SEP domain/UBX domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SEP domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XBW1_LEIDO

TriTrypDb:

LdBPK_365680.1 , LdCL_360064200 , LDHU3_36.7550

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A0A3S7XBW1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBW1

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.581
CLV_C14_Caspase3-7	226	230	PF00656	0.558
CLV_C14_Caspase3-7	465	469	PF00656	0.527
CLV_NRD_NRD_1	281	283	PF00675	0.488
CLV_NRD_NRD_1	413	415	PF00675	0.690
CLV_NRD_NRD_1	45	47	PF00675	0.494
CLV_NRD_NRD_1	505	507	PF00675	0.481
CLV_NRD_NRD_1	56	58	PF00675	0.600
CLV_NRD_NRD_1	6	8	PF00675	0.723
CLV_PCSK_KEX2_1	281	283	PF00082	0.449
CLV_PCSK_KEX2_1	413	415	PF00082	0.690
CLV_PCSK_KEX2_1	45	47	PF00082	0.493
CLV_PCSK_KEX2_1	5	7	PF00082	0.728
CLV_PCSK_KEX2_1	504	506	PF00082	0.467
CLV_PCSK_KEX2_1	56	58	PF00082	0.603
CLV_PCSK_SKI1_1	159	163	PF00082	0.502
CLV_PCSK_SKI1_1	211	215	PF00082	0.707
CLV_PCSK_SKI1_1	307	311	PF00082	0.486
CLV_PCSK_SKI1_1	447	451	PF00082	0.471
CLV_PCSK_SKI1_1	46	50	PF00082	0.520
CLV_PCSK_SKI1_1	611	615	PF00082	0.608
DEG_APCC_DBOX_1	45	53	PF00400	0.571
DEG_Nend_UBRbox_3	1	3	PF02207	0.739
DOC_AGCK_PIF_2	359	364	PF00069	0.474
DOC_CYCLIN_RxL_1	43	51	PF00134	0.610
DOC_CYCLIN_yClb5_NLxxxL_5	531	540	PF00134	0.423
DOC_CYCLIN_yCln2_LP_2	29	35	PF00134	0.626
DOC_MAPK_gen_1	319	328	PF00069	0.392
DOC_MAPK_MEF2A_6	319	328	PF00069	0.355
DOC_MAPK_MEF2A_6	604	612	PF00069	0.495
DOC_PP2B_LxvP_1	276	279	PF13499	0.517
DOC_USP7_MATH_1	174	178	PF00917	0.649
DOC_USP7_MATH_1	200	204	PF00917	0.791
DOC_USP7_MATH_1	207	211	PF00917	0.652
DOC_USP7_MATH_1	272	276	PF00917	0.514
DOC_USP7_MATH_1	527	531	PF00917	0.712
DOC_USP7_MATH_1	569	573	PF00917	0.444
DOC_USP7_MATH_1	58	62	PF00917	0.645
DOC_USP7_MATH_1	66	70	PF00917	0.572
DOC_USP7_UBL2_3	232	236	PF12436	0.652
DOC_USP7_UBL2_3	307	311	PF12436	0.503
DOC_USP7_UBL2_3	447	451	PF12436	0.347
DOC_WW_Pin1_4	11	16	PF00397	0.680
DOC_WW_Pin1_4	18	23	PF00397	0.679
DOC_WW_Pin1_4	183	188	PF00397	0.686
DOC_WW_Pin1_4	198	203	PF00397	0.645
DOC_WW_Pin1_4	251	256	PF00397	0.678
DOC_WW_Pin1_4	33	38	PF00397	0.658
DOC_WW_Pin1_4	422	427	PF00397	0.767
DOC_WW_Pin1_4	438	443	PF00397	0.545
DOC_WW_Pin1_4	516	521	PF00397	0.684
DOC_WW_Pin1_4	56	61	PF00397	0.679
LIG_14-3-3_CanoR_1	281	286	PF00244	0.545
LIG_14-3-3_CanoR_1	298	306	PF00244	0.385
LIG_14-3-3_CanoR_1	428	433	PF00244	0.698
LIG_14-3-3_CanoR_1	595	601	PF00244	0.433
LIG_APCC_ABBA_1	153	158	PF00400	0.413
LIG_BRCT_BRCA1_1	218	222	PF00533	0.598
LIG_BRCT_BRCA1_1	528	532	PF00533	0.645
LIG_deltaCOP1_diTrp_1	589	597	PF00928	0.535
LIG_eIF4E_1	156	162	PF01652	0.462
LIG_FHA_1	148	154	PF00498	0.459
LIG_FHA_1	238	244	PF00498	0.724
LIG_FHA_1	605	611	PF00498	0.369
LIG_FHA_2	152	158	PF00498	0.543
LIG_FHA_2	42	48	PF00498	0.588
LIG_FHA_2	429	435	PF00498	0.679
LIG_FHA_2	74	80	PF00498	0.752
LIG_Integrin_isoDGR_2	3	5	PF01839	0.667
LIG_LIR_Gen_1	596	602	PF02991	0.399
LIG_LIR_Nem_3	357	362	PF02991	0.467
LIG_LIR_Nem_3	572	576	PF02991	0.481
LIG_LIR_Nem_3	596	600	PF02991	0.472
LIG_Pex14_1	306	310	PF04695	0.411
LIG_Pex14_2	218	222	PF04695	0.692
LIG_Rb_pABgroove_1	150	158	PF01858	0.542
LIG_SH2_CRK	131	135	PF00017	0.556
LIG_SH2_CRK	440	444	PF00017	0.508
LIG_SH2_NCK_1	440	444	PF00017	0.586
LIG_SH2_STAT5	303	306	PF00017	0.526
LIG_SH2_STAT5	440	443	PF00017	0.587
LIG_SH3_2	206	211	PF14604	0.637
LIG_SH3_2	419	424	PF14604	0.602
LIG_SH3_3	181	187	PF00018	0.617
LIG_SH3_3	203	209	PF00018	0.735
LIG_SH3_3	336	342	PF00018	0.442
LIG_SH3_3	402	408	PF00018	0.683
LIG_SH3_3	416	422	PF00018	0.755
LIG_SH3_3	60	66	PF00018	0.717
LIG_SUMO_SIM_par_1	149	158	PF11976	0.482
LIG_SUMO_SIM_par_1	30	36	PF11976	0.670
LIG_SUMO_SIM_par_1	372	378	PF11976	0.431
LIG_SUMO_SIM_par_1	441	446	PF11976	0.426
LIG_SUMO_SIM_par_1	462	468	PF11976	0.485
LIG_TYR_ITIM	438	443	PF00017	0.615
LIG_UBA3_1	540	548	PF00899	0.417
LIG_UBA3_1	608	614	PF00899	0.458
LIG_WRPW_2	340	343	PF00400	0.431
MOD_CDC14_SPxK_1	21	24	PF00782	0.679
MOD_CDC14_SPxK_1	254	257	PF00782	0.668
MOD_CDC14_SPxK_1	425	428	PF00782	0.516
MOD_CDK_SPxK_1	18	24	PF00069	0.693
MOD_CDK_SPxK_1	251	257	PF00069	0.680
MOD_CDK_SPxK_1	422	428	PF00069	0.521
MOD_CDK_SPxxK_3	18	25	PF00069	0.691
MOD_CDK_SPxxK_3	183	190	PF00069	0.676
MOD_CK1_1	284	290	PF00069	0.517
MOD_CK1_1	482	488	PF00069	0.676
MOD_CK1_1	519	525	PF00069	0.648
MOD_CK1_1	59	65	PF00069	0.733
MOD_CK1_1	9	15	PF00069	0.613
MOD_CK2_1	41	47	PF00069	0.603
MOD_CK2_1	428	434	PF00069	0.636
MOD_CK2_1	494	500	PF00069	0.407
MOD_CK2_1	558	564	PF00069	0.332
MOD_CK2_1	569	575	PF00069	0.351
MOD_CK2_1	75	81	PF00069	0.685
MOD_Cter_Amidation	3	6	PF01082	0.620
MOD_Cter_Amidation	411	414	PF01082	0.712
MOD_GlcNHglycan	11	14	PF01048	0.803
MOD_GlcNHglycan	176	179	PF01048	0.642
MOD_GlcNHglycan	218	221	PF01048	0.654
MOD_GlcNHglycan	268	271	PF01048	0.705
MOD_GlcNHglycan	459	462	PF01048	0.593
MOD_GlcNHglycan	482	485	PF01048	0.608
MOD_GlcNHglycan	496	499	PF01048	0.318
MOD_GlcNHglycan	516	519	PF01048	0.450
MOD_GlcNHglycan	524	527	PF01048	0.641
MOD_GlcNHglycan	68	71	PF01048	0.665
MOD_GlcNHglycan	92	95	PF01048	0.583
MOD_GSK3_1	147	154	PF00069	0.547
MOD_GSK3_1	198	205	PF00069	0.722
MOD_GSK3_1	216	223	PF00069	0.614
MOD_GSK3_1	476	483	PF00069	0.597
MOD_GSK3_1	5	12	PF00069	0.768
MOD_GSK3_1	522	529	PF00069	0.622
MOD_GSK3_1	86	93	PF00069	0.648
MOD_NEK2_1	242	247	PF00069	0.655
MOD_NEK2_2	151	156	PF00069	0.543
MOD_NEK2_2	489	494	PF00069	0.520
MOD_NEK2_2	527	532	PF00069	0.493
MOD_PIKK_1	112	118	PF00454	0.570
MOD_PIKK_1	195	201	PF00454	0.754
MOD_PIKK_1	396	402	PF00454	0.569
MOD_PK_1	281	287	PF00069	0.473
MOD_PKA_1	281	287	PF00069	0.522
MOD_PKA_1	5	11	PF00069	0.616
MOD_PKA_2	281	287	PF00069	0.588
MOD_PKA_2	5	11	PF00069	0.657
MOD_PKA_2	64	70	PF00069	0.595
MOD_PKB_1	88	96	PF00069	0.609
MOD_Plk_1	555	561	PF00069	0.398
MOD_Plk_4	151	157	PF00069	0.493
MOD_Plk_4	527	533	PF00069	0.634
MOD_Plk_4	604	610	PF00069	0.358
MOD_ProDKin_1	11	17	PF00069	0.679
MOD_ProDKin_1	18	24	PF00069	0.679
MOD_ProDKin_1	183	189	PF00069	0.688
MOD_ProDKin_1	198	204	PF00069	0.646
MOD_ProDKin_1	251	257	PF00069	0.680
MOD_ProDKin_1	33	39	PF00069	0.652
MOD_ProDKin_1	422	428	PF00069	0.767
MOD_ProDKin_1	438	444	PF00069	0.536
MOD_ProDKin_1	516	522	PF00069	0.684
MOD_ProDKin_1	56	62	PF00069	0.679
MOD_SUMO_for_1	586	589	PF00179	0.587
MOD_SUMO_rev_2	229	239	PF00179	0.651
MOD_SUMO_rev_2	433	438	PF00179	0.645
TRG_DiLeu_BaLyEn_6	29	34	PF01217	0.627
TRG_ENDOCYTIC_2	131	134	PF00928	0.560
TRG_ENDOCYTIC_2	440	443	PF00928	0.519
TRG_ER_diArg_1	281	283	PF00400	0.565
TRG_ER_diArg_1	413	415	PF00400	0.723
TRG_ER_diArg_1	5	7	PF00400	0.788
TRG_ER_diArg_1	503	506	PF00400	0.503
TRG_ER_diArg_1	87	90	PF00400	0.636
TRG_Pf-PMV_PEXEL_1	132	136	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.598
TRG_Pf-PMV_PEXEL_1	159	163	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	298	302	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.616

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMT0	Leptomonas seymouri	56%	99%
A0A0S4JTW8	Bodo saltans	32%	100%
A0A1X0P060	Trypanosomatidae	35%	100%
A0A3R7LYT2	Trypanosoma rangeli	32%	100%
A4HQ59	Leishmania braziliensis	76%	99%
A4IDV8	Leishmania infantum	100%	100%
D0A458	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9ATX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%
Q4Q0L7	Leishmania major	93%	100%
V5BQB1	Trypanosoma cruzi	34%	100%