Adiponectin receptor protein 1, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Haemolysin-III related, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XBU6_LEIDO

TriTrypDb:

LdBPK_365750.1 , LdCL_360064900 , LDHU3_36.7640

Length:

508

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	18
GO:0110165	cellular anatomical entity	1	18

Expansion

Sequence features

A0A3S7XBU6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBU6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0038023	signaling receptor activity	2	3
GO:0060089	molecular transducer activity	1	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.730
CLV_C14_Caspase3-7	9	13	PF00656	0.606
CLV_NRD_NRD_1	16	18	PF00675	0.422
CLV_NRD_NRD_1	200	202	PF00675	0.488
CLV_PCSK_KEX2_1	16	18	PF00082	0.422
CLV_PCSK_KEX2_1	199	201	PF00082	0.539
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.531
CLV_PCSK_SKI1_1	17	21	PF00082	0.438
CLV_PCSK_SKI1_1	263	267	PF00082	0.327
CLV_PCSK_SKI1_1	299	303	PF00082	0.487
CLV_PCSK_SKI1_1	340	344	PF00082	0.245
CLV_PCSK_SKI1_1	63	67	PF00082	0.513
DEG_ODPH_VHL_1	418	430	PF01847	0.269
DEG_SPOP_SBC_1	125	129	PF00917	0.646
DOC_CKS1_1	146	151	PF01111	0.626
DOC_CKS1_1	175	180	PF01111	0.648
DOC_CKS1_1	85	90	PF01111	0.552
DOC_MAPK_DCC_7	36	45	PF00069	0.598
DOC_MAPK_gen_1	16	22	PF00069	0.639
DOC_MAPK_gen_1	34	42	PF00069	0.577
DOC_MAPK_HePTP_8	403	415	PF00069	0.425
DOC_MAPK_MEF2A_6	36	45	PF00069	0.598
DOC_MAPK_MEF2A_6	401	409	PF00069	0.434
DOC_PP1_RVXF_1	345	351	PF00149	0.469
DOC_PP4_FxxP_1	165	168	PF00568	0.624
DOC_PP4_FxxP_1	361	364	PF00568	0.391
DOC_USP7_MATH_1	125	129	PF00917	0.701
DOC_USP7_MATH_1	15	19	PF00917	0.656
DOC_USP7_MATH_1	41	45	PF00917	0.636
DOC_USP7_MATH_1	421	425	PF00917	0.330
DOC_USP7_MATH_1	433	437	PF00917	0.205
DOC_USP7_MATH_1	78	82	PF00917	0.694
DOC_WW_Pin1_4	145	150	PF00397	0.677
DOC_WW_Pin1_4	174	179	PF00397	0.689
DOC_WW_Pin1_4	84	89	PF00397	0.654
LIG_14-3-3_CanoR_1	139	149	PF00244	0.709
LIG_14-3-3_CanoR_1	16	20	PF00244	0.741
LIG_14-3-3_CanoR_1	160	166	PF00244	0.601
LIG_14-3-3_CanoR_1	200	205	PF00244	0.679
LIG_14-3-3_CanoR_1	219	225	PF00244	0.452
LIG_14-3-3_CanoR_1	253	262	PF00244	0.529
LIG_14-3-3_CanoR_1	340	348	PF00244	0.424
LIG_14-3-3_CanoR_1	406	410	PF00244	0.436
LIG_14-3-3_CanoR_1	57	65	PF00244	0.632
LIG_Actin_WH2_2	294	309	PF00022	0.192
LIG_BIR_II_1	1	5	PF00653	0.642
LIG_BRCT_BRCA1_1	38	42	PF00533	0.619
LIG_deltaCOP1_diTrp_1	469	478	PF00928	0.513
LIG_eIF4E_1	379	385	PF01652	0.330
LIG_FHA_1	141	147	PF00498	0.637
LIG_FHA_1	154	160	PF00498	0.707
LIG_FHA_1	221	227	PF00498	0.542
LIG_FHA_1	270	276	PF00498	0.480
LIG_FHA_1	279	285	PF00498	0.296
LIG_FHA_1	287	293	PF00498	0.416
LIG_FHA_1	352	358	PF00498	0.353
LIG_FHA_1	375	381	PF00498	0.271
LIG_FHA_1	386	392	PF00498	0.281
LIG_FHA_1	49	55	PF00498	0.623
LIG_FHA_2	7	13	PF00498	0.747
LIG_FHA_2	91	97	PF00498	0.600
LIG_IBAR_NPY_1	245	247	PF08397	0.506
LIG_LIR_Apic_2	164	168	PF02991	0.621
LIG_LIR_Apic_2	359	364	PF02991	0.394
LIG_LIR_Gen_1	129	140	PF02991	0.630
LIG_LIR_Gen_1	18	26	PF02991	0.629
LIG_LIR_Gen_1	281	290	PF02991	0.419
LIG_LIR_Gen_1	39	50	PF02991	0.622
LIG_LIR_Nem_3	129	135	PF02991	0.717
LIG_LIR_Nem_3	18	22	PF02991	0.630
LIG_LIR_Nem_3	240	244	PF02991	0.537
LIG_LIR_Nem_3	250	255	PF02991	0.583
LIG_LIR_Nem_3	259	265	PF02991	0.485
LIG_LIR_Nem_3	281	285	PF02991	0.410
LIG_LIR_Nem_3	327	333	PF02991	0.409
LIG_LIR_Nem_3	349	353	PF02991	0.355
LIG_LIR_Nem_3	39	45	PF02991	0.621
LIG_LIR_Nem_3	408	413	PF02991	0.424
LIG_LIR_Nem_3	75	79	PF02991	0.621
LIG_NRBOX	287	293	PF00104	0.259
LIG_PCNA_yPIPBox_3	326	340	PF02747	0.330
LIG_Pex14_1	395	399	PF04695	0.330
LIG_REV1ctd_RIR_1	97	106	PF16727	0.633
LIG_SH2_CRK	293	297	PF00017	0.282
LIG_SH2_NCK_1	79	83	PF00017	0.575
LIG_SH2_STAP1	187	191	PF00017	0.613
LIG_SH2_STAP1	256	260	PF00017	0.511
LIG_SH2_STAP1	276	280	PF00017	0.164
LIG_SH2_STAP1	293	297	PF00017	0.282
LIG_SH2_STAT3	455	458	PF00017	0.276
LIG_SH2_STAT5	187	190	PF00017	0.632
LIG_SH2_STAT5	247	250	PF00017	0.598
LIG_SH2_STAT5	256	259	PF00017	0.553
LIG_SH2_STAT5	293	296	PF00017	0.304
LIG_SH2_STAT5	366	369	PF00017	0.296
LIG_SH2_STAT5	379	382	PF00017	0.416
LIG_SH2_STAT5	448	451	PF00017	0.431
LIG_SH2_STAT5	455	458	PF00017	0.353
LIG_SH2_STAT5	490	493	PF00017	0.389
LIG_SH3_3	143	149	PF00018	0.623
LIG_SH3_3	175	181	PF00018	0.670
LIG_SH3_3	40	46	PF00018	0.744
LIG_SH3_3	82	88	PF00018	0.654
LIG_Sin3_3	382	389	PF02671	0.249
LIG_SUMO_SIM_anti_2	381	388	PF11976	0.330
LIG_SUMO_SIM_anti_2	424	429	PF11976	0.479
LIG_SUMO_SIM_par_1	381	388	PF11976	0.332
LIG_TYR_ITIM	291	296	PF00017	0.330
LIG_WRC_WIRS_1	279	284	PF05994	0.290
LIG_WRC_WIRS_1	358	363	PF05994	0.368
LIG_WW_1	363	366	PF00397	0.330
MOD_CDK_SPK_2	174	179	PF00069	0.656
MOD_CK1_1	124	130	PF00069	0.812
MOD_CK1_1	335	341	PF00069	0.532
MOD_CK1_1	434	440	PF00069	0.261
MOD_CK1_1	68	74	PF00069	0.759
MOD_CK2_1	15	21	PF00069	0.696
MOD_CK2_1	77	83	PF00069	0.660
MOD_CK2_1	90	96	PF00069	0.669
MOD_Cter_Amidation	197	200	PF01082	0.383
MOD_GlcNHglycan	123	126	PF01048	0.492
MOD_GlcNHglycan	149	152	PF01048	0.611
MOD_GlcNHglycan	168	171	PF01048	0.523
MOD_GlcNHglycan	326	329	PF01048	0.360
MOD_GlcNHglycan	415	418	PF01048	0.332
MOD_GlcNHglycan	433	436	PF01048	0.484
MOD_GlcNHglycan	449	452	PF01048	0.278
MOD_GlcNHglycan	67	70	PF01048	0.450
MOD_GlcNHglycan	80	83	PF01048	0.391
MOD_GSK3_1	121	128	PF00069	0.731
MOD_GSK3_1	154	161	PF00069	0.710
MOD_GSK3_1	183	190	PF00069	0.788
MOD_GSK3_1	274	281	PF00069	0.330
MOD_GSK3_1	291	298	PF00069	0.283
MOD_GSK3_1	302	309	PF00069	0.272
MOD_GSK3_1	374	381	PF00069	0.282
MOD_N-GLC_1	269	274	PF02516	0.337
MOD_N-GLC_1	48	53	PF02516	0.409
MOD_NEK2_1	140	145	PF00069	0.638
MOD_NEK2_1	226	231	PF00069	0.463
MOD_NEK2_1	286	291	PF00069	0.330
MOD_NEK2_1	292	297	PF00069	0.318
MOD_NEK2_1	306	311	PF00069	0.164
MOD_NEK2_1	324	329	PF00069	0.350
MOD_NEK2_1	332	337	PF00069	0.515
MOD_NEK2_1	356	361	PF00069	0.403
MOD_NEK2_1	378	383	PF00069	0.286
MOD_NEK2_1	384	389	PF00069	0.362
MOD_NEK2_1	413	418	PF00069	0.332
MOD_NEK2_1	447	452	PF00069	0.485
MOD_NEK2_1	454	459	PF00069	0.355
MOD_NEK2_1	480	485	PF00069	0.341
MOD_NEK2_2	114	119	PF00069	0.648
MOD_PIKK_1	103	109	PF00454	0.657
MOD_PIKK_1	454	460	PF00454	0.249
MOD_PKA_1	200	206	PF00069	0.608
MOD_PKA_2	15	21	PF00069	0.621
MOD_PKA_2	200	206	PF00069	0.625
MOD_PKA_2	226	232	PF00069	0.441
MOD_PKA_2	306	312	PF00069	0.222
MOD_PKA_2	405	411	PF00069	0.537
MOD_PKA_2	56	62	PF00069	0.783
MOD_Plk_1	269	275	PF00069	0.510
MOD_Plk_1	36	42	PF00069	0.671
MOD_Plk_1	6	12	PF00069	0.620
MOD_Plk_2-3	105	111	PF00069	0.644
MOD_Plk_4	261	267	PF00069	0.578
MOD_Plk_4	278	284	PF00069	0.237
MOD_Plk_4	292	298	PF00069	0.290
MOD_Plk_4	317	323	PF00069	0.402
MOD_Plk_4	357	363	PF00069	0.335
MOD_Plk_4	405	411	PF00069	0.469
MOD_Plk_4	434	440	PF00069	0.316
MOD_Plk_4	492	498	PF00069	0.314
MOD_ProDKin_1	145	151	PF00069	0.679
MOD_ProDKin_1	174	180	PF00069	0.690
MOD_ProDKin_1	84	90	PF00069	0.653
MOD_SUMO_for_1	101	104	PF00179	0.632
TRG_DiLeu_BaEn_2	95	101	PF01217	0.652
TRG_ENDOCYTIC_2	252	255	PF00928	0.494
TRG_ENDOCYTIC_2	276	279	PF00928	0.298
TRG_ENDOCYTIC_2	293	296	PF00928	0.282
TRG_ENDOCYTIC_2	313	316	PF00928	0.385
TRG_ENDOCYTIC_2	330	333	PF00928	0.466
TRG_ENDOCYTIC_2	366	369	PF00928	0.335
TRG_ER_diArg_1	15	17	PF00400	0.615
TRG_ER_diArg_1	200	202	PF00400	0.668
TRG_ER_diArg_1	248	251	PF00400	0.467
TRG_NLS_MonoExtN_4	196	203	PF00514	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEB9	Leptomonas seymouri	50%	94%
A0A3S7XBT4	Leishmania donovani	37%	100%
A0A3S7XC05	Leishmania donovani	38%	100%
A4HQ64	Leishmania braziliensis	67%	99%
A4HQ67	Leishmania braziliensis	35%	100%
A4HQ68	Leishmania braziliensis	39%	100%
A4IDW4	Leishmania infantum	37%	100%
A4IDW5	Leishmania infantum	99%	100%
A4IDW6	Leishmania infantum	38%	100%
D0A451	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9ATY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9ATY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	98%
E9ATY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
Q07959	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	94%
Q4Q0K9	Leishmania major	38%	100%
Q4Q0L0	Leishmania major	89%	100%
Q4Q0L1	Leishmania major	37%	100%
Q75F81	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	25%	100%