Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XBV5_LEIDO

TriTrypDb:

LdBPK_365940.1 , LdCL_360066800 , LDHU3_36.7850

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XBV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBV5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.481
CLV_C14_Caspase3-7	98	102	PF00656	0.641
CLV_NRD_NRD_1	291	293	PF00675	0.530
CLV_NRD_NRD_1	300	302	PF00675	0.549
CLV_NRD_NRD_1	39	41	PF00675	0.689
CLV_PCSK_KEX2_1	215	217	PF00082	0.393
CLV_PCSK_KEX2_1	281	283	PF00082	0.542
CLV_PCSK_KEX2_1	300	302	PF00082	0.402
CLV_PCSK_KEX2_1	39	41	PF00082	0.689
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.393
CLV_PCSK_PC1ET2_1	281	283	PF00082	0.558
CLV_PCSK_PC7_1	211	217	PF00082	0.425
CLV_PCSK_SKI1_1	143	147	PF00082	0.371
CLV_PCSK_SKI1_1	292	296	PF00082	0.575
CLV_PCSK_SKI1_1	306	310	PF00082	0.533
CLV_PCSK_SKI1_1	85	89	PF00082	0.536
DEG_APCC_DBOX_1	38	46	PF00400	0.746
DEG_Nend_UBRbox_3	1	3	PF02207	0.681
DOC_CKS1_1	245	250	PF01111	0.461
DOC_CKS1_1	295	300	PF01111	0.441
DOC_CYCLIN_RxL_1	137	150	PF00134	0.380
DOC_MAPK_MEF2A_6	118	125	PF00069	0.540
DOC_PP2B_LxvP_1	246	249	PF13499	0.615
DOC_PP2B_LxvP_1	309	312	PF13499	0.608
DOC_PP4_FxxP_1	286	289	PF00568	0.580
DOC_PP4_FxxP_1	295	298	PF00568	0.623
DOC_USP7_MATH_1	18	22	PF00917	0.652
DOC_USP7_MATH_1	233	237	PF00917	0.607
DOC_USP7_UBL2_3	143	147	PF12436	0.497
DOC_USP7_UBL2_3	54	58	PF12436	0.541
DOC_WW_Pin1_4	244	249	PF00397	0.501
DOC_WW_Pin1_4	294	299	PF00397	0.590
DOC_WW_Pin1_4	30	35	PF00397	0.678
LIG_14-3-3_CanoR_1	232	240	PF00244	0.655
LIG_14-3-3_CanoR_1	3	7	PF00244	0.658
LIG_14-3-3_CanoR_1	52	57	PF00244	0.545
LIG_APCC_ABBA_1	161	166	PF00400	0.541
LIG_FHA_1	105	111	PF00498	0.506
LIG_LIR_Apic_2	284	289	PF02991	0.588
LIG_LIR_Gen_1	150	157	PF02991	0.359
LIG_LIR_Gen_1	88	97	PF02991	0.649
LIG_LIR_Nem_3	173	178	PF02991	0.460
LIG_LIR_Nem_3	88	94	PF02991	0.537
LIG_Pex14_2	63	67	PF04695	0.541
LIG_SH2_CRK	53	57	PF00017	0.679
LIG_SH2_NCK_1	75	79	PF00017	0.665
LIG_SH2_SRC	178	181	PF00017	0.372
LIG_SH2_STAT5	103	106	PF00017	0.539
LIG_SH2_STAT5	178	181	PF00017	0.396
LIG_SH2_STAT5	285	288	PF00017	0.511
LIG_SH3_3	273	279	PF00018	0.512
LIG_SH3_3	309	315	PF00018	0.554
LIG_SUMO_SIM_par_1	121	128	PF11976	0.542
MOD_CDK_SPxK_1	294	300	PF00069	0.555
MOD_CDK_SPxxK_3	294	301	PF00069	0.439
MOD_CK1_1	21	27	PF00069	0.624
MOD_CK1_1	33	39	PF00069	0.633
MOD_CK2_1	247	253	PF00069	0.537
MOD_GlcNHglycan	157	160	PF01048	0.454
MOD_GlcNHglycan	235	238	PF01048	0.641
MOD_GlcNHglycan	255	258	PF01048	0.326
MOD_GSK3_1	18	25	PF00069	0.639
MOD_GSK3_1	249	256	PF00069	0.615
MOD_GSK3_1	26	33	PF00069	0.639
MOD_LATS_1	50	56	PF00433	0.626
MOD_LATS_1	83	89	PF00433	0.537
MOD_NEK2_1	1	6	PF00069	0.576
MOD_NEK2_1	155	160	PF00069	0.416
MOD_NEK2_1	22	27	PF00069	0.683
MOD_NEK2_2	18	23	PF00069	0.558
MOD_PKA_2	155	161	PF00069	0.474
MOD_PKA_2	2	8	PF00069	0.595
MOD_PKA_2	61	67	PF00069	0.669
MOD_Plk_1	217	223	PF00069	0.517
MOD_Plk_4	171	177	PF00069	0.425
MOD_Plk_4	23	29	PF00069	0.520
MOD_Plk_4	52	58	PF00069	0.544
MOD_ProDKin_1	244	250	PF00069	0.493
MOD_ProDKin_1	294	300	PF00069	0.594
MOD_ProDKin_1	30	36	PF00069	0.678
MOD_SUMO_rev_2	236	244	PF00179	0.713
TRG_ENDOCYTIC_2	53	56	PF00928	0.679
TRG_ENDOCYTIC_2	75	78	PF00928	0.584
TRG_ER_diArg_1	289	292	PF00400	0.569
TRG_ER_diArg_1	299	301	PF00400	0.584
TRG_Pf-PMV_PEXEL_1	264	268	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	43	47	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGJ4	Leptomonas seymouri	77%	99%
A0A0S4IS55	Bodo saltans	50%	100%
A0A1X0P0I2	Trypanosomatidae	62%	100%
A0A3R7M3K5	Trypanosoma rangeli	59%	100%
A4HQ85	Leishmania braziliensis	86%	100%
A4IDY3	Leishmania infantum	100%	100%
D0A426	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AU03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q0J2	Leishmania major	95%	100%