ENTH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XBW0_LEIDO

TriTrypDb:

LdBPK_365820.1 , LdCL_360065600 , LDHU3_36.7720

Length:

372

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XBW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBW0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	73	77	PF00656	0.540
CLV_NRD_NRD_1	118	120	PF00675	0.490
CLV_NRD_NRD_1	12	14	PF00675	0.495
CLV_NRD_NRD_1	196	198	PF00675	0.606
CLV_NRD_NRD_1	29	31	PF00675	0.481
CLV_NRD_NRD_1	47	49	PF00675	0.396
CLV_PCSK_KEX2_1	118	120	PF00082	0.540
CLV_PCSK_KEX2_1	12	14	PF00082	0.378
CLV_PCSK_KEX2_1	196	198	PF00082	0.605
CLV_PCSK_KEX2_1	29	31	PF00082	0.484
CLV_PCSK_KEX2_1	312	314	PF00082	0.527
CLV_PCSK_PC1ET2_1	312	314	PF00082	0.563
CLV_PCSK_SKI1_1	196	200	PF00082	0.773
CLV_PCSK_SKI1_1	259	263	PF00082	0.414
CLV_PCSK_SKI1_1	350	354	PF00082	0.680
DEG_APCC_DBOX_1	29	37	PF00400	0.397
DEG_SPOP_SBC_1	142	146	PF00917	0.577
DEG_SPOP_SBC_1	188	192	PF00917	0.630
DOC_CYCLIN_RxL_1	43	53	PF00134	0.413
DOC_MAPK_gen_1	43	52	PF00069	0.498
DOC_MAPK_MEF2A_6	214	222	PF00069	0.493
DOC_MIT_MIM_1	7	17	PF04212	0.387
DOC_PP2B_LxvP_1	102	105	PF13499	0.485
DOC_PP2B_LxvP_1	222	225	PF13499	0.366
DOC_USP7_MATH_1	142	146	PF00917	0.705
DOC_USP7_MATH_1	188	192	PF00917	0.630
DOC_WW_Pin1_4	134	139	PF00397	0.671
LIG_14-3-3_CanoR_1	196	201	PF00244	0.636
LIG_14-3-3_CanoR_1	244	250	PF00244	0.394
LIG_14-3-3_CanoR_1	259	269	PF00244	0.363
LIG_14-3-3_CanoR_1	29	34	PF00244	0.447
LIG_14-3-3_CanoR_1	338	343	PF00244	0.600
LIG_14-3-3_CanoR_1	48	53	PF00244	0.326
LIG_Actin_WH2_2	191	206	PF00022	0.591
LIG_APCC_ABBA_1	331	336	PF00400	0.569
LIG_BIR_II_1	1	5	PF00653	0.467
LIG_BRCT_BRCA1_1	324	328	PF00533	0.550
LIG_FHA_1	231	237	PF00498	0.504
LIG_FHA_1	241	247	PF00498	0.368
LIG_FHA_1	97	103	PF00498	0.423
LIG_FHA_2	181	187	PF00498	0.666
LIG_FHA_2	282	288	PF00498	0.445
LIG_FHA_2	357	363	PF00498	0.640
LIG_LIR_Gen_1	157	162	PF02991	0.668
LIG_LIR_Gen_1	172	179	PF02991	0.431
LIG_LIR_Gen_1	276	286	PF02991	0.412
LIG_LIR_Gen_1	325	334	PF02991	0.504
LIG_LIR_Nem_3	157	161	PF02991	0.680
LIG_LIR_Nem_3	172	176	PF02991	0.546
LIG_LIR_Nem_3	276	282	PF02991	0.411
LIG_LIR_Nem_3	325	331	PF02991	0.552
LIG_MYND_1	201	205	PF01753	0.583
LIG_Pex14_2	261	265	PF04695	0.482
LIG_Pex14_2	368	372	PF04695	0.591
LIG_SH2_CRK	158	162	PF00017	0.664
LIG_SH2_GRB2like	279	282	PF00017	0.519
LIG_SH2_NCK_1	87	91	PF00017	0.417
LIG_SH2_SRC	87	90	PF00017	0.412
LIG_SH2_STAP1	158	162	PF00017	0.664
LIG_SH2_STAP1	249	253	PF00017	0.391
LIG_SH2_STAP1	279	283	PF00017	0.519
LIG_SH2_STAT3	307	310	PF00017	0.553
LIG_SH2_STAT5	249	252	PF00017	0.473
LIG_SH2_STAT5	316	319	PF00017	0.487
LIG_SH2_STAT5	56	59	PF00017	0.360
LIG_SH3_3	130	136	PF00018	0.566
LIG_SUMO_SIM_anti_2	174	180	PF11976	0.606
LIG_SUMO_SIM_anti_2	6	12	PF11976	0.386
LIG_SUMO_SIM_anti_2	63	69	PF11976	0.378
LIG_SUMO_SIM_anti_2	99	104	PF11976	0.474
LIG_SUMO_SIM_par_1	76	83	PF11976	0.469
MOD_CK1_1	177	183	PF00069	0.671
MOD_CK1_1	189	195	PF00069	0.687
MOD_CK1_1	23	29	PF00069	0.518
MOD_CK1_1	96	102	PF00069	0.473
MOD_CK2_1	141	147	PF00069	0.727
MOD_CK2_1	180	186	PF00069	0.669
MOD_CK2_1	231	237	PF00069	0.466
MOD_CK2_1	281	287	PF00069	0.541
MOD_GlcNHglycan	127	130	PF01048	0.570
MOD_GlcNHglycan	179	182	PF01048	0.610
MOD_GlcNHglycan	253	256	PF01048	0.491
MOD_GlcNHglycan	262	265	PF01048	0.448
MOD_GlcNHglycan	284	287	PF01048	0.500
MOD_GlcNHglycan	318	321	PF01048	0.641
MOD_GSK3_1	188	195	PF00069	0.684
MOD_GSK3_1	245	252	PF00069	0.496
MOD_GSK3_1	297	304	PF00069	0.543
MOD_GSK3_1	312	319	PF00069	0.503
MOD_N-GLC_1	297	302	PF02516	0.576
MOD_N-GLC_1	338	343	PF02516	0.536
MOD_N-GLC_1	96	101	PF02516	0.373
MOD_NEK2_1	187	192	PF00069	0.664
MOD_NEK2_1	230	235	PF00069	0.489
MOD_NEK2_1	240	245	PF00069	0.353
MOD_NEK2_1	301	306	PF00069	0.656
MOD_NEK2_1	327	332	PF00069	0.496
MOD_PKA_1	196	202	PF00069	0.732
MOD_PKA_1	29	35	PF00069	0.447
MOD_PKA_1	312	318	PF00069	0.520
MOD_PKA_1	48	54	PF00069	0.392
MOD_PKA_2	196	202	PF00069	0.702
MOD_PKA_2	203	209	PF00069	0.651
MOD_PKA_2	23	29	PF00069	0.413
MOD_PKA_2	312	318	PF00069	0.497
MOD_Plk_1	231	237	PF00069	0.524
MOD_Plk_1	297	303	PF00069	0.578
MOD_Plk_1	338	344	PF00069	0.472
MOD_Plk_1	6	12	PF00069	0.479
MOD_Plk_1	96	102	PF00069	0.377
MOD_Plk_4	157	163	PF00069	0.642
MOD_Plk_4	174	180	PF00069	0.658
MOD_Plk_4	216	222	PF00069	0.368
MOD_Plk_4	301	307	PF00069	0.568
MOD_Plk_4	312	318	PF00069	0.457
MOD_Plk_4	327	333	PF00069	0.438
MOD_Plk_4	6	12	PF00069	0.512
MOD_ProDKin_1	134	140	PF00069	0.667
MOD_SUMO_for_1	352	355	PF00179	0.538
TRG_DiLeu_BaEn_1	53	58	PF01217	0.449
TRG_DiLeu_BaEn_1	63	68	PF01217	0.379
TRG_ENDOCYTIC_2	158	161	PF00928	0.663
TRG_ENDOCYTIC_2	279	282	PF00928	0.519
TRG_ER_diArg_1	11	13	PF00400	0.485
TRG_ER_diArg_1	196	198	PF00400	0.606
TRG_ER_diArg_1	288	291	PF00400	0.534
TRG_Pf-PMV_PEXEL_1	48	53	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9D5	Leptomonas seymouri	74%	99%
A0A3R7RKF3	Trypanosoma rangeli	36%	100%
A4HQ74	Leishmania braziliensis	81%	98%
A4IDX2	Leishmania infantum	100%	100%
D0A445	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ATZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q0K3	Leishmania major	94%	100%
V5B3M7	Trypanosoma cruzi	36%	100%