Leucine-rich repeat protein (LRRP), putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

leucine-rich repeat protein (LRRP), putative

Species:

Leishmania donovani

UniProt:

A0A3S7XBW4_LEIDO

TriTrypDb:

LdBPK_366040.1 , LdCL_360067800 , LDHU3_36.7970

Length:

256

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12

Expansion

Sequence features

A0A3S7XBW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBW4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	234	236	PF00675	0.580
CLV_NRD_NRD_1	33	35	PF00675	0.522
CLV_PCSK_KEX2_1	234	236	PF00082	0.573
CLV_PCSK_KEX2_1	33	35	PF00082	0.572
CLV_PCSK_SKI1_1	148	152	PF00082	0.618
CLV_PCSK_SKI1_1	98	102	PF00082	0.507
DEG_Nend_Nbox_1	1	3	PF02207	0.595
DEG_SPOP_SBC_1	190	194	PF00917	0.599
DOC_CDC14_PxL_1	115	123	PF14671	0.405
DOC_MAPK_MEF2A_6	214	223	PF00069	0.518
DOC_PP4_FxxP_1	28	31	PF00568	0.505
DOC_USP7_MATH_1	169	173	PF00917	0.580
DOC_USP7_MATH_1	212	216	PF00917	0.533
DOC_USP7_MATH_1	225	229	PF00917	0.477
DOC_WW_Pin1_4	138	143	PF00397	0.692
LIG_14-3-3_CanoR_1	170	177	PF00244	0.435
LIG_14-3-3_CanoR_1	185	190	PF00244	0.593
LIG_14-3-3_CanoR_1	60	65	PF00244	0.402
LIG_14-3-3_CanoR_1	9	16	PF00244	0.516
LIG_14-3-3_CterR_2	254	256	PF00244	0.557
LIG_Clathr_ClatBox_1	149	153	PF01394	0.587
LIG_DLG_GKlike_1	185	193	PF00625	0.578
LIG_DLG_GKlike_1	60	67	PF00625	0.526
LIG_EH1_1	84	92	PF00400	0.483
LIG_FHA_1	203	209	PF00498	0.615
LIG_FHA_1	222	228	PF00498	0.302
LIG_FHA_1	246	252	PF00498	0.735
LIG_FHA_2	133	139	PF00498	0.532
LIG_FHA_2	191	197	PF00498	0.613
LIG_FHA_2	224	230	PF00498	0.606
LIG_FHA_2	9	15	PF00498	0.462
LIG_LIR_Gen_1	215	223	PF02991	0.605
LIG_LIR_Nem_3	215	219	PF02991	0.591
LIG_SH2_STAT3	22	25	PF00017	0.532
LIG_SH2_STAT5	183	186	PF00017	0.584
LIG_SH3_3	111	117	PF00018	0.506
LIG_SUMO_SIM_anti_2	147	153	PF11976	0.559
LIG_SUMO_SIM_par_1	147	153	PF11976	0.505
LIG_SUMO_SIM_par_1	52	57	PF11976	0.446
LIG_TRAF2_2	142	147	PF00917	0.674
LIG_WRC_WIRS_1	213	218	PF05994	0.592
MOD_CDC14_SPxK_1	145	148	PF00782	0.503
MOD_CDK_SPxK_1	142	148	PF00069	0.517
MOD_CK1_1	108	114	PF00069	0.483
MOD_CK1_1	215	221	PF00069	0.567
MOD_CK1_1	228	234	PF00069	0.607
MOD_CK1_1	247	253	PF00069	0.421
MOD_CK1_1	62	68	PF00069	0.482
MOD_CK2_1	185	191	PF00069	0.549
MOD_CK2_1	223	229	PF00069	0.649
MOD_CK2_1	62	68	PF00069	0.453
MOD_GlcNHglycan	180	183	PF01048	0.484
MOD_GlcNHglycan	55	59	PF01048	0.409
MOD_GlcNHglycan	64	67	PF01048	0.480
MOD_GlcNHglycan	86	90	PF01048	0.412
MOD_GSK3_1	134	141	PF00069	0.706
MOD_GSK3_1	185	192	PF00069	0.499
MOD_GSK3_1	198	205	PF00069	0.512
MOD_GSK3_1	221	228	PF00069	0.601
MOD_GSK3_1	62	69	PF00069	0.541
MOD_GSK3_1	85	92	PF00069	0.440
MOD_N-GLC_1	202	207	PF02516	0.641
MOD_NEK2_1	16	21	PF00069	0.484
MOD_NEK2_1	184	189	PF00069	0.561
MOD_NEK2_1	223	228	PF00069	0.630
MOD_PIKK_1	16	22	PF00454	0.519
MOD_PK_1	105	111	PF00069	0.513
MOD_PKA_2	169	175	PF00069	0.449
MOD_PKA_2	184	190	PF00069	0.588
MOD_PKA_2	59	65	PF00069	0.479
MOD_PKA_2	8	14	PF00069	0.466
MOD_Plk_1	228	234	PF00069	0.594
MOD_Plk_1	85	91	PF00069	0.446
MOD_Plk_4	72	78	PF00069	0.472
MOD_ProDKin_1	138	144	PF00069	0.691
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.691
TRG_ENDOCYTIC_2	37	40	PF00928	0.475
TRG_ER_diArg_1	233	235	PF00400	0.452
TRG_ER_diArg_1	32	34	PF00400	0.494
TRG_Pf-PMV_PEXEL_1	148	153	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGK7	Leptomonas seymouri	47%	100%
A0A0S4JA81	Bodo saltans	31%	100%
A0A1X0NLL5	Trypanosomatidae	41%	100%
A0A3R7KRR0	Trypanosoma rangeli	44%	100%
A4HQ95	Leishmania braziliensis	71%	100%
A4IDZ3	Leishmania infantum	100%	100%
D0A416	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AU13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q0I2	Leishmania major	88%	100%
V5BNS2	Trypanosoma cruzi	39%	100%