CUE domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XBW7_LEIDO

TriTrypDb:

LdBPK_365950.1 , LdCL_360066900 , LDHU3_36.7860

Length:

790

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XBW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBW7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	365	369	PF00656	0.498
CLV_C14_Caspase3-7	4	8	PF00656	0.506
CLV_C14_Caspase3-7	550	554	PF00656	0.535
CLV_C14_Caspase3-7	587	591	PF00656	0.651
CLV_C14_Caspase3-7	663	667	PF00656	0.663
CLV_NRD_NRD_1	105	107	PF00675	0.525
CLV_NRD_NRD_1	254	256	PF00675	0.454
CLV_NRD_NRD_1	289	291	PF00675	0.613
CLV_NRD_NRD_1	677	679	PF00675	0.806
CLV_NRD_NRD_1	683	685	PF00675	0.617
CLV_NRD_NRD_1	77	79	PF00675	0.459
CLV_NRD_NRD_1	782	784	PF00675	0.619
CLV_PCSK_FUR_1	680	684	PF00082	0.623
CLV_PCSK_KEX2_1	105	107	PF00082	0.474
CLV_PCSK_KEX2_1	254	256	PF00082	0.456
CLV_PCSK_KEX2_1	289	291	PF00082	0.608
CLV_PCSK_KEX2_1	677	679	PF00082	0.806
CLV_PCSK_KEX2_1	682	684	PF00082	0.624
CLV_PCSK_KEX2_1	731	733	PF00082	0.577
CLV_PCSK_KEX2_1	736	738	PF00082	0.567
CLV_PCSK_KEX2_1	782	784	PF00082	0.656
CLV_PCSK_PC1ET2_1	731	733	PF00082	0.567
CLV_PCSK_PC1ET2_1	736	738	PF00082	0.553
CLV_PCSK_PC7_1	678	684	PF00082	0.653
CLV_PCSK_PC7_1	732	738	PF00082	0.666
CLV_PCSK_SKI1_1	124	128	PF00082	0.448
CLV_PCSK_SKI1_1	255	259	PF00082	0.530
CLV_PCSK_SKI1_1	481	485	PF00082	0.479
CLV_PCSK_SKI1_1	95	99	PF00082	0.369
CLV_Separin_Metazoa	390	394	PF03568	0.477
DOC_CYCLIN_RxL_1	121	130	PF00134	0.443
DOC_CYCLIN_yCln2_LP_2	340	346	PF00134	0.403
DOC_CYCLIN_yCln2_LP_2	507	513	PF00134	0.584
DOC_MAPK_gen_1	225	234	PF00069	0.458
DOC_MAPK_gen_1	380	389	PF00069	0.386
DOC_MAPK_MEF2A_6	124	133	PF00069	0.515
DOC_MAPK_MEF2A_6	225	234	PF00069	0.329
DOC_MAPK_MEF2A_6	353	362	PF00069	0.481
DOC_MAPK_MEF2A_6	382	391	PF00069	0.374
DOC_MAPK_MEF2A_6	54	62	PF00069	0.461
DOC_MAPK_MEF2A_6	88	96	PF00069	0.468
DOC_MAPK_RevD_3	92	106	PF00069	0.453
DOC_PP1_RVXF_1	122	128	PF00149	0.410
DOC_PP2B_LxvP_1	340	343	PF13499	0.347
DOC_PP4_FxxP_1	296	299	PF00568	0.388
DOC_SPAK_OSR1_1	172	176	PF12202	0.377
DOC_USP7_MATH_1	139	143	PF00917	0.421
DOC_USP7_MATH_1	15	19	PF00917	0.431
DOC_USP7_MATH_1	538	542	PF00917	0.744
DOC_USP7_MATH_1	552	556	PF00917	0.616
DOC_USP7_MATH_1	664	668	PF00917	0.619
DOC_USP7_MATH_1	69	73	PF00917	0.399
DOC_USP7_MATH_1	711	715	PF00917	0.691
DOC_USP7_MATH_1	770	774	PF00917	0.728
DOC_USP7_UBL2_3	763	767	PF12436	0.627
DOC_WW_Pin1_4	235	240	PF00397	0.339
DOC_WW_Pin1_4	249	254	PF00397	0.403
DOC_WW_Pin1_4	441	446	PF00397	0.648
DOC_WW_Pin1_4	448	453	PF00397	0.698
DOC_WW_Pin1_4	544	549	PF00397	0.708
DOC_WW_Pin1_4	714	719	PF00397	0.716
LIG_14-3-3_CanoR_1	116	120	PF00244	0.422
LIG_14-3-3_CanoR_1	172	176	PF00244	0.416
LIG_14-3-3_CanoR_1	260	265	PF00244	0.521
LIG_14-3-3_CanoR_1	304	313	PF00244	0.408
LIG_14-3-3_CanoR_1	710	719	PF00244	0.746
LIG_14-3-3_CanoR_1	95	104	PF00244	0.392
LIG_AP2alpha_1	563	567	PF02296	0.613
LIG_APCC_ABBAyCdc20_2	393	399	PF00400	0.526
LIG_BIR_II_1	1	5	PF00653	0.457
LIG_BIR_III_2	7	11	PF00653	0.484
LIG_BRCT_BRCA1_1	17	21	PF00533	0.427
LIG_BRCT_BRCA1_1	368	372	PF00533	0.494
LIG_BRCT_BRCA1_1	620	624	PF00533	0.700
LIG_Clathr_ClatBox_1	386	390	PF01394	0.395
LIG_EH1_1	126	134	PF00400	0.402
LIG_eIF4E_1	328	334	PF01652	0.403
LIG_EVH1_2	342	346	PF00568	0.446
LIG_FHA_1	144	150	PF00498	0.349
LIG_FHA_1	202	208	PF00498	0.449
LIG_FHA_1	279	285	PF00498	0.355
LIG_FHA_1	361	367	PF00498	0.528
LIG_FHA_1	42	48	PF00498	0.437
LIG_FHA_1	421	427	PF00498	0.441
LIG_FHA_1	455	461	PF00498	0.666
LIG_FHA_1	743	749	PF00498	0.660
LIG_FHA_2	163	169	PF00498	0.472
LIG_FHA_2	406	412	PF00498	0.391
LIG_FHA_2	548	554	PF00498	0.574
LIG_FHA_2	610	616	PF00498	0.791
LIG_FHA_2	62	68	PF00498	0.338
LIG_FHA_2	96	102	PF00498	0.443
LIG_FXI_DFP_1	560	564	PF00024	0.617
LIG_GBD_Chelix_1	113	121	PF00786	0.458
LIG_HP1_1	463	467	PF01393	0.541
LIG_LIR_Gen_1	18	26	PF02991	0.438
LIG_LIR_Gen_1	195	203	PF02991	0.520
LIG_LIR_Gen_1	218	227	PF02991	0.452
LIG_LIR_Gen_1	305	313	PF02991	0.383
LIG_LIR_Gen_1	44	50	PF02991	0.399
LIG_LIR_Gen_1	579	585	PF02991	0.540
LIG_LIR_Gen_1	699	709	PF02991	0.756
LIG_LIR_Nem_3	165	170	PF02991	0.493
LIG_LIR_Nem_3	18	24	PF02991	0.434
LIG_LIR_Nem_3	195	200	PF02991	0.475
LIG_LIR_Nem_3	218	223	PF02991	0.402
LIG_LIR_Nem_3	28	34	PF02991	0.316
LIG_LIR_Nem_3	305	309	PF02991	0.380
LIG_LIR_Nem_3	42	48	PF02991	0.300
LIG_LIR_Nem_3	470	475	PF02991	0.544
LIG_LIR_Nem_3	579	584	PF02991	0.588
LIG_LIR_Nem_3	699	705	PF02991	0.588
LIG_MLH1_MIPbox_1	17	21	PF16413	0.442
LIG_Pex14_1	123	127	PF04695	0.408
LIG_Pex14_2	162	166	PF04695	0.429
LIG_Pex14_2	563	567	PF04695	0.613
LIG_PTB_Apo_2	149	156	PF02174	0.318
LIG_PTB_Apo_2	300	307	PF02174	0.503
LIG_PTB_Phospho_1	149	155	PF10480	0.320
LIG_PTB_Phospho_1	300	306	PF10480	0.502
LIG_SH2_CRK	220	224	PF00017	0.409
LIG_SH2_GRB2like	487	490	PF00017	0.404
LIG_SH2_GRB2like	759	762	PF00017	0.708
LIG_SH2_SRC	339	342	PF00017	0.327
LIG_SH2_SRC	593	596	PF00017	0.624
LIG_SH2_SRC	692	695	PF00017	0.552
LIG_SH2_STAP1	487	491	PF00017	0.526
LIG_SH2_STAP1	581	585	PF00017	0.623
LIG_SH2_STAP1	642	646	PF00017	0.553
LIG_SH2_STAT3	282	285	PF00017	0.516
LIG_SH2_STAT3	312	315	PF00017	0.466
LIG_SH2_STAT5	155	158	PF00017	0.337
LIG_SH2_STAT5	312	315	PF00017	0.476
LIG_SH2_STAT5	339	342	PF00017	0.545
LIG_SH2_STAT5	696	699	PF00017	0.517
LIG_SH3_3	116	122	PF00018	0.456
LIG_SH3_3	233	239	PF00018	0.462
LIG_SH3_3	250	256	PF00018	0.531
LIG_SH3_3	281	287	PF00018	0.348
LIG_SH3_3	444	450	PF00018	0.626
LIG_SH3_3	457	463	PF00018	0.623
LIG_SUMO_SIM_anti_2	115	121	PF11976	0.412
LIG_SUMO_SIM_anti_2	130	135	PF11976	0.279
LIG_SUMO_SIM_anti_2	146	152	PF11976	0.351
LIG_SUMO_SIM_anti_2	385	390	PF11976	0.381
LIG_SUMO_SIM_par_1	232	238	PF11976	0.323
LIG_SUMO_SIM_par_1	358	363	PF11976	0.520
LIG_SUMO_SIM_par_1	385	390	PF11976	0.381
LIG_TRAF2_1	408	411	PF00917	0.521
LIG_TRAF2_1	526	529	PF00917	0.558
LIG_UBA3_1	359	364	PF00899	0.491
LIG_WRC_WIRS_1	159	164	PF05994	0.473
LIG_WRC_WIRS_1	194	199	PF05994	0.479
MOD_CDK_SPK_2	249	254	PF00069	0.493
MOD_CDK_SPxK_1	249	255	PF00069	0.490
MOD_CDK_SPxxK_3	544	551	PF00069	0.678
MOD_CK1_1	112	118	PF00069	0.393
MOD_CK1_1	418	424	PF00069	0.497
MOD_CK1_1	514	520	PF00069	0.608
MOD_CK1_1	547	553	PF00069	0.603
MOD_CK1_1	618	624	PF00069	0.607
MOD_CK1_1	71	77	PF00069	0.534
MOD_CK1_1	714	720	PF00069	0.678
MOD_CK1_1	773	779	PF00069	0.602
MOD_CK2_1	192	198	PF00069	0.558
MOD_CK2_1	405	411	PF00069	0.406
MOD_CK2_1	514	520	PF00069	0.594
MOD_Cter_Amidation	675	678	PF01082	0.572
MOD_GlcNHglycan	136	139	PF01048	0.427
MOD_GlcNHglycan	273	276	PF01048	0.424
MOD_GlcNHglycan	475	478	PF01048	0.465
MOD_GlcNHglycan	513	516	PF01048	0.653
MOD_GlcNHglycan	553	557	PF01048	0.640
MOD_GlcNHglycan	713	716	PF01048	0.712
MOD_GSK3_1	139	146	PF00069	0.342
MOD_GSK3_1	15	22	PF00069	0.393
MOD_GSK3_1	158	165	PF00069	0.390
MOD_GSK3_1	215	222	PF00069	0.399
MOD_GSK3_1	256	263	PF00069	0.413
MOD_GSK3_1	360	367	PF00069	0.445
MOD_GSK3_1	406	413	PF00069	0.575
MOD_GSK3_1	441	448	PF00069	0.628
MOD_N-GLC_1	270	275	PF02516	0.456
MOD_N-GLC_1	302	307	PF02516	0.492
MOD_N-GLC_1	329	334	PF02516	0.456
MOD_NEK2_1	1	6	PF00069	0.445
MOD_NEK2_1	134	139	PF00069	0.452
MOD_NEK2_1	278	283	PF00069	0.379
MOD_NEK2_1	511	516	PF00069	0.658
MOD_NEK2_1	742	747	PF00069	0.619
MOD_NEK2_2	538	543	PF00069	0.633
MOD_PK_1	260	266	PF00069	0.463
MOD_PKA_1	762	768	PF00069	0.606
MOD_PKA_2	115	121	PF00069	0.454
MOD_PKA_2	134	140	PF00069	0.426
MOD_PKA_2	171	177	PF00069	0.412
MOD_PKA_2	201	207	PF00069	0.455
MOD_Plk_1	302	308	PF00069	0.445
MOD_Plk_1	321	327	PF00069	0.460
MOD_Plk_1	41	47	PF00069	0.411
MOD_Plk_1	496	502	PF00069	0.464
MOD_Plk_1	604	610	PF00069	0.783
MOD_Plk_2-3	662	668	PF00069	0.705
MOD_Plk_4	115	121	PF00069	0.439
MOD_Plk_4	127	133	PF00069	0.260
MOD_Plk_4	144	150	PF00069	0.355
MOD_Plk_4	158	164	PF00069	0.417
MOD_Plk_4	16	22	PF00069	0.372
MOD_Plk_4	260	266	PF00069	0.418
MOD_Plk_4	329	335	PF00069	0.416
MOD_Plk_4	41	47	PF00069	0.323
MOD_Plk_4	615	621	PF00069	0.677
MOD_ProDKin_1	235	241	PF00069	0.337
MOD_ProDKin_1	249	255	PF00069	0.400
MOD_ProDKin_1	441	447	PF00069	0.649
MOD_ProDKin_1	448	454	PF00069	0.698
MOD_ProDKin_1	544	550	PF00069	0.706
MOD_ProDKin_1	714	720	PF00069	0.716
MOD_SUMO_rev_2	625	632	PF00179	0.636
TRG_DiLeu_BaEn_4	410	416	PF01217	0.538
TRG_ENDOCYTIC_2	220	223	PF00928	0.442
TRG_ENDOCYTIC_2	306	309	PF00928	0.358
TRG_ENDOCYTIC_2	573	576	PF00928	0.560
TRG_ENDOCYTIC_2	581	584	PF00928	0.522
TRG_ER_diArg_1	104	106	PF00400	0.473
TRG_ER_diArg_1	183	186	PF00400	0.605
TRG_ER_diArg_1	253	255	PF00400	0.500
TRG_ER_diArg_1	380	383	PF00400	0.393
TRG_ER_diArg_1	677	680	PF00400	0.690
TRG_ER_diArg_1	682	684	PF00400	0.658
TRG_ER_diArg_1	781	783	PF00400	0.497
TRG_NES_CRM1_1	235	250	PF08389	0.436
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	578	582	PF00026	0.654
TRG_Pf-PMV_PEXEL_1	635	639	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3W0	Leptomonas seymouri	62%	99%
A0A1X0P037	Trypanosomatidae	37%	100%
A0A422NSD1	Trypanosoma rangeli	39%	100%
A4HQ86	Leishmania braziliensis	80%	100%
A4IDY4	Leishmania infantum	99%	100%
D0A425	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AU04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q0J1	Leishmania major	92%	100%
V5BTA0	Trypanosoma cruzi	39%	100%