32 kDa ER-associated protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XBV9_LEIDO

TriTrypDb:

LdBPK_365280.1 , LdCL_360060000 , LDHU3_36.7060

Length:

260

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XBV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBV9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.339
CLV_NRD_NRD_1	130	132	PF00675	0.493
CLV_NRD_NRD_1	215	217	PF00675	0.532
CLV_NRD_NRD_1	236	238	PF00675	0.655
CLV_NRD_NRD_1	43	45	PF00675	0.674
CLV_PCSK_KEX2_1	130	132	PF00082	0.509
CLV_PCSK_KEX2_1	215	217	PF00082	0.567
CLV_PCSK_KEX2_1	235	237	PF00082	0.687
CLV_PCSK_KEX2_1	45	47	PF00082	0.649
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.593
CLV_PCSK_SKI1_1	236	240	PF00082	0.652
CLV_PCSK_SKI1_1	54	58	PF00082	0.589
CLV_PCSK_SKI1_1	92	96	PF00082	0.533
DEG_SPOP_SBC_1	15	19	PF00917	0.280
DOC_MAPK_FxFP_2	162	165	PF00069	0.381
DOC_MAPK_gen_1	143	152	PF00069	0.345
DOC_MAPK_gen_1	64	74	PF00069	0.329
DOC_MAPK_HePTP_8	140	152	PF00069	0.369
DOC_MAPK_MEF2A_6	143	152	PF00069	0.346
DOC_MAPK_MEF2A_6	67	76	PF00069	0.364
DOC_MAPK_NFAT4_5	145	153	PF00069	0.381
DOC_PP1_RVXF_1	2	8	PF00149	0.607
DOC_PP2B_LxvP_1	150	153	PF13499	0.395
DOC_PP4_FxxP_1	162	165	PF00568	0.351
DOC_PP4_FxxP_1	57	60	PF00568	0.449
DOC_USP7_MATH_1	15	19	PF00917	0.395
DOC_USP7_MATH_1	153	157	PF00917	0.348
DOC_WW_Pin1_4	202	207	PF00397	0.412
DOC_WW_Pin1_4	56	61	PF00397	0.356
DOC_WW_Pin1_4	78	83	PF00397	0.391
DOC_WW_Pin1_4	87	92	PF00397	0.362
LIG_14-3-3_CanoR_1	4	10	PF00244	0.684
LIG_14-3-3_CanoR_1	44	53	PF00244	0.499
LIG_14-3-3_CterR_2	256	260	PF00244	0.401
LIG_Actin_WH2_2	95	111	PF00022	0.400
LIG_BRCT_BRCA1_1	17	21	PF00533	0.392
LIG_BRCT_BRCA1_1	80	84	PF00533	0.380
LIG_deltaCOP1_diTrp_1	51	57	PF00928	0.395
LIG_FHA_1	167	173	PF00498	0.343
LIG_FHA_1	198	204	PF00498	0.476
LIG_FHA_1	225	231	PF00498	0.429
LIG_FHA_1	84	90	PF00498	0.409
LIG_FHA_2	142	148	PF00498	0.325
LIG_FHA_2	182	188	PF00498	0.330
LIG_LIR_Apic_2	155	160	PF02991	0.402
LIG_LIR_Apic_2	37	41	PF02991	0.344
LIG_LIR_Apic_2	55	60	PF02991	0.337
LIG_LIR_Gen_1	146	157	PF02991	0.377
LIG_LIR_Gen_1	71	79	PF02991	0.327
LIG_LIR_Gen_1	81	91	PF02991	0.307
LIG_LIR_Nem_3	146	152	PF02991	0.360
LIG_LIR_Nem_3	205	210	PF02991	0.428
LIG_LIR_Nem_3	47	52	PF02991	0.441
LIG_LIR_Nem_3	55	61	PF02991	0.430
LIG_LIR_Nem_3	71	76	PF02991	0.329
LIG_LIR_Nem_3	81	87	PF02991	0.325
LIG_PALB2_WD40_1	186	194	PF16756	0.396
LIG_Pex14_1	53	57	PF04695	0.438
LIG_Pex14_2	164	168	PF04695	0.330
LIG_Pex14_2	32	36	PF04695	0.374
LIG_SH2_CRK	157	161	PF00017	0.360
LIG_SH2_CRK	38	42	PF00017	0.378
LIG_SH2_CRK	58	62	PF00017	0.244
LIG_SH2_NCK_1	38	42	PF00017	0.441
LIG_SH2_SRC	149	152	PF00017	0.261
LIG_SH2_STAT5	113	116	PF00017	0.335
LIG_SH2_STAT5	125	128	PF00017	0.263
LIG_SH2_STAT5	149	152	PF00017	0.397
LIG_SH2_STAT5	49	52	PF00017	0.437
LIG_SH3_3	200	206	PF00018	0.475
LIG_SH3_3	76	82	PF00018	0.362
LIG_SUMO_SIM_par_1	75	81	PF11976	0.337
LIG_TRAF2_1	63	66	PF00917	0.382
LIG_UBA3_1	83	92	PF00899	0.372
MOD_CDK_SPK_2	87	92	PF00069	0.382
MOD_CK1_1	197	203	PF00069	0.385
MOD_CK1_1	39	45	PF00069	0.450
MOD_CK2_1	181	187	PF00069	0.331
MOD_CK2_1	228	234	PF00069	0.411
MOD_CK2_1	60	66	PF00069	0.347
MOD_GlcNHglycan	191	194	PF01048	0.687
MOD_GlcNHglycan	23	26	PF01048	0.341
MOD_GlcNHglycan	54	57	PF01048	0.631
MOD_GSK3_1	220	227	PF00069	0.413
MOD_GSK3_1	52	59	PF00069	0.421
MOD_GSK3_1	83	90	PF00069	0.417
MOD_LATS_1	141	147	PF00433	0.280
MOD_NEK2_1	14	19	PF00069	0.341
MOD_NEK2_1	172	177	PF00069	0.376
MOD_NEK2_1	181	186	PF00069	0.344
MOD_NEK2_1	194	199	PF00069	0.351
MOD_NEK2_1	21	26	PF00069	0.318
MOD_NEK2_1	220	225	PF00069	0.350
MOD_NEK2_1	5	10	PF00069	0.684
MOD_NEK2_1	52	57	PF00069	0.411
MOD_NEK2_1	83	88	PF00069	0.421
MOD_NEK2_1	95	100	PF00069	0.326
MOD_PKA_1	228	234	PF00069	0.445
MOD_PKA_1	44	50	PF00069	0.384
MOD_Plk_4	16	22	PF00069	0.337
MOD_Plk_4	72	78	PF00069	0.324
MOD_ProDKin_1	202	208	PF00069	0.406
MOD_ProDKin_1	56	62	PF00069	0.348
MOD_ProDKin_1	78	84	PF00069	0.401
MOD_ProDKin_1	87	93	PF00069	0.358
TRG_DiLeu_BaEn_4	65	71	PF01217	0.364
TRG_ENDOCYTIC_2	149	152	PF00928	0.316
TRG_ENDOCYTIC_2	217	220	PF00928	0.399
TRG_ENDOCYTIC_2	49	52	PF00928	0.429
TRG_ENDOCYTIC_2	58	61	PF00928	0.407
TRG_ER_diArg_1	129	131	PF00400	0.306
TRG_ER_diArg_1	215	217	PF00400	0.335
TRG_ER_diArg_1	235	237	PF00400	0.469
TRG_ER_diArg_1	43	46	PF00400	0.460
TRG_NLS_MonoExtN_4	41	48	PF00514	0.358
TRG_Pf-PMV_PEXEL_1	131	135	PF00026	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZW1	Leptomonas seymouri	69%	97%
A0A0S4JNP4	Bodo saltans	28%	100%
A0A1X0NDW5	Trypanosomatidae	39%	100%
A4HQ21	Leishmania braziliensis	83%	100%
A4IDS8	Leishmania infantum	97%	100%
D0A8U8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9ATT9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q0Q7	Leishmania major	93%	100%