LeishMANIAdb
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Pre-mRNA-splicing_factor_CWC22_putative/GeneDB:Lm jF.36.5160

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Pre-mRNA-splicing_factor_CWC22_putative/GeneDB:Lm jF.36.5160
Gene product:
pre-mRNA-splicing factor CWC22, putative
Species:
Leishmania donovani
UniProt:
A0A3S7XBU7_LEIDO
TriTrypDb:
LdBPK_365390.1 , LdCL_360061100 , LDHU3_36.7210
Length:
565

Annotations

LeishMANIAdb annotations

Certainly not TM

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 10
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005681 spliceosomal complex 3 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032991 protein-containing complex 1 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0071013 catalytic step 2 spliceosome 3 1
GO:0110165 cellular anatomical entity 1 1
GO:0140513 nuclear protein-containing complex 2 1
GO:1902494 catalytic complex 2 1
GO:1990904 ribonucleoprotein complex 2 1

Expansion

Sequence features

A0A3S7XBU7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBU7

Function

Biological processes
Term Name Level Count
GO:0000375 RNA splicing, via transesterification reactions 8 1
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 9 1
GO:0000398 mRNA splicing, via spliceosome 8 1
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006396 RNA processing 6 1
GO:0006397 mRNA processing 7 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0008380 RNA splicing 7 1
GO:0009987 cellular process 1 1
GO:0016070 RNA metabolic process 5 1
GO:0016071 mRNA metabolic process 6 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0046483 heterocycle metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 11
GO:0003723 RNA binding 4 11
GO:0005488 binding 1 11
GO:0097159 organic cyclic compound binding 2 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 320 324 PF00656 0.553
CLV_C14_Caspase3-7 350 354 PF00656 0.413
CLV_NRD_NRD_1 109 111 PF00675 0.255
CLV_NRD_NRD_1 120 122 PF00675 0.266
CLV_NRD_NRD_1 185 187 PF00675 0.594
CLV_NRD_NRD_1 229 231 PF00675 0.609
CLV_NRD_NRD_1 285 287 PF00675 0.535
CLV_NRD_NRD_1 356 358 PF00675 0.416
CLV_NRD_NRD_1 360 362 PF00675 0.208
CLV_NRD_NRD_1 406 408 PF00675 0.276
CLV_NRD_NRD_1 9 11 PF00675 0.403
CLV_PCSK_KEX2_1 109 111 PF00082 0.228
CLV_PCSK_KEX2_1 160 162 PF00082 0.546
CLV_PCSK_KEX2_1 185 187 PF00082 0.594
CLV_PCSK_KEX2_1 229 231 PF00082 0.609
CLV_PCSK_KEX2_1 360 362 PF00082 0.276
CLV_PCSK_KEX2_1 559 561 PF00082 0.551
CLV_PCSK_KEX2_1 9 11 PF00082 0.403
CLV_PCSK_PC1ET2_1 160 162 PF00082 0.546
CLV_PCSK_PC1ET2_1 559 561 PF00082 0.638
CLV_PCSK_PC7_1 555 561 PF00082 0.623
CLV_PCSK_SKI1_1 154 158 PF00082 0.550
CLV_PCSK_SKI1_1 197 201 PF00082 0.485
CLV_PCSK_SKI1_1 268 272 PF00082 0.537
CLV_PCSK_SKI1_1 287 291 PF00082 0.474
CLV_PCSK_SKI1_1 38 42 PF00082 0.269
CLV_PCSK_SKI1_1 548 552 PF00082 0.583
CLV_PCSK_SKI1_1 68 72 PF00082 0.235
DEG_SPOP_SBC_1 13 17 PF00917 0.647
DOC_CKS1_1 192 197 PF01111 0.268
DOC_CYCLIN_RxL_1 65 74 PF00134 0.443
DOC_MAPK_gen_1 357 365 PF00069 0.451
DOC_MAPK_MEF2A_6 358 367 PF00069 0.482
DOC_MAPK_MEF2A_6 529 538 PF00069 0.342
DOC_PP1_RVXF_1 130 137 PF00149 0.420
DOC_PP1_RVXF_1 388 395 PF00149 0.435
DOC_USP7_MATH_1 12 16 PF00917 0.705
DOC_USP7_MATH_1 331 335 PF00917 0.535
DOC_USP7_MATH_1 366 370 PF00917 0.420
DOC_USP7_MATH_1 527 531 PF00917 0.242
DOC_USP7_MATH_1 91 95 PF00917 0.481
DOC_WW_Pin1_4 191 196 PF00397 0.261
DOC_WW_Pin1_4 83 88 PF00397 0.567
LIG_14-3-3_CanoR_1 185 189 PF00244 0.314
LIG_14-3-3_CanoR_1 208 216 PF00244 0.279
LIG_14-3-3_CanoR_1 407 413 PF00244 0.492
LIG_14-3-3_CanoR_1 459 464 PF00244 0.543
LIG_14-3-3_CanoR_1 467 475 PF00244 0.454
LIG_14-3-3_CanoR_1 512 521 PF00244 0.291
LIG_Actin_WH2_2 192 210 PF00022 0.350
LIG_Actin_WH2_2 533 550 PF00022 0.384
LIG_APCC_ABBA_1 193 198 PF00400 0.368
LIG_APCC_ABBA_1 57 62 PF00400 0.509
LIG_BIR_II_1 1 5 PF00653 0.623
LIG_BIR_III_4 304 308 PF00653 0.534
LIG_BRCT_BRCA1_1 24 28 PF00533 0.600
LIG_Clathr_ClatBox_1 199 203 PF01394 0.309
LIG_Clathr_ClatBox_1 241 245 PF01394 0.286
LIG_deltaCOP1_diTrp_1 508 519 PF00928 0.389
LIG_FHA_1 174 180 PF00498 0.360
LIG_FHA_1 21 27 PF00498 0.639
LIG_FHA_1 39 45 PF00498 0.418
LIG_FHA_1 448 454 PF00498 0.455
LIG_FHA_1 458 464 PF00498 0.464
LIG_FHA_1 513 519 PF00498 0.287
LIG_FHA_1 542 548 PF00498 0.410
LIG_FHA_1 76 82 PF00498 0.565
LIG_FHA_1 84 90 PF00498 0.491
LIG_FHA_1 91 97 PF00498 0.443
LIG_FHA_2 100 106 PF00498 0.452
LIG_FHA_2 275 281 PF00498 0.395
LIG_FHA_2 339 345 PF00498 0.313
LIG_FHA_2 348 354 PF00498 0.389
LIG_GBD_Chelix_1 103 111 PF00786 0.347
LIG_LIR_Apic_2 2 7 PF02991 0.599
LIG_LIR_Gen_1 146 156 PF02991 0.297
LIG_LIR_Gen_1 239 248 PF02991 0.361
LIG_LIR_Gen_1 279 290 PF02991 0.335
LIG_LIR_Gen_1 362 371 PF02991 0.409
LIG_LIR_Gen_1 391 398 PF02991 0.420
LIG_LIR_Nem_3 123 127 PF02991 0.456
LIG_LIR_Nem_3 146 152 PF02991 0.309
LIG_LIR_Nem_3 194 199 PF02991 0.370
LIG_LIR_Nem_3 239 243 PF02991 0.346
LIG_LIR_Nem_3 279 285 PF02991 0.337
LIG_LIR_Nem_3 31 36 PF02991 0.465
LIG_LIR_Nem_3 391 397 PF02991 0.420
LIG_MYND_1 83 87 PF01753 0.557
LIG_PCNA_PIPBox_1 481 490 PF02747 0.389
LIG_PCNA_yPIPBox_3 481 490 PF02747 0.281
LIG_Pex14_1 115 119 PF04695 0.479
LIG_Pex14_2 173 177 PF04695 0.255
LIG_Pex14_2 424 428 PF04695 0.413
LIG_SH2_CRK 149 153 PF00017 0.277
LIG_SH2_NCK_1 410 414 PF00017 0.513
LIG_SH2_NCK_1 436 440 PF00017 0.409
LIG_SH2_PTP2 4 7 PF00017 0.587
LIG_SH2_SRC 4 7 PF00017 0.587
LIG_SH2_STAP1 269 273 PF00017 0.418
LIG_SH2_STAP1 410 414 PF00017 0.513
LIG_SH2_STAP1 449 453 PF00017 0.417
LIG_SH2_STAP1 454 458 PF00017 0.420
LIG_SH2_STAT5 119 122 PF00017 0.568
LIG_SH2_STAT5 126 129 PF00017 0.461
LIG_SH2_STAT5 133 136 PF00017 0.189
LIG_SH2_STAT5 240 243 PF00017 0.370
LIG_SH2_STAT5 364 367 PF00017 0.476
LIG_SH2_STAT5 4 7 PF00017 0.587
LIG_SH2_STAT5 449 452 PF00017 0.457
LIG_SH2_STAT5 487 490 PF00017 0.457
LIG_SH2_STAT5 535 538 PF00017 0.402
LIG_SUMO_SIM_anti_2 102 108 PF11976 0.447
LIG_SUMO_SIM_anti_2 144 149 PF11976 0.303
LIG_SUMO_SIM_anti_2 295 300 PF11976 0.400
LIG_SUMO_SIM_anti_2 470 476 PF11976 0.440
LIG_SUMO_SIM_par_1 141 146 PF11976 0.307
LIG_TRAF2_1 277 280 PF00917 0.339
LIG_TRAF2_1 550 553 PF00917 0.405
LIG_TYR_ITIM 147 152 PF00017 0.301
LIG_UBA3_1 147 154 PF00899 0.353
LIG_UBA3_1 243 251 PF00899 0.420
LIG_UBA3_1 484 490 PF00899 0.389
MOD_CDK_SPxK_1 191 197 PF00069 0.331
MOD_CK1_1 210 216 PF00069 0.431
MOD_CK1_1 22 28 PF00069 0.484
MOD_CK1_1 338 344 PF00069 0.315
MOD_CK1_1 440 446 PF00069 0.351
MOD_CK2_1 178 184 PF00069 0.422
MOD_CK2_1 274 280 PF00069 0.506
MOD_CK2_1 338 344 PF00069 0.339
MOD_CK2_1 435 441 PF00069 0.326
MOD_CK2_1 52 58 PF00069 0.330
MOD_CK2_1 99 105 PF00069 0.310
MOD_GlcNHglycan 325 328 PF01048 0.715
MOD_GlcNHglycan 341 344 PF01048 0.201
MOD_GlcNHglycan 437 440 PF01048 0.457
MOD_GlcNHglycan 529 532 PF01048 0.456
MOD_GlcNHglycan 54 57 PF01048 0.349
MOD_GSK3_1 14 21 PF00069 0.603
MOD_GSK3_1 155 162 PF00069 0.389
MOD_GSK3_1 331 338 PF00069 0.701
MOD_GSK3_1 34 41 PF00069 0.350
MOD_GSK3_1 459 466 PF00069 0.443
MOD_GSK3_1 71 78 PF00069 0.428
MOD_LATS_1 433 439 PF00433 0.389
MOD_N-GLC_1 128 133 PF02516 0.410
MOD_NEK2_1 173 178 PF00069 0.312
MOD_NEK2_1 20 25 PF00069 0.490
MOD_NEK2_1 207 212 PF00069 0.402
MOD_NEK2_1 345 350 PF00069 0.457
MOD_NEK2_1 36 41 PF00069 0.261
MOD_NEK2_1 367 372 PF00069 0.274
MOD_NEK2_1 417 422 PF00069 0.251
MOD_NEK2_1 457 462 PF00069 0.337
MOD_NEK2_1 52 57 PF00069 0.314
MOD_NEK2_1 71 76 PF00069 0.189
MOD_PIKK_1 210 216 PF00454 0.480
MOD_PIKK_1 477 483 PF00454 0.259
MOD_PIKK_1 512 518 PF00454 0.520
MOD_PIKK_1 75 81 PF00454 0.414
MOD_PK_1 459 465 PF00069 0.358
MOD_PKA_2 173 179 PF00069 0.310
MOD_PKA_2 184 190 PF00069 0.361
MOD_PKA_2 207 213 PF00069 0.367
MOD_PKA_2 367 373 PF00069 0.244
MOD_Plk_1 128 134 PF00069 0.342
MOD_Plk_1 262 268 PF00069 0.351
MOD_Plk_1 388 394 PF00069 0.260
MOD_Plk_1 440 446 PF00069 0.399
MOD_Plk_2-3 159 165 PF00069 0.429
MOD_Plk_2-3 184 190 PF00069 0.492
MOD_Plk_2-3 99 105 PF00069 0.310
MOD_Plk_4 347 353 PF00069 0.339
MOD_Plk_4 459 465 PF00069 0.444
MOD_Plk_4 99 105 PF00069 0.424
MOD_ProDKin_1 191 197 PF00069 0.323
MOD_ProDKin_1 83 89 PF00069 0.460
MOD_SUMO_rev_2 253 261 PF00179 0.552
MOD_SUMO_rev_2 353 359 PF00179 0.308
TRG_DiLeu_BaEn_1 479 484 PF01217 0.389
TRG_DiLeu_LyEn_5 479 484 PF01217 0.242
TRG_ENDOCYTIC_2 149 152 PF00928 0.288
TRG_ENDOCYTIC_2 240 243 PF00928 0.469
TRG_ENDOCYTIC_2 282 285 PF00928 0.414
TRG_ENDOCYTIC_2 364 367 PF00928 0.244
TRG_ENDOCYTIC_2 406 409 PF00928 0.246
TRG_ENDOCYTIC_2 454 457 PF00928 0.259
TRG_ENDOCYTIC_2 535 538 PF00928 0.433
TRG_ER_diArg_1 109 111 PF00400 0.297
TRG_ER_diArg_1 359 361 PF00400 0.337
TRG_ER_diArg_1 560 563 PF00400 0.494
TRG_ER_diArg_1 65 68 PF00400 0.296
TRG_NES_CRM1_1 190 206 PF08389 0.492
TRG_NES_CRM1_1 235 247 PF08389 0.496
TRG_NES_CRM1_1 526 542 PF08389 0.484
TRG_NLS_MonoExtC_3 558 564 PF00514 0.561
TRG_Pf-PMV_PEXEL_1 109 114 PF00026 0.344
TRG_Pf-PMV_PEXEL_1 357 362 PF00026 0.303
TRG_Pf-PMV_PEXEL_1 482 486 PF00026 0.393

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCA4 Leptomonas seymouri 79% 99%
A0A0S4JKH9 Bodo saltans 37% 100%
A0A1X0P4F9 Trypanosomatidae 51% 93%
A0A3S5IRG5 Trypanosoma rangeli 56% 95%
A4HQ32 Leishmania braziliensis 87% 100%
A4IDT8 Leishmania infantum 99% 100%
D0A8T4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 53% 97%
E9ATV0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
P0CM96 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 30% 68%
P0CM97 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 30% 68%
Q4Q0P6 Leishmania major 96% 100%
Q52KN9 Xenopus laevis 29% 70%
Q59XY0 Candida albicans (strain SC5314 / ATCC MYA-2876) 23% 87%
Q6BU84 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 25% 89%
Q751P4 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 23% 100%
V5DNB7 Trypanosoma cruzi 54% 89%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS