T5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ATU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
P46873	Caenorhabditis elegans	22%	89%
Q1MTQ1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
Q4Q0P7	Leishmania major	94%	100%
Q4QEL8	Leishmania major	23%	77%
V5B6Q5	Trypanosoma cruzi	44%	100%
V5D733	Trypanosoma cruzi	23%	83%