SEP domain/UBX domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SEP domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XBW1_LEIDO

TriTrypDb:

LdBPK_365680.1 , LdCL_360064200 , LDHU3_36.7550

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

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Expansion

Sequence features

A0A3S7XBW1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBW1

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.581
CLV_C14_Caspase3-7	226	230	PF00656	0.558
CLV_C14_Caspase3-7	465	469	PF00656	0.527
CLV_NRD_NRD_1	281	283	PF00675	0.488
CLV_NRD_NRD_1	413	415	PF00675	0.690
CLV_NRD_NRD_1	45	47	PF00675	0.494
CLV_NRD_NRD_1	505	507	PF00675	0.481
CLV_NRD_NRD_1	56	58	PF00675	0.600
CLV_NRD_NRD_1	6	8	PF00675	0.723
CLV_PCSK_KEX2_1	281	283	PF00082	0.449

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMT0	Leptomonas seymouri	56%	99%
A0A0S4JTW8	Bodo saltans	32%	100%
A0A1X0P060	Trypanosomatidae	35%	100%
A0A3R7LYT2	Trypanosoma rangeli	32%	100%
A4HQ59	Leishmania braziliensis	76%	99%
A4IDV8	Leishmania infantum	100%	100%
D0A458	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9ATX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%
Q4Q0L7	Leishmania major	93%	100%
V5BQB1	Trypanosoma cruzi	34%	100%

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